公开(公告)号：US20230159982A1

公开(公告)日：2023-05-25

申请号：US18100181

申请日：2023-01-23

Applicant: S.D. Sight Diagnostics Ltd.

Inventor： JOSEPH JOEL POLLAK ,  Daniel LEVNER ,  Yonatan BILU ,  Arnon HOURI YAFIN ,  Noam YORAV-RAPHAEL ,  Yuval GREENFIELD

IPC: C12Q1/68 ,  G01N1/30

CPC classification number: C12Q1/68 ,  G01N1/30

Abstract: Apparatus and methods for use with a blood sample are described. The blood sample is stained with a first dye that predominantly stains DNA, and a second dye that stains at least one other cellular component being different from DNA. A plurality of images of the blood sample are acquired. A candidate object is identified as being a candidate of a given entity. A first stained area, which is stained by the first dye and which is disposed within the candidate object, is identified. A second stained area, which is stained by the second dye and which is disposed within the candidate object, is identified. The entity is detected by determining that features of the stained areas satisfy predetermined criteria associated with the entity. Other applications are also described.

公开(公告)号：US20220381672A1

公开(公告)日：2022-12-01

申请号：US17770365

申请日：2020-10-22

Applicant: S.D. SIGHT DIAGNOSTICS LTD.

Inventor： Sharon PECKER ,  Yochay Shlomo ESHEL ,  Amir ZAIT ,  Dan GLUCK ,  Noam YORAV-RAPHAEL ,  Arnon HOURI YAFIN ,  Sarah LEVY SCHREIER ,  Joseph Joel POLLAK ,  Daniel LEVNER ,  Yonatan HALPERIN ,  Natalie LEZMY ,  Itamar WEISS

IPC: G01N15/14 ,  G01N33/49 ,  G06V20/69

Abstract: Apparatus and methods are described including placing at least a portion of a blood sample within a sample chamber (52), and acquiring microscopic images of the portion of the blood sample. Candidates of a given entity within the blood sample are identified, within the microscopic image. At least some of the candidates as being the given entity are validated, by performing further analysis of the candidates. A count of the candidates of the given entity is compared to a count of the validated candidates of the given entity, and at least the portion of the sample is invalidated from being used for performing at least some measurements upon the sample, at least partially based upon a relationship between the count of candidates and the count of validated candidates. Other applications are also described.

公开(公告)号：US20210327064A1

公开(公告)日：2021-10-21

申请号：US17362009

申请日：2021-06-29

Applicant: S.D. Sight Diagnostics Ltd.

Inventor： Noam YORAV-RAPHAEL ,  Uri WOLFOVITZ ,  Joseph Joel POLLAK

IPC: G06T7/00 ,  G02B21/24 ,  G06T7/90

Abstract: Apparatus and methods are described for use with a digital microscope unit that includes a digital microscope. A biological cell sample that is disposed within a sample carrier is received into the digital microscope unit. It is determined that there is a variation in the focal depth of the biological sample with respect to the microscope due to curvature in the sample carrier and/or due to tolerance in setup of the microscope. In response to determining that there is the variation in the focal depth of the biological sample with respect to the microscope, the variation in the focal depth of the biological sample with respect to the microscope is accounted for. Other applications are also described.

公开(公告)号：US20210072526A1

公开(公告)日：2021-03-11

申请号：US17083659

申请日：2020-10-29

Applicant: S.D. Sight Diagnostics Ltd.

Inventor： Noam YORAV-RAPHAEL ,  Joseph Joel POLLAK ,  Sarah LEVY SCHREIER ,  Yochay Shlomo ESHEL

IPC: G02B21/00 ,  G01N21/64 ,  G02B21/36

Abstract: Apparatus and methods for determining a property of a bodily sample using a microscope are described. A sample carrier includes a plurality of microscopy sample chambers configured to receive a least a portion of the bodily sample, while the sample is imaged by the microscope. Each of the microscopy sample chambers has an upper and a lower surface, and the microscopy sample chambers have respective heights between the upper and lower surfaces that are different from each other. The sample carrier defines a microscopy sample chamber inlet hole, that is fluid communication with all of the microscopy sample chambers, such as to facilitate filling of all of the microscopy sample chambers with the portion of the bodily sample, via the microscopy sample chamber inlet hole. Other applications are also described.