摘要:
This invention relates three dimensional porous cell culture matrices or scaffolds which have directional porous structure. More particularly, this invention relates to three dimensional porous cell culture matrices or scaffolds for cell culture which are derived from or contain gums including naturally occurring gums, plant gums, galactomannan gums or derivatives thereof. The invention also relates to methods of making the matrices, articles of manufacture (e.g., cell culture vessels and labware) having such matrices or scaffolds, methods of applying these materials to cell culture surfaces, and methods of using cell culture vessels having these three dimensional porous cell culture matrices or scaffolds.
摘要:
Disclosed are compositions and methods related to modulation of KATP channels and methods of treating liver disorders by modulating KATP and mito-KATP channels.
摘要:
This invention relates to coatings for cell culture surfaces. More particularly, this invention relates to coatings for cell culture surfaces which are derived from or contain gums including naturally occurring gums, plant gums, galactomannan gums or derivatives thereof. The invention also relates to articles of manufacture (e.g., cell culture vessels and labware) having such coatings, methods of applying these coatings to cell culture surfaces, and methods of using coated cell culture vessel.
摘要:
The disclosure provides methods for characterizing the toxicity of a candidate molecule to liver cells as defined herein; methods of culturing metabolically active liver cells on a biosensor as defined herein; and biosensor liver culture systems as defined herein.
摘要:
Disclosed are compounds having structural formula (I, II) or a pharmaceutically acceptable sale, solvate, clathrate, or prodrug thereof, wherein R1, R2, R3, R6, R5, and R4 are defined herein. These compounds can be useful as therapeutic agents for modulating hERG ion channels, and for improving prevention and treatment of hERG associated cardiac repolarization disorders.
摘要:
An article for culturing cells includes a substrate on which cells can be cultured. The substrate has a base surface. An array of projections extends from the base surface. The projections have a height of about 1 micrometer to about 100 micrometers, and have a gap distance along the major surface from center to center between neighboring projections of about 10 micrometers to 80 micrometers. A plurality of arrays of projections may extend from the surface with gaps in the base surface between the arrays. Hepatocytes cultures on such microprojection array substrates maintained in vivo like morphology and membrane polarity. Hepatocytes co-cultured with helper cells on such substrates tended to grow in the area of the arrays, while the helper cells tended to grow in the areas between the arrays.
摘要:
A prism sheet (10) includes a substrate (12) and a plurality of prism structures (14). The substrate includes a plurality of diffusing particles (122) dispersed therein. The prism structures are at a light output side of the substrate. The diffusing particles can diffuse light beams traveling through the substrate. This configuration performs the same function as that of a diffusing sheet of a conventional backlight module. The prism structures can gather light beams to improve a brightness of a backlight module (6) incorporating the prism sheet. Thus, the backlight module can provide bright and uniform light at a low cost and while having a reduced thickness.
摘要:
A prism sheet (10) includes a substrate (12) and a plurality of prism structures (14). The substrate includes a plurality of diffusing particles (122) dispersed therein. The prism structures are at a light output side of the substrate. The diffusing particles can diffuse light beams traveling through the substrate. This configuration performs the same function as that of a diffusing sheet of a conventional backlight module. The prism structures can gather light beams to improve a brightness of a backlight module (6) incorporating the prism sheet. Thus, the backlight module can provide bright and uniform light at a low cost and while having a reduced thickness.