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    Medical devices having a bioresorbable coating layer with a pre-determined pattern for fragmentation
    11.
    发明授权
    Medical devices having a bioresorbable coating layer with a pre-determined pattern for fragmentation 有权

    公开(公告)号：US09597435B2

    公开(公告)日：2017-03-21

    申请号：US12434856

    申请日：2009-05-04

    Applicant: Peter Edelman ,  Afsar Ali

    Inventor： Peter Edelman ,  Afsar Ali

    IPC: A61F2/00 ,  A61L31/14 ,  A61L31/10 ,  A61L31/16

    CPC classification number: A61L31/148 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00

    Abstract: Intravascular medical devices comprising a coating layer disposed on a substrate associated with the medical device, wherein the coating layer has a pre-determined fragmentation pattern. At least a portion of the coating layer comprises a plurality of discontinuous bioresorbable members, wherein the discontinuous bioresorbable members have a size less than the luminal diameter of an arteriole. The coating layer may be formed by excavating portions of a coating layer (e.g., by laser ablation) to create gaps which define the discontinuous bioresorbable members. In certain embodiments, the coating layer is formed of a heat-bondable material. In such embodiments, the discontinuous bioresorbable members may be adhered to the substrate via heat bonds. Also disclosed are methods of forming a coating layer on medical devices and methods of treating intravascular sites.

    Photoresist coating to apply a coating to select areas of a medical device
    12.
    发明授权
    Photoresist coating to apply a coating to select areas of a medical device 失效
    光刻胶涂层以涂覆涂层以选择医疗器械的区域

    公开(公告)号：US08257777B2

    公开(公告)日：2012-09-04

    申请号：US12100602

    申请日：2008-04-10

    Applicant: Peter Edelman

    Inventor： Peter Edelman

    IPC: B05D3/06 ,  B05D5/00 ,  A61F2/06

    CPC classification number: B05D1/32 ,  A61F2250/0067 ,  A61F2310/0097 ,  B05D3/06 ,  B05D3/065 ,  Y10T428/31

    Abstract: Methods and devices for coating a medical device, such as a stent, including the steps of coating the medical device with a photoresist polymeric coating, irradiating a portion of the medical device, optionally applying a post-exposure bake step, and removing all or a portion of the coating from the irradiated portion of the medical device, if a positive photoresist coating material is used, or from a portion of the medical device not exposed to the radiation, if a negative photoresist coating material is used. The photoresist polymeric coating may optionally include a drug.

    Abstract translation: 用于涂覆诸如支架的医疗装置的方法和装置，包括以下步骤：用光致抗蚀剂聚合物涂层涂覆医疗装置，照射医疗装置的一部分，可选地应用曝光后烘烤步骤，以及去除所有或一个 如果使用正性光致抗蚀剂涂层材料，或者如果使用负性光致抗蚀剂涂层材料，则来自医疗装置的照射部分的涂层的部分或未暴露于辐射的部分医疗装置。 光致抗蚀剂聚合物涂层可以任选地包括药物。

    PHOTORESIST COATING TO APPLY A COATING TO SELECT AREAS OF A MEDICAL DEVICE
    13.
    发明申请
    PHOTORESIST COATING TO APPLY A COATING TO SELECT AREAS OF A MEDICAL DEVICE 失效
    光电涂层，以涂覆选择医疗器械的领域

    公开(公告)号：US20080254297A1

    公开(公告)日：2008-10-16

    申请号：US12100602

    申请日：2008-04-10

    Applicant: Peter Edelman

    Inventor： Peter Edelman

    IPC: B32B33/00 ,  B05D7/00

    CPC classification number: B05D1/32 ,  A61F2250/0067 ,  A61F2310/0097 ,  B05D3/06 ,  B05D3/065 ,  Y10T428/31

    Abstract: Methods and devices for coating a medical device, such as a stent, including the steps of coating the medical device with a photoresist polymeric coating, irradiating a portion of the medical device, optionally applying a post-exposure bake step, and removing all or a portion of the coating from the irradiated portion of the medical device, if a positive photoresist coating material is used, or from a portion of the medical device not exposed to the radiation, if a negative photoresist coating material is used. The photoresist polymeric coating may optionally include a drug.

    Abstract translation: 用于涂覆诸如支架的医疗装置的方法和装置，包括以下步骤：用光致抗蚀剂聚合物涂层涂覆医疗装置，照射医疗装置的一部分，可选地应用曝光后烘烤步骤，以及去除所有或一个 如果使用正性光致抗蚀剂涂层材料，或者如果使用负性光致抗蚀剂涂层材料，则来自医疗装置的照射部分的涂层的部分或未暴露于辐射的部分医疗装置。 光致抗蚀剂聚合物涂层可以任选地包括药物。

    Sensors for measuring analyte concentrations and methods of making same
    14.
    发明授权
    Sensors for measuring analyte concentrations and methods of making same 失效
    用于测量分析物浓度的传感器及其制备方法

    公开(公告)号：US5707502A

    公开(公告)日：1998-01-13

    申请号：US680050

    申请日：1996-07-12

    Applicant: Robert McCaffrey ,  Katarina Tkacik ,  Brian Holman ,  James Flaherty ,  Josef Brown ,  Peter Edelman

    Inventor： Robert McCaffrey ,  Katarina Tkacik ,  Brian Holman ,  James Flaherty ,  Josef Brown ,  Peter Edelman

    IPC: C12Q1/00 ,  G01N27/26

    CPC classification number: C12Q1/001 ,  C12Q1/002 ,  Y10S435/817

    Abstract: A sensor for measuring a concentration of an analyte in a solution. The sensor comprises a substrate layer, an electrode layer and an immobilized enzyme layer. The sensor further includes an enzyme/polymer layer and/or a hydrophobic layer. The enzyme/polymer layer includes an enzyme disposed within a polymer matrix. The hydrophobic layer is formed from a material that is more hydrophobic than the immobilized enzyme layer material. In certain embodiments, the sensor includes the enzyme/polymer layer and the hydrophobic layer disposed between the enzyme/polymer layer and the immobilized enzyme layer such that the enzyme/polymer layer is disposed along the hydrophobic layer within an area above the immobilized enzyme layer.

    Abstract translation: 用于测量溶液中分析物浓度的传感器。 传感器包括基底层，电极层和固定化酶层。 传感器还包括酶/聚合物层和/或疏水层。 酶/聚合物层包括设置在聚合物基质内的酶。 疏水层由比固定化酶层材料更疏水的材料形成。 在某些实施方案中，传感器包括酶/聚合物层和设置在酶/聚合物层和固定化酶层之间的疏水层，使得酶/聚合物层沿着疏水层设置在固定化酶层上方的区域内。

    Medical devices having a coating of biologic macromolecules
    15.
    发明授权
    Medical devices having a coating of biologic macromolecules 有权
    具有生物大分子涂层的医疗器械

    公开(公告)号：US08574612B2

    公开(公告)日：2013-11-05

    申请号：US12708993

    申请日：2010-02-19

    Applicant: Peter Edelman

    Inventor： Peter Edelman

    IPC: A61F2/12 ,  A61K38/02

    CPC classification number: A61L31/10 ,  A61L31/148 ,  A61L31/16

    Abstract: A medical device having a coating of biologic macromolecules. The coating of biologic macromolecules is protected by a temporary protective layer disposed over the biologic macromolecules. The temporary protective layer serves to protect the structure (e.g., conformation) and/or function (e.g., target binding capacity) of the biologic macromolecules during processing, storage, handling, and/or delivery (e.g., implantation or insertion into a patient) of the medical device. Upon implantation or insertion into a patient's body, the temporary protective layer may dissolve to expose the biologic macromolecules to the physiologic environment.

    Abstract translation: 具有生物大分子涂层的医疗装置。 生物大分子的涂层由位于生物大分子上的临时保护层保护。 临时保护层用于在处理，储存，处理和/或递送期间保护生物大分子的结构（例如，构象）和/或功能（例如，靶结合能力）（例如，植入或插入患者体内） 的医疗器械。 在植入或插入患者体内时，临时保护层可以溶解以将生物大分子暴露于生理环境。

    EMBOLIC FILTER DELIVERY SYSTEM AND METHOD
    17.
    发明申请
    EMBOLIC FILTER DELIVERY SYSTEM AND METHOD 有权
    EMBOLIC过滤器输送系统和方法

    公开(公告)号：US20100152829A1

    公开(公告)日：2010-06-17

    申请号：US12563758

    申请日：2009-09-21

    Applicant: Peter Edelman ,  Lawrence Wasicek ,  Nayan Ashar ,  Husnija Mujkanovic ,  Eduardo Sucgang

    Inventor： Peter Edelman ,  Lawrence Wasicek ,  Nayan Ashar ,  Husnija Mujkanovic ,  Eduardo Sucgang

    IPC: A61F2/06 ,  A61F2/01

    CPC classification number: A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61F2250/0048

    Abstract: The disclosure pertains to a medical device deployment system comprising a restraint member which holds the embolic protection filter in a restrained, or partially collapsed, state for insertion into a lumen and transit to a desired deployment site. The restraint member comprises two or more portions which differ in their mechanical ability to resist the radial forces exerted by various portions of the medical device when it is in a restrained, or partially collapsed, state. The restraint member is maintained in a restraint configuration by an actuation member which engages portions of the restraint member lying on opposite sides of a generally axial gap until deployment of the medical device is desired. Withdrawal of the actuation member allows the restraint member to release the medical device which may then return to a deployed state. The invention also provides a method for assembling a medical device deployment system.

    Abstract translation: 本公开涉及一种医疗装置展开系统，其包括限制构件，该限制构件将栓塞保护过滤器保持在限制或部分折叠的状态，用于插入管腔并且转运到期望的部署位置。 约束构件包括两个或更多个部分，其在机械能力方面不同，以抵抗由医疗装置的各部分施加的径向力在其处于受限制或部分塌缩状态时。 约束构件通过致动构件保持在约束构造中，所述致动构件接合位于大致轴向间隙的相对侧上的限制构件的部分，直到需要部署医疗装置。 致动构件的抽出允许约束构件释放医疗装置，然后可以返回到展开状态。 本发明还提供了一种用于组装医疗装置展开系统的方法。

    OFFSET COUPLING REGION
    18.
    发明申请
    OFFSET COUPLING REGION 审中-公开
    偏差耦合区域

    公开(公告)号：US20100152711A1

    公开(公告)日：2010-06-17

    申请号：US12548499

    申请日：2009-08-27

    Applicant: Allen Utke ,  Kyle Hendrikson ,  Peter Edelman ,  Ben Arcand ,  James Anderson ,  Ari Ryan

    Inventor： Allen Utke ,  Kyle Hendrikson ,  Peter Edelman ,  Ben Arcand ,  James Anderson ,  Ari Ryan

    IPC: A61M25/00 ,  A61F2/84 ,  A61M29/00

    CPC classification number: A61F2/95 ,  A61F2/013 ,  A61F2/97 ,  A61F2002/011 ,  A61F2002/9505 ,  A61F2002/9511 ,  A61F2002/9665

    Abstract: The invention provides a medical device delivery system comprising an offset coupling region interposed between an elongated hypotube guide member or catheter and a support segment. The medical device to be delivered is disposed about the support segment and contained and/or constrained within a containment element. The medical device may be released from the containment element by moving an actuation element from a first position to a second position. The offset coupling region allows the actuation element to exit a lumen within the guide member and to engage the containment element in the first position while traveling along a line generally coaxial with the lumen of the guide member.

    Abstract translation: 本发明提供了一种医疗装置输送系统，其包括插入在细长海波导管构件或导管与支撑段之间的偏置联接区域。 要传送的医疗装置围绕支撑段布置并且包含和/或限制在容纳元件内。 医疗装置可以通过将致动元件从第一位置移动到第二位置而从容纳元件释放。 偏置联接区域允许致动元件离开引导构件内的内腔并且在沿着与引导构件的内腔大致同轴的线的同时沿着第一位置接合容纳元件。

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