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21 条记录 (耗时 0.029 秒)

    Sensors for measuring analyte concentrations and methods of making same
    1.
    发明授权
    Sensors for measuring analyte concentrations and methods of making same 失效
    用于测量分析物浓度的传感器及其制备方法

    公开(公告)号：US5707502A

    公开(公告)日：1998-01-13

    申请号：US680050

    申请日：1996-07-12

    申请人： Robert McCaffrey ,  Katarina Tkacik ,  Brian Holman ,  James Flaherty ,  Josef Brown ,  Peter Edelman

    发明人： Robert McCaffrey ,  Katarina Tkacik ,  Brian Holman ,  James Flaherty ,  Josef Brown ,  Peter Edelman

    IPC分类号： C12Q1/00 ,  G01N27/26

    CPC分类号： C12Q1/001 ,  C12Q1/002 ,  Y10S435/817

    摘要： A sensor for measuring a concentration of an analyte in a solution. The sensor comprises a substrate layer, an electrode layer and an immobilized enzyme layer. The sensor further includes an enzyme/polymer layer and/or a hydrophobic layer. The enzyme/polymer layer includes an enzyme disposed within a polymer matrix. The hydrophobic layer is formed from a material that is more hydrophobic than the immobilized enzyme layer material. In certain embodiments, the sensor includes the enzyme/polymer layer and the hydrophobic layer disposed between the enzyme/polymer layer and the immobilized enzyme layer such that the enzyme/polymer layer is disposed along the hydrophobic layer within an area above the immobilized enzyme layer.

    摘要翻译： 用于测量溶液中分析物浓度的传感器。 传感器包括基底层，电极层和固定化酶层。 传感器还包括酶/聚合物层和/或疏水层。 酶/聚合物层包括设置在聚合物基质内的酶。 疏水层由比固定化酶层材料更疏水的材料形成。 在某些实施方案中，传感器包括酶/聚合物层和设置在酶/聚合物层和固定化酶层之间的疏水层，使得酶/聚合物层沿着疏水层设置在固定化酶层上方的区域内。

    Multilayer enzyme electrode membranes and methods of making same
    2.
    发明授权
    Multilayer enzyme electrode membranes and methods of making same 失效
    多层酶电极膜及其制备方法

    公开(公告)号：US5696314A

    公开(公告)日：1997-12-09

    申请号：US679089

    申请日：1996-07-12

    申请人： Robert McCaffrey ,  Bonnie Dalzell ,  Katarina Tkacik ,  Susan Holbert ,  Mark Boden ,  James Flaherty ,  Michael Flanagan ,  Josef Brown ,  Kimiya Takeshita ,  Peter Edelman

    发明人： Robert McCaffrey ,  Bonnie Dalzell ,  Katarina Tkacik ,  Susan Holbert ,  Mark Boden ,  James Flaherty ,  Michael Flanagan ,  Josef Brown ,  Kimiya Takeshita ,  Peter Edelman

    IPC分类号： G01N27/327 ,  C12Q1/00 ,  G01N27/26 ,  G01N33/535 ,  G01N33/66 ,  H01L29/78

    CPC分类号： C12Q1/002 ,  Y10S435/817

    摘要： An electrochemical sensor is designed for use in detecting a concentration of an analyte in a sample solution. The sensor to have a longer useful lifetime, improved stability and improved response time for single or multiple use applications. In one aspect, some of these goals are achieved by providing the multilayer enzyme electrode membrane having both nonporous and microporous layers. The microporous layer is formed from a polymer binder, a polymer powder, a surfactant and a mineral powder. In another aspect, certain of these goals are achieved by the use of a layer comprised of an enzyme disposed within a polymer matrix. In certain embodiments, the multilayer enzyme electrode membrane includes an outermost layer which is capable of dissolving in the sample solution such that the interface between the multilayer enzyme electrode membrane and the sample solution is continually renewed. The sensor provides an electrical current output proportional to the reagent chemical interaction of the analyte with an immobilized enzyme layer during exposure of the sensor in such solution.

    摘要翻译： 电化学传感器设计用于检测样品溶液中分析物的浓度。 该传感器具有更长的使用寿命，提高了单个或多个使用应用的稳定性和改进的响应时间。 在一个方面，通过提供具有无孔和多孔层的多层酶电极膜来实现这些目标中的一些。 微孔层由聚合物粘合剂，聚合物粉末，表面活性剂和矿物粉末形成。 在另一方面，这些目标中的某些通过使用由置于聚合物基质内的酶构成的层来实现。 在某些实施方案中，多层酶电极膜包括能够溶解在样品溶液中的最外层，使得多层酶电极膜和样品溶液之间的界面不断更新。 传感器在这种溶液中曝光期间，传感器提供与分析物与固定化酶层的试剂化学相互作用成比例的电流输出。

    Embolic filter delivery system and method
    3.
    发明授权
    Embolic filter delivery system and method 有权
    栓塞过滤器输送系统及方法

    公开(公告)号：US08444669B2

    公开(公告)日：2013-05-21

    申请号：US12563758

    申请日：2009-09-21

    申请人： Peter Edelman ,  Lawrence Wasicek ,  Nayan Ashar ,  Husnija Mujkanovic ,  Eddie Sucgang

    发明人： Peter Edelman ,  Lawrence Wasicek ,  Nayan Ashar ,  Husnija Mujkanovic ,  Eddie Sucgang

    IPC分类号： A61F2/01

    CPC分类号： A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61F2250/0048

    摘要： The disclosure pertains to a medical device deployment system comprising a restraint member which holds the embolic protection filter in a restrained, or partially collapsed, state for insertion into a lumen and transit to a desired deployment site. The restraint member comprises two or more portions which differ in their mechanical ability to resist the radial forces exerted by various portions of the medical device when it is in a restrained, or partially collapsed, state. The restraint member is maintained in a restraint configuration by an actuation member which engages portions of the restraint member lying on opposite sides of a generally axial gap until deployment of the medical device is desired. Withdrawal of the actuation member allows the restraint member to release the medical device which may then return to a deployed state. The invention also provides a method for assembling a medical device deployment system.

    摘要翻译： 本公开涉及一种医疗装置展开系统，其包括限制构件，该限制构件将栓塞保护过滤器保持在限制或部分折叠的状态，用于插入管腔并且转运到期望的部署位置。 约束构件包括两个或更多个部分，其在机械能力方面不同，以抵抗由医疗装置的各部分施加的径向力在其处于受限制或部分塌缩状态时。 约束构件通过致动构件保持在约束构造中，所述致动构件接合位于大致轴向间隙的相对侧上的限制构件的部分，直到需要部署医疗装置。 致动构件的抽出允许约束构件释放医疗装置，然后可以返回到展开状态。 本发明还提供了一种用于组装医疗装置展开系统的方法。

    Method for controlling the power consumption of a hydrodynamic clutch by controlling the volumetric efficiency and a hydrodynamic clutch
    9.
    发明授权
    Method for controlling the power consumption of a hydrodynamic clutch by controlling the volumetric efficiency and a hydrodynamic clutch 失效
    通过控制体积效率和流体动力学离合器来控制流体动力离合器的功率消耗的方法

    公开(公告)号：US06910330B2

    公开(公告)日：2005-06-28

    申请号：US10363335

    申请日：2001-08-29

    申请人： Werner Klement ,  Klaus Vogelsang ,  Peter Edelman ,  Heinz Höller ,  Jürgen Friedrich

    发明人： Werner Klement ,  Klaus Vogelsang ,  Peter Edelman ,  Heinz Höller ,  Jürgen Friedrich

    IPC分类号： F16H61/64 ,  F16D33/06 ,  F16D33/16

    CPC分类号： F16D33/16 ,  Y10T477/6333

    摘要： A method for controlling the power consumption of a starting element (1) in the form of a hydrodynamic clutch (2). The clutch comprises an impeller (4) and a turbine wheel (5), which together form at least one toroidal working chamber (6) that can be filled with an operating medium, and is located in a drive train (3) with at least one other drive motor that can be coupled to the hydrodynamic clutch. The method is characterized in that the power consumption can be freely adjusted as a function of the volumetric efficiency of the hydrodynamic clutch and the method has the following characteristics: the supply or evacuation of the operating medium to or from the working chamber is influenced by the generation and introduction of a static superposition pressure in the closed rotating circuit; the operating medium is supplied or evacuated to or from the working chamber by the application of a superposition or influencing pressure to the operating medium level in the operating medium reservoir (40).

    摘要翻译： 一种用于控制液力离合器（2）形式的起动元件（1）的功率消耗的方法。 离合器包括叶轮（4）和涡轮机叶轮（5），它们一起形成至少一个能够填充有操作介质的环形工作室（6），并且至少位于传动系（3）中 另一个驱动马达可以联接到流体动力离合器。 该方法的特征在于，能够根据流体动力离合器的体积效率自由调节功率消耗，该方法具有以下特征：向或从工作室供给或排出操作介质受到 在闭合旋转电路中产生和引入静态叠加压力; 操作介质通过对操作介质储存器（40）中的操作介质水平施加叠加或影响的压力而被供给或抽空到工作室。

    Medical devices having a bioresorbable coating layer with a pre-determined pattern for fragmentation
    10.
    发明授权
    Medical devices having a bioresorbable coating layer with a pre-determined pattern for fragmentation 有权

    公开(公告)号：US09597435B2

    公开(公告)日：2017-03-21

    申请号：US12434856

    申请日：2009-05-04

    申请人： Peter Edelman ,  Afsar Ali

    发明人： Peter Edelman ,  Afsar Ali

    IPC分类号： A61F2/00 ,  A61L31/14 ,  A61L31/10 ,  A61L31/16

    CPC分类号： A61L31/148 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00

    摘要： Intravascular medical devices comprising a coating layer disposed on a substrate associated with the medical device, wherein the coating layer has a pre-determined fragmentation pattern. At least a portion of the coating layer comprises a plurality of discontinuous bioresorbable members, wherein the discontinuous bioresorbable members have a size less than the luminal diameter of an arteriole. The coating layer may be formed by excavating portions of a coating layer (e.g., by laser ablation) to create gaps which define the discontinuous bioresorbable members. In certain embodiments, the coating layer is formed of a heat-bondable material. In such embodiments, the discontinuous bioresorbable members may be adhered to the substrate via heat bonds. Also disclosed are methods of forming a coating layer on medical devices and methods of treating intravascular sites.