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公开(公告)号：US20230026108A1
公开(公告)日：2023-01-26
申请号：US17783839
申请日：2020-12-10
Applicant: S.D. SIGHT DIAGNOSTICS LTD
Inventor： Amir ZAIT , Dan GLUCK , Arnon HOURI YAFIN , David BRAILOVSKY , Yochay Shlomo ESHEL , Sarah LEVY , Joseph Joel POLLAK
Abstract: Apparatus and methods are described including analyzing one or more microscopic images of the blood sample using a machine-learning classifier. An entity within the one or more microscopic images is identified using a first classification model, and a first estimated concentration of the entity within the sample is determined, based upon the entity as identified using the first classification model. The entity is identified within the one or more microscopic images using a second classification model, and a second estimated concentration of the entity within the sample is determined, based upon the entity as identified using the second classification model. The first and second estimated concentrations are compared to each other, and, in response to the comparison, a hybrid classification model that is a hybrid of the first and second classification models is used. Other applications are also described.
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公开(公告)号：US20200300750A1
公开(公告)日：2020-09-24
申请号：US16088321
申请日：2017-03-23
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo ESHEL , Arnon HOURI YAFIN , Joseph Joel POLLAK , Neta BACHAR , Annael MARCIANO , Sarah LEVY SCHREIER
Abstract: Apparatus and methods are described for use with an output device (34), and a blood sample (12) that was drawn from a subject. A microscope system (10) acquires first and second images of the blood sample at respective times. A computer processor (28) determines whether, between acquisitions of the first and second images, there was relative motion between at least one erythrocyte within the sample and at least one entity within the sample, by comparing the first and second images to one another. At least partially in response thereto, the computer processor determines whether the entity is an extra-erythrocytic or an intra-erythrocytic entity, and generates an output on the output device, at least partially in response thereto. Other applications are also described.
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公开(公告)号：US20210041422A1
公开(公告)日：2021-02-11
申请号：US17082615
申请日：2020-10-28
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Amir ZAIT , Arnon HOURI YAFIN , Dan GLUCK , Sharon PECKER , Yochay Shlomo ESHEL , Sarah LEVY SCHREIER , Joseph Joel POLLAK
IPC: G01N33/50 , G01N33/49 , G01N15/06 , G01N33/569
Abstract: Apparatus and methods are described including placing a first portion of a biological sample into a source sample portion chamber of a sample carrier, and placing a second portion of the biological sample into a diluted sample portion chamber. The second portion of the biological sample is diluted with respect to the first portion of the biological sample. Using an optical measurement device, a bulk-level measurand of the sample that relates to a parameter of the biological sample as a whole is measured, by performing a measurement upon the first portion of the biological sample. Microscopic images of the second portion of the biological sample are acquired. Other applications are also described.
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公开(公告)号：US20160208306A1
公开(公告)日：2016-07-21
申请号：US15083610
申请日：2016-03-29
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Joseph Joel POLLAK , Arnon HOURI YAFIN , Seth J. SALPETER
CPC classification number: C12Q1/04 , G01N1/2813 , G01N1/38 , G01N15/1463 , G01N15/1475 , G01N21/6428 , G01N21/6486 , G01N33/49 , G01N2015/0065 , G01N2021/6439 , G02B21/361
Abstract: Provided is a method for imaging a blood sample and a kit and system for executing the method. The method includes introducing a cell suspension including red blood cells onto a base surface of a carrier having a vertical height (H) being greater than or equal to a vertical depth (h) of the cell suspension when on the base carrier, the cell suspension including a cell concentration (C) being determined by a defined function; allowing the cells in the cell suspension to settle on the base surface of the carrier to form a monolayer of cells thereon; and acquiring at least one microscope image of at least a portion of the monolayer of cells; wherein the at least one microscope image is obtained by a microscope set to Depth Of Field that is not more than 20% of the vertical height of the cell suspension settled on the base surface.
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公开(公告)号：US20250076287A1
公开(公告)日：2025-03-06
申请号：US18951911
申请日：2024-11-19
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Amir ZAIT , Arnon HOURI YAFIN , Dan GLuck , Sharon PECKER , Yochay Shlomo ESHEL , Sarah LEVYS CHREIER , Joseph Joel POLLAK
Abstract: Apparatus and methods are described including measuring a measurand within a first portion of a bodily sample, measuring relative amounts of first and second components within a second portion of the bodily sample that is diluted relative to the first portion of the bodily sample, and determining a parameter of the bodily sample based upon the measurand within the first portion of the bodily sample and the relative amounts of first and second components within the second portion of the bodily sample. Other applications are also described.
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Patent Agency Ranking
公开(公告)号：US20220019070A1
公开(公告)日：2022-01-20
申请号：US17490767
申请日：2021-09-30
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo ESHEL , Natalie LEZMY , Dan GLUCK , Arnon HOURI YAFIN , Joseph Joel POLLAK
Abstract: Apparatus and methods are described for analyzing a bodily sample. One or more microscope images of the bodily sample are acquired. Using at least one computer processor at least one sample-informative feature that is indicative of a characteristic of the bodily sample is extracted from the images. Based upon the sample-informative feature, the computer processor determines that there is a defect associated with the bodily sample, and determines a source of the defect. Other applications are also described.
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公开(公告)号：US20200249459A1
公开(公告)日：2020-08-06
申请号：US16851686
申请日：2020-04-17
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo ESHEL , Natalie LEZMY , Dan GLUCK , Arnon HOURI YAFIN , Joseph Joel POLLAK
Abstract: Apparatus and methods are described including staining a blood sample with one or more stains. A plurality of microscopic images of the stained blood sample are acquired, using a microscope. Staining-quality parameters for respective microscopic images are determined, using a computer processor, the staining-quality parameters being indicative of a quality of the staining within each of the respective microscopic images. An action is performed by the computer processor, based upon the staining-quality parameters of the respective microscopic images. Other applications are also described.
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公开(公告)号：US20250076176A1
公开(公告)日：2025-03-06
申请号：US18952650
申请日：2024-11-19
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo ESHEL , Arnon HOURI YAFIN , Joseph Joel POLLAK , Neta BACHAR , Annael MARCIANO , Sarah LEVY SCHREIER
Abstract: Apparatus and methods are described including acquiring first and second images of a blood sample at respective times and determining whether, between acquisitions of the first and second images, there was motion of an entity, by comparing the first and second images to one another. At least partially in response thereto, the entity is identified, and an output is generated on the output device, at least partially in response to identification of the entity. Other applications are also described.
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公开(公告)号：US20230011382A1
公开(公告)日：2023-01-12
申请号：US17783831
申请日：2020-12-10
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Dan GLUCK , Amir ZAIT , Arnon HOURI YAFIN , Yonatan HALPERIN , Yochay Shlomo ESHEL , Sarah LEVY , Joseph Joel POLLAK , Sharon PECKER , Peretz YAFIN , Dana BENBASSAT , David BRAILOVSKY , Uriyah PUMERANTZ
Abstract: Apparatus and methods are described use with a bodily sample that contains cells. A microscope (24) is focused, such that a focal plane of the microscope (24) at least approximately coincides with a level at which at least some cells belonging to the sample are at least partially disposed. At least one on-focus microscopic image of the sample, while the focal plane of the microscope (24) approximately coincides with the level. The microscope (24) is focused such that the focal plane of the microscope is offset with respect to the level, at least one off-focus microscopic image of the sample is acquired, while the focal plane of the microscope (24) is offset with respect to the level. A property of at least a portion of the sample is determined, at least partially based upon the on-focus and off-focus images. Other applications are also described.
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公开(公告)号：US20220390372A1
公开(公告)日：2022-12-08
申请号：US17770339
申请日：2020-10-22
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Sharon PECKER , Yochay Shlomo ESHEL , Amir ZAIT , Dan GLUCK , Noam YORAV-RAPHAEL , Arnon HOURI YAFIN , Sarah LEVY SCHREIER , Joseph Joel POLLAK , Daniel LEVNER , Yonatan HALPERIN , Natalie LEZMY , Itamar WEISS
Abstract: Apparatus and methods are described including preparing a blood sample for analysis by depositing the blood sample within a sample chamber (52), and placing the sample chamber, with the blood sample deposited therein, within a microscopy unit (24). One or more microscopic images of the sample chamber (52) with the blood sample deposited therein are acquired, using a microscope of the microscopy unit. Based upon the one or more images, an amount of one or more cell types within the sample chamber that had already settled within the sample chamber, prior to acquisition of the one or more microscopic images is determined. A characteristic of the sample is determined, at least partially in response thereto. Other applications are also described.
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