Non-irritating dentifrice
    13.
    发明授权
    Non-irritating dentifrice 失效
    无刺激性洁牙剂

    公开(公告)号:US4391798A

    公开(公告)日:1983-07-05

    申请号:US357918

    申请日:1982-03-15

    摘要: A dentifrice composition containing an anionic surfactant, and a minor amount of a water soluble positively charged protein hydrolysate having an isoionic point above 7, and a Bloom gel value of zero, selected from the group consisting of a protein hydrolysate fraction containing high concentrations of basic amino acids or a quaternary derivative of a protein hydrolysate, which counters the irritation to the oral tissue and reduces the bitterness caused by said anionic surfactant, without reducing its foaming and cleansing properties.The present invention relates to novel oral compositions which are substantially non-irritating to the oral tissue, comprising an anionic surfactant and a positively charged water soluble protein hydrolysate fraction containing a high concentration of basic amino acids or a quaternary derivative of a protein hydrolysate. The protein hydrolysate fraction is obtained by extraction from a partially hydrolyzed protein mixture by means of ion exchange separation with an anion exchange resin. The quaternary derivative is obtained by quaternizing a protein hydrolysate mixture by chemically modifying the available terminal amino groups of the protein.

    摘要翻译: 含有阴离子表面活性剂的洁牙剂组合物和少量具有高于7的等离子点的水溶性带正电荷的蛋白质水解产物和Bloom凝胶值为零,选自含有高浓度碱性的蛋白质水解产物 氨基酸或蛋白质水解产物的季衍生物,其反映了对口腔组织的刺激,并降低了由所述阴离子表面活性剂引起的苦味,而不降低其起泡和清洁性能。 本发明涉及对口腔组织基本无刺激性的新型口服组合物,其包含阴离子表面活性剂和含有高浓度碱性氨基酸或蛋白质水解产物的季衍生物的带正电荷的水溶性蛋白质水解产物级分。 通过用阴离子交换树脂通过离子交换分离从部分水解的蛋白质混合物中提取蛋白质水解产物级分。 通过化学修饰蛋白质的可用末端氨基,通过蛋白质水解产物混合物季铵化获得季衍生物。