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1.发明授权公开(公告)号：US06482600B1
公开(公告)日：2002-11-19
申请号：US09306564
申请日：1999-05-06
IPC分类号： G01M3353
CPC分类号： G01N33/57415 , Y10S435/96 , Y10S435/962
摘要： This invention relates to the discovery of the association of certain nucleic acid sequences and proteins with breast cancer, the use of such sequences as a diagnostic indicator and treatments based on the association.
摘要翻译： 本发明涉及某些核酸序列和蛋白质与乳腺癌的关联的发现，使用这样的序列作为诊断指标和基于该关联的治疗。
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2.发明授权公开(公告)号：US06183995B2
公开(公告)日：2001-02-06
申请号：US08925818
申请日：1997-09-05
IPC分类号： C12P1934
CPC分类号： C12N15/1096 , C12N15/1003 , C12Q1/6806 , C12Q1/6809 , Y10T436/143333
摘要： This invention provides methods for the isolation of complete representation of cellular messenger ribonucleic acid from wax-embedded tissue samples. Expression of genes of interest can thus be fortuitously determined and cDNA probes can be readily developed.
摘要翻译： 本发明提供从蜡嵌入的组织样品中分离细胞信使核糖核酸的完整表示的方法。 因此可以偶然地确定感兴趣的基因的表达，并且可以容易地开发cDNA探针。
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公开(公告)号：US5882756A
公开(公告)日：1999-03-16
申请号：US806957
申请日：1997-02-26
CPC分类号： B29C66/721 , B29C65/564 , B29C66/7392 , B29C66/7394 , B29C70/24 , B29C73/10 , B29C73/30 , B64F5/0081 , B29C66/71 , B29C66/7212 , B29C66/73755 , B29K2105/06 , B29L2031/3082 , Y10T428/20 , Y10T428/24033 , Y10T428/249923
摘要： The strength of composite patches is improved over conventional bolted or bonded patches by including Z-pins in the patch/parent structure interface to provide a mechanical link with small stress concentration between the patch and the parent structure. In some cases, we achieve a stronger repair removing the pins to leave holes that fill with resin from the patch during the curing or bonding operation.
摘要翻译： 通过在贴片/母体结构界面中包括Z形针来提供复合贴片的强度比常规螺栓连接或粘合贴片提高，以提供贴片和母体结构之间的小应力集中的机械连接。 在某些情况下，在固化或粘合操作期间，我们可以实现更好的修复，以消除针脚，从孔中填充填充树脂的孔。
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公开(公告)号：US5868886A
公开(公告)日：1999-02-09
申请号：US577035
申请日：1995-12-22
CPC分类号： B29C66/721 , B29C65/564 , B29C66/7392 , B29C66/7394 , B29C70/24 , B29C73/10 , B29C73/30 , B64F5/0081 , B29C66/71 , B29C66/7212 , B29C66/73755 , B29K2105/06 , B29L2031/3082 , Y10T428/20 , Y10T428/24033 , Y10T428/249923
摘要： The strength of composite patches is improved over conventional bolted or bonded patches by including Z-pins in the patch/parent structure interface to provide a mechanical link with small stress concentration between the patch and the parent structure. In some cases, we achieve a stronger repair removing the pins to leave holes that fill with resin from the patch during the curing or bonding operation.
摘要翻译： 通过在贴片/母体结构界面中包括Z形针来提供复合贴片的强度比常规螺栓连接或粘合贴片提高，以提供贴片和母体结构之间的小应力集中的机械连接。 在某些情况下，在固化或粘合操作期间，我们可以实现更好的修复，以消除针脚，从孔中填充填充树脂的孔。
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公开(公告)号：US5795067A
公开(公告)日：1998-08-18
申请号：US643841
申请日：1996-05-07
申请人： Jacob Fraden , Joseph P. Brown , Robert P. Lackey , Randall R. Howe , Heinz Bultges , Wolfram Debus , Gunther Bautz , Helmut Franke
发明人： Jacob Fraden , Joseph P. Brown , Robert P. Lackey , Randall R. Howe , Heinz Bultges , Wolfram Debus , Gunther Bautz , Helmut Franke
摘要： A disposable cover for an infrared thermometer provides IR window isolation of handling and usage generated forces. The cover comprises a thin sidewall linked to the film window with a collar structure. The collar structure includes one or more characteristics that either isolate the film window from externally applied forces, or develops counter forces in a way that precludes film stretching and other transmission distorting effects. The cover of the present invention permits sanitary application of an infrared clinical thermometer without hindering reading accuracy or patient comfort.
摘要翻译： 用于红外线温度计的一次性盖子可提供IR窗口隔离处理和使用量产生的力。 盖子包括一个薄壁的侧壁，与薄膜窗口相连，带有一个领子结构。 套环结构包括一个或多个特性，其将薄膜窗口与外部施加的力隔离，或以防止膜拉伸和其它传递失真效应的方式产生反作用力。 本发明的盖子可以卫生地应用红外线体温计而不会妨碍读取精度或病人的舒适度。
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公开(公告)号：US06260575B1
公开(公告)日：2001-07-17
申请号：US09162343
申请日：1998-09-28
IPC分类号： F16K1734
CPC分类号： F16K17/34 , B05B15/70 , B05B15/74 , Y10T137/1789 , Y10T137/7849 , Y10T137/7873
摘要： A flow control valve arrests fluid flow from a primary line to a branch line when flow into the branch line exceeds a predetermined flow rate. In one embodiment for use with an irrigation system, the valve includes a T-fitting. The fitting defines a primary passage, which communicates with irrigation pipes, and a branch passage, which communicates with a riser and sprinkler assembly. A valve seat is located within a housing that couples with the fitting. The valve seat is located within the T-fitting when the valve is assembled. The location of the valve seat within the fitting allows the valve to function even when the riser and/or a portion of the housing is sheared off. A stopper selectively engages a valve seat to inhibit water flow through the branch passage when the flow rate through the branch passage exceeds the predetermined flow rate. In one embodiment, a biasing device prevents the stopper from engaging with the valve seat while the predetermined flow rate through the branch passage is momentarily exceeded by transient flow conditions.
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公开(公告)号：US5849876A
公开(公告)日：1998-12-15
申请号：US179875
申请日：1994-01-11
申请人： Peter S. Linsley , Diane Horn , Joseph P. Brown
发明人： Peter S. Linsley , Diane Horn , Joseph P. Brown
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , C07K14/00 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/30 , C07K19/00 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/574 , G01N33/577
CPC分类号： C07K16/3023 , C07K16/3015 , A61K38/00
摘要： Novel hybridoma cell lines producing monoclonal antibodies reactive with purified mucin antigens from normal and tumor sources are generated using mucins, including purified mucins from tumor sources. Epitopes on mucin antigens from normal and tumor sources are demonstrated to be distinct, using these new antibodies. The antibodies may be useful alone or in combination, in the diagnosis and treatment of cancer including malignancies of the breast and lung.
摘要翻译： 使用粘蛋白（包括来自肿瘤来源的纯化的粘蛋白）产生产生与来自正常和肿瘤来源的纯化的粘蛋白抗原反应的单克隆抗体的新型杂交瘤细胞系。 使用这些新抗体，证明来自正常和肿瘤来源的粘蛋白抗原的表位是不同的。 抗体可以单独或组合地用于诊断和治疗包括乳腺和肺的恶性肿瘤的癌症。
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8.发明授权
公开(公告)号：US4906562A
公开(公告)日：1990-03-06
申请号：US776321
申请日：1985-10-18
IPC分类号： G01N33/53 , C07K16/00 , C07K16/30 , C07K16/32 , C07K19/00 , C12N5/10 , C12N15/00 , C12N15/02 , C12P21/00 , C12R1/91 , G01N33/574 , G01N33/577
CPC分类号： C07K16/3023 , C07K2317/732 , Y10S530/806 , Y10S530/808 , Y10S530/828 , Y10S530/866
摘要： The present invention is concerned with novel monoclonal antibodies which define a glycolipid antigen associated with human non-small cell lung carcinomas ("NSCLC") and certain other human carcinomas. The antibodies bind to normal human cells to a much lesser degree than to tumor cells. The antibodies find use in diagnostic methods such as the detection of malignant cells associated with NSCLC and in therapeutic methods. Also disclosed in a novel glycolipid antigen. The invention also comprises a method for determining the presence of a malignant condition in lung tissue and other human tissue. The method involves examining the human tissue for the presence of a glycolipid antigen having the terminal carbohydrate sequence: GalNAc.beta.l.fwdarw.4Gal.beta.l.fwdarw.3GalNAc.beta.l.fwdarw.4Gal.beta.l.fwdarw.R.
摘要翻译： 本发明涉及定义与人非小细胞肺癌（“NSCLC”）和某些其他人类癌症相关的糖脂抗原的新型单克隆抗体。 抗体与正常人细胞结合的程度远低于肿瘤细胞。 抗体可用于诊断方法，例如检测与NSCLC相关的恶性细胞和治疗方法。 还在新型糖脂抗原中公开。 本发明还包括用于确定肺组织和其他人体组织中恶性病症的存在的方法。 该方法包括检查人组织中存在具有末端碳水化合物序列的糖脂抗原：GalNAcβ1->4Galβ1-> 3GalNAcβ1->4Galβ1-> R。
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公开(公告)号：US4803169A
公开(公告)日：1989-02-07
申请号：US826477
申请日：1986-02-05
申请人： Peter S. Linsley , Vincent W. Ochs , Diane Horn , Joseph P. Brown , David B. Ring , Arthur E. Frankel
发明人： Peter S. Linsley , Vincent W. Ochs , Diane Horn , Joseph P. Brown , David B. Ring , Arthur E. Frankel
IPC分类号： C12N15/00 , C12N15/02 , C12P21/00 , C12P21/08 , G01N33/574 , G01N33/577
CPC分类号： G01N33/57415 , Y10S436/813
摘要： Methods are disclosed for detecting, staging and monitoring breast cancer. The methods involve determining the amount of certain antigens, designated W1 and W9, in serum via quantitative immunoassays using anti-W1 or anti-W9 monoclonal antibodies. The amount detected is compared with amounts of the antigen found in normal sera, sera from breast cancer patients of predetermined stage, or other samples of the patient's own serum, depending upon the purpose of the assay.
摘要翻译： 公开了用于检测，分期和监测乳腺癌的方法。 所述方法包括使用抗-W1或抗-W9单克隆抗体通过定量免疫测定来测定血清中某些抗原（称为W1和W9）的量。 根据测定的目的，将检测到的量与在正常血清，预定阶段的乳腺癌患者的血清或患者自身血清的其他样品中发现的抗原的量进行比较。
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10.发明授权Pharmaceutical preparations containing a polymeric agent for releasing 5-aminosalicylic acid or its salts into the gastrointestinal tract 失效含有用于将5-氨基水杨酸或其盐释放到胃肠道中的聚合物的药物制剂
公开(公告)号：US4298595A
公开(公告)日：1981-11-03
申请号：US095411
申请日：1979-11-29
IPC分类号： A61K31/785 , A61K31/795 , A61K47/48 , C08F8/30 , C08F8/34 , C08G65/334 , C08G65/48 , C08G85/00 , A61K31/74
CPC分类号： C08G85/004 , A61K31/785 , A61K31/795 , A61K47/48176 , A61K47/48192 , A61K47/48215 , C08F8/30 , C08F8/34 , C08G65/334 , C08G65/48
摘要： An intestinal anti-inflammatory preparation comprising a polymeric agent for releasing 5-aminosalicylic acid or its salts is disclosed. The polymeric agent comprises a nonabsorbable pharmacologically acceptable organic polymer backbone containing aromatic rings to which are covalently bonded via azo bonds a plurality of salicylic acid or salicylate salt groups. The azo bonds attach to the salicylates' 5-position carbon. The polymer's azo bonds undergo bacterial cleavage in the mammalian lower bowel to release 5-aminosalicylic acid and/or its salts.
摘要翻译： 公开了包含用于释放5-氨基水杨酸或其盐的聚合物的肠道抗炎制剂。 聚合物包含含有芳环的不可吸收的药理学上可接受的有机聚合物主链，通过偶氮键与多个水杨酸盐或水杨酸盐基团共价键合。 偶氮键附着在水杨酸盐的5位碳上。 聚合物的偶氮键在哺乳动物下肠中经历细菌切割以释放5-氨基水杨酸和/或其盐。
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