公开(公告)号：US10233215B2

公开(公告)日：2019-03-19

申请号：US16134153

申请日：2018-09-18

Applicant: OSAKA UNIVERSITY

Inventor： Hironori Nakagami ,  Ryuichi Morishita ,  Hiroshi Koriyama ,  Akiko Tenma

IPC: A61K39/39 ,  C07K7/08 ,  A61K8/64 ,  A61Q7/00 ,  A61K38/00 ,  A61K39/00

Abstract: The invention provides a peptide and an immunostimulant or hair grower containing the peptide as an active ingredient, as well as a method for hair growth or regrowth promotion by administering an effective amount of the peptide to a mammal. The peptide has 23 or less amino acids and includes the amino acid sequence LHRLKRLRKRL (SEQ ID NO: 1), preferably the amino acid sequence LHRLKRLRKRLK (SEQ ID NO: 9).

公开(公告)号：US10112978B2

公开(公告)日：2018-10-30

申请号：US15514310

申请日：2015-09-25

Applicant: OSAKA UNIVERSITY

Inventor： Hironori Nakagami ,  Ryuichi Morishita ,  Hiroshi Koriyama ,  Akiko Tenma

IPC: A61K39/39 ,  C07K7/08 ,  A61K8/64 ,  A61Q7/00 ,  A61K38/00 ,  A61K39/00

Abstract: An object of the present invention is to provide a novel peptide and a novel immunostimulant or hair grower containing the peptide as an active ingredient. The present invention provides a peptide of 23 or less amino acids comprising the amino acid sequence LHRLKRLRKRL (SEQ ID NO: 1), preferably the amino acid sequence LHRLKRLRKRLK (SEQ ID NO: 9), and also provides an immunostimulant containing the peptide, a vaccine adjuvant containing the peptide, a vaccine composition containing the peptide, and a hair grower containing the peptide.

公开(公告)号：US20150202271A1

公开(公告)日：2015-07-23

申请号：US14424937

申请日：2013-08-28

Applicant: OSAKA UNIVERSITY ,  ANGES MG, INC.

Inventor： Hironori Nakagami ,  Mariko Kyutoku ,  Ryuichi Morishita ,  Hideki Tomioka

IPC: A61K39/00 ,  C12N7/00

CPC classification number: A61K39/0011 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/545 ,  C12N7/00 ,  C12N2730/10134 ,  C12N2730/10143

Abstract: The present invention provides a therapeutic or prophylactic agent for cancer, containing an expression vector encoding a chimeric Hepatitis B virus core antigen polypeptide inserted with an amino acid sequence containing a specific epitope of VEGF and/or a specific epitope of angiopoietin-2, wherein the amino acid sequence containing the specific epitope is inserted between the amino acid residues 80 and 81 of the hepatitis B virus core antigen polypeptide.

Abstract translation: 本发明提供一种癌症治疗或预防剂，其含有编码嵌合乙型肝炎病毒核心抗原多肽的表达载体，其插入含有VEGF特异性表位的氨基酸序列和/或血管生成素-2的特异性表位，其中， 含有特异性表位的氨基酸序列插入到乙型肝炎病毒核心抗原多肽的氨基酸残基80和81之间。

公开(公告)号：US12070498B2

公开(公告)日：2024-08-27

申请号：US17200552

申请日：2021-03-12

Applicant: OSAKA UNIVERSITY ,  FUNPEP CO., LTD.

Inventor： Hironori Nakagami ,  Ryuichi Morishita ,  Akiko Tenma

IPC: A61K39/395 ,  A61K39/00 ,  A61K39/39 ,  A61P37/04

CPC classification number: A61K39/39 ,  A61K39/00 ,  A61K39/00114 ,  A61K39/39533 ,  A61P37/04 ,  A61K2039/55527

Abstract: The present invention provides a vaccine containing a complex of a peptide consisting of the amino acid sequence of SEQ ID NO: 1 and an epitope of a disease-causing biological protein such as DPP4, IL-17A, IgE, S100A9 or PCSK9, which vaccine uses a less antigenic carrier protein and is capable of inducing antibody production to serve as an effective vaccine.

公开(公告)号：US11020464B2

公开(公告)日：2021-06-01

申请号：US16486768

申请日：2018-02-20

Applicant: OSAKA UNIVERSITY ,  FUNPEP CO., LTD.

Inventor： Munehisa Shimamura ,  Tomohiro Kawano ,  Hironori Nakagami ,  Ryuichi Morishita ,  Hideki Mochizuki ,  Akiko Tenma ,  Takako Ehara

IPC: A61K39/00 ,  A61P7/02 ,  A61P9/10 ,  A61K39/39 ,  A61K47/42 ,  C07K14/435

Abstract: Provided is an immunogenic composition comprising an antigenic peptide capable of inducing production of a neutralizing antibody against S100A9 and a carrier protein. The immunogenic composition can be used as a highly safe antithrombotic vaccine having antithrombotic effect without a long-term bleeding risk and is useful for the prevention of a disease associated with thrombus formation in which platelet aggregation is involved, particularly for the prevention of recurrent ischemic stroke.

公开(公告)号：US20180147259A1

公开(公告)日：2018-05-31

申请号：US15575211

申请日：2016-05-16

Applicant: Osaka University

Inventor： Munehisa Shimamura ,  Hironori Nakagami ,  Hitomi Kurinami ,  Ryuichi Morishita

IPC: A61K38/17 ,  A61K38/19 ,  C07K14/47 ,  C07K7/06 ,  A61P29/00 ,  A61P35/00 ,  A61P19/10 ,  C07K14/52

Abstract: Provided is an oligopeptide having preventive and therapeutic effects on infarction diseases. The oligopeptide contains a DE loop sequence of RANKL protein, and has inhibitory activity on proinflammatory cytokine secretion from cells.

公开(公告)号：US20160101032A1

公开(公告)日：2016-04-14

申请号：US14780122

申请日：2014-03-27

Applicant: OSAKA UNIVERSITY

Inventor： Hironori Nakagami ,  Ryuichi Morishita ,  Hideki Tomioka ,  Akiko Tenma

IPC: A61K8/64 ,  A61Q19/08 ,  C07K7/06 ,  C07K7/08

CPC classification number: A61K8/64 ,  A23L33/18 ,  A61K38/10 ,  A61K2800/78 ,  A61Q19/08 ,  C07K7/06 ,  C07K7/08

Abstract: An object of the present invention to discover a short peptide having an anti-aging effect and to provide a novel anti-aging agent comprising the peptide as an active ingredient. The inventors have discovered that a peptide consisting of an amino acid sequence ELKLIFLHRLKRLRKRLKRK (SEQ ID NO: 1) or a partial sequence thereof and having one or more effects selected from the group consisting of promoting fibroblast growth, promoting hyaluronic acid production and contracting a collagen gel, or a derivative or salt of the peptide is useful as an active ingredient of an anti-aging agent.

Abstract translation: 本发明的目的是发现具有抗衰老作用的短肽，并提供包含该肽作为活性成分的新型抗衰老剂。 本发明人已经发现，由氨基酸序列ELKLIFLHRLKRLRKRLKRK（SEQ ID NO：1）或其部分序列组成的肽具有选自促进成纤维细胞生长，促进透明质酸产生和收缩胶原的一种或多种作用 凝胶或肽的衍生物或盐可用作抗老化剂的活性成分。