公开(公告)号：US20170045514A1

公开(公告)日：2017-02-16

申请号：US15223365

申请日：2016-07-29

申请人： Nongjian Tao ,  Karan Syal

发明人： Nongjian Tao ,  Karan Syal

IPC分类号： G01N33/569 ,  G06T7/00

CPC分类号： G01N33/56916 ,  G01N33/54373 ,  G01N33/56911

摘要： A rapid antibiotic susceptibility test (AST) based on the detection and quantification of the movement of single bacterial cells with a plasmonic imaging and tracking (PIT) technology. The PIT-based AST detects changes in the metabolic activity of the bacterial cells long before cell replication, and allows rapid AST for both cultivable and non-cultivable strains. PIT tracks 3D movement with sub-nanometer resolution and millisecond temporal resolution. PIT also allows simultaneous measurement of the binding kinetic constants of antibiotics and bacterial metabolic state after the introduction of antibiotics.

摘要翻译： 基于用等离子体成像和跟踪（PIT）技术检测和定量单细菌细胞运动的快速抗生素敏感性试验（AST）。 基于PIT的AST可以在细胞复制前长时间检测细菌细胞代谢活动的变化，并允许可培养和不可培养菌株的快速AST。 PIT跟踪亚纳米分辨率和毫秒时间分辨率的3D运动。 PIT还允许在引入抗生素后同时测量抗生素的结合动力学常数和细菌代谢状态。

公开(公告)号：US20160169873A1

公开(公告)日：2016-06-16

申请号：US14968331

申请日：2015-12-14

申请人： Nongjian Tao ,  Yan Guan

发明人： Nongjian Tao ,  Yan Guan

IPC分类号： G01N33/53 ,  G01N21/77 ,  G01N33/566

CPC分类号： G01N21/77 ,  G01N33/5008 ,  G02B21/365

摘要： A system for quantitative detection and analysis of the interactions of molecules with molecular receptors on the surfaces of biological cells based on detecting a mechanical deformation in the membrane of a cell associated with the molecular interactions, which works for both large and small molecules. The mechanical deformation can be detected with high precision in real time from an optical image of the cell with a differential detection method. The system can be also used to detect the electrical activities, such as ion channel opening and closing, as well as action potential propagation in neuronal cells.

摘要翻译： 基于检测与分子相互作用的细胞的膜中的机械变形，其用于大分子和小分子的作用，用于定量检测和分析分子与生物细胞表面上的分子受体的相互作用的系统。 利用微分检测方法可以从单元的光学图像实时地高精度地检测机械变形。 该系统还可用于检测电活动，如离子通道的开启和关闭，以及神经细胞中的动作电位传播。

公开(公告)号：US20160042529A1

公开(公告)日：2016-02-11

申请号：US14823364

申请日：2015-08-11

申请人： Nongjian Tao ,  Yuting Yang

发明人： Nongjian Tao ,  Yuting Yang

IPC分类号： G06T7/20 ,  G06T5/50 ,  G06K9/62 ,  G06T5/40

CPC分类号： G06K9/6202 ,  G06K9/00342 ,  G06T7/20 ,  G06T2207/30196 ,  G06T2207/30221

摘要： Systems and methods for tracking and analysis physical activity is disclosed. In some aspects, a provided method includes receiving a time sequence of images captured while with an individual is performing the physical activity, and generating, using the time sequence of images, at least one map indicating a movement of the individual. The method also includes identifying at least one body portion using the at least one map, and computing at least one index associated with the identified body portions to characterize the physical activity of the individual. The method further includes generating a report using the at least one index.

摘要翻译： 公开了用于跟踪和分析身体活动的系统和方法。 在一些方面，所提供的方法包括：接收个体所捕获的图像的时间序列，同时个体正在执行身体活动，并且使用图像的时间序列生成指示个体移动的至少一个地图。 所述方法还包括使用所述至少一个地图来识别至少一个身体部位，以及计算与所识别的身体部分相关联的至少一个索引以表征个体的身体活动。 该方法还包括使用至少一个索引生成报告。

公开(公告)号：US20140131223A1

公开(公告)日：2014-05-15

申请号：US14160035

申请日：2014-01-21

申请人： Nongjian Tao ,  Erica Forzani ,  Rodrigo A. Iglesias

发明人： Nongjian Tao ,  Erica Forzani ,  Rodrigo A. Iglesias

IPC分类号： G01N27/27

CPC分类号： G01N27/27 ,  G01N21/05 ,  G01N21/783 ,  G01N31/223 ,  G01N33/0037 ,  Y02A50/245 ,  Y10T436/173845

摘要： A gas-phase detection system based on detecting optochemical and optoelectrochemical signals. The sensing platform is particularly powerful for detection of nitrogen oxides at low ppbV concentrations. The optochemical analysis is based on the color development due to a chemical reaction taking place in an optimized material. The electrochemical analysis can be based on the doping level or redox potential changes of an electrochemical sensor; and optoelectrochemical detection can be based on a combination of the electrochemical and optoelectrochemical methodologies. Each independent signal can be simultaneously detected, increasing the reliability of detection.

摘要翻译： 一种基于光电化学和光电信号检测的气相检测系统。 传感平台对于检测低ppbV浓度的氮氧化物特别强大。 光化学分析是由于化学反应发生在优化材料中的颜色发展。 电化学分析可以基于电化学传感器的掺杂水平或氧化还原电位变化; 光电化学检测可以基于电化学和光电化学方法的组合。 可以同时检测每个独立信号，提高检测的可靠性。

公开(公告)号：US08545683B2

公开(公告)日：2013-10-01

申请号：US13063499

申请日：2009-09-11

申请人： Nongjian Tao ,  Erica Forzani ,  Alvaro Diaz Aguilar

发明人： Nongjian Tao ,  Erica Forzani ,  Alvaro Diaz Aguilar

IPC分类号： G01N27/416

CPC分类号： G01N27/4145 ,  G01N21/25 ,  G01N21/552 ,  G01N21/64

摘要： An integrated sensor is capable of detecting analytes using electrochemical (EC), electrical (E), and optical (O) signals or EC and O signals. The sensor introduces synergetic new capabilities and enhances the sensitivity and selectivity for real-time detection of an analyte in complex matrices, including the presence of high concentration of interferences in liquids and in gas phases.

摘要翻译： 集成传感器能够使用电化学（EC），电（E）和光（O）信号或EC和O信号来检测分析物。 该传感器引入了协同的新功能，并增强了对复杂基质中分析物的实时检测的灵敏度和选择性，包​​括在液体和气相中存在高浓度的干扰。

公开(公告)号：US20130239655A1

公开(公告)日：2013-09-19

申请号：US13877486

申请日：2011-10-03

申请人： Nongjian Tao ,  Francis Tsow ,  Ananti Rai

发明人： Nongjian Tao ,  Francis Tsow ,  Ananti Rai

IPC分类号： G01N33/497

CPC分类号： G01N33/497 ,  A61B5/083 ,  A61B5/087

摘要： The present invention describes a device and method for measuring flow rate from air flow using acoustic resonance. It is shown that the device can be used to measure breath flow rate and biomarker concentration within human breath.

摘要翻译： 本发明描述了一种用于使用声共振测量来自气流的流量的装置和方法。 显示该装置可用于测量人体呼吸中的呼吸流速和生物标志物浓度。

公开(公告)号：US20130115137A1

公开(公告)日：2013-05-09

申请号：US13695883

申请日：2011-05-04

申请人： Nongjian Tao ,  Erica Forzani

发明人： Nongjian Tao ,  Erica Forzani

IPC分类号： G01N5/02

CPC分类号： G01N5/02 ,  G01N29/022 ,  G01N29/036 ,  G01N35/1097 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0427

摘要： A method and apparatus including: 1) Synthesis of a sensing material with high density of binding sites and excellent selectivity for toxic hydrocarbons and acid vapors; 2) Coating of the sensing material onto the surface of sensors, such as quartz crystal tuning forks; and 3) integration of the coated sensors with proper sample conditioning unit. The device achieves high sensitivity and selectivity, and has been tested in various field environments.

摘要翻译： 一种方法和装置，包括：1）合成具有高密度结合位点的感测材料，并且对有毒烃和酸性蒸气具有优异的选择性; 2）将传感材料涂覆在传感器表面，如石英晶体调音叉; 和3）涂覆的传感器与适当的样品调节单元的整合。 该器件实现了高灵敏度和选择性，并已在各种现场环境中进行了测试。

公开(公告)号：US07879619B2

公开(公告)日：2011-02-01

申请号：US11544796

申请日：2006-10-06

申请人： Tianwei Jing ,  Feimeng Zhou ,  Nongjian Tao

发明人： Tianwei Jing ,  Feimeng Zhou ,  Nongjian Tao

IPC分类号： G01N21/41 ,  G01N21/01

CPC分类号： G01N21/553 ,  G01N21/05 ,  G01N2021/0346 ,  Y10T436/112499 ,  Y10T436/117497 ,  Y10T436/143333

摘要： An apparatus for detecting one or more substances includes a radiation source emitting a beam of radiation and also includes a material capable of reflecting the beam of radiation with a first characteristic and capable of reflecting the beam of radiation with a second characteristic when the material interacts with the one or more substances. The apparatus also includes two or more radiation detectors to detect the first and second characteristics of the beam of radiation. A first one of the two or more radiation detectors is adjustably aligned to detect the first and second characteristics of the beam of radiation reflected from a first region of the material. A second one of the two or more radiation detectors is adjustably aligned to detect the first and second characteristics of the beam of radiation reflected from a second region of the material.

摘要翻译： 用于检测一种或多种物质的装置包括发射辐射束的辐射源，并且还包括能够以第一特性反射辐射束的材料，并且当物质与 一种或多种物质。 该装置还包括两个或更多个辐射检测器，以检测辐射束的第一和第二特性。 两个或更多个辐射检测器中的第一个可调整地对准以检测从材料的第一区域反射的辐射束的第一和第二特性。 两个或更多个辐射检测器中的第二个可调整地对准以检测从材料的第二区域反射的辐射束的第一和第二特性。

公开(公告)号：US11020030B2

公开(公告)日：2021-06-01

申请号：US16526883

申请日：2019-07-30

申请人： Nongjian Tao ,  Dangdang Shao

发明人： Nongjian Tao ,  Dangdang Shao

IPC分类号： A61B5/1455 ,  A61B5/0205 ,  A61B5/00 ,  A61B5/024

摘要： A device for non-contact measurement of blood oxygen saturation (SpO2) in a mammalian subject including a camera and one or more arrays of LEDs each having a first set of LEDs emitting near infrared (NIR), and the second set of LEDs emitting orange light located in an optical path adapted to transmit reflected light from a subject to the camera. A controller transmits a camera trigger to the camera, and is further coupled to transmit control signals to the one or more arrays of LEDs. A processor receives photoplethysmography (PPG) data signal values from the camera. The PPG data signal values are present in the reflected light and include pulsatile and non-pulsatile components. The processor determines SpO2 values from the PPG data signal values from the measured ratios of pulsatile to non-pulsatile components of the PPG signals.

公开(公告)号：US20200022628A1

公开(公告)日：2020-01-23

申请号：US16526883

申请日：2019-07-30

申请人： Nongjian Tao ,  Dangdang Shao

发明人： Nongjian Tao ,  Dangdang Shao

IPC分类号： A61B5/1455 ,  A61B5/0205 ,  A61B5/00

摘要： A device for non-contact measurement of blood oxygen saturation (SpO2) in a mammalian subject including a camera and one or more arrays of LEDs each having a first set of LEDs emitting near infrared (NIR), and the second set of LEDs emitting orange light located in an optical path adapted to transmit reflected light from a subject to the camera. A controller transmits a camera trigger to the camera, and is further coupled to transmit control signals to the one or more arrays of LEDs. A processor receives photoplethysmography (PPG) data signal values from the camera. The PPG data signal values are present in the reflected light and include pulsatile and non-pulsatile components. The processor determines SpO2 values from the PPG data signal values from the measured ratios of pulsatile to non-pulsatile components of the PPG signals.