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公开(公告)号：US20090247506A1
公开(公告)日：2009-10-01
申请号：US11894208
申请日：2007-08-20
申请人： Niels H. Andersen , Jason Bowman , Alice L. Erwin , Eric A. Harwood , Toni Kline , Khisimuzi E. Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
发明人： Niels H. Andersen , Jason Bowman , Alice L. Erwin , Eric A. Harwood , Toni Kline , Khisimuzi E. Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
IPC分类号： A61K31/55 , C07C237/48 , C07D223/04 , A61K31/496 , A61K31/164 , C07D241/04 , A61P31/04
CPC分类号： C07D453/00 , C07C233/83 , C07C239/16 , C07C251/40 , C07C255/24 , C07C255/25 , C07C255/44 , C07C255/57 , C07C259/06 , C07C275/14 , C07C275/16 , C07C275/26 , C07C279/14 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C317/32 , C07C323/25 , C07C323/41 , C07C323/60 , C07C323/62 , C07C335/08 , C07C337/08 , C07C381/00 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/27 , C07D207/327 , C07D211/26 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/74 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D263/34 , C07D285/01 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/192 , C07D295/215 , C07D307/68 , C07D311/24 , C07D317/60 , C07D317/68 , C07D333/20 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/58
摘要： Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要翻译： 提供式I的抗菌化合物：以及立体异构体，其药学上可接受的盐，酯和前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。
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公开(公告)号：US08153843B2
公开(公告)日：2012-04-10
申请号：US12563697
申请日：2009-09-21
申请人： Niels H. Andersen , Jason Bowman , Alice L. Erwin , Eric A. Harwood , Toni Kline , Khisimuzi E. Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
发明人： Niels H. Andersen , Jason Bowman , Alice L. Erwin , Eric A. Harwood , Toni Kline , Khisimuzi E. Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
IPC分类号： C07C259/04 , A61K31/19
CPC分类号： C07D453/00 , C07C233/83 , C07C239/16 , C07C251/40 , C07C255/24 , C07C255/25 , C07C255/44 , C07C255/57 , C07C259/06 , C07C275/14 , C07C275/16 , C07C275/26 , C07C279/14 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C317/32 , C07C323/25 , C07C323/41 , C07C323/60 , C07C323/62 , C07C335/08 , C07C337/08 , C07C381/00 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/27 , C07D207/327 , C07D211/26 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/74 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D263/34 , C07D285/01 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/192 , C07D295/215 , C07D307/68 , C07D311/24 , C07D317/60 , C07D317/68 , C07D333/20 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/58
摘要： Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要翻译： 提供式I的抗菌化合物：以及立体异构体，其药学上可接受的盐，酯和前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。
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公开(公告)号：US08101640B2
公开(公告)日：2012-01-24
申请号：US11981279
申请日：2007-10-31
申请人： Niels H. Andersen , Jason Bowman , Alice Erwin , Eric Harwood , Toni Kline , Khisimuzi Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
发明人： Niels H. Andersen , Jason Bowman , Alice Erwin , Eric Harwood , Toni Kline , Khisimuzi Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
IPC分类号： A61K31/44 , C07D213/56
CPC分类号： C07D453/00 , C07C233/83 , C07C239/16 , C07C251/40 , C07C255/24 , C07C255/25 , C07C255/44 , C07C255/57 , C07C259/06 , C07C275/14 , C07C275/16 , C07C275/26 , C07C279/14 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C317/32 , C07C323/25 , C07C323/41 , C07C323/60 , C07C323/62 , C07C335/08 , C07C337/08 , C07C381/00 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/27 , C07D207/327 , C07D211/26 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/74 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D263/34 , C07D285/01 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/192 , C07D295/215 , C07D307/68 , C07D311/24 , C07D317/60 , C07D317/68 , C07D333/20 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/58
摘要： Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
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公开(公告)号：US08084615B2
公开(公告)日：2011-12-27
申请号：US11928122
申请日：2007-10-30
申请人： Niels H. Andersen , Jason Bowman , Alice L. Erwin , Eric A. Harwood , Toni Kline , Khisimuzi E. Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
发明人： Niels H. Andersen , Jason Bowman , Alice L. Erwin , Eric A. Harwood , Toni Kline , Khisimuzi E. Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
IPC分类号： C07D213/00 , C07D213/24 , C07D333/22 , C07D413/04 , C07D239/10 , C07D239/02 , C07D241/12 , C07D401/04 , A61K31/55 , A61K31/535 , A61K31/497 , A61K31/505 , A61K31/44 , A61K31/38 , A61K31/445
CPC分类号： C07D453/00 , C07C233/83 , C07C239/16 , C07C251/40 , C07C255/24 , C07C255/25 , C07C255/44 , C07C255/57 , C07C259/06 , C07C275/14 , C07C275/16 , C07C275/26 , C07C279/14 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C317/32 , C07C323/25 , C07C323/41 , C07C323/60 , C07C323/62 , C07C335/08 , C07C337/08 , C07C381/00 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/27 , C07D207/327 , C07D211/26 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/74 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D263/34 , C07D285/01 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/192 , C07D295/215 , C07D307/68 , C07D311/24 , C07D317/60 , C07D317/68 , C07D333/20 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/58
摘要： Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
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公开(公告)号：US07989660B2
公开(公告)日：2011-08-02
申请号：US11837327
申请日：2007-08-10
申请人： Niels H. Andersen , Jason Bowman , Alice Erwin , Eric Harwood , Toni Kline , Khisimuzi Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
发明人： Niels H. Andersen , Jason Bowman , Alice Erwin , Eric Harwood , Toni Kline , Khisimuzi Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
IPC分类号： C07C259/06 , A61K31/19
CPC分类号： C07D453/00 , C07C233/83 , C07C239/16 , C07C251/40 , C07C255/24 , C07C255/25 , C07C255/44 , C07C255/57 , C07C259/06 , C07C275/14 , C07C275/16 , C07C275/26 , C07C279/14 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C317/32 , C07C323/25 , C07C323/41 , C07C323/60 , C07C323/62 , C07C335/08 , C07C337/08 , C07C381/00 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/27 , C07D207/327 , C07D211/26 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/74 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D263/34 , C07D285/01 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/192 , C07D295/215 , C07D307/68 , C07D311/24 , C07D317/60 , C07D317/68 , C07D333/20 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/58
摘要： Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要翻译： 提供式I的抗菌化合物：以及立体异构体，其药学上可接受的盐，酯和前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。
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公开(公告)号：US20110172174A1
公开(公告)日：2011-07-14
申请号：US11981279
申请日：2007-10-31
申请人： Niels H. Andersen , Jason Bowman , Alice Erwin , Eric Harwood , Toni Kline , Khisimuzi Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
发明人： Niels H. Andersen , Jason Bowman , Alice Erwin , Eric Harwood , Toni Kline , Khisimuzi Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
IPC分类号： A61K31/166 , C07C259/04 , C07D207/16 , A61K31/40 , A61K31/165 , C07D265/30 , A61K31/5375 , C07D213/56 , A61K31/4406 , C07D413/04 , A61K31/5377 , C07D241/04 , A61K31/495 , C07D211/32 , A61K31/4453 , C07C275/64 , A61K31/17 , C07D401/04 , A61K31/55 , A61K31/7048 , A61P31/04
CPC分类号： C07D453/00 , C07C233/83 , C07C239/16 , C07C251/40 , C07C255/24 , C07C255/25 , C07C255/44 , C07C255/57 , C07C259/06 , C07C275/14 , C07C275/16 , C07C275/26 , C07C279/14 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C317/32 , C07C323/25 , C07C323/41 , C07C323/60 , C07C323/62 , C07C335/08 , C07C337/08 , C07C381/00 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/27 , C07D207/327 , C07D211/26 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/74 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D263/34 , C07D285/01 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/192 , C07D295/215 , C07D307/68 , C07D311/24 , C07D317/60 , C07D317/68 , C07D333/20 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/58
摘要： Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
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公开(公告)号：US20100324025A1
公开(公告)日：2010-12-23
申请号：US12563697
申请日：2009-09-21
申请人： Niels H. Andersen , Jason Bowman , Alice L. Erwin , Eric A. Harwood , Toni Kline , Khisimuzi E. Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
发明人： Niels H. Andersen , Jason Bowman , Alice L. Erwin , Eric A. Harwood , Toni Kline , Khisimuzi E. Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
IPC分类号： A61K31/55 , C07C259/06 , A61K31/16 , C07D295/155 , A61K31/5375 , C07D213/56 , A61K31/4406 , C07D413/04 , A61K31/5377 , A61K31/495 , C07D211/34 , A61K31/4453 , C07D207/27 , A61K31/40 , C07D207/16 , C07D401/06 , A61K31/4439 , C07D233/64 , A61K31/4164 , C07D217/26 , A61K31/472 , C07D241/04 , C07D401/04 , A61K31/4545 , C07D263/14 , A61K31/421 , C07D409/06 , A61K31/497 , A61K31/175 , C07C281/12 , C07C337/10 , C07D223/04 , C07D453/02 , A61K31/439 , C07D239/42 , A61K31/505 , C07D241/12 , A61K31/4965 , A61P31/04 , A61P11/00
CPC分类号： C07D453/00 , C07C233/83 , C07C239/16 , C07C251/40 , C07C255/24 , C07C255/25 , C07C255/44 , C07C255/57 , C07C259/06 , C07C275/14 , C07C275/16 , C07C275/26 , C07C279/14 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C317/32 , C07C323/25 , C07C323/41 , C07C323/60 , C07C323/62 , C07C335/08 , C07C337/08 , C07C381/00 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/27 , C07D207/327 , C07D211/26 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/74 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D263/34 , C07D285/01 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/192 , C07D295/215 , C07D307/68 , C07D311/24 , C07D317/60 , C07D317/68 , C07D333/20 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/58
摘要： Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要翻译： 提供式I的抗菌化合物：以及立体异构体，其药学上可接受的盐，酯和前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。
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公开(公告)号：US08293769B2
公开(公告)日：2012-10-23
申请号：US12451326
申请日：2008-05-20
申请人： Simon C. Ng , Keith B. Pfister , Martin Sendzik , James Sutton , Allan S. Wagman , Marion Wiesmann
发明人： Simon C. Ng , Keith B. Pfister , Martin Sendzik , James Sutton , Allan S. Wagman , Marion Wiesmann
IPC分类号： A61K31/5377 , A61K31/519 , A61K31/506 , A61K31/501 , A61K31/497 , A61K31/4745 , A61K31/4545 , A61K31/454 , A61K31/444 , A61K31/4439 , C07D495/04 , C07D487/04 , C07D417/12 , C07D417/14 , C07D413/12 , C07D413/14
CPC分类号： C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04
摘要： Benzoxazole and benzothiazole compounds and their oxides, esters, prodrugs, solvates, and pharmaceutically acceptable salts thereof are disclosed. Compositions of the compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier, and uses of the compounds, either alone or in combination with at least one additional therapeutic agent are also disclosed. The embodiments are useful for inhibiting cellular proliferation, inhibiting the growth and/or metathesis of tumors, treating or preventing cancer, treating or preventing degenerating bone diseases such as rheumatoid arthritis, and/or inhibiting molecules such as CSF 1R.
摘要翻译： 公开了苯并恶唑和苯并噻唑化合物及其氧化物，酯，前药，溶剂合物及其药学上可接受的盐。 还公开了单独或与至少一种另外的治疗剂组合的化合物与药学上可接受的载体的组合，以及化合物单独或与至少一种另外的治疗剂组合的用途。 这些实施方案可用于抑制细胞增殖，抑制肿瘤的生长和/或复分解，治疗或预防癌症，治疗或预防退行性骨疾病如类风湿性关节炎和/或抑制分子如CSF 1R。
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公开(公告)号：US07045519B2
公开(公告)日：2006-05-16
申请号：US09949035
申请日：2001-09-06
申请人： John M. Nuss , Stephen D. Harrison , David B. Ring , Rustum S. Boyce , Kirk Johnson , Keith B. Pfister , Savithri Ramurthy , Lynn Seely , Allan S. Wagman , Manoj C. Desai , Barry H. Levine
发明人： John M. Nuss , Stephen D. Harrison , David B. Ring , Rustum S. Boyce , Kirk Johnson , Keith B. Pfister , Savithri Ramurthy , Lynn Seely , Allan S. Wagman , Manoj C. Desai , Barry H. Levine
IPC分类号： A61K31/506 , C07D403/04
CPC分类号： C07D213/74 , C07D213/75 , C07D213/80 , C07D213/85 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： New pyrimidine or pyridine based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.
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公开(公告)号：US20100130490A1
公开(公告)日：2010-05-27
申请号：US12451326
申请日：2008-05-20
申请人： Simon C. Ng , Keith B. Pfister , Martin Sendzik , James Sutton , Allan S. Wagman , Marion Wiesmann
发明人： Simon C. Ng , Keith B. Pfister , Martin Sendzik , James Sutton , Allan S. Wagman , Marion Wiesmann
IPC分类号： A61K31/428 , C12N5/00 , A61K31/5377 , A61K31/501 , A61K31/497 , A61K31/519 , A61K31/517 , A61K31/506 , A61K31/4439 , C07D417/12 , C07D487/04 , C07D417/14 , C07D277/82 , A61P35/00 , A61P19/10 , A61P19/02 , A61P13/00
CPC分类号： C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04
摘要： Benzoxazole and benzothiazole compounds and their oxides, esters, prodrugs, solvates, and pharmaceutically acceptable salts thereof are disclosed. Compositions of the compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier, and uses of the compounds, either alone or in combination with at least one additional therapeutic agent are also disclosed. The embodiments are useful for inhibiting cellular proliferation, inhibiting the growth and/or metathesis of tumors, treating or preventing cancer, treating or preventing degenerating bone diseases such as rheumatoid arthritis, and/or inhibiting molecules such as CSF 1R.
摘要翻译： 公开了苯并恶唑和苯并噻唑化合物及其氧化物，酯，前药，溶剂合物及其药学上可接受的盐。 还公开了单独或与至少一种另外的治疗剂组合的化合物与药学上可接受的载体的组合，以及化合物单独或与至少一种另外的治疗剂组合的用途。 这些实施方案可用于抑制细胞增殖，抑制肿瘤的生长和/或复分解，治疗或预防癌症，治疗或预防退行性骨疾病如类风湿性关节炎和/或抑制分子如CSF 1R。
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