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公开(公告)号：US20180088052A1
公开(公告)日：2018-03-29
申请号：US15808940
申请日：2017-11-10
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Benjamin Cipriany , Jack Jewell , Lawrence C. West , Michael Ferrigno , Paul E. Glenn , Adam Ezra Cohen , Anthony Bellofiore
Abstract: Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.
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12.发明公开公开(公告)号：US20240068943A1
公开(公告)日：2024-02-29
申请号：US18500999
申请日：2023-11-02
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Benjamin Cipriany , Faisal R. Ahmad , Joseph D. Clark , Daniel B. Frier , Michael Ferrigno , Mel Davey , Thomas Raymond Thurston , Brett J. Gyarfas , Todd Rearick , Jeremy Christopher Jordan
CPC classification number: G01N21/6402 , G01N21/6486 , G06F1/08 , G01N2021/6495 , G01N2201/125 , G01N2201/126
Abstract: Instrument control and data acquisition in advanced analytic systems that utilize optical pulses for sample analysis are described. Clocking signals for data acquisition, data processing, communication, and/or other data handling functionalities can be derived from an on-board pulsed optical source, such as a passively mode-locked laser. The derived clocking signals can operate in combination with one or more clocking signals from a stable oscillator, so that instrument operation and data handling can tolerate interruptions in operation of the pulsed optical source.
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Patent Agency Ranking
13.发明授权公开(公告)号：US11808700B2
公开(公告)日：2023-11-07
申请号：US16442206
申请日：2019-06-14
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Benjamin Cipriany , Faisal R. Ahmad , Joseph D. Clark , Daniel B. Frier , Michael Ferrigno , Mel Davey , Tom Thurston , Brett J. Gyarfas , Todd Rearick , Jeremy Christopher Jordan
CPC classification number: G01N21/6402 , G01N21/6486 , G06F1/08 , G01N2021/6495 , G01N2201/125 , G01N2201/126
Abstract: Instrument control and data acquisition in advanced analytic systems that utilize optical pulses for sample analysis are described. Clocking signals for data acquisition, data processing, communication, and/or other data handling functionalities can be derived from an on-board pulsed optical source, such as a passively mode-locked laser. The derived clocking signals can operate in combination with one or more clocking signals from a stable oscillator, so that instrument operation and data handling can tolerate interruptions in operation of the pulsed optical source.
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公开(公告)号：US20220214279A1
公开(公告)日：2022-07-07
申请号：US17704691
申请日：2022-03-25
Applicant: Quantum-Si Incorporated
Inventor： JONATHAN M. ROTHBERG , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Benjamin Ciperiany , Jack Jewell , Lawrence C. West , Michael Ferrigno , Paul E. Glenn , Adam Ezra Cohen , Anthony Bellofiore
IPC: G01N21/64 , B01L3/00 , G01N21/77 , C12Q1/6874 , C12Q1/6869
Abstract: Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.
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公开(公告)号：US20200088643A1
公开(公告)日：2020-03-19
申请号：US16689004
申请日：2019-11-19
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Benjamin Cipriany , Jack Jewell , Lawrence C. West , Michael Ferrigno , Paul E. Glenn , Adam Ezra Cohen , Anthony Bellofiore
IPC: G01N21/64 , C12Q1/6869 , B01L3/00 , G01N21/77 , C12Q1/6874
Abstract: Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.
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16.发明授权公开(公告)号：US10048208B2
公开(公告)日：2018-08-14
申请号：US14543865
申请日：2014-11-17
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Benjamin Cipriany , Jack Jewell , Lawrence West , Michael Ferrigno , Paul E. Glenn , Anthony Bellofiore
IPC: G01N21/00 , G01N21/64 , C12Q1/6874 , G01N21/77 , C12Q1/6869
Abstract: Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits radiation; at least one element for directing the emission radiation in a particular direction; and a light path along which the emission radiation travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the integrated device. Each sensor may detect emission radiation from a sample in a respective sample well. The instrument includes an excitation light source for exciting the sample in each sample well.
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公开(公告)号：US09863880B2
公开(公告)日：2018-01-09
申请号：US14543867
申请日：2014-11-17
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Benjamin Cipriany , Jack Jewell , Lawrence West , Michael Ferrigno , Paul E. Glenn , Adam E. Cohen , Anthony Bellofiore
CPC classification number: G01N21/6486 , B01L3/5085 , B01L2200/12 , B01L2300/0829 , B01L2300/0887 , B01L2300/0893 , B01L2300/168 , C12Q1/6869 , C12Q1/6874 , C12Q2521/101 , C12Q2537/157 , C12Q2563/107 , C12Q2565/607 , G01N21/64 , G01N21/645 , G01N21/6452 , G01N21/648 , G01N21/7743 , G01N21/7746 , G01N2021/6419 , G01N2021/6441 , G01N2021/6478 , G01N2201/02 , G01N2201/06113 , G01N2201/0612 , G01N2201/062 , G01N2201/068 , G01N2201/125 , Y10T29/49016 , C12Q2525/101
Abstract: Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.
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