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37 条记录 (耗时 0.031 秒)

    Systems for quantifying the illumination characteristics of vessels such as blood processing containers with respect to light energy
    13.
    发明授权
    Systems for quantifying the illumination characteristics of vessels such as blood processing containers with respect to light energy 失效
    用于量化血液处理容器等容器相对于光能的照明特性的系统

    公开(公告)号：US5866074A

    公开(公告)日：1999-02-02

    申请号：US771206

    申请日：1996-12-20

    申请人： John R. Chapman ,  Jean M. Mathias

    发明人： John R. Chapman ,  Jean M. Mathias

    IPC分类号： A61M1/36 ,  A61K31/00 ,  A61K31/54 ,  A61K31/5415 ,  A61K41/00 ,  A61P31/00 ,  A61P31/12 ,  G01N21/75 ,  G01N21/78

    CPC分类号： A61K41/0019 ,  Y10S436/904 ,  Y10S436/905

    摘要： A vessel holds a liquid content for exposure to prescribed light energy. The vessel has a region transparent to the prescribed light energy. The liquid content of the vessel includes a solution comprising a material undergoing reduction oxidation as a result of exposure to the prescribed light energy, and a reducing agent for the photoactive material. A device measures optical absorbance of the vessel and the liquid content. The device operates in a first instance to measure a first optical absorbance value before exposing the vessel and the liquid content to the prescribed light energy. The device also operates in a second instance to measure a second optical absorbance value after exposing the vessel and the liquid content to the prescribed light energy, to obtain a difference between the first and second optical absorbance values. The difference comprises an illumination characteristic for the vessel with respect to the prescribed light energy.

    摘要翻译： 容器保持用于暴露于规定光能的液体含量。 容器具有对规定光能透明的区域。 容器的液体含量包括由于暴露于规定的光能而经历还原氧化的材料的溶液和用于光活性材料的还原剂。 器件测量容器的光吸收和液体含量。 该装置首先操作以在将容器暴露于容器和液体含量之前测量第一光吸收值至规定的光能。 该装置还在第二种情况下操作以在容器和液体含量暴露于规定的光能之后测量第二光吸收值，以获得第一和第二光吸收值之间的差。 该差异包括相对于规定的光能的容器的照明特性。

    Method for testing blood units for viral contamination
    14.
    发明授权
    Method for testing blood units for viral contamination 失效
    测试血液单位病毒感染的方法

    公开(公告)号：US5663045A

    公开(公告)日：1997-09-02

    申请号：US456443

    申请日：1995-06-01

    申请人： John R. Chapman

    发明人： John R. Chapman

    IPC分类号： B01D17/02 ,  B01D21/24 ,  B01D21/26 ,  C12Q1/68 ,  G01N33/49 ,  C12Q1/70 ,  B01D33/15

    CPC分类号： B01D21/2405 ,  B01D17/0217 ,  B01D21/2444 ,  B01D21/245 ,  B01D21/262 ,  C12Q1/6806 ,  G01N33/491 ,  B01D2221/10

    摘要： The present invention provides a method for testing a blood unit for viral contamination without rendering the blood unit unusable for therapeutic applications. The method comprises the steps of: removing and collecting from a blood unit a majority of the leukocytes present therein; and using the collected leukocytes to test the blood unit for viral contamination. The present invention also provides a method for validating viral inactivation processes.

    摘要翻译： 本发明提供了一种用于测试用于病毒污染的血液单元的方法，而不使得血液单元不能用于治疗应用。 该方法包括以下步骤：从血液单元中去除和收集大部分存在于其中的白细胞; 并使用收集的白细胞测试血液单位以进行病毒感染。 本发明还提供了用于验证病毒灭活过程的方法。

    Centrifuge separation method and apparatus using a medium density fluid
    15.
    发明授权
    Centrifuge separation method and apparatus using a medium density fluid 有权
    离心分离方法和使用中密度流体的装置

    公开(公告)号：US09095798B2

    公开(公告)日：2015-08-04

    申请号：US13199129

    申请日：2011-08-19

    申请人： John R. Chapman ,  Rodney Sparks

    发明人： John R. Chapman ,  Rodney Sparks

    IPC分类号： B01L3/00 ,  B01D21/26 ,  G01N33/49 ,  A61M1/36

    CPC分类号： B01D21/26 ,  A61M1/3693 ,  B01D21/262 ,  B01D2221/10 ,  B01L3/5021 ,  B01L2200/026 ,  B01L2300/0864 ,  G01N33/491

    摘要： The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation. A medium density fluid is used within the vessel to further isolate constituents of differing densities.

    摘要翻译： 离心容器包括包含内部空间的外壁。 大坝定义了将内部空间分成至少两个区域的障碍物，所述至少两个区域包括限定更高的gee区域的捕集池和限定较低的gee区域的储存器。 这些地区通过大坝连接在一起。 大坝包括一个优选为锥形的面，以便优化放置在容器内的样品的分离速度。 该容器可用于生物样品处理方法，通过使容器的较高gee区域配置为具有细长形式，并且为了收集样品的较高密度部分而优化的体积。 供应和取出管延伸到区域以进行可靠的提取，并通过离心分离后分离收集不同密度的馏分。 在容器内使用中密度流体以进一步分离不同密度的成分。

    Apparatus and Method for Separating and Isolating Components of a Biological Fluid
    16.
    发明申请
    Apparatus and Method for Separating and Isolating Components of a Biological Fluid 有权
    用于分离和分离生物流体组分的装置和方法

    公开(公告)号：US20130327688A1

    公开(公告)日：2013-12-12

    申请号：US13969313

    申请日：2013-08-16

    申请人： John R. Chapman ,  Vijay Kumar ,  Brian K. Cinquini ,  Phillip D. Kingsley

    发明人： John R. Chapman ,  Vijay Kumar ,  Brian K. Cinquini ,  Phillip D. Kingsley

    IPC分类号： B01D21/26

    CPC分类号： B01D21/26 ,  A61M1/029 ,  A61M2202/0413 ,  A61M2202/0464 ,  A61M2202/10 ,  B01D21/262 ,  B01D21/307 ,  B01D21/34 ,  B01D2221/10 ,  B01L3/50215 ,  B01L2300/048 ,  B01L2300/049 ,  B01L2300/0681 ,  B01L2400/0605 ,  B01L2400/0611 ,  G01N2035/00495

    摘要： A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for dosing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.

    摘要翻译： 一种用于分离和分离生物流体组分的装置，包括用于容纳待处理流体的容器，用于对容器进行计量的管帽组件，同时提供与其的填充和抽出连通;漂浮组件，设置在容器内，用于漏斗和控制生物 流体流入浮子内的反向圆顶形隔离室，并控制生物流体流出隔离室，用于在离心过程中进行隔离室内至少一种组分或分离的生物流体流的密封隔离 处理。 所述装置还包括用于连接设置在所述浮子组件内的抽吸通道的柔性管和所述管帽组件的抽吸阀，用于允许至少提取在所述室内封装或隔离的所述一个部件或部件。

    Radial torque limiter
    20.
    发明授权
    Radial torque limiter 失效
    径向力矩限制器

    公开(公告)号：US5040643A

    公开(公告)日：1991-08-20

    申请号：US566032

    申请日：1990-08-13

    申请人： John R. Chapman ,  Gregory C. Hopkins

    发明人： John R. Chapman ,  Gregory C. Hopkins

    IPC分类号： F16D59/00 ,  F16H35/10

    CPC分类号： F16H35/10 ,  F16D59/00

    摘要： A radial torque limiter, for example, for a geared rotary actuator (1, 1') including input member (S, 8) coupled to an output member (3 or 3') driving a sun gear (4) and planet gears (5) through axially projecting tabs (3g). Roller elements (2) are arranged at ramp sections (3a, 3b, 3c, 3d, 8a, 8b, 8c, 8d) formed at the input member (S, 8) and output member (3 or 3') for radially outwardly displacing the beam spring portions of the output member (3 or 3') to radially apply braking force between an external surface (14) of the beam springs and an internal surface (13) of a grounded reaction member (12) so as to brake the input member (S, 8) and output member (3 or 3') upon an occurrence of an excess transmitted torque.

    摘要翻译： 径向扭矩限制器，例如用于包括输入构件（S，8）的齿轮传动旋转致动器（1,1'），该输入构件联接到驱动太阳齿轮（4）的输出构件（3或3'）和行星齿轮（5） ）通过轴向突出的突片（3g）。 滚子元件（2）布置在形成在输入构件（S，8）和输出构件（3或3'）处的径向向外移位的斜坡部分（3a，3b，3c，3d，8a，8b，8c，8d） 输出构件（3或3'）的梁弹簧部分在梁弹簧的外表面（14）和接地的反作用构件（12）的内表面（13）之间径向施加制动力，以制动 输入构件（S，8）和输出构件（3或3'）。