公开(公告)号：US06683301B2

公开(公告)日：2004-01-27

申请号：US10056671

申请日：2002-01-25

申请人： Craig Whitehouse ,  David G. Welkie

发明人： Craig Whitehouse ,  David G. Welkie

IPC分类号： H01J4916

CPC分类号： H01J49/40 ,  B82Y30/00 ,  H01J49/0068

摘要： A Time-Of-Flight mass spectrometer is configured with a pulsing region and electronic controls that generate a potential well for ions in the pulsing region, due to the repelling effect of a high-frequency electric field that is created in the space immediately proximate to a surface, and an additional static electric field that accelerates ions toward the surface. Ions can be constrained and accumulated over time in the potential well prior to acceleration into the Time-Of-Flight tube for mass analysis. Ions can also be directed to collide with the surface with high energy to cause Surface Induced Dissociation (SID) fragmentation, or with low energy to effect collisional cooling, hence, better spatial focusing, prior to mass analysis. The apparatus and methods described in the invention result in refined control of ion fragmentation energy and improved Time-Of-Flight mass analysis performance.

摘要翻译： 飞行时间质谱仪配置有脉冲区域和电子控制器，由于在紧邻的空间中产生的高频电场的排斥效应，脉冲区域中的离子产生潜在的阱 一个表面和一个额外的静电场，可以将离子加速到表面。 在加速进入飞行时间管以进行质量分析之前，离子可以在潜在的时间内受到约束和积累。 离子也可以被引导与高能量的表面碰撞以引起表面诱导解离（SID）碎裂，或者以低能量来实现碰撞冷却，因此在质量分析之前更好地进行空间聚焦。 本发明描述的装置和方法可以精确控制离子碎片能量和改进的飞行时间质量分析性能。

公开(公告)号：US07982185B2

公开(公告)日：2011-07-19

申请号：US12474379

申请日：2009-05-29

申请人： Craig Whitehouse ,  Victor Laiko

发明人： Craig Whitehouse ,  Victor Laiko

IPC分类号： H01J49/26

CPC分类号： H01J49/145 ,  H01J49/045 ,  H01J49/168

摘要： An Atmospheric Pressure Chemical Ionization (APCI) source interfaced to a mass spectrometer is configured with a corona discharge needle positioned inside the APCI inlet probe assembly. Liquid sample flowing into the APCI inlet probe is nebulized and vaporized prior to passing through the corona discharge region all contained in the APCI inlet probe assembly Ions produced in the corona discharge region are focused toward the APCI probe centerline to maximize ion transmission through the APCI probe exit. External electric fields penetrating into the APCI probe exit end opening providing additional centerline focusing of sample ions exiting the APCI probe. The APCI probe is configured to shield the electric field from the corona discharge region while allowing penetration of an external electric field to focus APCI generated ions into an orifice into vacuum for mass to charge analysis. Ions that exit the APCI probe are directed only by external electric fields and gas flow maximizing ion transmission into a mass to charge analyzer. The new APCI probe can be configured to operate as a stand alone APCI source inlet probe, as a reagent ion gun for ionizing samples introduced on solids or liquid sample probes or through gas inlets in a multiple function ion source or as the APCI portion of a combination Electrospray and APCI multiple function ion source. Sample ions and gas phase reagent ions are generated in the APCI probe from liquid or gas inlet species or mixtures of both.

摘要翻译： 与质谱仪接口的大气压化学电离（APCI）源配置有位于APCI入口探针组件内部的电晕放电针。 流入APCI入口探针的液体样品在通过包含在APCI入口探针组件中的电晕放电区域之前被雾化和蒸发。 在电晕放电区域产生的离子聚焦到APCI探针中心线，以通过APCI探针出口最大化离子传输。 外部电场穿透到APCI探针出口端开口，提供离开APCI探针的样品离子的附加中心线聚焦。 APCI探针被配置为屏蔽来自电晕放电区域的电场，同时允许穿透外部电场以将APCI产生的离子聚焦到孔中以进行质量电荷分析。 离开APCI探头的离子仅由外部电场和气流引导，将离子传输最大化成质量计量分析仪。 新的APCI探针可以配置为作为独立的APCI源入口探针进行操作，作为用于将固体或液体样品探针上引入的样品或通过多功能离子源中的气体入口电离的样品的反应离子枪或作为 组合电喷雾和APCI多功能离子源。 样品离子和气相试剂离子在APCI探针中从液体或气体入口物质或两者的混合物中产生。

公开(公告)号：US20050258361A1

公开(公告)日：2005-11-24

申请号：US11132956

申请日：2005-05-19

申请人： Craig Whitehouse ,  Allan Burt ,  Glenn Whitehouse ,  Mike Sansone

发明人： Craig Whitehouse ,  Allan Burt ,  Glenn Whitehouse ,  Mike Sansone

IPC分类号： H01J49/00 ,  H01J49/04 ,  H01J49/16

CPC分类号： H01J49/167

摘要： An improved sample introduction probe is disclosed for the production of ions from liquid sample solutions in an electrospray ion source. Nebulization of a liquid sample emerging from the end of an inner flow tube is pneumatically assisted by gas flowing from the end of an outer gas flow tube essentially coaxial with the inner sample flow tube. The disclosed probe provides for adjustment of the relative axial positions of the ends of the liquid and gas flow tubes without degrading the precise concentricity between the inner and outer tubes. Additionally, the terminal portion of the outer gas flow tube may be fabricated either from a conductive or dielectric material, thereby allowing the pneumatic nebulization and electrospray processes to be optimized separately and independently. Hence, the disclosed invention provides a pneumatically-assisted electrospray probe with improved mechanical and operational stability, reliability, reproducibility, and ease of use compared to prior art probes.

摘要翻译： 公开了用于在电喷雾离子源中从液体样品溶液中产生离子的改进的样品引入探针。 从内流管端部出现的液体样品的雾化由气体从与内部样品流管同轴的外部气体流管的端部流动的气体辅助。 所公开的探针提供了调节液体和气体流管的端部的相对轴向位置，而不会降低内管和外管之间的精确同心度。 此外，外部气体流动管的端子部分可以由导电材料或介电材料制成，从而允许气动雾化和电喷雾工艺被独立地和独立地优化。 因此，与现有技术的探针相比，所公开的发明提供了具有改进的机械和操作稳定性，可靠性，再现性和易用性的气动辅助电喷雾探针。

公开(公告)号：US20050258360A1

公开(公告)日：2005-11-24

申请号：US11132953

申请日：2005-05-19

申请人： Craig Whitehouse ,  Thomas White

发明人： Craig Whitehouse ,  Thomas White

IPC分类号： H01J27/26 ,  H01J49/04 ,  H01J49/10 ,  H01J49/16

CPC分类号： H01J49/165 ,  B01D61/00 ,  B01D61/425 ,  B01D2313/345 ,  G01N30/7266 ,  H01J49/0018 ,  H01J49/167 ,  Y10T436/212 ,  Y10T436/24

摘要： Charged droplet spray is formed from a solution with all or a portion of the charged droplet spray current generated from reduction or oxidation (redox) reactions occurring on surfaces removed from the first or sample solution flow path. In one embodiment of the invention, two solution flow channels are separated by a semipermeable membrane. A first or sample solution flowing through the first solution flow channel exchanges cation or anion charged species through the semipermeable membrane with a second solution or gas flowing through the second flow channel. Charge exchange is driven by the electric field applied at the charged droplet sprayer sample solution outlet. Redox reactions occur at an electrode surface in contact with the second solution. The invention increases the control and range of the Electrospray ionization process during ES/MS operation. Alternative embodiments of the invention provide for conducting redox reactions on conductive surfaces removed from the first or sample solution flow path but not separated by semipermeable membranes.

摘要翻译： 由溶液形成带电的液滴喷雾，其中从在第一或样品溶液流动路径上去除的表面上发生的还原或氧化（氧化还原）反应产生的全部或一部分带电液滴喷雾电流。 在本发明的一个实施方案中，两个溶液流动通道被半透膜隔开。 流过第一溶液流动通道的第一或样品溶液通过半透膜与穿过第二流动通道的第二溶液或气体交换阳离子或阴离子带电物质。 电荷交换由在带电液滴喷雾器样品溶液出口处施加的电场驱动。 在与第二溶液接触的电极表面处发生氧化还原反应。 本发明增加了ES / MS操作期间电喷雾电离过程的控制和范围。 本发明的替代实施例提供了在从第一或样品溶液流动路径移除但不被半透膜隔离的导电表面上进行氧化还原反应。

公开(公告)号：US5689111A

公开(公告)日：1997-11-18

申请号：US689459

申请日：1996-08-09

申请人： Thomas Dresch ,  Erol E. Gulcicek ,  Craig Whitehouse

发明人： Thomas Dresch ,  Erol E. Gulcicek ,  Craig Whitehouse

IPC分类号： G01N27/62 ,  H01J49/04 ,  H01J49/06 ,  H01J49/40

CPC分类号： H01J49/401 ,  H01J49/004 ,  H01J49/063

摘要： A method and an apparatus which combines a linear two dimensional ion guide or a two dimensional ion storage device in tandem with a time-of-flight mass analyzer to analyze ionic chemical species generated by an ion source. The method improves the duty cycle, and therefore, the overall instrument sensitivity with respect to the analyzed chemical species.

摘要翻译： 一种将线性二维离子导向器或二维离子存储装置与飞行时间质量分析仪串联组合以分析由离子源产生的离子化学物质的方法和装置。 该方法提高了相对于分析的化学物质的占空比，因此提高了仪器的整体灵敏度。