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公开(公告)号：US20240272354A1
公开(公告)日：2024-08-15
申请号：US18627563
申请日：2024-04-05
Applicant: Quantum-Si Incorporated
Inventor： Ali Kabiri , Bing Shen , Gerard Schmid , James Beach , Kyle Preston , Sharath Hosali
CPC classification number: G02B6/122 , G02B6/136 , G02B2006/12109 , G02B2006/12138
Abstract: Apparatus and methods for improving optical signal collection in an integrated device are described. A microdisk can be formed in an integrated device and increase collection and/or concentration of radiation incident on the microdisk and re-radiated by the microdisk. An example integrated device that can include a microdisk may be used for analyte detection and/or analysis. Such an integrated device may include a plurality of pixels, each having a reaction chamber for receiving a sample to be analyzed, an optical microdisk, and an optical sensor configured to detect optical emission from the reaction chamber. The microdisk can comprise a dielectric material having a first index of refraction that is embedded in one or more surrounding materials having one or more different refractive index values.
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公开(公告)号：US11454758B2
公开(公告)日：2022-09-27
申请号：US16987937
申请日：2020-08-07
Applicant: Quantum-Si Incorporated
Inventor： Ali Kabiri , Bing Shen , Gerard Schmid , James Beach , Kyle Preston , Sharath Hosali
Abstract: Apparatus and methods for improving optical signal collection in an integrated device are described. A microdisk can be formed in an integrated device and increase collection and/or concentration of radiation incident on the microdisk and re-radiated by the microdisk. An example integrated device that can include a microdisk may be used for analyte detection and/or analysis. Such an integrated device may include a plurality of pixels, each having a reaction chamber for receiving a sample to be analyzed, an optical microdisk, and an optical sensor configured to detect optical emission from the reaction chamber. The microdisk can comprise a dielectric material having a first index of refraction that is embedded in one or more surrounding materials having one or more different refractive index values.
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公开(公告)号：US11422092B2
公开(公告)日：2022-08-23
申请号：US17161425
申请日：2021-01-28
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Ali Kabiri , Gerard Schmid , Keith G. Fife , James Beach , Jason W. Sickler , Lawrence C. West , Paul E. Glenn , Kyle Preston , Farshid Ghasemi , Benjamin Cipriany , Jeremy Lackey
IPC: G01N21/64 , C12Q1/6869 , C12Q1/6874 , G01N21/77 , G01N33/543
Abstract: System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device may include multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes a surface having a trench region recessed from a portion of the surface and an array of sample wells, disposed in the trench region. The integrated device also includes a waveguide configured to couple excitation energy to at least one sample well in the array and positioned at a first distance from a surface of the trench region and at a second distance from the surface in a region separate from the trench region. The first distance is smaller than the second distance. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device.
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公开(公告)号：US20220113469A1
公开(公告)日：2022-04-14
申请号：US17555323
申请日：2021-12-17
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Gerard Schmid , Alexander Gondarenko , James Beach , Kyle Preston , Farshid Ghasemi , Jeremy Lackey , Jack Jewell , Keith G. Fife , Ali Kabiri
Abstract: An integrated device and related instruments and systems for analyzing samples in parallel are described. The integrated device may include sample wells arranged on a surface of where individual sample wells are configured to receive a sample labeled with at least one fluorescent marker configured to emit emission light in response to excitation light. The integrated device may further include photodetectors positioned in a layer of the integrated device, where one or more photodetectors are positioned to receive a photon of emission light emitted from a sample well. The integrated device further includes one or more photonic structures positioned between the sample wells and the photodetectors, where the one or more photonic structures are configured to attenuate the excitation light relative to the emission light such that a signal generated by the one or more photodetectors indicates detection of photons of emission light.
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公开(公告)号：US11226290B2
公开(公告)日：2022-01-18
申请号：US15611583
申请日：2017-06-01
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Ali Kabiri , Gerard Schmid , Keith G. Fife , James Beach , Jason W. Sickler , Lawrence C. West , Paul E. Glenn , Kyle Preston , Farshid Ghasemi , Benjamin Cipriany , Jeremy Lackey
IPC: G01N21/64 , C12Q1/68 , G01N21/77 , G01N33/543 , C12Q1/6869 , C12Q1/6874
Abstract: System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device may include multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes a surface having a trench region recessed from a portion of the surface and an array of sample wells, disposed in the trench region. The integrated device also includes a waveguide configured to couple excitation energy to at least one sample well in the array and positioned at a first distance from a surface of the trench region and at a second distance from the surface in a region separate from the trench region. The first distance is smaller than the second distance. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device.
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Patent Agency Ranking
公开(公告)号：US20210215606A1
公开(公告)日：2021-07-15
申请号：US17149605
申请日：2021-01-14
Applicant: Quantum-Si Incorporated
Inventor： Gerard Schmid , Sharath Hosali , James Beach , Kyle Preston , Ali Kabiri , Bing Shen
IPC: G01N21/64 , G02B6/14 , G02B6/122 , B01L3/00 , C12Q1/6816
Abstract: Systems and methods for optical power distribution within an integrated device, in a substantially uniform manner, to a large number of sample wells and/or other photonic elements. The integrated device and related instruments and systems may be used to analyze samples in parallel. The integrated device may include a grating coupler configured to receive light from an excitation source and optically couple with multiple waveguides configured to couple with sample wells. Vertical extents of optical modes of individual waveguides may be modulated to adjust confinement of light within the waveguides. This modulation may enable more uniform distribution of excitation light to the sample wells, improve excitation efficiency, and prevent overpower on regions of the integrated device.
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公开(公告)号：US12259323B2
公开(公告)日：2025-03-25
申请号：US17862297
申请日：2022-07-11
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Ali Kabiri , Gerard Schmid , Keith G. Fife , James Beach , Jason W. Sickler , Lawrence C. West , Paul E. Glenn , Kyle Preston , Farshid Ghasemi , Benjamin Cipriany , Jeremy Lackey
IPC: G01N21/64 , C12Q1/6869 , C12Q1/6874 , G01N21/77 , G01N33/543
Abstract: System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device may include multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes a surface having a trench region recessed from a portion of the surface and an array of sample wells, disposed in the trench region. The integrated device also includes a waveguide configured to couple excitation energy to at least one sample well in the array and positioned at a first distance from a surface of the trench region and at a second distance from the surface in a region separate from the trench region. The first distance is smaller than the second distance. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device.
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公开(公告)号：US12179204B2
公开(公告)日：2024-12-31
申请号：US16580877
申请日：2019-09-24
Applicant: Quantum-Si Incorporated
Inventor： Guojun Chen , James Beach , Kathren Fink Croce , Jeremy Lackey , Gerard Schmid
Abstract: A method of forming an integrated device includes forming a sample well within a cladding layer of a substrate; forming a sacrificial spacer layer over the substrate and into the sample well; performing a directional etch of the sacrificial spacer layer so as to form a sacrificial sidewall spacer on sidewalls of the sample well; forming, over the substrate and into the sample well, a functional layer that provides a location for attachment of a biomolecule; and removing the sacrificial spacer material.
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公开(公告)号：US20230375475A1
公开(公告)日：2023-11-23
申请号：US18356150
申请日：2023-07-20
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Ali Kabiri , Gerard Schmid , Keith G. Fife , James Beach , Jason W. Sickler , Lawrence C. West , Paul E. Glenn , Kyle Preston , Farshid Ghasemi , Benjamin Cipriany , Jeremy Lackey
IPC: G01N21/64 , C12Q1/6869 , C12Q1/6874 , G01N21/77 , G01N33/543
CPC classification number: G01N21/6428 , G01N21/648 , C12Q1/6869 , C12Q1/6874 , G01N21/6408 , G01N21/6454 , G01N21/6486 , G01N21/7743 , G01N33/54373 , G01N2021/6421 , G01N2021/6419
Abstract: System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device may include multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes a surface having a trench region recessed from a portion of the surface and an array of sample wells, disposed in the trench region. The integrated device also includes a waveguide configured to couple excitation energy to at least one sample well in the array and positioned at a first distance from a surface of the trench region and at a second distance from the surface in a region separate from the trench region. The first distance is smaller than the second distance. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device.
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公开(公告)号：US20230258862A1
公开(公告)日：2023-08-17
申请号：US18138700
申请日：2023-04-24
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Ali Kabir , Gerard Schmid , Jason w. Sickler , Paul E. Glenn , Lawrence C. West , Kyle Preston , Alexander Gondarenko , Benjamin Cipriany , James Beach , Keith G. Fife , Farshid Ghasemi
CPC classification number: G02B6/12016 , G01N21/253 , G01N21/6452 , G01N21/648 , G01N21/7703 , G01M11/35 , G02B6/1228 , G02B6/29319 , G02B6/29344 , G02B6/305 , G02B2006/12147 , G02B2006/12195
Abstract: System and methods for optical power distribution to a large numbers of sample wells within an integrated device that can analyze single molecules and perform nucleic acid sequencing are described. The integrated device may include a grating coupler configured to receive an optical beam from an optical source and optical splitters configured to divide optical power of the grating coupler to waveguides of the integrated device positioned to couple with the sample wells. Outputs of the grating coupler may vary in one or more dimensions to account for an optical intensity profile of the optical source.
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