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11.发明授权Nucleotide sequence encoding the tumor rejection antigen precursor, MAGE-1 失效编码肿瘤排斥抗原前体MAGE-1的核苷酸序列
公开(公告)号：US5342774A
公开(公告)日：1994-08-30
申请号：US807043
申请日：1991-12-12
申请人： Thierry Boon , Pierre van der Bruggen , Benoit Van den Eynde , Aline Van Pel , Etienne De Plaen , Christophe Lurquin , Patrick Chomez , Catia Traversari
发明人： Thierry Boon , Pierre van der Bruggen , Benoit Van den Eynde , Aline Van Pel , Etienne De Plaen , Christophe Lurquin , Patrick Chomez , Catia Traversari
IPC分类号： A61K31/70 , A61K9/127 , A61K35/12 , A61K35/14 , A61K35/18 , A61K38/00 , A61K39/00 , A61K39/395 , A61K48/00 , A61P35/00 , C07K7/06 , C07K14/00 , C07K14/47 , C07K14/52 , C07K14/525 , C07K14/54 , C07K14/55 , C07K14/705 , C07K16/00 , C07K16/30 , C07K16/42 , C07K17/00 , C12N1/00 , C12N1/20 , C12N1/21 , C12N5/10 , C12N7/00 , C12N15/00 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/00 , C12Q1/68 , C12R1/19 , G01N33/50 , G01N33/53 , G01N33/574 , G01N33/577 , G01N33/68 , C07H15/12 , C07K3/00 , C12N1/16 , C12N1/18 , C12N5/00 , C12P19/34
CPC分类号： C07K16/30 , C07K14/4748 , A61K38/00 , A61K39/00
摘要： The invention relates to an isolated DNA sequence which codes for an antigen expressed by tumor cells which is recognized by cytotoxic T cells, leading to lysis of the tumor which expresses it. Also described are cells transfected by the DNA sequence, and various therapeutic and diagnostic uses arising out of the properties of the DNA and the antigen for which it codes.
摘要翻译： 本发明涉及编码由细胞毒性T细胞识别的肿瘤细胞表达的抗原的分离的DNA序列，导致表达肿瘤的裂解。 还描述了由DNA序列转染的细胞，以及由其编码的DNA和抗原的性质产生的各种治疗和诊断用途。
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12.发明授权Isolated nucleic acid molecule encoding peptides which form complexes with MHC molecules HLA-Cw*1601 and uses thereof 失效编码与MHC分子HLA-Cw * 1601形成复合物的肽的分离的核酸分子及其用途公开(公告)号：US06465184B1
公开(公告)日：2002-10-15
申请号：US09435524
申请日：1999-11-08
申请人： Pascale Bo{haeck over (e)}l , Claude Wildmann , Thierry Boon-Falleur , Pierre van der Bruggen , Pierre Coulie , Jean-Christophe Renauld
发明人： Pascale Bo{haeck over (e)}l , Claude Wildmann , Thierry Boon-Falleur , Pierre van der Bruggen , Pierre Coulie , Jean-Christophe Renauld
IPC分类号： C12Q168
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/70539
摘要： A family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as BAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as BAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigen precursor molecules are described.
摘要翻译： 公开了一系列肿瘤排斥抗原前体和编码它们的核酸分子。 这些肿瘤排斥抗原前体被称为BAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为BAGE编码分子。 描述了编码序列和肿瘤排斥抗原前体分子的各种诊断和治疗用途。
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公开(公告)号：US06353089B1
公开(公告)日：2002-03-05
申请号：US09348797
申请日：1999-07-07
IPC分类号： C07K706
CPC分类号： C07K16/30 , A61K38/00 , C07K14/4748 , Y10S530/828
摘要： Tumor rejection antigens derived from tumor rejection precursor MAGE-3 have been identified. These “T-RAS” bind to the MHC-class I molecule HLA-A2, and the resulting complexes stimulate the production of cytolytic T cell clones which lyse the presenting cells. The peptides and complexes may be used diagnostically, therapeutically, and as immunogens for the production of antibodies, or as targets for the generation of cytolytic T cell clones.
摘要翻译： 已经鉴定了源于肿瘤排斥前体MAGE-3的肿瘤排斥抗原。 这些“T-RAS”与MHC-I类分子HLA-A2结合，并且所得复合物刺激裂解呈递细胞的溶细胞T细胞克隆的产生。 肽和复合物可以用于诊断，治疗和用作产生抗体的免疫原，或用作产生溶细胞T细胞克隆的靶标。
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14.发明授权Isolated nucleic acid molecules which encode TAGE molecules, and uses thereof 失效编码TAGE分子的分离的核酸分子及其用途公开(公告)号：US06194156B1
公开(公告)日：2001-02-27
申请号：US09324231
申请日：1999-06-02
IPC分类号： C12Q168
CPC分类号： C07K14/4748 , A61K38/00
摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as TAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as TAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigens, and their precursor molecules are described.
摘要翻译： 公开了一种新的肿瘤排斥抗原前体家族及其编码的核酸分子。 这些肿瘤排斥抗原前体被称为TAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为TAGE编码分子。 描述了编码序列和肿瘤排斥抗原及其前体分子的各种诊断和治疗用途。
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15.发明授权
公开(公告)号：US5977300A
公开(公告)日：1999-11-02
申请号：US531864
申请日：1995-09-21
IPC分类号： G01N33/50 , A61K31/00 , A61K35/14 , A61K38/00 , A61K39/00 , A61P35/00 , C07H21/04 , C07K7/06 , C07K14/47 , C07K14/705 , C07K14/74 , C12N1/21 , C12N5/02 , C12N5/06 , C12N5/08 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/68 , C12R1/91 , G01N33/569 , A61K38/08
CPC分类号： C12Q1/6881 , C07K14/4748 , C07K14/70539 , C12Q1/6886 , G01N33/56977 , A61K39/00 , C12Q2600/112
摘要： Tumor rejection antigens presented by HLA-B44 molecules are described. These peptides are useful in diagnostic and therapeutic methodologies. The tumor rejection antigens are not derived from tyrosinase, which has previously been identified as a tumor rejection antigen precursor processed to an antigen presented by HLA-B44.
摘要翻译： 描述了由HLA-B44分子呈递的肿瘤排斥抗原。 这些肽可用于诊断和治疗方法。 肿瘤排斥抗原不是源自酪氨酸酶，酪氨酸酶先前被鉴定为被HLA-B44呈递的抗原加工的肿瘤排斥抗原前体。
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16.发明授权Isolated nucleic acid molecules which encode TAGE molecules, and uses thereof 失效编码TAGE分子的分离的核酸分子及其用途
公开(公告)号：US5952468A
公开(公告)日：1999-09-14
申请号：US160845
申请日：1998-09-25
IPC分类号： C12N15/09 , A61K38/00 , C07K14/47 , C12N5/10 , C12P21/02 , C12Q1/68 , C07K14/435 , A61K38/17 , A61K38/19 , C07K14/53
CPC分类号： C07K14/4748 , A61K38/00
摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as TAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as TAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigens, and their precursor molecules are described.
摘要翻译： 公开了一种新的肿瘤排斥抗原前体家族及其编码的核酸分子。 这些肿瘤排斥抗原前体被称为TAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为TAGE编码分子。 描述了编码序列和肿瘤排斥抗原及其前体分子的各种诊断和治疗用途。
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公开(公告)号：US5585461A
公开(公告)日：1996-12-17
申请号：US217186
申请日：1994-03-24
CPC分类号： C07K14/4748 , A61K38/00 , Y10S530/828 , Y10S530/865
摘要： Tumor rejection antigens derived from tumor rejection precursor MAGE-3 have been identified. These "TRAS" bind to the MHC-class I molecule HLA-A2, and the resulting complexes stimulate the production of cytolytic T cell clones which lyse the presenting cells. The peptides and complexes may be used diagnostically, therapeutically, and as immunogens for the production of antibodies, or as targets for the generation of cytolytic T cell clones.
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18.发明授权Isolated nucleic acid molecules coding for BAGE tumor rejection antigen precursors 失效分离的编码BAGE肿瘤排斥抗原前体的核酸分子
公开(公告)号：US5571711A
公开(公告)日：1996-11-05
申请号：US79110
申请日：1993-06-17
IPC分类号： C12N15/09 , A61K38/00 , A61P35/00 , C07H21/02 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/74 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/91 , C12P19/34 , C12N1/15 , C12N1/19 , C12N5/00 , C12N15/00
CPC分类号： C07K14/4748 , C07K14/70539 , A61K38/00
摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as BAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as BAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigen precursor molecules are described.
摘要翻译： 公开了一种新的肿瘤排斥抗原前体家族及其编码的核酸分子。 这些肿瘤排斥抗原前体被称为BAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为BAGE编码分子。 描述了编码序列和肿瘤排斥抗原前体分子的各种诊断和治疗用途。
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19.发明授权Method for treating subjects by using BAGE tumor rejection antigen precursors or tumor rejection antigens 失效通过使用BAGE肿瘤排斥抗原前体或肿瘤排斥抗原治疗受试者的方法公开(公告)号：US06638512B1
公开(公告)日：2003-10-28
申请号：US09382497
申请日：1999-08-25
申请人： Pascale Bo{haeck over (e)}l , Claude Wildmann , Thierry Boon-Falleur , Pierre van der Bruggen , Pierre Coulie , Jean-Christophe Renauld
发明人： Pascale Bo{haeck over (e)}l , Claude Wildmann , Thierry Boon-Falleur , Pierre van der Bruggen , Pierre Coulie , Jean-Christophe Renauld
IPC分类号： A61K3900
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/70539
摘要： A family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as BAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as BAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigen precursor molecules are described.
摘要翻译： 公开了一系列肿瘤排斥抗原前体和编码它们的核酸分子。 这些肿瘤排斥抗原前体被称为BAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为BAGE编码分子。 描述了编码序列和肿瘤排斥抗原前体分子的各种诊断和治疗用途。
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20.发明授权Isolated molecules which complex with HLA-Cw*16 molecules, and uses thereof 有权与HLA-Cw * 16分子复合的分离的分子及其用途公开(公告)号：US06429287B1
公开(公告)日：2002-08-06
申请号：US09495562
申请日：2000-02-01
IPC分类号： A61K3804
CPC分类号： C07K14/4748 , A61K38/00
摘要： The invention involves the identification of peptides which complex with HLA-Cw*16 molecules, and which may then provoke lysis of the cells to which they bind, by cytolytic T cells. Diagnostic and therapeutic uses are described.
摘要翻译： 本发明涉及鉴定与HLA-Cw * 16分子复合的肽，然后可以通过溶细胞T细胞引起它们结合的细胞的裂解。 描述诊断和治疗用途。
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