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    BIODEGRADABLE FIBRE AND ITS PROCESS OF MANUFACTURE
    9.
    发明申请
    BIODEGRADABLE FIBRE AND ITS PROCESS OF MANUFACTURE 审中-公开
    生物可变光纤及其制造工艺

    公开(公告)号：US20120202398A1

    公开(公告)日：2012-08-09

    申请号：US13497209

    申请日：2010-10-21

    申请人： Colin Marshall ,  Jamie Moffat

    发明人： Colin Marshall ,  Jamie Moffat

    IPC分类号： C08L1/12 ,  D03D15/00 ,  D01F6/18

    CPC分类号： A24D3/068 ,  A24D3/10 ,  B29C48/05 ,  D01F2/00 ,  D01F2/02 ,  D01F2/28 ,  Y10T442/30

    摘要： The present invention concerns a biodegradable fibre comprising composite filaments of cellulose and cellulose acetate, and a process for making such a fibre comprising providing a solution dope comprising a blend of cellulose and cellulose acetate in an ionic liquid or in N-methylmorphilone-N-oxide (NMMO), and spinning casting the blend into a protic solvent to generate fibres. The invention also concerns materials made from such a fibre, and garments or soft furnishings made from such a material.

    摘要翻译： 本发明涉及包含纤维素和乙酸纤维素的复合长丝的生物可降解纤维，以及制备这种纤维的方法，包括提供溶液涂料，所述溶液涂料包含离子液体中的纤维素和乙酸纤维素的混合物或N-甲基吗啉酮-N-氧化物 （NMMO），并将共混物旋转浇铸成质子溶剂以产生纤维。 本发明还涉及由这种纤维制成的材料，以及由这种材料制成的衣服或软的家具。

    3,7-diamino-10H-phenothiazine salts and their use
    10.
    发明授权
    3,7-diamino-10H-phenothiazine salts and their use 有权
    3,7-二氨基-10H-吩噻嗪盐及其用途

    公开(公告)号：US07888350B2

    公开(公告)日：2011-02-15

    申请号：US12294599

    申请日：2007-03-28

    申请人： Claude Michel Wischik ,  Janet Elizabeth Rickard ,  Charles Robert Harrington ,  David Horsley ,  John Mervyn David Storey ,  Colin Marshall ,  James Peter Sinclair ,  Thomas Craven Baddeley

    发明人： Claude Michel Wischik ,  Janet Elizabeth Rickard ,  Charles Robert Harrington ,  David Horsley ,  John Mervyn David Storey ,  Colin Marshall ,  James Peter Sinclair ,  Thomas Craven Baddeley

    IPC分类号： C07D279/18 ,  A61K31/5415

    CPC分类号： A61K31/5415 ,  C07D279/20 ,  C07D279/22 ,  C09B21/00 ,  Y02A50/393 ,  Y02A50/411

    摘要： This invention pertains generally to the field of phenothiazine compounds, and more particularly to certain stably reduced phenothiazine compounds, specifically, certain 3,7 diamino-10H-phenothiazine (DAPTZ) compounds of the following formula wherein: each of R1 and R9 is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of HX1 and HX2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These compounds are useful as drugs, for example, in the treatment of tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs (for example, methythioninium chloride, MTC).

    摘要翻译： 本发明一般涉及吩噻嗪化合物领域，更具体地涉及某些稳定还原的吩噻嗪化合物，具体地，下列通式的某些3,7-二氨基-10H-吩噻嗪（DAPTZ）化合物其中：R 1和R 9各自独立地选自 从：-H; C 1-4烷基; C2-4烯基; 和卤代C 1-4烷基; R3NA和R3NB中的每一个独立地选自：-H; C 1-4烷基; C2-4烯基; 和卤代C 1-4烷基; R7NA和R7NB中的每一个独立地选自：-H; C 1-4烷基; C2-4烯基; 和卤代C 1-4烷基; HX1和HX2各自独立地是质子酸; 及其药学上可接受的盐，溶剂化物和水合物。 这些化合物可用作药物，例如用于治疗tau蛋白病如阿尔茨海默氏病，以及作为相应的氧化硫堇药物（例如氯化甲硫氨酸，MTC）的前药。