公开(公告)号：US09220773B2

公开(公告)日：2015-12-29

申请号：US13988968

申请日：2011-11-28

Applicant: Nthato Chirwa ,  Viness Pillay ,  Yahya Essop Choonara ,  Pradeep Kumar ,  Lisa Claire Du Toit

Inventor： Nthato Chirwa ,  Viness Pillay ,  Yahya Essop Choonara ,  Pradeep Kumar ,  Lisa Claire Du Toit

IPC: A61K39/395 ,  A61K9/00 ,  A61K9/107 ,  A61K31/337 ,  A61K39/44 ,  A61K31/282 ,  A61K31/4745 ,  A61K9/51 ,  A61K47/48 ,  C07K16/30 ,  A61K9/127

CPC classification number: A61K39/39558 ,  A61K9/0024 ,  A61K9/1075 ,  A61K9/1273 ,  A61K9/5146 ,  A61K9/5153 ,  A61K31/282 ,  A61K31/337 ,  A61K31/4745 ,  A61K39/44 ,  A61K47/6907 ,  C07K16/3092

Abstract: A pharmaceutical composition for intraperitoneal delivery of an anti-neoplastic agent is provided for treating cancers associated with aberrant mucin expression, preferably ovarian cancer and pancreatic, prostate, metastatic breast, bladder and lung cancers. The composition comprises nanomicelles loaded with the anti-neoplastic agent, and antibodies such as anti-MUC16, anti-MUC1 or anti-MUC4 are conjugated to these nanomicelles. The antibody-bound nanomicelles are optionally embedded in a biodegradable pH- and thermo-responsive hydrogel capable of sol-gel transition at body temperature. The pharmaceutical composition is implantable in the peritoneum, where it transforms into a semi-solid gel at the body's core temperature. In response to pH, the hydrogel swells and releases the antibody-bound nanomicelles. The nanomicelles specifically target mucin antigens on cancer cells. The anti-mucin antibodies can be internalized by the tumor cells, enabling the drug-loaded nanomicelles to gain entry and deliver the chemotherapeutic drugs inside the tumor cell.

Abstract translation: 提供用于腹膜内递送抗肿瘤剂的药物组合物用于治疗与异常粘蛋白表达相关的癌症，优选卵巢癌和胰腺，前列腺，转移性乳腺，膀胱和肺癌。 组合物包含负载有抗肿瘤剂的纳米胶囊，抗体如抗MUC16，抗-MUC1或抗-MUC4与这些纳米胶束缀合。 抗体结合的纳米胶囊任选地嵌入能够在体温下溶胶 - 凝胶转变的可生物降解的pH和热响应性水凝胶中。 药物组合物可植入腹膜中，其在身体核心温度下转化为半固体凝胶。 响应于pH，水凝胶溶胀并释放抗体结合的纳米胶束。 纳米胶囊特异性靶向癌细胞上的粘蛋白抗原。 抗粘蛋白抗体可以被肿瘤细胞内化，使载药纳米胶囊能够进入肿瘤细胞内并输送化学治疗药物。

公开(公告)号：US09071963B2

公开(公告)日：2015-06-30

申请号：US13232736

申请日：2011-09-14

Applicant: Mohammad Khan ,  Philippe Martin ,  Pradeep Kumar ,  Jean-Christophe Raynon ,  Kaushik Roy ,  Roshan Vijayshankar

Inventor： Mohammad Khan ,  Philippe Martin ,  Pradeep Kumar ,  Jean-Christophe Raynon ,  Kaushik Roy ,  Roshan Vijayshankar

IPC: H04B5/00 ,  H04W12/06 ,  H04L29/06

CPC classification number: G06Q30/0238 ,  H04B5/0031 ,  H04L63/0492 ,  H04L63/0823 ,  H04W4/80 ,  H04W12/06

Abstract: According to one aspect, the subject matter described herein includes a method for secure near field communication (NFC) of a non-secure memory element payload. The method includes receiving, at an NFC enabled mobile device and from a content provider, a payload. The method also includes storing the received payload in a non-secure memory element of the NFC enabled mobile device. The method further includes transferring the stored payload from the non-secure memory element of the NFC enabled mobile device to a secure memory element of the NFC enabled mobile device, wherein transferring the stored payload includes loading the stored payload into a secure reloadable payload instance. The method further includes establishing a NFC link between the NFC enabled mobile device and an NFC reader. The method further includes communicating, via the NFC link, the transferred payload from the secure reloadable payload instance to the NFC reader.

Abstract translation: 根据一个方面，本文描述的主题包括用于非安全存储器元件有效载荷的安全近场通信（NFC）的方法。 该方法包括在NFC功能的移动设备和内容提供商处接收有效载荷。 该方法还包括将接收到的有效载荷存储在支持NFC的移动设备的非安全存储器元件中。 所述方法还包括将所存储的有效载荷从支持NFC的移动设备的非安全存储器元件传送到支持NFC的移动设备的安全存储器元件，其中传送所存储的有效载荷包括将所存储的有效载荷加载到安全的可重新加载的有效载荷实例中。 该方法还包括在支持NFC的移动设备和NFC读取器之间建立NFC链路。 该方法还包括经由NFC链路将传送的有效负载从安全可加载有效载荷实例传送到NFC读取器。

公开(公告)号：US08854955B2

公开(公告)日：2014-10-07

申请号：US13714516

申请日：2012-12-14

Applicant: Anurag Prakash ,  Mohit Chhillar ,  Pradeep Kumar ,  Rajagopalan Kannan

Inventor： Anurag Prakash ,  Mohit Chhillar ,  Pradeep Kumar ,  Rajagopalan Kannan

IPC: H04J1/16 ,  H04B10/032

CPC classification number: H04B10/032 ,  H04L45/28

Abstract: A method, a node, and a network include mesh restoration and bandwidth allocation systems and methods for shared risk connection groups for source-based routing control planes. The mesh restoration and bandwidth allocation systems and methods utilize signaling from a node closest to a point of failure to “advise” source nodes about protect paths to be taken for a particular unidirectional or bidirectional connection in the event of mesh restoration. Specifically, the systems and methods include an ability to correlate connection information as Shared Risk Connection Groups (SRCG) to optimally utilize network bandwidth in the event of failure. The systems and methods could also be used to optimally distribute connections in a mesh network as well, trying to utilize maximum bandwidth, in distributed or centralized environments. Effectively, the systems and method distributed path computation in the network away from solely being the responsibility of source nodes.

Abstract translation: 方法，节点和网络包括用于基于源的路由控制平面的共享风险连接组的网格恢复和带宽分配系统和方法。 网格恢复和带宽分配系统和方法利用来自最接近故障点的节点的信令，以便在网格恢复的情况下向源节点提供关于用于特定单向或双向连接的保护路径的信息。 具体来说，系统和方法包括将连接信息作为共享风险连接组（SRCG）进行关联的能力，以在发生故障时最佳地利用网络带宽。 系统和方法也可用于在网状网络中优化分布连接，并尝试在分布式或集中式环境中利用最大带宽。 有效地，网络中的系统和方法分布式路径计算不仅仅是源节点的责任。

公开(公告)号：US08488592B2

公开(公告)日：2013-07-16

申请号：US11890016

申请日：2007-08-03

Applicant: Justin W. Haddad ,  Pradeep Kumar ,  Richard J. Schmidt

Inventor： Justin W. Haddad ,  Pradeep Kumar ,  Richard J. Schmidt

IPC: H04L12/66

CPC classification number: H04L29/06027 ,  H04L12/14 ,  H04L12/1403 ,  H04L65/1006 ,  H04L65/1069 ,  H04M3/2218

Abstract: A unified session detail records of a multi-hop session is provided. The multi-hop session may be established through multiple nodes in a VoIP network. Each node may generate session detail records for the legs of the multi-hop session that are connected to the node. The nodes on the path of the multi-hop call may send the record to a single node to consolidate the session detail records of the legs of the multi-hop call in the single node so that the single node can provide unified session detail records of the multi-hop session. By providing unified session detail records, the user does not need to track down the nodes that are on the path of the multi-hop call to obtain the session detail records of the multi-hop session.

Abstract translation: 提供了多跳会话的统一会话详细记录。 可以通过VoIP网络中的多个节点来建立多跳会话。 每个节点可以生成连接到节点的多跳会话的分支的会话细节记录。 多跳呼叫路径上的节点可以将记录发送到单个节点，以在单个节点中合并多跳呼叫的分支的会话详细记录，使得单个节点可以提供统一的会话详细记录 多跳会话。 通过提供统一的会话详细记录，用户不需要跟踪多跳呼叫路径上的节点，以获取多跳会话的会话详细记录。

公开(公告)号：US07967215B2

公开(公告)日：2011-06-28

申请号：US12105778

申请日：2008-04-18

Applicant: Pradeep Kumar ,  Ming-Li Liu ,  Roshan Vijayshankar ,  Philippe Martin

Inventor： Pradeep Kumar ,  Ming-Li Liu ,  Roshan Vijayshankar ,  Philippe Martin

IPC: G06K19/06

CPC classification number: H04L9/088 ,  H04L9/0838 ,  H04L63/0853 ,  H04L2209/80 ,  H04W4/80 ,  H04W12/02 ,  H04W12/08

Abstract: Systems, methods, and computer program products for supporting multiple contactless applications using different security keys on a wireless smart device are disclosed. According to one aspect, the subject matter described herein includes a method for supporting multiple contactless applications using different security keys on a wireless smart device. The method includes, at a wireless smart device configured to communicate with a wireless smart device reader, the wireless device including a plurality of contactless applications and a contactless application memory for use by the plurality of contactless applications, initializing a portion of the memory such that access to the portion of memory requires the use of a shared secret key known to the plurality of contactless applications. The method includes reserving the portion of memory for use by one of the plurality of contactless applications by using the shared secret key to set access privileges for the portion of memory such that access to the portion of memory requires the use of a application-specific secret key associated with the one application and not known to the other applications.

Abstract translation: 公开了用于在无线智能设备上使用不同安全密钥来支持多个非接触式应用的系统，方法和计算机程序产品。 根据一个方面，本文描述的主题包括一种在无线智能设备上支持使用不同安全密钥的多个非接触式应用的方法。 该方法包括在被配置为与无线智能设备读取器进行通信的无线智能设备中，该无线设备包括多个非接触式应用和非接触式应用存储器，供多个非接触式应用使用，初始化存储器的一部分，使得 对存储器部分的访问需要使用多个非接触应用已知的共享秘密密钥。 该方法包括通过使用共享秘密密钥来为存储器的该部分设置访问特权来保留存储器的一部分供多个非接触式应用中的一个使用，使得对该部分存储器的访问需要使用特定应用程序的秘密 密钥与一个应用程序相关联，并且不被其他应用程序所知。

公开(公告)号：US20100174598A1

公开(公告)日：2010-07-08

申请号：US12651420

申请日：2009-12-31

Applicant: Mohammad Khan ,  Pradeep Kumar

Inventor： Mohammad Khan ,  Pradeep Kumar

IPC: G06Q30/00 ,  G06F3/048 ,  G06F15/16 ,  H04W4/12

CPC classification number: G06Q30/02 ,  G06Q30/0232

Abstract: Methods, systems, and computer readable media for redeeming and delivering electronic loyalty reward certificates using a mobile device are disclosed. In one example, the method includes utilizing a loyalty reward certificate selection device to generate electronic loyalty reward certificate selection information and providing the loyalty reward certificate selection information and a recipient mobile device identifier to a loyalty management server. Electronic loyalty reward certificate data derived from the loyalty reward certificate selection information and the recipient mobile device identifier is received from the loyalty management server. The method also includes establishing a communications link with a mobile device corresponding to the recipient mobile device identifier and provisioning the electronic loyalty reward certificate data on the mobile device over the communications link via over the air (OTA) communications.

Abstract translation: 公开了使用移动设备来兑换和递送电子积分奖励证书的方法，系统和计算机可读介质。 在一个示例中，该方法包括使用忠诚度奖励证书选择装置来生成电子积分奖励证书选择信息，并向忠诚管理服务器提供忠诚度奖励证书选择信息和接收者移动设备标识符。 从忠诚度管理服务器接收从忠诚度奖励证书选择信息导出的电子积分奖励证书数据和收件人移动设备标识符。 该方法还包括与对应于接收者移动设备标识符的移动设备建立通信链路，并通过空中通信（OTA）通过通信链路在移动设备上提供电子积分奖励证书数据。

公开(公告)号：US20090164322A1

公开(公告)日：2009-06-25

申请号：US12340568

申请日：2008-12-19

Applicant: Mohammad Khan ,  Pradeep Kumar ,  Roshan Vijayshankar ,  Ming-Li Liu ,  Narendra Narayanan

Inventor： Mohammad Khan ,  Pradeep Kumar ,  Roshan Vijayshankar ,  Ming-Li Liu ,  Narendra Narayanan

IPC: G06Q30/00 ,  H04W4/12 ,  H04M1/00 ,  G06Q40/00

CPC classification number: H04L63/0853 ,  G06Q20/105 ,  G06Q20/3278 ,  G06Q20/355 ,  G06Q30/0207 ,  G06Q30/0212 ,  H04W8/245 ,  H04W12/06

Abstract: Methods, systems, and computer readable media for over the air provisioning of soft cards on devices with wireless communications capabilities are disclosed. According to one method, a soft card provisioning application is instantiated on a device with wireless communications capabilities. A card number for a soft card desired to be provisioned on the device is obtained from a user of the device. An issuer identification number retrieved from the card number is communicated to a provisioning configuration server over an air interface. A provisioning issuer server network address is obtained from the provisioning configuration server based on the issuer identification number. The provisioning information server is connected to, and card-issuer-specific challenge information is obtained therefrom. The challenges are presented to the user, and the user's responses to the challenges are received. A connection is made to the provisioning issuer server corresponding to the network address. The challenge responses are communicated to the provisioning issuer server. Soft card image data and personalization data, where the personalization data includes personalized embossed and pre-printed data, are received from the provisioning issuer server over the air interface. The soft card is provisioned for use on the device based on the data received over the air interface.

Abstract translation: 公开了用于通过具有无线通信能力的设备上的软卡的空中供应的方法，系统和计算机可读介质。 根据一种方法，在具有无线通信能力的设备上实例化软卡供应应用。 从设备的用户获得想要在设备上配置的软卡的卡号。 从卡号检索出的发行者识别号码通过空中接口传送到配置配置服务器。 基于发行者识别号从供应配置服务器获得配置发行者服务器网络地址。 配置信息服务器被连接到，并从其获得特定于发卡者的挑战信息。 向用户呈现挑战，并且接收用户对挑战的响应。 与配置发行者服务器对应的网络地址进行连接。 挑战响应被传送给配置发行者服务器。 通过空中接口从配置发行者服务器接收到软卡图像数据和个性化数据，其中个性化数据包括个性化压印和预打印数据。 基于通过空中接口接收的数据，软卡被设置在设备上使用。

公开(公告)号：US20080306849A1

公开(公告)日：2008-12-11

申请号：US11811342

申请日：2007-06-08

Applicant: William S. Johnson, JR. ,  Pradeep Kumar ,  Ming-Li Liu ,  Xuejun Jiao

Inventor： William S. Johnson, JR. ,  Pradeep Kumar ,  Ming-Li Liu ,  Xuejun Jiao

IPC: G06Q40/00 ,  H04B5/00

CPC classification number: G06Q20/3278 ,  G06F21/35 ,  G06K7/10297 ,  G06Q20/341 ,  G06Q20/352 ,  G06Q20/357 ,  G06Q20/3574 ,  G06Q40/00 ,  G07F7/08 ,  G07F7/0886 ,  G07F7/1008 ,  G07F7/12

Abstract: Methods, systems, and computer program products for interacting with ISO 14443-4 and MIFARE® applications on the same wireless smart device during a common transaction are disclosed. According to one aspect, the method includes detecting and communicating with an ISO 14443-4 application located on a wireless smart device that includes an ISO 14443-4 and a MIFARE® application to perform at least part of the common transaction. Termination of the ISO 14443-4 application is detected, and the MIFARE® application located on the wireless smart device is detected and communicated with for performing at least part of the common transaction.

Abstract translation: 公开了在公共事务期间在同一无线智能设备上与ISO 14443-4和MIFARE（R）应用交互的方法，系统和计算机程序产品。 根据一个方面，该方法包括检测并与位于无线智能设备上的ISO 14443-4应用进行通信，所述应用包括ISO 14443-4和MIFARE应用程序，以执行至少部分公共交易。 检测到ISO 14443-4应用的终止，并且检测并传送位于无线智能设备上的MIFARE应用程序用于执行至少部分公共事务。

公开(公告)号：US5942608A

公开(公告)日：1999-08-24

申请号：US829166

申请日：1997-03-31

Applicant: Pradeep Kumar ,  Kailash Chand Gupta

Inventor： Pradeep Kumar ,  Kailash Chand Gupta

IPC: C07H21/00

CPC classification number: C07H21/00

Abstract: A process for preparing oligoribo- or oligodeoxyribonucleotides comprising treating an alkanediol or alkanetriol of formula I ##STR1## wherein R.sup.1 =H--(CH.sub.2).sub.n --; andR.sup.2 =--CH.sub.2 OH or --(CH.sub.2).sub.n --Hn=1-4;with 4,4'-dimethoxytrityl chloride to generate a monosubstituted tritylated compound of formula II ##STR2## wherein R.sup.3 =H--(CH.sub.2).sub.p --; andR.sup.4 =-CH.sub.2 OH or --(CH.sub.2).sub.p --H;R.sup.5 is 4,4'-dimethoxytrityl and concommitantly R.sup.6 is hydrogen, orR.sup.5 is hydrogen and concommitantly R.sup.6 is 4,4'-dimethoxytrityl;p=1-4;and treating the compound of formula II with one equivalent of a homobifunctional alkanedioic acid halide, and contacting the resulting mixture with a polymer support bearing hydroxyl or aminoalkyl functionalities.

Abstract translation: 一种制备寡核苷酸或寡脱氧核糖核苷酸的方法，包括处理式I的链烷二醇或烷三醇，其中R1 = H-（CH2）n-; R2 = -CH2OH或 - （CH2）n-Hn = 1-4; 与4,4'-二甲氧基三苯甲基氯反应以产生式II的单取代三苯甲基化合物，其中R 3 = H-（CH 2）p - ; 和R4 = -CH2OH或 - （CH2）p-H; R5是4,4'-二甲氧基三苯甲基，同时R6是氢，或R5是氢，并且R6是4,4'-二甲氧基三苯甲基; p = 1-4; 并用一当量的同双功能链烷二酰卤处理式II化合物，并将所得混合物与带有羟基或氨基烷基官能团的聚合物载体接触。

公开(公告)号：US5676256A

公开(公告)日：1997-10-14

申请号：US736275

申请日：1996-10-24

Applicant: Pradeep Kumar ,  Richard B. Wolanski ,  Mark S. Wolanski

Inventor： Pradeep Kumar ,  Richard B. Wolanski ,  Mark S. Wolanski

IPC: B07C5/342 ,  G06K9/46

CPC classification number: B07C5/3422 ,  B07C5/368 ,  G06K9/46 ,  Y10S209/938 ,  Y10S209/939

Abstract: A scrap particle sorting system and attendant sorting process employs a conveyor for conveying the randomly shaped particles in a random orientation, a position sensor for determining the advancement of the scrap particles in the direction of conveyance by determining the position of the conveyor belt, an image detector for periodically recording the image of a predefined viewing area through which the scrap particles are conveyed, and an image processor for periodic acquisition and processing of the images. The image processor includes logic for defining each image of the viewing area into a matrix of cells, and for each acquired image, analyzing the digital data corresponding to the image to determine for each cell in the matrix whether the pixels in that cell satisfy a predetermined criteria, and establishing a discriminator signal for each cell in the matrix as a function of that analysis. The system employs an image detector controller for receiving a signal from the conveyor position sensor and sending an activation signal to the image processor at timed intervals to acquire sequential image frames which include each of the scrap particles as they are conveyed past the viewing area, and a separator controller for receiving the discriminator signals from the image processor and for sending a control signal to selectively activate the appropriate portion of the separator to eject desired from undesired particles.

Abstract translation: 废料粒子分选系统和伴随分拣过程采用用于以随机取向输送随机形状的颗粒的输送机，用于通过确定输送带的位置来确定废料颗粒在输送方向上的前进的位置传感器，图像 用于周期性地记录传送废料颗粒的预定义观察区域的图像的检测器，以及用于周期性地获取和处理图像的图像处理器。 图像处理器包括用于将观看区域的每个图像定义成单元矩阵的逻辑，并且对于每个获取的图像，分析与图像相对应的数字数据，以确定矩阵中的每个单元是否满足预定的像素 标准，并且作为该分析的函数为矩阵中的每个单元建立鉴别器信号。 该系统采用图像检测器控制器，用于接收来自输送机位置传感器的信号，并以定时的间隔向图像处理器发送激活信号，以获取包括每个废料颗粒在传送通过观察区域时的每个废料颗粒的顺序图像帧;以及 分离器控制器，用于从图像处理器接收鉴别器信号，并发送控制信号以选择性地激活分离器的适当部分以从不期望的颗粒喷射所需的物体。