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公开(公告)号：US06770435B1
公开(公告)日：2004-08-03
申请号：US09431384
申请日：1999-11-01
申请人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , John C. Russell , Christi P. Scheffel , Stephen D. Stroupe
发明人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , John C. Russell , Christi P. Scheffel , Stephen D. Stroupe
IPC分类号： C12Q168
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BU101 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BU101-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BU101 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.
摘要翻译： 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为BU101并从乳腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对乳腺疾病和病症如乳腺癌的倾向。 还提供了特异性结合BU101编码的多肽或蛋白质的抗体，以及预防组织特异性BU101多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤。
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公开(公告)号：US06660834B2
公开(公告)日：2003-12-09
申请号：US10278547
申请日：2002-10-23
申请人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Mark A. Hayden , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe
发明人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Mark A. Hayden , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe
IPC分类号： C07K1447
CPC分类号： G01N33/6893 , C07K14/47 , C07K16/3046 , C12Q1/6886 , C12Q2600/136 , G01N2800/06 , Y10S435/81 , Y10S530/828
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS198 and transcribed from GI tract tissue, is described. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS198-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS198 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.
摘要翻译： 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为CS198并从胃肠道组织转录。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对胃肠道疾病和病症（例如胃肠道癌）的倾向。 还提供了特异性结合CS198编码的多肽或蛋白质的抗体，以及预防组织特异性CS198多肽的作用的激动剂或抑制剂，该分子可用于胃肠道疾病，肿瘤或转移瘤的治疗性治疗。
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公开(公告)号：US6130043A
公开(公告)日：2000-10-10
申请号：US071710
申请日：1998-05-01
申请人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe , Hong Yu
发明人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe , Hong Yu
CPC分类号： C07K16/3069 , C12Q1/6886 , G01N33/57434 , A61K38/00 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N2500/04
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS108 and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS108-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS108 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.
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公开(公告)号：US06207380B1
公开(公告)日：2001-03-27
申请号：US09153804
申请日：1998-09-15
申请人： Patricia A. Billing-Medel , Maurice Cohen , Paula N. Friedman , Julian Gordon , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Eric Russell , Stephen D. Stroupe
发明人： Patricia A. Billing-Medel , Maurice Cohen , Paula N. Friedman , Julian Gordon , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Eric Russell , Stephen D. Stroupe
IPC分类号： C12Q168
CPC分类号： C12Q1/6883 , C07K16/18 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： Polypeptides and polynucleotides useful for detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the urinary tract, such as urinary cancer, are described. These sequences are derived from keratin/cytokeratin, CAS, or mat-8 polypeptides and polynucleotides. Also provided are antibodies which specifically bind to keratin/cytokeratin, CAS, or mat-8-encoded polypeptides or proteins, which molecules are useful for the therapeutic treatment of urinary tract diseases, tumors or metastases.
摘要翻译： 描述了可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对尿路疾病和状况（例如尿癌）的倾向的多肽和多核苷酸。 这些序列衍生自角蛋白/细胞角蛋白，CAS或mat-8多肽和多核苷酸。 还提供了特异性结合角蛋白/细胞角蛋白，CAS或mat-8编码的多肽或蛋白质的抗体，该分子可用于治疗尿路疾病，肿瘤或转移瘤。
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公开(公告)号：US6110675A
公开(公告)日：2000-08-29
申请号：US946869
申请日：1997-10-08
申请人： Maurice Cohen , Paula N. Friedman , Julian Gordon , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe , Hong Yu
发明人： Maurice Cohen , Paula N. Friedman , Julian Gordon , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe , Hong Yu
IPC分类号： C12N15/09 , C07K14/47 , C07K14/82 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12Q1/68 , G01N33/574 , C12Q1/70 , C07H21/04 , C12P19/34 , G01N33/53
CPC分类号： C07K14/82 , C07K14/47 , C12Q1/6886 , G01N33/57434 , C12Q2600/136
摘要： A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS112 and transcribed from prostate tissue is described. A fully sequenced clone representing a continuous sequence of PS112 is also disclosed. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS112-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS112 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.
摘要翻译： 描述了一组由其编码的连续和部分重叠的RNA序列和多肽，称为PS112并从前列腺组织转录。 还公开了表示PS112的连续序列的完全测序的克隆。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对前列腺疾病和病症如前列腺癌的倾向。 还提供了特异性结合PS112编码的多肽或蛋白质的抗体，以及预防组织特异性PS112多肽的作用的激动剂或抑制剂，该分子可用于治疗前列腺疾病，肿瘤或转移瘤。
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公开(公告)号：US5939265A
公开(公告)日：1999-08-17
申请号：US964725
申请日：1997-11-05
申请人： Maurice Cohen , Paula N. Friedman , Julian Gordon , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Steven D. Stroupe
发明人： Maurice Cohen , Paula N. Friedman , Julian Gordon , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Steven D. Stroupe
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as LU103 and transcribed from lung tissue is described. A fully sequenced clone representing the longest continuous sequence of LU103 is also disclosed. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the lung such as lung cancer.
摘要翻译： 描述了一组由此编码的连续和部分重叠的RNA序列和多肽，命名为LU103并从肺组织转录。 还公开了表示LU103的最长连续序列的完全测序的克隆。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗，或确定个体对肺部疾病和病症的倾向，如肺癌。
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公开(公告)号：US20060029963A1
公开(公告)日：2006-02-09
申请号：US11201347
申请日：2005-08-10
申请人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Julian Gordon , Edward Granados , Steven Hodges , Michael Klass , Jon Kratochvil , John Russell , Stephen Stroupe
发明人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Julian Gordon , Edward Granados , Steven Hodges , Michael Klass , Jon Kratochvil , John Russell , Stephen Stroupe
CPC分类号： C12Q1/6886 , C07K14/47 , C07K16/3015 , C12Q2600/136 , C12Q2600/156
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS325 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to SB325-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS325 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.
摘要翻译： 描述了一组连续且部分重叠的cDNA序列和由此编码的多肽，命名为BS325并从乳腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对乳腺疾病和病症如乳腺癌的倾向。 还提供了特异性结合SB325编码的多肽或蛋白质的抗体，以及预防组织特异性BS325多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤。
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公开(公告)号：US20050191633A1
公开(公告)日：2005-09-01
申请号：US10719144
申请日：2003-11-21
申请人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Julian Gordon , Edward Granados , Steven Hodges , Michael Klass , Jon Kratochvil , Lisa Roberts-Rapp , John Russell , Stephen Stroupe
发明人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Julian Gordon , Edward Granados , Steven Hodges , Michael Klass , Jon Kratochvil , Lisa Roberts-Rapp , John Russell , Stephen Stroupe
IPC分类号： A61K38/00 , C07K14/47 , C12Q1/68 , G01N33/574
CPC分类号： C07K14/47 , A61K38/00 , C12Q1/6886 , C12Q2600/136
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS274 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BS274-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS274 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases
摘要翻译： 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为BS274并从乳腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对乳腺疾病和病症如乳腺癌的倾向。 还提供了特异性结合BS274编码的多肽或蛋白质的抗体，以及预防组织特异性BS274多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤
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公开(公告)号：US20050181401A1
公开(公告)日：2005-08-18
申请号：US11043675
申请日：2005-01-26
申请人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Julian Gordon , Edward Granados , Steven Hodges , Michael Klass , Jon Kratochvil , Lisa Roberts-Rapp , John Russell , Stephen Stroupe
发明人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Julian Gordon , Edward Granados , Steven Hodges , Michael Klass , Jon Kratochvil , Lisa Roberts-Rapp , John Russell , Stephen Stroupe
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS116 and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS116-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS116 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.
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公开(公告)号：US20060154291A1
公开(公告)日：2006-07-13
申请号：US11348129
申请日：2006-02-06
申请人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Julian Gordon , Edward Granados , Steven Hodges , Michael Klass , Jon Kratochvil , John Russell , Stephen Stroupe
发明人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Julian Gordon , Edward Granados , Steven Hodges , Michael Klass , Jon Kratochvil , John Russell , Stephen Stroupe
CPC分类号： C07K14/47 , C07K16/3015 , C07K2317/34 , C12Q1/6886 , C12Q2600/136
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS322 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BS322-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS322 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases
摘要翻译： 描述了一组连续且部分重叠的cDNA序列和由此编码的多肽，命名为BS322并从乳腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对乳腺疾病和病症如乳腺癌的倾向。 还提供了特异性结合BS322编码的多肽或蛋白质的抗体以及预防组织特异性BS322多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤
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