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    Query Classification
    12.
    发明申请
    Query Classification 有权
    查询分类

    公开(公告)号：US20150169739A1

    公开(公告)日：2015-06-18

    申请号：US13462126

    申请日：2012-05-02

    申请人： Peter Linsley

    发明人： Peter Linsley

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30675 ,  G06F17/30029 ,  G06F17/3071 ,  G06F17/30867 ,  G06F17/30935

    摘要： Methods, apparatus and software for classifying queries. In an aspect, for each of a plurality of queries, determines a first value based on a first number of occurrences for which the query was received for unfiltered search operations, and a determines a second value based on a second number of occurrences for which the query was received for filtered search operations. The method determines a first content type value based on the first value and the second value, and for each of the plurality of queries having a first content type value that meets a first threshold, classifies the query as a first content type seeking query, the classification being indicative of likely user interest in content of the first type.

    摘要翻译： 用于分类查询的方法，设备和软件。 在一方面，对于多个查询中的每一个，基于针对未过滤的搜索操作接收到查询的第一个出现次数来确定第一个值，并且a基于第二个数量的事件来确定第二个值， 收到过滤搜索操作的查询。 该方法基于第一值和第二值确定第一内容类型值，并且对于具有满足第一阈值的第一内容类型值的多个查询中的每一个，将该查询分类为第一内容类型查询查询， 分类表示可能的用户对第一类内容的兴趣。

    Iterative probe design and detailed expression profiling with flexible in-situ synthesis arrays
    15.
    发明申请
    Iterative probe design and detailed expression profiling with flexible in-situ synthesis arrays 审中-公开
    迭代探针设计和具有灵活原位合成阵列的详细表达谱

    公开(公告)号：US20060141501A1

    公开(公告)日：2006-06-29

    申请号：US11282025

    申请日：2005-11-16

    申请人： Stephen Friend ,  Roland Stoughton ,  Peter Linsley ,  Julia Burchard

    发明人： Stephen Friend ,  Roland Stoughton ,  Peter Linsley ,  Julia Burchard

    IPC分类号： C12Q1/68

    CPC分类号： G16B25/00

    摘要： Methods and compositions are provided that are useful for detecting and reporting a plurality of different target polynucleotide sequences in a sample, such as polynucleotides corresponding to a plurality of different genes expressed by a cell or cells. In particular, the invention provides methods for screening a plurality of candidate polynucleotide probes to evaluate both the sensitivity and the specificity with which each candidate probe hybridizes to a target polynucleoide sequence. Candidate polynucleotide probes can then be ranked according to both their sensitivity and specificity, and probes that have optimal sensitivity and specificity for a target polynucleotide sequence can be selected. In one embodiment, polynucleotide probes can be selected according to the methods described herein to prepare “screening chips” wherein a large number of target polynucleotide sequences are detected using a single microarray have a few (e.g., 1-5) probes for each target polynucleotide sequence. In a particularly preferred embodiment, the invention provides a screening chip that can detect genetic transcripts from the entire genome of an organism. In an alternative embodiment, polynucleotide probes can be selected according to the methods described herein to prepare “signature chips” to more accurately detect certain selected “signature genes” using several polynucleotide probes (e:g., 10-20) for each signature gene. The invention additionally provides microarrays containing polynucleotide probes for a large number of genes expressed by a cell or organism. Further, methods for detecting a plurality of polynucleotide molecules, including a large number of genes expressed by a cell or organism, are also provided.

    摘要翻译： 提供了可用于检测和报告样品中多个不同靶多核苷酸序列的方法和组合物，例如对应于由细胞或细胞表达的多种不同基因的多核苷酸。 特别地，本发明提供了筛选多个候选多核苷酸探针以评估每个候选探针与目标多核苷酸序列杂交的灵敏度和特异性的方法。 然后可以根据其灵敏度和特异性对候选多核苷酸探针进行排序，并且可以选择对靶多核苷酸序列具有最佳敏感性和特异性的探针。 在一个实施方案中，可以根据本文所述的方法选择多核苷酸探针以制备“筛选芯片”，其中使用单个微阵列检测大量目标多核苷酸序列，其中每个靶多核苷酸具有少量（例如1-5）探针 序列。 在一个特别优选的实施方案中，本发明提供了可以检测来自生物体的整个基因组的遗传转录物的筛选芯片。 在替代实施方案中，可以根据本文所述的方法选择多核苷酸探针，以制备“签名芯片”，以使用每个签名基因的多个多核苷酸探针（例如，10-20）更准确地检测某些所选择的“签名基因” 。 本发明另外提供含有由细胞或生物表达的大量基因的多核苷酸探针的微阵列。 此外，还提供了用于检测多个多核苷酸分子的方法，包括由细胞或生物体表达的大量基因。

    Query classification
    17.
    发明授权
    Query classification 有权
    查询分类

    公开(公告)号：US09152701B2

    公开(公告)日：2015-10-06

    申请号：US13462126

    申请日：2012-05-02

    申请人： Peter Linsley

    发明人： Peter Linsley

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30675 ,  G06F17/30029 ,  G06F17/3071 ,  G06F17/30867 ,  G06F17/30935

    摘要： Methods, apparatus and software for classifying queries. In an aspect, for each of a plurality of queries, determines a first value based on a first number of occurrences for which the query was received for unfiltered search operations, and a determines a second value based on a second number of occurrences for which the query was received for filtered search operations. The method determines a first content type value based on the first value and the second value, and for each of the plurality of queries having a first content type value that meets a first threshold, classifies the query as a first content type seeking query, the classification being indicative of likely user interest in content of the first type.

    摘要翻译： 用于分类查询的方法，设备和软件。 在一方面，对于多个查询中的每一个，基于针对未过滤的搜索操作接收到查询的第一个出现次数来确定第一个值，并且a基于第二个数量的事件来确定第二个值， 收到过滤搜索操作的查询。 该方法基于第一值和第二值确定第一内容类型值，并且对于具有满足第一阈值的第一内容类型值的多个查询中的每一个，将该查询分类为第一内容类型查询查询， 分类表示可能的用户对第一类内容的兴趣。

    Previewing search results
    18.
    发明授权
    Previewing search results 有权
    预览搜索结果

    公开(公告)号：US08645360B2

    公开(公告)日：2014-02-04

    申请号：US13288859

    申请日：2011-11-03

    申请人： Peter Linsley ,  Kenneth W. Dauber

    发明人： Peter Linsley ,  Kenneth W. Dauber

    IPC分类号： G06F7/00 ,  G06F17/30

    CPC分类号： G06F17/30277 ,  G06F17/30572 ,  G06F17/30864

    摘要： Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for previewing search results. In one aspect, a method includes receiving a query from a client device. One or more image search results are provided to the client device, each of the one or more image search results identifying a corresponding image resource and each of the one or more image search results including an image representation of the corresponding image resource. One or more related queries are provided to the client device, the one or more related queries having been determined to be related to the query, wherein each of the one or more related queries includes a preview image to be displayed at the client device, the preview image representing an image search result responsive to the related query.

    摘要翻译： 方法，系统和装置，包括在计算机存储介质上编码的计算机程序，用于预览搜索结果。 一方面，一种方法包括从客户端设备接收查询。 将一个或多个图像搜索结果提供给客户端设备，所述一个或多个图像搜索结果中的每一个标识对应的图像资源，并且所述一个或多个图像搜索结果中的每一个包括对应的图像资源的图像表示。 将一个或多个相关查询提供给客户端设备，所述一个或多个相关查询已被确定为与查询相关，其中所述一个或多个相关查询中的每一个包括要在客户端设备处显示的预览图像， 响应于相关查询的表示图像搜索结果的预览图像。

    Methods and Compositions for Treating Cancer
    19.
    发明申请
    Methods and Compositions for Treating Cancer 审中-公开
    治疗癌症的方法和组成

    公开(公告)号：US20100166731A1

    公开(公告)日：2010-07-01

    申请号：US11992798

    申请日：2006-09-29

    申请人： Steven R. Bartz ,  Peter Linsley

    发明人： Steven R. Bartz ,  Peter Linsley

    IPC分类号： A61K39/395 ,  A61K33/24 ,  C12Q1/68 ,  C12Q1/48 ,  C12N5/02 ,  A61K38/00 ,  A61P35/04 ,  A61K31/7088

    CPC分类号： C12Q1/485 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/14 ,  C12N2310/15

    摘要： The present invention relates to methods and compositions for treating cancers by reducing the expression or activity of one or more of the genes encoding protein kinases ATR, MAST2, MAP3K6, TBK1, ADRBK2, CDKL2, LATS2, STK32B, STK11, DDR13 PSKH2, and NEK8, and/or the encoded kinases. The invention also relates to methods and compositions for determining the responsiveness of a cancer patient to anti-cancer drugs based on the status of one or more of such kinases. The invention further relates to methods and compositions for screening compounds that can be used to modulate the expression/activity of these kinases.

    摘要翻译： 本发明涉及通过降低编码蛋白激酶ATR，MAST2，MAP3K6，TBK1，ADRBK2，CDKL2，LATS2，STK32B，STK11，DDR13 PSKH2和NEK8的一种或多种基因的表达或活性来治疗癌症的方法和组合物 ，和/或编码的激酶。 本发明还涉及用于基于一种或多种这样的激酶的状态确定癌症患者对抗癌药物的反应性的方法和组合物。 本发明还涉及用于筛选可用于调节这些激酶的表达/活性的化合物的方法和组合物。