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    High purity diaminophenothiazinium compounds including methylthioninium chloride (MTC)
    11.
    发明授权
    High purity diaminophenothiazinium compounds including methylthioninium chloride (MTC) 有权
    高纯度二氨基吩噻嗪鎓化合物，包括甲基硫堇（MTC）

    公开(公告)号：US09242946B2

    公开(公告)日：2016-01-26

    申请号：US12875465

    申请日：2010-09-03

    申请人： John Mervyn David Storey ,  James Peter Sinclair ,  Colin Marshall ,  Han Wan Tan ,  Claude Michel Wischik

    发明人： John Mervyn David Storey ,  James Peter Sinclair ,  Colin Marshall ,  Han Wan Tan ,  Claude Michel Wischik

    IPC分类号： C07D279/18 ,  C09B19/02

    CPC分类号： A61K31/5415 ,  A61K9/0019 ,  A61K49/006 ,  C07D279/18 ,  C09B19/02 ,  G01N33/52 ,  Y02A50/393

    摘要： This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiaziniumcompounds”) including Methylhioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt-formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g., tablets, capsules), and their use in methods of inactivating pathogens, and methods of medical treatment and diagnosis, etc., for example, for tauopathies, Alzheimer's disease (AD), skin cancer, melanoma, viral diseases, bacterial diseases, or protozoal diseases.

    摘要翻译： 本发明一般涉及化学合成和纯化领域，更具体地涉及合成和纯化某些3,7-二氨基 - 吩噻嗪-5-鎓化合物（本文称为“二氨基吩噻嗪鎓化合物”）的方法，包括甲基氯化铑（MTC）（ 也称为亚甲基蓝）。 在一个实施方案中，该方法包括以下步骤：按顺序：亚硝基化（NOS）; 亚硝酰还原（NR）; 硫代磺酸形成（TSAF）; 氧化偶合（OC）; Cr（VI）还原（CR）; 两性离子中间体（IAPOZI）的分离和纯化; 闭环（RC）; 氯化物盐形成（CSF）; 一种：硫化物处理（ST）; 二甲基二硫代氨基甲酸酯处理（DT）; 碳酸盐处理（CT）; 乙二胺四乙酸处理（EDTAT）; 有机萃取（OE）; 和重结晶（RX）。 本发明还涉及所得的（高纯度）化合物，包含它们的组合物（例如片剂，胶囊）及其在灭活病原体的方法中的用途，以及治疗和诊断方法等，例如对于tau蛋白病 ，阿尔茨海默病（AD），皮肤癌，黑素瘤，病毒性疾病，细菌性疾病或原生动物疾病。

    PROCESS FOR PRODUCING CELLULOSE FILM
    13.
    发明申请
    PROCESS FOR PRODUCING CELLULOSE FILM 审中-公开
    生产纤维素膜的方法

    公开(公告)号：US20130192489A1

    公开(公告)日：2013-08-01

    申请号：US13805885

    申请日：2011-06-21

    申请人： Martin Cockcroft ,  Colin Marshall

    发明人： Martin Cockcroft ,  Colin Marshall

    IPC分类号： C09D7/00

    CPC分类号： C09D7/20 ,  B29C41/24 ,  B29K2001/00 ,  B29K2001/12 ,  C08B1/003 ,  C08J3/091 ,  C08J5/18 ,  C08J2301/02 ,  C08L1/02

    摘要： The present invention provides a process for producing a cellulose film in which a) cellulose is at least partly dissolved at a temperature of about 100° C. or lower in a dope comprising an ionic liquid and a cosolvent to form a cellulose solution, wherein said cosolvent comprises a polar aprotic component, and B) cellulose film is cast from the cellulose solution.

    摘要翻译： 本发明提供一种纤维素膜的制造方法，其中a）在包含离子液体和共溶剂的涂料中，纤维素在约100℃以下的温度下至少部分溶解以形成纤维素溶液，其中所述 助溶剂包括极性非质子成分，B）纤维素膜从纤维素溶液中流出。

    PROCESS FOR PRODUCING CELLULOSE SHAPED ARTICLES
    14.
    发明申请
    PROCESS FOR PRODUCING CELLULOSE SHAPED ARTICLES 审中-公开
    生产纤维素形成品的方法

    公开(公告)号：US20130154139A1

    公开(公告)日：2013-06-20

    申请号：US13805616

    申请日：2011-06-21

    申请人： Martin Cockcroft ,  Colin Marshall

    发明人： Martin Cockcroft ,  Colin Marshall

    IPC分类号： B29D99/00

    CPC分类号： B29D99/0078 ,  C08B1/003 ,  C08J3/091 ,  C08J2301/00 ,  D01F2/02 ,  Y02P20/542

    摘要： The present invention provides a process for producing cellulose shaped articles in which a) cellulose is at least partly dissolved at a temperature of about 100° C. or lower in a dope comprising an ionic liquid and a cosolvent to form a cellulose solution, wherein said cosolvent comprises a polar aprotic component, and b) cellulose shaped articles are cast from the cellulose solution.

    摘要翻译： 本发明提供一种生产纤维素成型制品的方法，其中a）纤维素在包含离子液体和共溶剂的涂料中在约100℃或更低的温度下至少部分溶解以形成纤维素溶液，其中所述 共溶剂包括极性非质子组分，和b）纤维素成形制品从纤维素溶液中流出。

    Powered access platform units
    17.
    发明授权
    Powered access platform units 失效
    动力访问平台单元

    公开(公告)号：US4967876A

    公开(公告)日：1990-11-06

    申请号：US345426

    申请日：1989-05-01

    申请人： Mark J. Richardson ,  Colin Marshall

    发明人： Mark J. Richardson ,  Colin Marshall

    IPC分类号： B66F11/04

    CPC分类号： B66F11/044

    摘要： A powered access platform unit having a wheeled base carrying a corner pillar to which is articulated one end of a parallel linkage boom articulated at the other end to the remote corner of a platform structure on the same side of said structure as the side of the base which carries the corner pillar, and a drive unit on the base for raising and lowering the platform structure on the parallel linkage boom by means of an hydraulic ram articulated between the base pillar and the boom.

    Biodegradable composites
    18.
    发明授权
    Biodegradable composites 有权
    可生物降解复合材料

    公开(公告)号：US08833376B2

    公开(公告)日：2014-09-16

    申请号：US13497220

    申请日：2010-09-17

    申请人： Colin Marshall ,  Jamie Moffat

    发明人： Colin Marshall ,  Jamie Moffat

    IPC分类号： A24D3/06 ,  D01F2/28 ,  D01F2/00 ,  B29C47/00 ,  A24D3/10 ,  D01F2/02

    CPC分类号： A24D3/068 ,  A24D3/10 ,  B29C47/0014 ,  D01F2/00 ,  D01F2/02 ,  D01F2/28 ,  Y10T442/30

    摘要： The present invention concerns a biodegradable cigarette filter tow comprising composite filaments of cellulose and cellulose acetate, and a process for making such a filter tow comprising providing a solution dope comprising a blend of cellulose and cellulose acetate in an ionic liquid or in N-methylmorphilone-N-oxide (NMMO), and spinning casting the blend into a protic solvent to generate fibers or films, and converting the fibers or films into cigarette filter tow. The invention also concerns cigarette filters and cigarettes made from such a filter tow.

    摘要翻译： 本发明涉及一种包括纤维素和乙酸纤维素的复合长丝的可生物降解的香烟过滤丝束，以及制备这种过滤丝束的方法，包括提供溶液涂料，该溶液涂料包含离子液体中的纤维素和乙酸纤维素的混合物或N-甲基吗啉酮 - N-氧化物（NMMO），并将共混物纺丝成质子溶剂以产生纤维或膜，并将纤维或膜转化为香烟过滤丝束。 本发明还涉及由这种过滤丝束制成的香烟过滤嘴和香烟。

    METHODS OF CHEMICAL SYNTHESIS OF DIAMINOPHENOTHIAZINIUM COMPOUNDS INVOLVING THE USE OF PERSULFATE OXIDANTS
    19.
    发明申请
    METHODS OF CHEMICAL SYNTHESIS OF DIAMINOPHENOTHIAZINIUM COMPOUNDS INVOLVING THE USE OF PERSULFATE OXIDANTS 有权
    涉及使用聚氨酯氧化物的二氨基苯并嗪化合物的化学合成方法

    公开(公告)号：US20120058995A1

    公开(公告)日：2012-03-08

    申请号：US13318907

    申请日：2010-05-11

    申请人： Christopher Paul Larch ,  John Mervyn David Storey ,  Craig Williamson ,  Colin Marshall ,  Steven John Kemp

    发明人： Christopher Paul Larch ,  John Mervyn David Storey ,  Craig Williamson ,  Colin Marshall ,  Steven John Kemp

    IPC分类号： A61K31/5415 ,  C07C309/01 ,  A61P33/02 ,  A61P35/00 ,  A61P31/12 ,  A61P31/04 ,  C07D279/18 ,  A61P25/28

    CPC分类号： C07D279/18 ,  C07C381/02

    摘要： This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the e//i method comprises the steps of in order: a thiosulfonic acid formation (TSAF) as illustrated below, wherein the reaction is carried out in the presence of a thio sulfate and an oxidizing agent that is or comprises persulfate an oxidative coupling (OC); and a ring closure (RC). The resulting compounds and compositions comprising them (e.g., tablets, capsules) are useful in methods of medical treatment and diagnosis, etc., for example, tauopathies, or Alzheimer's disease (AD).

    摘要翻译： 本发明一般涉及化学合成和纯化领域，更具体地涉及合成和纯化某些3,7-二氨基吩噻嗪-5-肟化合物（本文称为“二氨基吩噻嗪鎓化合物”）的方法，包括甲基硫堇（MTC） ）（也称为亚甲基蓝）。 在一个实施方案中，所述方法包括以下步骤：如下所示的硫代磺酸形成（TSAF），其中所述反应在硫代硫酸盐和氧化剂存在下进行，所述硫酸硫酸盐和氧化剂是或包含过硫酸盐 氧化偶联（OC）; 和闭环（RC）。 所得到的化合物和包含它们的组合物（例如片剂，胶囊剂）可用于治疗和诊断等方法，例如tau蛋白病或阿尔茨海默病（AD）。