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公开(公告)号：US20250076287A1
公开(公告)日：2025-03-06
申请号：US18951911
申请日：2024-11-19
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Amir ZAIT , Arnon HOURI YAFIN , Dan GLuck , Sharon PECKER , Yochay Shlomo ESHEL , Sarah LEVYS CHREIER , Joseph Joel POLLAK
Abstract: Apparatus and methods are described including measuring a measurand within a first portion of a bodily sample, measuring relative amounts of first and second components within a second portion of the bodily sample that is diluted relative to the first portion of the bodily sample, and determining a parameter of the bodily sample based upon the measurand within the first portion of the bodily sample and the relative amounts of first and second components within the second portion of the bodily sample. Other applications are also described.
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公开(公告)号：US20220019070A1
公开(公告)日：2022-01-20
申请号：US17490767
申请日：2021-09-30
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo ESHEL , Natalie LEZMY , Dan GLUCK , Arnon HOURI YAFIN , Joseph Joel POLLAK
Abstract: Apparatus and methods are described for analyzing a bodily sample. One or more microscope images of the bodily sample are acquired. Using at least one computer processor at least one sample-informative feature that is indicative of a characteristic of the bodily sample is extracted from the images. Based upon the sample-informative feature, the computer processor determines that there is a defect associated with the bodily sample, and determines a source of the defect. Other applications are also described.
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公开(公告)号：US20200249459A1
公开(公告)日：2020-08-06
申请号：US16851686
申请日：2020-04-17
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo ESHEL , Natalie LEZMY , Dan GLUCK , Arnon HOURI YAFIN , Joseph Joel POLLAK
Abstract: Apparatus and methods are described including staining a blood sample with one or more stains. A plurality of microscopic images of the stained blood sample are acquired, using a microscope. Staining-quality parameters for respective microscopic images are determined, using a computer processor, the staining-quality parameters being indicative of a quality of the staining within each of the respective microscopic images. An action is performed by the computer processor, based upon the staining-quality parameters of the respective microscopic images. Other applications are also described.
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公开(公告)号：US20250108367A1
公开(公告)日：2025-04-03
申请号：US18832199
申请日：2023-01-25
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Sharon PECKER , Noam MORALI , Aviram STEINBOK , Yochay Shlomo ESHEL , Trevor RUGGIERO , Kristofer KURTIN , Joseph Joel POLLAK , Daniel LEVNER , Julie RICHARDSON
IPC: B01L3/00
Abstract: Apparatus and methods are described for analyzing a bodily sample. A sample carrier (22), which houses the bodily sample, includes at least one fluidic channel (120), at least one analysis chamber (68), and a receptacle (92) that houses a diluent. A pump system (150) pumps the diluent from the receptacle (92) into the fluidic channel (120) in a first fluid flow direction, and subsequently, pumps the diluent and the bodily sample in a second fluid flow direction, which is a reverse of the first fluid flow direction, to thereby mix the diluent and the bodily sample within the receptacle (92). Other applications are also described.
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公开(公告)号：US20230026108A1
公开(公告)日：2023-01-26
申请号：US17783839
申请日：2020-12-10
Applicant: S.D. SIGHT DIAGNOSTICS LTD
Inventor： Amir ZAIT , Dan GLUCK , Arnon HOURI YAFIN , David BRAILOVSKY , Yochay Shlomo ESHEL , Sarah LEVY , Joseph Joel POLLAK
Abstract: Apparatus and methods are described including analyzing one or more microscopic images of the blood sample using a machine-learning classifier. An entity within the one or more microscopic images is identified using a first classification model, and a first estimated concentration of the entity within the sample is determined, based upon the entity as identified using the first classification model. The entity is identified within the one or more microscopic images using a second classification model, and a second estimated concentration of the entity within the sample is determined, based upon the entity as identified using the second classification model. The first and second estimated concentrations are compared to each other, and, in response to the comparison, a hybrid classification model that is a hybrid of the first and second classification models is used. Other applications are also described.
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Patent Agency Ranking
公开(公告)号：US20220138944A1
公开(公告)日：2022-05-05
申请号：US17576023
申请日：2022-01-14
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yuval GREENFIELD , Yonatan BILU , Joseph Joel POLLAK , Noam YORAV-RAPHAEL
Abstract: Apparatus and methods are described for use with a cell sample that includes a plurality of cells disposed in a monolayer. A series of images associated with a series of depth levels of the cell sample are acquired, by performing a depth scan of cell sample with a microscope. One of the depth levels is identified as being an optimum focal plane for imaging one or more entities within the cell sample using the microscope, by identifying that a drop in image contrast occurs at the identified depth level relative to the image contrast of images acquired at depth levels within a given range of distances from the identified depth level. The cell sample is imaged using the microscope, by focusing the microscope at an investigative depth level that is based on the identified depth level. Other applications are also described.
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公开(公告)号：US20210018743A1
公开(公告)日：2021-01-21
申请号：US17063320
申请日：2020-10-05
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Noam YORAV RAPHAEL , Yuval GREENFIELD , Joseph Joel POLLAK , Yonatan BILU
Abstract: Apparatus and methods are described including a microscope system configured to acquire first and second images of a blood sample at respective times. A computer processor determines whether, between acquisitions of the first and second images, there was motion of a given entity within the sample, by comparing the first and second images to one another. At least partially in response thereto, the computer processor distinguishes between the given entity being a non-parasitic entity and the given entity being a parasite, and generates an output on the output device, at least partially in response thereto. Other applications are also described.
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公开(公告)号：US20200300750A1
公开(公告)日：2020-09-24
申请号：US16088321
申请日：2017-03-23
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo ESHEL , Arnon HOURI YAFIN , Joseph Joel POLLAK , Neta BACHAR , Annael MARCIANO , Sarah LEVY SCHREIER
Abstract: Apparatus and methods are described for use with an output device (34), and a blood sample (12) that was drawn from a subject. A microscope system (10) acquires first and second images of the blood sample at respective times. A computer processor (28) determines whether, between acquisitions of the first and second images, there was relative motion between at least one erythrocyte within the sample and at least one entity within the sample, by comparing the first and second images to one another. At least partially in response thereto, the computer processor determines whether the entity is an extra-erythrocytic or an intra-erythrocytic entity, and generates an output on the output device, at least partially in response thereto. Other applications are also described.
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公开(公告)号：US20250067968A1
公开(公告)日：2025-02-27
申请号：US18940926
申请日：2024-11-08
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yonatan HALPERIN , Dan GLUCK , Noam YORAV-RAPHAEL , Yochay Shlomo ESHEL , Sarah LEVY , Joseph Joel POLLAK
Abstract: Apparatus and methods are described for use with a blood sample and a display, including acquiring a plurality of images of a microscopic imaging field of the blood sample, each of the images being acquired using respective, different imaging conditions. An artificial color microscopic display image of the microscopic imaging field is generated having a similar appearance to that of a color smear image, by mapping the plurality of images to respective channels of the artificial color microscopic display image. A display is driven to display the artificial color microscopic display image of the microscopic imaging field to a user. Other applications are also described.
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公开(公告)号：US20210101147A1
公开(公告)日：2021-04-08
申请号：US17064193
申请日：2020-10-06
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Ido BACHELET , Joseph Joel POLLAK , Daniel LEVNER , Yonatan BILU , Noam YORAV-RAPHAEL
Abstract: Apparatus and methods are described including successively acquiring a plurality of microscopic images of a portion of a blood sample, and tracking motion of pixels within the successively acquired microscopic images. Trypomastigote parasite candidates within the blood sample are identified, by identifying pixel motion that is typical of trypomastigote parasites. It is determined that the blood sample is infected with trypomastigote parasites, at least partially in response thereto. An output is generated indicating that that the blood sample is infected with trypomastigote parasites. Other applications are also described.
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