摘要:
The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a thioredoxin-like 32 kDa protein (TXNL) as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.
摘要:
The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize an adenosine kinase as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.
摘要:
A tube fitting for a tube end has a female threaded member that cooperates with a male threaded member. The female member includes a tube gripping device in the form of a gripping ring or ferrule that is attached to the female member by a frangible web. Upon a partial pull-up the ferrule engages a camming surface on the male threaded member and breaks off or separates from the female threaded member to become a separate piece so that the fitting then functions as a single ferrule tube fitting. Additional features include a steep camming angle on the camming surface to cause the ferrule to grip the tube end with a bite-type action and to form a primary seal between the camming surface and a front end of the separated ferrule. The ferrule front end, and optionally the entire female threaded member including the initially integral tube gripping device, are hardened to be at least about 3.3 times harder than the material of the tube end.
摘要:
The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a CLLD8 protein as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.
摘要:
A composite wheel assembly includes a wheel having an outboard surface and a wheel ornamentation disposed over the outboard surface. The wheel ornamentation has a plurality of vent openings and a plurality of lug stud holes. The composite wheel assembly also includes an adhesive disposed between the wheel ornamentation and the wheel around each of the vent openings. The composite wheel assembly further includes at least one seal comprising an o-ring disposed between the wheel ornamentation and the wheel about at least one of the lug stud holes to prevent contaminants from entering the assembly between the wheel ornamentation and the wheel.
摘要:
A tube fitting for a tube end has a female member that cooperates with a male member. A tube gripping device in the form of a gripping ring or ferrule is retained with the female member. Upon a partial pull-up, the tube gripping device separates from the female member.
摘要:
The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a BAP-37 as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.
摘要:
The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a chloride intracellular channel 1 (CLIC1) as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.
摘要:
A seal (10) includes a seal structure (130) for engagement with first (24) and second fluid components (26) in first (84) and second counterbores (88). The seal also includes a holding plate (20, 30) structure for engagement with first (81) and second surfaces (85) of the components. The holding plate structure includes one or more layers that are preferably formed with the outer layers of the seal structure (30). The seal structure preferably includes at least three abutting layers of metal, the inner layer (70) having a hardness that is selected to be greater than the hardness of the first and second outer layers (20, 30). The invention also relates to a method of achieving a metal to metal seal between two relatively hard metal components in a fluid System.
摘要:
The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a BAP-37 as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.