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公开(公告)号：US20250067968A1
公开(公告)日：2025-02-27
申请号：US18940926
申请日：2024-11-08
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yonatan HALPERIN , Dan GLUCK , Noam YORAV-RAPHAEL , Yochay Shlomo ESHEL , Sarah LEVY , Joseph Joel POLLAK
Abstract: Apparatus and methods are described for use with a blood sample and a display, including acquiring a plurality of images of a microscopic imaging field of the blood sample, each of the images being acquired using respective, different imaging conditions. An artificial color microscopic display image of the microscopic imaging field is generated having a similar appearance to that of a color smear image, by mapping the plurality of images to respective channels of the artificial color microscopic display image. A display is driven to display the artificial color microscopic display image of the microscopic imaging field to a user. Other applications are also described.
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公开(公告)号：US20210041422A1
公开(公告)日：2021-02-11
申请号：US17082615
申请日：2020-10-28
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Amir ZAIT , Arnon HOURI YAFIN , Dan GLUCK , Sharon PECKER , Yochay Shlomo ESHEL , Sarah LEVY SCHREIER , Joseph Joel POLLAK
IPC: G01N33/50 , G01N33/49 , G01N15/06 , G01N33/569
Abstract: Apparatus and methods are described including placing a first portion of a biological sample into a source sample portion chamber of a sample carrier, and placing a second portion of the biological sample into a diluted sample portion chamber. The second portion of the biological sample is diluted with respect to the first portion of the biological sample. Using an optical measurement device, a bulk-level measurand of the sample that relates to a parameter of the biological sample as a whole is measured, by performing a measurement upon the first portion of the biological sample. Microscopic images of the second portion of the biological sample are acquired. Other applications are also described.
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公开(公告)号：US20190302099A1
公开(公告)日：2019-10-03
申请号：US16098893
申请日：2017-05-11
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Joseph Joel POLLAK , Sarah LEVY SCHREIER , Yochay Shlomo ESHEL , Amir ZAIT , Sharon PECKER
Abstract: Apparatus and methods are described for determining a property of a biological sample. A sample carrier (22) includes one or more sample chambers (40) that define at least a first region (42) and a second region (44), the height of the one or more sample chambers varying between the first and second regions in a predefined manner. A computer processor (28) receives data relating to a first optical measurement that is performed upon a portion of the sample that is disposed within the first region, receives data relating to a second optical measurement that is performed upon a portion of the sample that is disposed within the second region, and determines the property of the sample by using a relationship between the first optical measurement, the second optical measurement, and the predefined variation in height between the regions. Other applications are also described.
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公开(公告)号：US20250108367A1
公开(公告)日：2025-04-03
申请号：US18832199
申请日：2023-01-25
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Sharon PECKER , Noam MORALI , Aviram STEINBOK , Yochay Shlomo ESHEL , Trevor RUGGIERO , Kristofer KURTIN , Joseph Joel POLLAK , Daniel LEVNER , Julie RICHARDSON
IPC: B01L3/00
Abstract: Apparatus and methods are described for analyzing a bodily sample. A sample carrier (22), which houses the bodily sample, includes at least one fluidic channel (120), at least one analysis chamber (68), and a receptacle (92) that houses a diluent. A pump system (150) pumps the diluent from the receptacle (92) into the fluidic channel (120) in a first fluid flow direction, and subsequently, pumps the diluent and the bodily sample in a second fluid flow direction, which is a reverse of the first fluid flow direction, to thereby mix the diluent and the bodily sample within the receptacle (92). Other applications are also described.
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公开(公告)号：US20230026108A1
公开(公告)日：2023-01-26
申请号：US17783839
申请日：2020-12-10
Applicant: S.D. SIGHT DIAGNOSTICS LTD
Inventor： Amir ZAIT , Dan GLUCK , Arnon HOURI YAFIN , David BRAILOVSKY , Yochay Shlomo ESHEL , Sarah LEVY , Joseph Joel POLLAK
Abstract: Apparatus and methods are described including analyzing one or more microscopic images of the blood sample using a machine-learning classifier. An entity within the one or more microscopic images is identified using a first classification model, and a first estimated concentration of the entity within the sample is determined, based upon the entity as identified using the first classification model. The entity is identified within the one or more microscopic images using a second classification model, and a second estimated concentration of the entity within the sample is determined, based upon the entity as identified using the second classification model. The first and second estimated concentrations are compared to each other, and, in response to the comparison, a hybrid classification model that is a hybrid of the first and second classification models is used. Other applications are also described.
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Patent Agency Ranking
公开(公告)号：US20200300750A1
公开(公告)日：2020-09-24
申请号：US16088321
申请日：2017-03-23
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo ESHEL , Arnon HOURI YAFIN , Joseph Joel POLLAK , Neta BACHAR , Annael MARCIANO , Sarah LEVY SCHREIER
Abstract: Apparatus and methods are described for use with an output device (34), and a blood sample (12) that was drawn from a subject. A microscope system (10) acquires first and second images of the blood sample at respective times. A computer processor (28) determines whether, between acquisitions of the first and second images, there was relative motion between at least one erythrocyte within the sample and at least one entity within the sample, by comparing the first and second images to one another. At least partially in response thereto, the computer processor determines whether the entity is an extra-erythrocytic or an intra-erythrocytic entity, and generates an output on the output device, at least partially in response thereto. Other applications are also described.
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公开(公告)号：US20200249458A1
公开(公告)日：2020-08-06
申请号：US16851410
申请日：2020-04-17
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo ESHEL , Natalie Lezmy , Dan Gluck , Arnon Houri Yafin , Joseph Joel Pollak
Abstract: Apparatus and methods are described including acquiring microscopic images of a blood sample, and identifying deformed red blood cells within the microscopic images. A degree of red blood cell deformity within the sample is determined, at least partially based upon the identified deformed red blood cells. A sample-informative parameter that is indicative of a characteristic of the blood sample as a whole is determined, at least partially based upon the degree of red blood cell deformity within the sample. Other applications are also described.
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公开(公告)号：US20250076287A1
公开(公告)日：2025-03-06
申请号：US18951911
申请日：2024-11-19
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Amir ZAIT , Arnon HOURI YAFIN , Dan GLuck , Sharon PECKER , Yochay Shlomo ESHEL , Sarah LEVYS CHREIER , Joseph Joel POLLAK
Abstract: Apparatus and methods are described including measuring a measurand within a first portion of a bodily sample, measuring relative amounts of first and second components within a second portion of the bodily sample that is diluted relative to the first portion of the bodily sample, and determining a parameter of the bodily sample based upon the measurand within the first portion of the bodily sample and the relative amounts of first and second components within the second portion of the bodily sample. Other applications are also described.
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公开(公告)号：US20220019070A1
公开(公告)日：2022-01-20
申请号：US17490767
申请日：2021-09-30
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo ESHEL , Natalie LEZMY , Dan GLUCK , Arnon HOURI YAFIN , Joseph Joel POLLAK
Abstract: Apparatus and methods are described for analyzing a bodily sample. One or more microscope images of the bodily sample are acquired. Using at least one computer processor at least one sample-informative feature that is indicative of a characteristic of the bodily sample is extracted from the images. Based upon the sample-informative feature, the computer processor determines that there is a defect associated with the bodily sample, and determines a source of the defect. Other applications are also described.
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公开(公告)号：US20200249459A1
公开(公告)日：2020-08-06
申请号：US16851686
申请日：2020-04-17
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo ESHEL , Natalie LEZMY , Dan GLUCK , Arnon HOURI YAFIN , Joseph Joel POLLAK
Abstract: Apparatus and methods are described including staining a blood sample with one or more stains. A plurality of microscopic images of the stained blood sample are acquired, using a microscope. Staining-quality parameters for respective microscopic images are determined, using a computer processor, the staining-quality parameters being indicative of a quality of the staining within each of the respective microscopic images. An action is performed by the computer processor, based upon the staining-quality parameters of the respective microscopic images. Other applications are also described.
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