公开(公告)号：US20170087274A1

公开(公告)日：2017-03-30

申请号：US15286861

申请日：2016-10-06

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Alptekin Aksan ,  Allison Hubel ,  Eduardo Reategui

IPC: A61L27/24 ,  A61L27/54 ,  A61L27/02 ,  A61L27/42 ,  A61F2/14 ,  G02B1/04

CPC classification number: A61L27/24 ,  A61F2/142 ,  A61L27/025 ,  A61L27/427 ,  A61L27/54 ,  A61L2400/12 ,  A61L2430/16 ,  G02B1/043

Abstract: Disclosed herein are synthetic silica-based ocular devices fabricated from a composite material comprising silica and a fibrillar protein, together with methods of making and using the ocular devices.

公开(公告)号：US09556412B2

公开(公告)日：2017-01-31

申请号：US14394693

申请日：2013-04-17

Applicant: Regents of the University of Minnesota

Inventor： Allison Hubel ,  Jacob Hanna

IPC: C12M1/00 ,  B01L3/00

CPC classification number: C12M47/02 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502753 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2300/0858 ,  B01L2300/0861 ,  B01L2400/0409 ,  C12M23/16 ,  C12M47/12

Abstract: An example includes an apparatus for separating cells from a fluid sample, including a plenum, defining: a centrally located top inlet, and respective side outlets disposed below the inlet and to the side of the inlet; and a bottom outlet disposed below the top inlet, to the side of the two or more outlets, wherein the plenum is configured to receive a fluid and cells suspension through the inlet, and direct it to the bottom outlet, against respective side-walls extending between the bottom outlet and the two or more side outlets, and wherein the distance between each of the two or more side outlets and the bottom outlet is selected to encourage cells to exit through the bottom outlet under a force. Lateral/vertical distance between the inlet and side outlets can provide lateral fluid travel, thereby allowing time for gravity to bias cells toward an outlet.

Abstract translation: 一个实例包括一个用于从流体样品分离细胞的装置，包括一个集气室，其限定：位于中心的顶部入口，以及设置在入口的下方和入口侧的相应的侧部出口; 以及底部出口，其设置在所述顶部入口的下方，到所述两个或更多个出口的侧面，其中所述增压室被构造成接收通过所述入口的流体和细胞悬浮液，并将其引导到所述底部出口，以抵抗相应的侧壁延伸 在底部出口和两个或更多个侧部出口之间，并且其中两个或更多个侧部出口和底部出口中的每一个之间的距离被选择为鼓励细胞在力下通过底部出口排出。 入口侧和出口之间的横向/垂直距离可以提供侧向流体行进，从而允许重力的时间使细胞偏向出口。