Abstract:
An inflator, more particularly for a vehicle occupant restraint system, has a tubular inflator housing which is closed off at its end faces and has radial exit ports via which the gas is able to exit the inflator. The inflator housing has in its interior at least one combustion chamber packed with propellant, at least one ignition unit for igniting the propellant in the combustion chamber and at least one filter which is located upstream of the exit ports. A filter insert featuring an outer housing is provided, the outer housing having a plurality of housing parts which at least partly surround the filter disposed in the filter insert. The outer housing together with its housing parts is radially secured to the inflator housing without the provision of an axial stop. The outer geometry of the outer housing and the inner geometry of the inflator housing permit total insertion of the outer housing or its housing parts in the axial direction into the inflator housing to different insertion depths when the outer housing is still in the non-secured condition.
Abstract:
The present invention relates to immunotherapies that are based on myeloid cell depletion. In particular, the present invention relates to CD33 binding agents for use in such therapies, e.g. in the treatment of myeloid cell malignancies and myelodysplastic syndrome (MDS).
Abstract:
A landscape edging system is disclosed in which the landscape edging system comprises a plurality of blocks for forming a edging with each of the blocks comprising a back face that is configured to be placed against a raised area, a bottom face for placement on the ground, an elevated top portion, a lower top portion, an elevated front face between the elevated top portion and the lower top portion, a lower side front face, a right elevated side face, a right lower side face having a tongue portion extending out from the right lower side face, a left elevated side face, a left lower side face having a groove portion formed in the left lower side face.
Abstract:
Antibody molecules, in particular fully human antibodies that bind to human IGF-1 and cross-react with IGF-2 such that binding of IGF-1 and IGF-2 to the IGF-1 receptor is prevented and IGF-1 receptor-mediated signaling is inhibited. The antibodies do not bind to insulin and thus do not affect the mitogenic properties of insulin that are mediated by its binding to the insulin receptors. The antibodies are useful for the treatment of hyperproliferative diseases, in particular cancer.
Abstract:
A modular block system comprises a first block, a second block, a third block, a fourth block, and a capstone, the first block having a front face, a back face, a first side, a second side, a top, and a bottom, with the front face being wider than the back face and the first side being slanted from the front face toward the back face, the second block having a front face, a back face, a first side, a second side, a top, and a bottom, with the front face being wider than the back face and the first and second sides being slanted from the front face toward the back face, the third block having a front face, a back face, a first side, a second side, a top, and a bottom, with the front face being wider than the back face and the first side being slanted from the front face toward the back face, and the fourth block having a front face, a back face, a first side, a second side, a top, and a bottom, with the front face being wider than the back face and the first side and the second side being from the front face toward the back face.
Abstract:
A capacitive proximity and/or contact sensor has an electrically conductive plastic body, which is disposed between an electrically insulating cover plate and an electrically conductive contact surface of a carrier plate disposed at a distance therefrom. The contact surface can be connected to a gating circuit, through which a change in a capacitance of a condenser formed by the cover plate, the plastic body and the contact surface as a result of proximity and/or contact of a contact region of the cover plate by an element, having a potential different to the potential of the contact surface, can be ascertained and evaluated. The plastic body is configured as a plug-in and/or clamp part and by plugging-in or clipping on the or by clamping on the carrier plate is connected form lockingly and/or force lockingly to the latter and thus to the contact surface.
Abstract:
A hybrid gas generator includes a pyrotechnic gas generator joined to a high-pressure vessel which is sealed with a sealing disk composed of a substance which chemically reacts with propellant gas produced in use so that the sealing disk is opened with an advantageously reduced acoustic pressure. The propellant gas is chemically reactive and is produced from a propellant composition which is present in a surplus amount and which is composed of a propellant which is oxidizable and at least one oxidant for oxidizing the propellant. The propellant gas attacks the sealing disk chemically and thermally, and continuously burns through it to release the gas from the high-pressure vessel into a mixing chamber in the pyrotechnic gas generator.
Abstract:
A mold system for forming a multilevel block is disclosed which comprises a multilevel mold box insert for forming a multilevel block, a mold box frame adapted for receiving therein the multilevel mold box insert, a multilevel plunger assembly, and a press head plate adapted for receiving thereon the multilevel plunger assembly.
Abstract:
Antibody molecules, in particular fully human antibodies that bind to human IGF-1 and cross-react with IGF-2 such that binding of IGF-1 and IGF-2 to the IGF-1 receptor is prevented and IGF-1 receptor-mediated signaling is inhibited. The antibodies do not bind to insulin and thus do not affect the mitogenic properties of insulin that are mediated by its binding to the insulin receptors. The antibodies are useful for the treatment of hyperproliferative diseases, in particular cancer.
Abstract:
A paver stone system comprises a first paver stone having a generally trapezoidal configuration, a second paver stone having a generally triangular configuration, and a third paver stone having a generally rhombus configuration. The paver stones are used to construct a path having any desired pattern.