公开(公告)号：US11185537B2

公开(公告)日：2021-11-30

申请号：US16504376

申请日：2019-07-08

Applicant: Novartis AG

Inventor： Rohan Eric John Beckwith ,  Simone Bonazzi ,  Artiom Cernijenko ,  Fupeng Ma ,  Nathaniel F. Ware

IPC: C07D401/14 ,  A61K31/454 ,  A61P35/00 ,  A61K31/4545 ,  A61K31/498 ,  C07D401/04

Abstract: The present disclosure provides a compound of Formula (I′): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein Ra, Rb, Rx, R1, R2, X2, and q are as defined herein, and methods of making and using same.

公开(公告)号：US10800793B2

公开(公告)日：2020-10-13

申请号：US16141856

申请日：2018-09-25

Applicant: NOVARTIS AG

Inventor： Simone Bonazzi ,  Michael Connolly ,  David Jonathan Glass ,  Manuel Mihalic ,  Andrew William Patterson ,  Silvio Roggo ,  Tea Shavlakadze

IPC: C07D498/18 ,  A61P35/00 ,  A61P13/12 ,  A61P1/16 ,  A61P25/16 ,  A61P37/00 ,  A61P9/10 ,  A61P19/10 ,  A61P19/00 ,  A61P29/00 ,  A61P31/10 ,  A61P19/02 ,  A61P25/28 ,  A61P3/10 ,  A61P9/12 ,  A61P11/00 ,  A61P3/04 ,  C07F9/6561 ,  A61P25/02

Abstract: The disclosure relates to compounds of formula (I) and pharmaceutically acceptable salts, and compositions thereof, wherein the substituents are as defined herein. Also provided are methods of making compounds of formula (I), and methods involving the compounds or compositions for treating disorders and diseases described herein.

公开(公告)号：US12172984B2

公开(公告)日：2024-12-24

申请号：US18460428

申请日：2023-09-01

Applicant: Novartis AG

Inventor： Simone Bonazzi ,  Artiom Cernijenko ,  Jennifer Stroka Cobb ,  Natalie Alysia Dales ,  Janetta Dewhurst ,  Matthew James Hesse ,  Rama Jain ,  John Ryan Kerrigan ,  Hasnain Ahmed Malik ,  James R. Manning ,  Gary O'Brien ,  Andrew W. Patterson ,  Noel Marie-France Thomsen ,  Pamela Yf Ting

IPC: C07D403/14 ,  A61P7/00 ,  C07D405/14 ,  C07D417/14

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

公开(公告)号：US12091424B2

公开(公告)日：2024-09-17

申请号：US17499433

申请日：2021-10-12

Applicant: NOVARTIS AG

Inventor： Simone Bonazzi ,  Michael Connolly ,  David Jonathan Glass ,  Manuel Mihalic ,  Andrew William Patterson ,  Silvio Roggo ,  Tea Shavlakadze

IPC: C07D498/18 ,  A61P1/16 ,  A61P3/04 ,  A61P3/10 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P13/12 ,  A61P19/00 ,  A61P19/02 ,  A61P19/10 ,  A61P25/02 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/10 ,  A61P35/00 ,  A61P37/00 ,  C07F9/6561

CPC classification number: C07D498/18 ,  A61P1/16 ,  A61P3/04 ,  A61P3/10 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P13/12 ,  A61P19/00 ,  A61P19/02 ,  A61P19/10 ,  A61P25/02 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/10 ,  A61P35/00 ,  A61P37/00 ,  C07F9/6561

Abstract: The disclosure relates to compounds of formula (I)




and pharmaceutically acceptable salts, and compositions thereof, wherein the substituents are as defined herein. Also provided are methods of making compounds of formula (I), and methods involving the compounds or compositions for treating disorders and diseases described herein.

公开(公告)号：US11833142B2

公开(公告)日：2023-12-05

申请号：US17493055

申请日：2021-10-04

Applicant: Novartis AG

Inventor： Rohan Eric John Beckwith ,  Simone Bonazzi ,  Artiom Cernijenko ,  Fupeng Ma ,  Nathaniel F. Ware

IPC: A61K31/454 ,  A61P35/00 ,  A61K31/4545 ,  A61K31/498 ,  C07D401/04 ,  C07D401/14

CPC classification number: A61K31/454 ,  A61K31/4545 ,  A61K31/498 ,  A61P35/00 ,  C07D401/04 ,  C07D401/14

Abstract: The present disclosure provides a compound of Formula (I′):






or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein Ra, Rb, Rx, R1, R2, X2, and q are as defined herein, and methods of making and using same.

公开(公告)号：US11787785B2

公开(公告)日：2023-10-17

申请号：US17693759

申请日：2022-03-14

Applicant: NOVARTIS AG

Inventor： Simone Bonazzi ,  Artiom Cernijenko ,  Jennifer Stroka Cobb ,  Natalie Alysia Dales ,  Janetta Dewhurst ,  Matthew James Hesse ,  Rama Jain ,  John Ryan Kerrigan ,  Hasnain Ahmed Malik ,  James R. Manning ,  Gary O'Brien ,  Andrew W. Patterson ,  Noel Marie-France Thomsen ,  Pamela Y F Ting

IPC: C07D403/14 ,  A61P7/00 ,  C07D405/14 ,  C07D417/14

CPC classification number: C07D403/14 ,  A61P7/00 ,  C07D405/14 ,  C07D417/14

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

公开(公告)号：US10647701B2

公开(公告)日：2020-05-12

申请号：US16532118

申请日：2019-08-05

Applicant: Novartis AG

Inventor： Rohan Eric John Beckwith ,  Simone Bonazzi ,  Artiom Cernijenko ,  Ritesh Bhanudasji Tichkule ,  Michael Scott Visser

IPC: C07D401/14 ,  A61K31/44 ,  C07D401/04 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D495/04 ,  C07D513/04 ,  A61P35/00

Abstract: The present disclosure provides a compound of Formula (I′): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein R1, R2, Rx, X1, n, n1, and q are as defined herein, and methods of making and using same.