公开(公告)号：US4677110A

公开(公告)日：1987-06-30

申请号：US741134

申请日：1985-06-04

申请人： Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi ,  Hiroshi Okada

发明人： Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi ,  Hiroshi Okada

IPC分类号： A61K31/17 ,  A61K31/505 ,  A61P35/00 ,  C07D239/34 ,  C07D239/30

CPC分类号： C07D239/34

摘要： N-benzoyl-N'-pyrimidinyloxyphenyl urea compounds having the formula: ##STR1## wherein X represents a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group and Z represents a hydrogen atom or a halogen atom, are useful as active ingredients of antitumorous compositions.

摘要翻译： 具有下式的N-苯甲酰基-N'-嘧啶氧基苯基脲化合物：其中X表示氢原子，卤素原子，硝基或三氟甲基，Z表示氢原子或卤素原子，可用作活性 抗肿瘤成分的成分。

公开(公告)号：US5102884A

公开(公告)日：1992-04-07

申请号：US554449

申请日：1990-07-19

申请人： Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi ,  Hiroshi Okada

发明人： Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi ,  Hiroshi Okada

IPC分类号： A61K31/505 ,  C07C237/42 ,  C07C275/46 ,  C07C311/31 ,  C07D239/34 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

CPC分类号： C07D239/34 ,  C07C237/42 ,  C07C311/31

摘要： A substituted benzoylurea compound of the formula (I): ##STR1## wherein R.sup.1 is a hydrogen atom, a halogen atom or a nitro group, each of R.sup.2 and R.sup.3 is a hydrogen atom, an alkyl group, --COR.sup.6 (wherein R.sup.6 is an alkyl group or an alkoxy group) or --SO.sub.2 R.sup.6 (wherein R.sup.6 is as defined above), or R.sup.2 and R.sup.3 may form together with the adjacent nitrogen atom a heterocyclic ring, R.sup.4 is a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted alkylthio group or a nitro group, and R.sup.5 is a halogen atom, a nitro group or a substituted or unsubstituted alkyl group, or its salt.

公开(公告)号：US4987135A

公开(公告)日：1991-01-22

申请号：US324559

申请日：1989-03-16

申请人： Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi ,  Hiroshi Okada

发明人： Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi ,  Hiroshi Okada

IPC分类号： C07D295/12 ,  A61K31/50 ,  A61K31/505 ,  A61P35/00 ,  C07C257/08 ,  C07C275/54 ,  C07C313/34 ,  C07C323/44 ,  C07C327/58 ,  C07C329/04 ,  C07C381/04 ,  C07C381/08 ,  C07D213/64 ,  C07D213/81 ,  C07D237/14 ,  C07D239/34 ,  C07D295/155 ,  C07D401/12 ,  C07F9/24 ,  C07F9/6512

CPC分类号： C07D213/64 ,  C07C257/08 ,  C07C327/58 ,  C07D237/14 ,  C07D239/34 ,  C07D295/155 ,  C07D401/12 ,  C07F9/65127 ,  C07C2101/08 ,  C07C2101/14

摘要： A substituted benzene derivative represented by a formula: ##STR1## where A represents: ##STR2## wherein X is a hydrogen atom, a halogen atom or a nitro group, R.sup.1 is --X.sup.1 Z.sup.1 (X.sup.1 is an oxygen atom or a sulfur atom and Z.sup.1 is a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group), --COZ.sup.1 group (Z.sup.1 is as defined above), ##STR3## group (Z.sup.1 is as defined above, Z.sup.2 is --CO.sub.2 Z.sup.3 wherein Z.sup.3 is the same as Z.sup.1, or --SO.sub.2 Z.sup.3 wherein Z.sup.3 is as defined above and n is 0 or 1), ##STR4## (Z.sup.1 and Z.sup.3 are as defined above) or ##STR5## (X.sup.2, X.sup.3 and X.sup.4 are, respectively, an oxygen atom or a sulfur atom and Z.sup.4 and Z.sup.5 are the same as Z.sup.1), and R.sup.3 is a nitro group or ##STR6## (R.sup.4 and R.sup.5 are, respectively, an alkyl group, or they may form a heterocyclic group together with the adjacent nitrogen atom), or ##STR7## wherein X and R.sup.3 are as defined above and R.sup.2 is --X.sup.1 Z.sup.1 (X.sup.1 and Z.sup.1 are as defined above); Y is a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted alkylthio group, a nitro group or ##STR8## (R.sup.6 and R.sup.7 are, respectively, a substituted or unsubstituted alkyl group); R is ##STR9## (R.sup.8 is the same as Y and q is an integer of 1 to 4), ##STR10## (R.sup.8 is as defined above, and r is an integer of 1 to 3) or ##STR11## (R.sup.8 and r are defined above); and m is an integer, of 1 to 4, or its salt.

公开(公告)号：US5256674A

公开(公告)日：1993-10-26

申请号：US631992

申请日：1990-12-21

申请人： Takahiro Haga ,  Tadaaki Toki ,  Toru Koyanagi ,  Masato Omatsu ,  Hiroshi Sasaki ,  Masayuki Morita ,  Kiyomitsu Yoshida

发明人： Takahiro Haga ,  Tadaaki Toki ,  Toru Koyanagi ,  Masato Omatsu ,  Hiroshi Sasaki ,  Masayuki Morita ,  Kiyomitsu Yoshida

IPC分类号： A01N43/50 ,  A01N55/10 ,  A01P7/04 ,  C07D401/06 ,  C07D401/14 ,  C07D417/06 ,  C07D417/14 ,  C07F7/08 ,  C07F7/10 ,  C07F7/12 ,  A01N43/40

CPC分类号： C07D401/06 ,  C07D401/14 ,  C07D417/06

摘要： An imidazolidine derivative having the formula (I) or its salt: ##STR1## wherein X is an alkyl group which may be substituted, an alkenyl group which may be substituted, an alkynyl group which may be substituted, ##STR2## (in which each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 is independently a hydrogen atom or an alkyl group, R.sup.5 is an alkyl group which may be substituted with a halogen atom, a cycloalkyl group which may be substituted or a phenyl group which may be substituted, W is an oxygen atom or a sulfur atom, and each of k, l, m and n is independently 0 or 1, provided that (a) case where all of k, l and m are 0 at the same time and (b) case where m and n are 0 at the same time and R.sup.5 is an alkyl group which may be substituted with a halogen atom, are excluded), or ##STR3## group (in which each of R.sup.6 and R.sup.7 is independently a hydrogen atom or an alkyl group, each of R.sup.8 and R.sup.9 is independently an alkyl gorup, R.sup.10 is an alkyl group which may be substituted, an aryl group which may be substituted, a pyridyl group which may be substituted, an alkenyl group which may be substituted with a halogen atom or an alkynyl group which may be substituted with a halogen atom); Y is a 6-chloro-3-pyridyl group or a 2-chloro-5-thiazolyl group; Z is a hydrogen atom, an alkyl group or an acyl group; and j is an integer of from 0 to 2.

公开(公告)号：US4327089A

公开(公告)日：1982-04-27

申请号：US215777

申请日：1980-12-12

申请人： Takahiro Haga ,  Tadaaki Toki ,  Toru Koyanagi ,  Osamu Imai

发明人： Takahiro Haga ,  Tadaaki Toki ,  Toru Koyanagi ,  Osamu Imai

IPC分类号： A01N57/16 ,  A01N57/08 ,  A01N57/24 ,  C07D213/78 ,  C07F9/58

CPC分类号： C07D213/78 ,  A01N57/08 ,  C07F9/582

摘要： A novel O-(N-alkoxy-pyridinecarboximidoyl)-phosphate represented by the following formula: ##STR1## wherein X is a halogen atom, a lower alkyl group, a lower acyloxy group, a trifluoromethyl group or a nitro group; Y is an oxygen atom or a sulfur atom; R is a lower alkyl group; n is an integer of 0 to 3; and Z.sub.1 and Z.sub.2 are each a lower alkoxy group, a lower alkylthio group, a phenyl group which may be substituted by a lower alkyl group, a phenoxy group, a haloalkoxy group or a lower alkylamino group, useful as an active ingredient of insecticides or acaricides.

摘要翻译： 由下式表示的新型O-（N-烷氧基 - 吡啶甲酰亚胺基） - 磷酸酯：其中X为卤素原子，低级烷基，低级酰氧基，三氟甲基或硝基; Y是氧原子或硫原子; R是低级烷基; n为0〜3的整数， 并且Z 1和Z 2各自为低级烷氧基，低级烷硫基，可被低级烷基取代的苯基，苯氧基，卤代烷氧基或低级烷基氨基，可用作杀虫剂的活性成分或 杀螨剂

公开(公告)号：US4783451A

公开(公告)日：1988-11-08

申请号：US878266

申请日：1986-06-25

申请人： Takahiro Haga ,  Tadaaki Toki ,  Toru Koyanagi ,  Hiroshi Okada ,  Kiyomitsu Yoshida ,  Osamu Imai

发明人： Takahiro Haga ,  Tadaaki Toki ,  Toru Koyanagi ,  Hiroshi Okada ,  Kiyomitsu Yoshida ,  Osamu Imai

IPC分类号： A01N57/32 ,  C07F9/553 ,  C07F9/572 ,  C07F9/59 ,  C07F9/6503 ,  C07F9/653 ,  C07F9/6533 ,  C07F9/6539 ,  C07F9/6544 ,  C07F9/6558 ,  C07F9/40

CPC分类号： C07F9/5721 ,  A01N57/32 ,  C07F9/5532 ,  C07F9/591 ,  C07F9/65032 ,  C07F9/653 ,  C07F9/6533 ,  C07F9/6539 ,  C07F9/6544 ,  C07F9/65586

摘要： An organophosphorus compound having the formula: ##STR1## wherein X is ##STR2## Z is an oxygen atom or a sulfur atom, and each of R.sub.1 and R.sub.2 is an alkyl group which may be substituted by halogen, alkoxy or alkylthio. The compound is useful as an insecticide, miticide, nematicide or soil pesticide.

摘要翻译： 具有下式的有机磷化合物：其中X是氧原子或硫原子，R 1和R 2各自是烷基 其可以被卤素，烷氧基或烷硫基取代。 该化合物可用作杀虫剂，杀螨剂，杀线虫剂或土壤农药。

公开(公告)号：US4985449A

公开(公告)日：1991-01-15

申请号：US365607

申请日：1989-06-13

申请人： Takahiro Haga ,  Tadaaki Toki ,  Toru Koyanagi ,  Yasuhiro Fujii ,  Kiyomitsu Yoshida ,  Osamu Imai

发明人： Takahiro Haga ,  Tadaaki Toki ,  Toru Koyanagi ,  Yasuhiro Fujii ,  Kiyomitsu Yoshida ,  Osamu Imai

IPC分类号： A01N43/40 ,  A01N47/34 ,  A01N47/36 ,  A01P7/04 ,  C07C275/54 ,  C07D213/64 ,  C07D213/643 ,  C07D213/70 ,  C07D213/74 ,  C07D213/75 ,  C07D333/38

CPC分类号： C07D213/643 ,  A01N47/34 ,  A01N47/36 ,  C07C275/54 ,  C07D213/70 ,  C07D213/74 ,  C07D213/75 ,  C07D333/38

摘要： A benzoylurea compound having the formula: ##STR1## wherein each of X.sub.1 and X.sub.2 is a hydrogen atom, a halogen atom or a methyl group, provided that X.sub.1 and X.sub.2 are not simultanously hydrogen atoms, Y is independently a hydrogen atom, a halogen atom, an alkyl group which may be substituted by halogen, a --CO.sub.2 R.sub.1 group wherein R.sub.1 is a hydrogen atom, a cation or an alkyl group, or a --OR.sub.1 group wherein R.sub.1 is as defined above, A.sub.1 is .dbd.N-- or ##STR2## wherein Y is as defined above, W is an oxygen atom, a sulfur atom or ##STR3## wherein R.sub.1 is as defined above, k is an integer of from 1 to 3, l is 0 or 1, and Ar is ##STR4## wherein Z is independently a hydrogen atom, a halogen atom, an alkyl group which may be substituted by halogen, an alkoxy group which may be substituted by halogen, a nitro group, a cyano group or a --S(O).sub.n R.sub.2 group wherein R.sub.2 is an alkyl group which may be substituted by halogen and n is 0, 1 or 2, A.sub.2 is --S--, ##STR5## wherein Z is as defined above, or ##STR6## wherein Z is as defined above, and m is an integer of from 1 to 3, or a salt thereof.

公开(公告)号：US4861886A

公开(公告)日：1989-08-29

申请号：US215532

申请日：1988-07-06

申请人： Takahiro Haga ,  Itaru Shigehara ,  Toru Koyanagi ,  Kazutoshi Hara ,  Masaru Maeda

发明人： Takahiro Haga ,  Itaru Shigehara ,  Toru Koyanagi ,  Kazutoshi Hara ,  Masaru Maeda

IPC分类号： C07D497/20

CPC分类号： C07D497/20

摘要： A method for isomerization of trans-form 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine or acid addition salts thereof, which comprises isomerizing said trans-form quinuclidine or acid addition salts thereof to cis-form 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine or acid addition salts thereof in the presence of at least one acid catalyst selected from the group consisting of an organic sulfuric acid, a halide functioning as a Lewis acid, and sulfuric acid.

公开(公告)号：US4645761A

公开(公告)日：1987-02-24

申请号：US810266

申请日：1985-12-18

申请人： Takahiro Haga ,  Tadaaki Toki ,  Toru Koyanagi ,  Hiroshi Okada ,  Kiyomitsu Yoshida ,  Osamu Imai

发明人： Takahiro Haga ,  Tadaaki Toki ,  Toru Koyanagi ,  Hiroshi Okada ,  Kiyomitsu Yoshida ,  Osamu Imai

IPC分类号： A01N57/32 ,  A01P5/00 ,  A01P7/02 ,  A01P7/04 ,  C07F9/547 ,  C07F9/59 ,  C07F9/6506 ,  A01N57/08 ,  C07F9/65

CPC分类号： C07F9/65061 ,  A01N57/32

摘要： An organophosphorus compound having the formula: ##STR1## wherein each of X.sub.1, X.sub.2 and X.sub.3 is a hydrogen atom; an alkyl, alkoxy or alkenyl group which may be substituted by halogen, alkoxy, alkylthio, cycloalkyl or phenyl; a phenyl group which may be substituted by halogen; or a cycloalkyl group, each of Y.sub.1, Y.sub.2 and Y.sub.3 is an oxygen atom or a sulfur atom, Z is a carbonyl group; or a methylene group which may be substituted by a cycloalkyl group, by a phenyl group which may be substituted by halogen, or by an alkyl, alkoxy or alkenyl group which may be substituted by halogen, alkoxy alkylthio, cycloalkyl or phenyl, and each of R.sub.1 and R.sub.2 is an alkyl group which may be substituted by halogen, alkoxy or alkylthio.

摘要翻译： 具有下式的有机磷化合物：其中X1，X2和X3各自为氢原子; 可被卤素，烷氧基，烷硫基，环烷基或苯基取代的烷基，烷氧基或烯基; 可被卤素取代的苯基; 或环烷基，Y1，Y2和Y3各自为氧原子或硫原子，Z为羰基; 或可以被环烷基取代的亚甲基，被卤素取代的苯基，或被卤素，烷氧基烷硫基，环烷基或苯基取代的烷基，烷氧基或烯基，以及 R1和R2是可被卤素，烷氧基或烷硫基取代的烷基。

公开(公告)号：US4590182A

公开(公告)日：1986-05-20

申请号：US668938

申请日：1984-11-07

申请人： Takahiro Haga ,  Tadaaki Toki ,  Toru Koyanagi ,  Hiroshi Okada ,  Kiyomitsu Yoshida ,  Osamu Imai

发明人： Takahiro Haga ,  Tadaaki Toki ,  Toru Koyanagi ,  Hiroshi Okada ,  Kiyomitsu Yoshida ,  Osamu Imai

IPC分类号： A01N57/16 ,  A01N57/32 ,  C07F9/653 ,  C07F9/6536 ,  C07F9/6539 ,  C07F9/6541 ,  C07F9/65

CPC分类号： A01N57/32 ,  C07F9/653 ,  C07F9/6539 ,  C07F9/6541

摘要： An organophosphorus compound represented by the general formula: ##STR1## where each of X.sub.1 and X.sub.3 is a hydrogen atom; an alkyl or alkoxy group which may be substituted by halogen, alkoxy, alkylthio, phenoxy, halogenated phenoxy, phenylthio or halogenated phenylthio; a carboxyl group; an alkoxycarbonyl group; or a phenyl group which may be substituted by halogen, each of X.sub.2 and X.sub.4 is a hydrogen atom or an alkyl group, provided that X.sub.2 and X.sub.3 may together form an alkylene group, each of Y.sub.1, Y.sub.2 and Z is an oxygen atom or a sulfur atom, and each of R.sub.1 and R.sub.2 is an alkyl group.

摘要翻译： 由以下通式表示的有机磷化合物：其中X1和X3各自为氢原子; 可被卤素，烷氧基，烷硫基，苯氧基，卤代苯氧基，苯硫基或卤代苯硫基取代的烷基或烷氧基; 羧基; 烷氧基羰基; 或可被卤素取代的苯基，X 2和X 4各自为氢原子或烷基，条件是X 2和X 3可以一起形成亚烷基，Y 1，Y 2和Z各自为氧原子或 硫原子，R1和R2各自为烷基。