公开(公告)号：US20190031951A1

公开(公告)日：2019-01-31

申请号：US16071024

申请日：2017-01-17

Applicant: Research Triangle Institute

Inventor： Leah Marie Johnson ,  Ginger Denison Rothrock ,  Chasity Antoninette Norton ,  Sarah Dorothy Shepherd ,  Nicolas Daniel Huffman ,  Jeffrey Brent Mecham

IPC: C09K8/92 ,  C09K8/70

Abstract: The present disclosure relates to delivery and release systems wherein a plurality of particles is provided, and the particles are formed of a vehicle component and a cargo component. The systems and methods particularly can be useful in delivery of various chemicals to a petroleum reservoir. The vehicle component can undergo a change in situ such that at least a portion of the cargo component is released.

公开(公告)号：US20180325781A1

公开(公告)日：2018-11-15

申请号：US15918026

申请日：2018-03-12

Applicant: Research Triangle Institute ,  The University of North Carolina at Chapel Hill

Inventor： Leah Marie Johnson ,  Ginger Denison Rothrock ,  Sarah Dorothy Shepherd ,  Sandra Cordel O'Buckley ,  Andrea Gail Neely

IPC: A61K6/00 ,  A61K9/16 ,  A61K47/42 ,  A61K9/00

CPC classification number: A61K6/0067 ,  A61K6/0002 ,  A61K9/006 ,  A61K9/06 ,  A61K9/5026 ,  A61K31/00 ,  A61K47/42 ,  A61K47/46 ,  A61K2300/00

Abstract: The disclosure provides biocompatible dental material that is moldable and biodegradable and provides sustained and/or controlled delivery of one or more local anesthetics within a dental cavity or space. Such dental material is customizable for the size and shape needed for a particular patient or particular application. The dental material may also provide customizable sustained and/or controlled delivery of one or more local anesthetics.

公开(公告)号：US11078411B2

公开(公告)日：2021-08-03

申请号：US16071024

申请日：2017-01-17

Applicant: Research Triangle Institute

Inventor： Leah Marie Johnson ,  Ginger Denison Rothrock ,  Chasity Antoninette Norton ,  Sarah Dorothy Shepherd ,  Nicolas Daniel Huffman ,  Jeffrey Brent Mecham

IPC: C09K8/92 ,  E21B47/11 ,  C09K8/60 ,  C09K8/70 ,  C09K8/03

Abstract: The present disclosure relates to delivery and release systems wherein a plurality of particles is provided, and the particles are formed of a vehicle component and a cargo component. The systems and methods particularly can be useful in delivery of various chemicals to a petroleum reservoir. The vehicle component can undergo a change in situ such that at least a portion of the cargo component is released.

公开(公告)号：US20200165555A1

公开(公告)日：2020-05-28

申请号：US16695550

申请日：2019-11-26

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Leah Marie Johnson ,  Ninell Pollas Mortensen ,  Ginger Denison Rothrock ,  Nicolas D. Huffman

IPC: C12M1/00 ,  B29C64/40 ,  C12N5/00

Abstract: A three-dimensional cell growth containment article is described, which includes a molded body channelized by removal of sacrificial channelizing element(s) therefrom, so that the molded body contains one or more channel(s) therein, with a matrix material in at least one of such channel(s) that is supportive of three-dimensional cell growth in the matrix material. A method for making such articles is also described, in which a molded body is formed with one or more sacrificial channelizing element(s) therein, following which the sacrificial channelizing element(s) are removed. The three-dimensional cell growth containment articles of the present disclosure may be utilized in any applications in which there exists a need to reproducibly generate three-dimensional cellular structures, e.g., islet transplantation for diabetes treatment, transplantation of hormone secreting cells, cellular scaffolds for wound healing, and generation of tissue engineering structures to regain structural usefulness for orthopedic applications.

公开(公告)号：US20180235900A1

公开(公告)日：2018-08-23

申请号：US15890171

申请日：2018-02-06

Applicant: Research Triangle Institute

Inventor： Stephanie Lynn Swarner ,  Leah Johnson ,  Robert F. Praino, JR. ,  Phillip Gregory Durham ,  Mark E. Kleiman ,  Ginger Denison Rothrock ,  Ariane van der Straten Ponthoz

IPC: A61K9/70 ,  A61K9/00 ,  A61K47/34 ,  A61K31/685 ,  C07K16/10 ,  B29C43/18 ,  B29C43/56 ,  B29C65/08 ,  B29C65/00

CPC classification number: A61K9/7007 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/4816 ,  A61K31/685 ,  A61K47/34 ,  B29C43/18 ,  B29C43/56 ,  B29C65/08 ,  B29C65/10 ,  B29C65/18 ,  B29C66/1122 ,  B29C66/24244 ,  B29C66/43 ,  B29C66/71 ,  B29C66/723 ,  B29C66/727 ,  B29C66/731 ,  B29C66/7352 ,  B29C66/73791 ,  B29C66/73921 ,  B29C66/8122 ,  B29C66/81431 ,  B29C66/8242 ,  B29C66/8322 ,  B29C66/849 ,  B29C66/919 ,  B29C66/949 ,  B29C2043/561 ,  B29K2067/00 ,  B29K2105/04 ,  B29K2105/253 ,  B29K2995/0097 ,  B29L2031/7148 ,  B29L2031/753 ,  C07K16/1045 ,  B29K2067/046 ,  B29K2827/18

Abstract: The medical devices of the present disclosure are filled reservoirs such as a cylinder comprised of a polymer film which contains a reservoir of active agent, plus excipient, in some cases, for disease prevention, treatment, and/or contraception. The polymer film is permeable to the active agent after subcutaneous implantation of the device into a body. The cylinder is comprised by the lamination of one or two polymer films which are ultrasonically welded to contain the drug material. The use of an ultrasonic welding process enables sealing of the polymer films to create the closed cylinder. The medical device is useful for long term disease prevention, such as prevention of HIV infection.

公开(公告)号：US20170369766A1

公开(公告)日：2017-12-28

申请号：US15634340

申请日：2017-06-27

Applicant: Research Triangle Institute

Inventor： Leah Marie Johnson ,  Ginger Denison Rothrock ,  Chasity Antoninette Norton ,  Nicolas Daniel Huffman ,  Jeffrey Brent Mecham

IPC: C09K8/588 ,  E21B33/138 ,  E21B43/20

Abstract: The present disclosure relates to delivery and release systems, such as core-shell particles. An exemplary composition according to the disclosure can include a degradable polymeric shell surrounding a core that includes a crosslinker, which can encompass a metal, such as chromium. The core-shell particles can be provided with a gel-forming polymer, such as a polyacrylamide, into a subterranean reservoir having conditions such that the shell of the core-shell polymer degrades, and the so-released metal is effective to at least partially crosslink the gel-forming polymer to form a gel. The so-formed gel can be effective to control water flow through the subterranean reservoir, such as in relation to a waterflood of the reservoir.