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公开(公告)号：US20080177194A1
公开(公告)日：2008-07-24
申请号：US11625045
申请日：2007-01-19
申请人： Yi Zhang , Richard Fogoros , Julie Thompson , Bruce H. KenKnight , Michael J. Pederson , Abhilash Patangay , Tamara Colette Baynham , Yatheendhar D. Manicka , Scott T. Mazar
发明人： Yi Zhang , Richard Fogoros , Julie Thompson , Bruce H. KenKnight , Michael J. Pederson , Abhilash Patangay , Tamara Colette Baynham , Yatheendhar D. Manicka , Scott T. Mazar
IPC分类号： A61B5/04
CPC分类号： A61N1/365 , A61B5/0031 , A61B5/0205 , A61B5/0215 , A61B5/0452 , A61B5/053 , A61B5/7203 , A61B7/023 , A61N1/36521 , A61N1/36542 , A61N1/3655 , A61N1/36557 , A61N1/36564 , A61N1/36585
摘要： A system including an implantable trigger event detector and an implantable ischemia detector. The implantable trigger event detector is adapted to detect at least one first condition and to output a responsive trigger signal including information about whether the first condition has been detected. The implantable ischemia detector is adapted to detect a second condition indicative of one or more physiologic cardiovascular events in a subject that are indicative of ischemia. The ischemia detector is coupled to the trigger event detector to receive the trigger signal, and the ischemia detector is enabled upon the trigger signal indicating that the first condition has been detected.
摘要翻译： 一种包括可植入触发事件检测器和可植入缺血检测器的系统。 可植入触发事件检测器适合于检测至少一个第一状态并输出包括关于是否检测到第一条件的信息的响应触发信号。 可植入缺血检测器适于检测指示受试者中指示缺血的一种或多种生理性心血管事件的第二状态。 缺血检测器耦合到触发事件检测器以接收触发信号，并且在触发信号指示已经检测到第一条件的情况下启用缺血检测器。
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公开(公告)号：US07392084B2
公开(公告)日：2008-06-24
申请号：US10669170
申请日：2003-09-23
申请人： Bruce H. KenKnight , Qingsheng Zhu
发明人： Bruce H. KenKnight , Qingsheng Zhu
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3684
摘要： A method and device for delivering cardiac function therapy on a demand basis. An implantable device for delivering cardiac function therapy is programmed to suspend such therapy at periodic intervals or upon command from an external programmer. Measurements related to hemodynamic performance are then taken using one or more sensing modalities incorporated into the device. Based upon these measurements, the device uses a decision algorithm to determine whether further delivery of the cardiac function therapy is warranted.
摘要翻译： 一种用于在需求的基础上提供心脏功能治疗的方法和装置。 用于递送心脏功能治疗的可植入装置被编程为以周期性间隔或根据来自外部编程器的命令来暂停这种治疗。 然后使用结合到该装置中的一种或多种感测模式进行与血液动力学性能相关的测量。 基于这些测量，该设备使用决策算法来确定是否需要进一步递送心脏功能治疗。
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公开(公告)号：US07194307B2
公开(公告)日：2007-03-20
申请号：US10744952
申请日：2003-12-22
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/3684
摘要： An implantable device for delivering cardiac pacing therapy in order to improve cardiac function is programmed to allow some amount of intrinsic activity to occur without otherwise the disturbing the pacing algorithm used to deliver therapy. Intrinsic cardiac cycles utilize the heart's native conduction system and thus serve to prevent the atrophy which may otherwise result from continuous pacing.
摘要翻译： 用于递送心脏起搏治疗以改善心脏功能的可植入装置被编程为允许发生一定量的内在活动，而无需另外打扰用于递送治疗的起搏算法。 内在心脏周期利用心脏的天然传导系统，从而用于预防由连续起搏引起的萎缩。
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14.发明授权公开(公告)号：US06957105B2
公开(公告)日：2005-10-18
申请号：US10106836
申请日：2002-03-26
CPC分类号： A61N1/3622 , A61N1/3627 , A61N1/3684
摘要： A cardiac rhythm management device is configured to detect oscillations in cardiac rhythm by comparing electrogram signals during successive heart beats. Upon detection of electrical alternans, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.
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公开(公告)号：US06893438B2
公开(公告)日：2005-05-17
申请号：US10286548
申请日：2002-11-01
CPC分类号： A61B18/1492 , A61B2017/00243 , A61B2017/22038 , A61B2017/22068 , A61B2018/00214 , A61B2018/0022 , A61B2018/00261 , A61B2018/00285 , A61B2018/00375 , A61B2018/00702 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/124 , A61B2018/1407 , A61B2018/1435
摘要： A cardiac ablation apparatus for producing a circumferential ablation that electrically isolates a heart chamber wall portion from vessel such as a pulmonary vein extending into said wall portion comprises (a) an elongate centering catheter having a distal end portion; (b) an expandable centering element connected to said centering catheter distal end portion and configured for positioning within said vessel when in a retracted configuration, and for securing said elongate centering catheter in a substantially axially aligned position with respect to said vessel when said centering element is in an expanded configuration; (c) an ablation catheter slidably connected to said centering catheter said ablation element having a distal end portion, and (d) an expandable ablation element connected to said ablation catheter distal end portion. The ablation element is configured to form a circumferential ablation on the wall around the elongate centering catheter when the centering catheter is axially aligned with respect to the vessel. In a further embodiment, a non-expandable, compliant centering element is employed, such as an elastic finger. Systems incorporating such an apparatus and methods of use thereof are also disclosed.
摘要翻译： 一种心脏消融装置，用于产生将心脏室壁部分与血管延伸到所述壁部分中的肺静脉电隔离的周缘消融，包括：（a）具有远端部分的细长定心导管; （b）连接到所述定心导管远端部分并且构造成当处于缩回构型时定位在所述容器内的可扩张定心元件，并且用于当所述定心元件相对于所述容器基本轴向对准的位置时将所述细长定心导管固定 处于扩展配置; （c）消融导管，其可滑动地连接到所述定心导管，所述消融元件具有远端部分，以及（d）可扩张的消融元件，其连接到所述消融导管远端部分。 消融元件构造成当定心导管相对于血管轴向对准时，在围绕细长定心导管的壁上形成周边消融。 在另一个实施例中，使用不可膨胀的柔性定心元件，例如弹性指状物。 还公开了包含这种装置及其使用方法的系统。
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16.发明授权Method and apparatus for treating cardiac arrhythmia using electrogram features 有权使用电描记图特征治疗心律失常的方法和装置公开(公告)号：US06839591B2
公开(公告)日：2005-01-04
申请号：US10396946
申请日：2003-03-24
申请人： Bruce H. KenKnight , William Hsu , Yayun Lin , Janice Jones
发明人： Bruce H. KenKnight , William Hsu , Yayun Lin , Janice Jones
IPC分类号： A61N1/39
CPC分类号： A61N1/3962
摘要： A method and system for ventricular defibrillation by coordinating the delivery of defibrillation shocks with sensed ventricular fibrillation complexes in a way which improves the probability of success of the defibrillation shock. Ventricular electrical activity is monitored in two ventricular locations during ventricular fibrillation to detect coarse ventricular fibrillation complexes and contractions of the ventricular cardiac tissue. The defibrillation shock is delivered in coordination with the occurrence of coarse ventricular fibrillation complexes and the contractions of ventricular cardiac tissue, and specifically to occur on the up-slope portion thereof, for optimal probability of success.
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17.发明授权公开(公告)号：US06400982B2
公开(公告)日：2002-06-04
申请号：US09850283
申请日：2001-05-07
IPC分类号： A61B50452
CPC分类号： A61N1/3622 , G06F19/00 , G16H50/30
摘要： A cardiac rhythm management system predicts when an arrhythmia will occur and in one embodiment invokes a therapy to prevent or reduce the consequences of the arrhythmia. A cardiac arrhythmia trigger/marker is detected from a patient, and based on the trigger/marker, the system estimates a probability of a cardiac arrhythmia occurring during a predetermined future time interval. The system provides a list of triggers/markers, for which detection values are recurrently obtained at various predetermined time intervals. Based on detection values and conditional probabilities associated with the triggers/markers, a probability estimate of a future arrhythmia is computed. An arrhythmia prevention therapy is selected and activated based on the probability estimate of the future arrhythmia.
摘要翻译： 心律管理系统预测何时发生心律失常，并且在一个实施例中调用治疗以预防或减少心律失常的后果。 从患者检测到心律失常触发/标记，并且基于触发/标记，系统估计在预定的未来时间间隔期间发生心律失常的概率。 该系统提供了一个触发/标记列表，为各种预定时间间隔循环获得检测值。 基于与触发/标记相关联的检测值和条件概率，计算未来心律失常的概率估计。 基于对未来心律失常的概率估计，选择并激活心律失常预防疗法。
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公开(公告)号：US06275730B1
公开(公告)日：2001-08-14
申请号：US09390442
申请日：1999-09-07
IPC分类号： A61N139
CPC分类号： A61N1/3937 , A61N1/3918 , A61N1/3943
摘要： An implantable system for the cardioversion of the heart of a patient in need of such treatment comprises a plurality of primary electrodes, a power supply, and a control circuit. Preferably, at least one auxiliary electrode is also included. The plurality of primary electrodes are configured for delivering a cardiversion pulse along a predetermined current pathway in a first portion of the heart, the current pathway defining a weak field area in a second portion of the heart.
摘要翻译： 用于需要这种治疗的患者的心脏的心脏复律的可植入系统包括多个初级电极，电源和控制电路。 优选地，还包括至少一个辅助电极。 多个主电极被配置用于沿着心脏的第一部分中的预定电流通路输送引导脉冲，该电流通路在心脏的第二部分中限定弱磁场区域。
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公开(公告)号：US6122553A
公开(公告)日：2000-09-19
申请号：US393857
申请日：1999-09-09
CPC分类号： A61N1/3918 , A61N1/395
摘要： An implantable system for the defibrillation or cardioversion of the atria and the ventricles of a patient's heart comprises: a first catheter configured for positioning in the right ventricle of the heart; a second catheter configured for positioning through the coronary sinus ostium and in the coronary sinus of the heart, with the first and second catheters together carrying at least three defibrillation electrodes; a power supply; and a control circuit operatively associated with the power supply and the electrodes. The control circuit is configured for delivering an atrial defibrillation pulse through at least two of the electrodes, or a ventricular defibrillation pulse through at least two of the electrodes.
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公开(公告)号：US6112117A
公开(公告)日：2000-08-29
申请号：US852103
申请日：1997-05-06
申请人： Bruce H. KenKnight , William Hsu , Yayun Lin , Janice Jones
发明人： Bruce H. KenKnight , William Hsu , Yayun Lin , Janice Jones
IPC分类号： A61N1/39
CPC分类号： A61N1/3962
摘要： A method and system for ventricular defibrillation by coordinating the delivery of defibrillation shocks with sensed ventricular fibrillation complexes in a way which improves the probability of success of the defibrillation shock. Ventricular electrical activity is monitored in two ventricular locations during ventricular fibrillation to detect coarse ventricular fibrillation complexes and contractions of the ventricular cardiac tissue. The defibrillation shock is delivered in coordination with the occurrence of coarse ventricular fibrillation complexes and the contractions of ventricular cardiac tissue, and specifically to occur on the up-slope portion thereof, for optimal probability of success.
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