公开(公告)号：US08014863B2

公开(公告)日：2011-09-06

申请号：US11625045

申请日：2007-01-19

申请人： Yi Zhang ,  Richard Fogoros ,  Julie Thompson ,  Bruce H. KenKnight ,  Michael J. Pederson ,  Abhilash Patangay ,  Tamara Colette Baynham ,  Yatheendhar D. Manicka ,  Scott T. Mazar

发明人： Yi Zhang ,  Richard Fogoros ,  Julie Thompson ,  Bruce H. KenKnight ,  Michael J. Pederson ,  Abhilash Patangay ,  Tamara Colette Baynham ,  Yatheendhar D. Manicka ,  Scott T. Mazar

IPC分类号： A61B5/02

CPC分类号： A61N1/365 ,  A61B5/0031 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/0452 ,  A61B5/053 ,  A61B5/7203 ,  A61B7/023 ,  A61N1/36521 ,  A61N1/36542 ,  A61N1/3655 ,  A61N1/36557 ,  A61N1/36564 ,  A61N1/36585

摘要： A system including an implantable trigger event detector and an implantable ischemia detector. The implantable trigger event detector is adapted to detect at least one first condition and to output a responsive trigger signal including information about whether the first condition has been detected. The implantable ischemia detector is adapted to detect a second condition indicative of one or more physiologic cardiovascular events in a subject that are indicative of ischemia. The ischemia detector is coupled to the trigger event detector to receive the trigger signal, and the ischemia detector is enabled upon the trigger signal indicating that the first condition has been detected.

摘要翻译： 一种包括可植入触发事件检测器和可植入缺血检测器的系统。 可植入触发事件检测器适合于检测至少一个第一状态并输出包括关于是否检测到第一条件的信息的响应触发信号。 可植入缺血检测器适于检测指示受试者中指示缺血的一种或多种生理性心血管事件的第二状态。 缺血检测器耦合到触发事件检测器以接收触发信号，并且在触发信号指示已经检测到第一条件的情况下启用缺血检测器。

公开(公告)号：US20080177194A1

公开(公告)日：2008-07-24

申请号：US11625045

申请日：2007-01-19

申请人： Yi Zhang ,  Richard Fogoros ,  Julie Thompson ,  Bruce H. KenKnight ,  Michael J. Pederson ,  Abhilash Patangay ,  Tamara Colette Baynham ,  Yatheendhar D. Manicka ,  Scott T. Mazar

发明人： Yi Zhang ,  Richard Fogoros ,  Julie Thompson ,  Bruce H. KenKnight ,  Michael J. Pederson ,  Abhilash Patangay ,  Tamara Colette Baynham ,  Yatheendhar D. Manicka ,  Scott T. Mazar

IPC分类号： A61B5/04

CPC分类号： A61N1/365 ,  A61B5/0031 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/0452 ,  A61B5/053 ,  A61B5/7203 ,  A61B7/023 ,  A61N1/36521 ,  A61N1/36542 ,  A61N1/3655 ,  A61N1/36557 ,  A61N1/36564 ,  A61N1/36585

摘要： A system including an implantable trigger event detector and an implantable ischemia detector. The implantable trigger event detector is adapted to detect at least one first condition and to output a responsive trigger signal including information about whether the first condition has been detected. The implantable ischemia detector is adapted to detect a second condition indicative of one or more physiologic cardiovascular events in a subject that are indicative of ischemia. The ischemia detector is coupled to the trigger event detector to receive the trigger signal, and the ischemia detector is enabled upon the trigger signal indicating that the first condition has been detected.

摘要翻译： 一种包括可植入触发事件检测器和可植入缺血检测器的系统。 可植入触发事件检测器适合于检测至少一个第一状态并输出包括关于是否检测到第一条件的信息的响应触发信号。 可植入缺血检测器适于检测指示受试者中指示缺血的一种或多种生理性心血管事件的第二状态。 缺血检测器耦合到触发事件检测器以接收触发信号，并且在触发信号指示已经检测到第一条件的情况下启用缺血检测器。

公开(公告)号：US08628471B2

公开(公告)日：2014-01-14

申请号：US12827985

申请日：2010-06-30

申请人： Scott T. Mazar ,  Richard Fogoros ,  Yatheendhar D. Manicka ,  Bruce H. KenKnight ,  Michael J. Pederson

发明人： Scott T. Mazar ,  Richard Fogoros ,  Yatheendhar D. Manicka ,  Bruce H. KenKnight ,  Michael J. Pederson

IPC分类号： A61B5/0452 ,  A61B5/026 ,  A61B5/0205 ,  A61B5/053

CPC分类号： A61B5/14546 ,  A61B5/0031 ,  A61B5/0205 ,  A61B5/0456 ,  A61B5/0464 ,  A61B5/0809 ,  A61B5/11 ,  A61B5/14532 ,  A61B2562/0219

摘要： Systems and Methods for predicting patient health and patient relative well-being within a patient management system are disclosed. A preferred embodiment utilizes an implantable medical device comprising an analysis component and a sensing component further comprising a three-dimensional accelerometer, a transthoracic impedance sensor, a cardio-activity sensor, an oxygen saturation sensor and a blood glucose sensor. Some embodiments of a system disclosed herein also can be configured as an Advanced Patient Management System that helps better monitor, predict and manage chronic diseases.

摘要翻译： 公开了用于预测患者健康状况和患者管理系统内患者相对健康的系统和方法。 优选实施例利用包括分析部件和感测部件的可植入医疗装置，其进一步包括三维加速度计，经胸阻抗传感器，心脏活动传感器，氧饱和度传感器和血糖传感器。 本文公开的系统的一些实施例还可以被配置为有助于更好地监测，预测和管理慢性疾病的高级患者管理系统。

公开(公告)号：US20100268095A1

公开(公告)日：2010-10-21

申请号：US12827985

申请日：2010-06-30

申请人： Scott Thomas Mazar ,  Richard Fogoros ,  Yatheendhar Manicka ,  Bruce H. KenKnight ,  Michael J. Pederson

发明人： Scott Thomas Mazar ,  Richard Fogoros ,  Yatheendhar Manicka ,  Bruce H. KenKnight ,  Michael J. Pederson

IPC分类号： A61B5/0205 ,  A61B5/08

CPC分类号： A61B5/14546 ,  A61B5/0031 ,  A61B5/0205 ,  A61B5/0456 ,  A61B5/0464 ,  A61B5/0809 ,  A61B5/11 ,  A61B5/14532 ,  A61B2562/0219

摘要： Systems and Methods for predicting patient health and patient relative well-being within a patient management system are disclosed. A preferred embodiment utilizes an implantable medical device comprising an analysis component and a sensing component further comprising a three-dimensional accelerometer, a transthoracic impedance sensor, a cardio-activity sensor, an oxygen saturation sensor and a blood glucose sensor. Some embodiments of a system disclosed herein also can be configured as an Advanced Patient Management System that helps better monitor, predict and manage chronic diseases.

摘要翻译： 公开了用于预测患者健康状况和患者管理系统内患者相对健康的系统和方法。 优选实施例利用包括分析部件和感测部件的可植入医疗装置，其进一步包括三维加速度计，经胸阻抗传感器，心脏活动传感器，氧饱和度传感器和血糖传感器。 本文公开的系统的一些实施例还可以被配置为有助于更好地监测，预测和管理慢性疾病的高级患者管理系统。

公开(公告)号：US20080177156A1

公开(公告)日：2008-07-24

申请号：US11624974

申请日：2007-01-19

申请人： Yi Zhang ,  Krzysztof Z. Siejko ,  Richard Fogoros ,  Abhilash Patangay

发明人： Yi Zhang ,  Krzysztof Z. Siejko ,  Richard Fogoros ,  Abhilash Patangay

IPC分类号： A61B5/0205 ,  A61B5/0215

CPC分类号： A61B5/0215 ,  A61B5/02028 ,  A61B5/0205 ,  A61B5/145

摘要： This document discusses, among other things, a system and method for sensing a pulmonary artery pressure (“PAP”) signal of a pulmonary artery (“PA”) and computing an indication of a reduction of blood supply to at least a portion of a heart using information from the PAP signal. The reduction of blood supply to at least a portion of the heart can be detected using a PAP signal characteristic or measurement, using a change in the PAP, using an interval between multiple PAP signal features, using a mitral valve performance, or using information from the PAP and information from a different physiological signal, including a cardiac signal, a heart sound signal, right ventricular pressure signal, a left ventricular pressure signal, a blood pressure signal, and an oxygen saturation signal.

摘要翻译： 本文件尤其涉及用于感测肺动脉（“PA”）的肺动脉压（“PAP”）信号的系统和方法，并且计算将血液供应减少到至少一部分 心脏使用来自PAP信号的信息。 使用PAP信号特征或测量可以使用PAP信号特征或多个PAP信号特征之间的间隔，使用二尖瓣性能来使用PAP信号特征或测量来检测对心脏的至少一部分的血液供应，或使用来自 PAP和来自不同生理信号的信息，包括心脏信号，心音信号，右心室压力信号，左心室压力信号，血压信号和氧饱和度信号。

公开(公告)号：US20120004565A1

公开(公告)日：2012-01-05

申请号：US13231152

申请日：2011-09-13

申请人： Yi Zhang ,  Richard Fogoros ,  Carlos Haro ,  Yousufali Dalal ,  Marina V. Brockway ,  Krzysztof Z. Siejko

发明人： Yi Zhang ,  Richard Fogoros ,  Carlos Haro ,  Yousufali Dalal ,  Marina V. Brockway ,  Krzysztof Z. Siejko

IPC分类号： A61B5/02 ,  A61B5/0205

CPC分类号： A61N1/3627 ,  A61B5/0031 ,  A61B5/024 ,  A61B5/0452 ,  A61B5/0456 ,  A61B7/04 ,  A61N1/36578 ,  A61N1/395

摘要： A system comprising an implantable medical device (IMD) includes an implantable heart sound sensor to produce an electrical signal representative of at least one heart sound. The heart sound is associated with mechanical activity of a patient's heart. Additionally, the IMD includes a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal, and a signal analyzer circuit coupled to the heart sound sensor interface circuit. The signal analyzer circuit measures a baseline heart sound signal, and deems that an ischemic event has occurred using, among other things, a measured subsequent change in the heart sound signal from the established baseline heart sound signal.

摘要翻译： 包括可植入医疗装置（IMD）的系统包括可植入心音传感器，以产生代表至少一个心音的电信号。 心脏声音与患者心脏的机械活动有关。 另外，IMD包括耦合到心脏声音传感器以产生心脏声音信号的心脏声音传感器接口电路，以及耦合到心脏声音传感器接口电路的信号分析器电路。 信号分析器电路测量基线心音信号，并且认为已经发生了缺血事件，其中使用来自已建立的基线心音信号的心音信号的测量后续变化。

公开(公告)号：US08758260B2

公开(公告)日：2014-06-24

申请号：US13231152

申请日：2011-09-13

申请人： Yi Zhang ,  Richard Fogoros ,  Carlos Haro ,  Yousufali Dalal ,  Marina V. Brockway ,  Krzysztof Z. Siejko

发明人： Yi Zhang ,  Richard Fogoros ,  Carlos Haro ,  Yousufali Dalal ,  Marina V. Brockway ,  Krzysztof Z. Siejko

IPC分类号： A61B5/04

CPC分类号： A61N1/3627 ,  A61B5/0031 ,  A61B5/024 ,  A61B5/0452 ,  A61B5/0456 ,  A61B7/04 ,  A61N1/36578 ,  A61N1/395

摘要： A system comprising an implantable medical device (IMD) includes an implantable heart sound sensor to produce an electrical signal representative of at least one heart sound. The heart sound is associated with mechanical activity of a patient's heart. Additionally, the IMD includes a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal, and a signal analyzer circuit coupled to the heart sound sensor interface circuit. The signal analyzer circuit measures a baseline heart sound signal, and deems that an ischemic event has occurred using, among other things, a measured subsequent change in the heart sound signal from the established baseline heart sound signal.

摘要翻译： 包括可植入医疗装置（IMD）的系统包括可植入心音传感器，以产生代表至少一个心音的电信号。 心脏声音与患者心脏的机械活动有关。 另外，IMD包括耦合到心脏声音传感器以产生心脏声音信号的心脏声音传感器接口电路，以及耦合到心脏声音传感器接口电路的信号分析器电路。 信号分析器电路测量基线心音信号，并且认为已经发生了缺血事件，其中使用来自已建立的基线心音信号的心音信号的测量后续变化。

公开(公告)号：US08034000B2

公开(公告)日：2011-10-11

申请号：US12510962

申请日：2009-07-28

申请人： Yi Zhang ,  Richard Fogoros ,  Carlos Haro ,  Yousufali Dalal ,  Marina V. Brockway ,  Krzysztof Z. Siejko

发明人： Yi Zhang ,  Richard Fogoros ,  Carlos Haro ,  Yousufali Dalal ,  Marina V. Brockway ,  Krzysztof Z. Siejko

IPC分类号： A61B5/04

CPC分类号： A61N1/3627 ,  A61B5/0031 ,  A61B5/024 ,  A61B5/0452 ,  A61B5/0456 ,  A61B7/04 ,  A61N1/36578 ,  A61N1/395

摘要： A system comprising an implantable medical device (IMD) includes an implantable heart sound sensor to produce an electrical signal representative of at least one heart sound. The heart sound is associated with mechanical activity of a patient's heart. Additionally, the IMD includes a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal, and a signal analyzer circuit coupled to the heart sound sensor interface circuit. The signal analyzer circuit measures a baseline heart sound signal, and deems that an ischemic event has occurred using, among other things, a measured subsequent change in the heart sound signal from the established baseline heart sound signal.

公开(公告)号：US07922669B2

公开(公告)日：2011-04-12

申请号：US11148107

申请日：2005-06-08

申请人： Yi Zhang ,  Richard Fogoros ,  Carlos Haro ,  Yousufali Dalal ,  Marina Brockway ,  Krzysztof Z. Siejko

发明人： Yi Zhang ,  Richard Fogoros ,  Carlos Haro ,  Yousufali Dalal ,  Marina Brockway ,  Krzysztof Z. Siejko

IPC分类号： A61B5/02

CPC分类号： A61N1/3627 ,  A61B5/0031 ,  A61B5/024 ,  A61B5/0452 ,  A61B5/0456 ,  A61B7/04 ,  A61N1/36578 ,  A61N1/395

摘要： A system comprising an implantable medical device (IMD) includes an implantable heart sound sensor to produce an electrical signal representative of at least one heart sound. The heart sound is associated with mechanical activity of a patient's heart. Additionally, the IMD includes a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal, and a signal analyzer circuit coupled to the heart sound sensor interface circuit. The signal analyzer circuit measures a baseline heart sound signal, and deems that an ischemic event has occurred using, among other things, a measured subsequent change in the heart sound signal from the established baseline heart sound signal.

摘要翻译： 包括可植入医疗装置（IMD）的系统包括可植入心音传感器，以产生代表至少一个心音的电信号。 心脏声音与患者心脏的机械活动有关。 另外，IMD包括耦合到心脏声音传感器以产生心脏声音信号的心脏声音传感器接口电路，以及耦合到心脏声音传感器接口电路的信号分析器电路。 信号分析器电路测量基线心音信号，并且认为已经发生了缺血事件，其中使用来自已建立的基线心音信号的心音信号的测量后续变化。

公开(公告)号：US20090287106A1

公开(公告)日：2009-11-19

申请号：US12510962

申请日：2009-07-28

申请人： Yi Zhang ,  Richard Fogoros ,  Carlos Haro ,  Yousufali Dalal ,  Marina Brockway ,  Krzysztof Z. Siejko

发明人： Yi Zhang ,  Richard Fogoros ,  Carlos Haro ,  Yousufali Dalal ,  Marina Brockway ,  Krzysztof Z. Siejko

IPC分类号： A61B5/02

CPC分类号： A61N1/3627 ,  A61B5/0031 ,  A61B5/024 ,  A61B5/0452 ,  A61B5/0456 ,  A61B7/04 ,  A61N1/36578 ,  A61N1/395

摘要： A system comprising an implantable medical device (IMD) includes an implantable heart sound sensor to produce an electrical signal representative of at least one heart sound. The heart sound is associated with mechanical activity of a patient's heart. Additionally, the IMD includes a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal, and a signal analyzer circuit coupled to the heart sound sensor interface circuit. The signal analyzer circuit measures a baseline heart sound signal, and deems that an ischemic event has occurred using, among other things, a measured subsequent change in the heart sound signal from the established baseline heart sound signal.

摘要翻译： 包括可植入医疗装置（IMD）的系统包括可植入心音传感器，以产生代表至少一个心音的电信号。 心脏声音与患者心脏的机械活动有关。 另外，IMD包括耦合到心脏声音传感器以产生心脏声音信号的心脏声音传感器接口电路，以及耦合到心脏声音传感器接口电路的信号分析器电路。 信号分析器电路测量基线心音信号，并且认为已经发生了缺血事件，其中使用来自已建立的基线心音信号的心音信号的测量后续变化。