公开(公告)号：US10660974B2

公开(公告)日：2020-05-26

申请号：US16072848

申请日：2017-01-24

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Doron Shabat ,  Ronit Satchi-Fainaro ,  Nir Hananya ,  Ori Green ,  Tal Eilon

IPC: A61K49/00 ,  C07F5/04 ,  C07D321/00 ,  C07D405/00 ,  C07F9/655 ,  C07H15/26 ,  C09B11/24 ,  C09B23/04 ,  C09B23/08 ,  C09K11/06 ,  C07F9/12 ,  C09B23/01 ,  C07F5/02 ,  C07H15/203 ,  C07F7/18

Abstract: Dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and π* acceptor group-containing dioxetane based chemiluminescence probes can be included in compositions. The chemiluminescence probes are useful for both diagnostics and in vivo imaging.

公开(公告)号：US09427474B2

公开(公告)日：2016-08-30

申请号：US14816228

申请日：2015-08-03

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ronit Satchi-Fainaro ,  Keren Miller ,  Doron Shabat ,  Rotem Erez

IPC: A61K31/74 ,  A61K47/48 ,  A61K49/00 ,  C07F9/38 ,  C07F9/655 ,  C07F9/6558 ,  C07K5/065 ,  C07K5/103 ,  A61K31/337 ,  A61K9/16

CPC classification number: A61K47/48084 ,  A61K9/1676 ,  A61K31/337 ,  A61K47/548 ,  A61K47/58 ,  A61K47/65 ,  A61K49/0017 ,  A61K49/0054 ,  A61K2800/57 ,  C07F9/3873 ,  C07F9/65517 ,  C07F9/65586 ,  C07K5/06078 ,  C07K5/1008

Abstract: Conjugates of polymers or copolymers having attached thereto an anti-angiogenesis agent and a bisphosphonate bone targeting agent, and processes of preparing same, are disclosed.Pharmaceutical compositions containing these conjugates and uses thereof in the treatment of bone related disorders are also disclosed.

公开(公告)号：US12173350B2

公开(公告)日：2024-12-24

申请号：US16616356

申请日：2018-05-23

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Doron Shabat ,  Michal Eli Roth-Konforti

IPC: C12Q1/37 ,  C07K5/062 ,  C07K7/06 ,  C09K11/06 ,  G01N21/76

Abstract: The present invention provides turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe, which are capable of detecting or imaging, more specifically, determining the presence, or measuring the level, of proteases, as well as compositions and uses thereof.

公开(公告)号：US20200093942A1

公开(公告)日：2020-03-26

申请号：US16616336

申请日：2018-05-23

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Doron Shabat ,  Ori Green

IPC: A61K49/00 ,  C07D407/10

Abstract: The present invention provides turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe, which emit light in the near-infrared (NIR) region and are therefore useful for in vivo imaging, as well as compositions and uses thereof.

公开(公告)号：US10420845B2

公开(公告)日：2019-09-24

申请号：US15737247

申请日：2016-06-16

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Doron Shabat ,  Ronit Satchi-Fainaro ,  Samer Gnaim ,  Anna Scomparin

IPC: C07D491/22 ,  A61K47/54 ,  A61K31/436 ,  A61K31/4188 ,  A61K31/497 ,  A61K31/519 ,  C07D487/04 ,  C07D215/44 ,  A61P35/00 ,  A61K31/4184 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/513

Abstract: The present disclosure provides heteroarene-based drug derivatives having a “clickable” ketone group, as well as conjugates of said drug derivatives with targeting moieties capable of binding to extracellular antigens; and pharmaceutical compositions comprising them.

公开(公告)号：US10071983B2

公开(公告)日：2018-09-11

申请号：US15131129

申请日：2016-04-18

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Doron Shabat ,  Ronit Satchi-Fainaro

IPC: A61K49/00 ,  C07D401/14 ,  C09B23/01 ,  C09B23/08 ,  C09B23/12 ,  G01N33/58 ,  C07D209/08 ,  C07D209/12 ,  C07D213/30 ,  C07D213/71 ,  C07D213/76 ,  C07D213/85 ,  G01N33/52 ,  A61K47/54

CPC classification number: C07D401/14 ,  A61K47/558 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0052 ,  A61K49/0056 ,  C07D209/08 ,  C07D209/12 ,  C07D213/30 ,  C07D213/71 ,  C07D213/76 ,  C07D213/85 ,  C09B23/0066 ,  C09B23/086 ,  C09B23/12 ,  G01N33/52 ,  G01N33/582

Abstract: Novel fluorogenic compounds designed such that upon a chemical event, compounds capable of emitting NIR light are generated, are disclosed. The compounds comprise two or more acceptor-containing moieties and a cleavable donor-containing moiety, being in complete pi-electrons conjugation and being such that no delocalization of pi-electrons is enabled. Also disclosed are fluorescent compounds generated upon subjecting the fluorogenic compounds to a chemical event (e.g., deprotonation). Also disclosed are uses of the fluorogenic compounds as NIR probed with a Turn-ON mechanism in monitoring presence and/or level of various analytes.