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公开(公告)号：US20220138944A1
公开(公告)日：2022-05-05
申请号：US17576023
申请日：2022-01-14
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yuval GREENFIELD , Yonatan BILU , Joseph Joel POLLAK , Noam YORAV-RAPHAEL
Abstract: Apparatus and methods are described for use with a cell sample that includes a plurality of cells disposed in a monolayer. A series of images associated with a series of depth levels of the cell sample are acquired, by performing a depth scan of cell sample with a microscope. One of the depth levels is identified as being an optimum focal plane for imaging one or more entities within the cell sample using the microscope, by identifying that a drop in image contrast occurs at the identified depth level relative to the image contrast of images acquired at depth levels within a given range of distances from the identified depth level. The cell sample is imaged using the microscope, by focusing the microscope at an investigative depth level that is based on the identified depth level. Other applications are also described.
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公开(公告)号：US20230028360A1
公开(公告)日：2023-01-26
申请号：US17783924
申请日：2020-12-10
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yonatan HALPERIN , Dan GLUCK , Noam YORAV-RAPHAEL , Yochay Shlomo ESHEL , Sarah LEVY , Joseph Joel POLLAK
Abstract: Apparatus and methods are described for use with a blood sample. Using a microscope (24), three images of a microscopic imaging field of the blood sample are acquired, each of the images being acquired using respective, different imaging conditions, and the first one of the three images being acquired under violet-light brightfield imaging. Using at least one computer processor (28), an artificial color microscopic image of the microscopic imaging field is generated, by mapping the first one of the three images to a red channel of the artificial color microscopic image, mapping a second one of the three images to a second color channel of the artificial color microscopic image, and mapping a third one of the three images to a third color channel of the artificial color microscopic image. Other applications are also described.
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公开(公告)号：US20220390372A1
公开(公告)日：2022-12-08
申请号：US17770339
申请日：2020-10-22
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Sharon PECKER , Yochay Shlomo ESHEL , Amir ZAIT , Dan GLUCK , Noam YORAV-RAPHAEL , Arnon HOURI YAFIN , Sarah LEVY SCHREIER , Joseph Joel POLLAK , Daniel LEVNER , Yonatan HALPERIN , Natalie LEZMY , Itamar WEISS
Abstract: Apparatus and methods are described including preparing a blood sample for analysis by depositing the blood sample within a sample chamber (52), and placing the sample chamber, with the blood sample deposited therein, within a microscopy unit (24). One or more microscopic images of the sample chamber (52) with the blood sample deposited therein are acquired, using a microscope of the microscopy unit. Based upon the one or more images, an amount of one or more cell types within the sample chamber that had already settled within the sample chamber, prior to acquisition of the one or more microscopic images is determined. A characteristic of the sample is determined, at least partially in response thereto. Other applications are also described.
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公开(公告)号：US20250067968A1
公开(公告)日：2025-02-27
申请号：US18940926
申请日：2024-11-08
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yonatan HALPERIN , Dan GLUCK , Noam YORAV-RAPHAEL , Yochay Shlomo ESHEL , Sarah LEVY , Joseph Joel POLLAK
Abstract: Apparatus and methods are described for use with a blood sample and a display, including acquiring a plurality of images of a microscopic imaging field of the blood sample, each of the images being acquired using respective, different imaging conditions. An artificial color microscopic display image of the microscopic imaging field is generated having a similar appearance to that of a color smear image, by mapping the plurality of images to respective channels of the artificial color microscopic display image. A display is driven to display the artificial color microscopic display image of the microscopic imaging field to a user. Other applications are also described.
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公开(公告)号：US20210101147A1
公开(公告)日：2021-04-08
申请号：US17064193
申请日：2020-10-06
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Ido BACHELET , Joseph Joel POLLAK , Daniel LEVNER , Yonatan BILU , Noam YORAV-RAPHAEL
Abstract: Apparatus and methods are described including successively acquiring a plurality of microscopic images of a portion of a blood sample, and tracking motion of pixels within the successively acquired microscopic images. Trypomastigote parasite candidates within the blood sample are identified, by identifying pixel motion that is typical of trypomastigote parasites. It is determined that the blood sample is infected with trypomastigote parasites, at least partially in response thereto. An output is generated indicating that that the blood sample is infected with trypomastigote parasites. Other applications are also described.
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Patent Agency Ranking
公开(公告)号：US20190087953A1
公开(公告)日：2019-03-21
申请号：US15506997
申请日：2015-08-27
Applicant: S.D. Sight Diagnostics Ltd
Inventor： Noam YORAV-RAPHAEL , Uri WOLFOVITZ , Joseph Joel POLLAK
CPC classification number: G06T7/0012 , G02B21/244 , G06T7/0002 , G06T7/90 , G06T2207/10056 , G06T2207/10061 , G06T2207/30072 , G06T2207/30168
Abstract: A digital microscopy method, comprising: obtaining data representative of a series of images of at least a portion of a cell sample, the images being captured by performing a depth scan using a digital microscope, the series of images being associated with a series of depth levels of the cell sample, wherein the portion encompasses a mapping field, and the mapping field comprises a plurality of focus analysis regions; and calculating, using the images, a focus configuration for at least two of the focus analysis regions within the mapping field, giving rise to data indicative of focus variations within the mapping field.
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公开(公告)号：US20250085525A1
公开(公告)日：2025-03-13
申请号：US18956363
申请日：2024-11-22
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Noam YORAV-RAPHAEL , Joseph Joel POLLAK , Sarah Levy SCHREIER , Yochay Shlomo ESHEL
Abstract: Apparatus and methods are described for determining a property of a bodily sample, using a microscope and optical-density-measurement apparatus. A sample carrier includes a microscopy sample chamber configured to receive a first portion of the sample and to facilitate imaging of the first portion of the sample by the microscope, and an optical-density-measurement chamber configured to receive a second portion of the sample, and to facilitate optical density measurements being performed by the optical-density-measurement apparatus upon the second portion of the sample. The sample carrier includes an upper surface and a lower surface. At least one of the upper surface and the lower surface of the sample carrier is defined by a glass sheet, and the other surface is defined by a molded component. Other applications are also described.
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公开(公告)号：US20240126060A1
公开(公告)日：2024-04-18
申请号：US18397324
申请日：2023-12-27
Applicant: S.D. SIGHT DIAGNOSTICS LTD
Inventor： Noam YORAV-RAPHAEL , Joseph Joel POLLAK , Sarah Levy , Yochay Shlomo ESHEL
CPC classification number: G02B21/0076 , G01N21/6456 , G02B21/36
Abstract: Apparatus and methods are described for determining a property of a bodily sample using a microscope and optical-density-measurement apparatus, the apparatus including a sample carrier that includes a plurality of microscopy sample chambers configured to receive a first portion of the sample and to facilitate imaging of the first portion of the sample by the microscope, each of the microscopy sample chambers having an upper and a lower surface, and having respective heights between the upper and lower surfaces that are different from each other. The sample carrier includes at least one optical-density-measurement chamber configured to receive a second portion of the sample, and to facilitate optical density measurements being performed optical-density-measurement apparatus upon the second portion of the sample. Other applications are also described.
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公开(公告)号：US20240029250A1
公开(公告)日：2024-01-25
申请号：US18376680
申请日：2023-10-04
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yuval GREENFIELD , Yonatan BILU , Joseph Joel POLLAK , Noam YORAV-RAPHAEL
CPC classification number: G06T7/0012 , G02B7/38 , G02B21/244 , G06T7/507 , G02B21/16 , G02B21/367 , G02B21/361 , G06T2207/10056 , G06T2207/30024
Abstract: Apparatus and methods are described for use with a cell sample that includes a plurality of cells. A series of images associated with a series of depth levels of the cell sample are acquired, by performing a depth scan of cell sample with a microscope. One of the depth levels is identified as being an optimum focal plane for imaging one or more entities within the cell sample using the microscope, under a first illumination condition. The cell sample is imaged under a second illumination condition that is different from the first illumination condition, using the microscope, by focusing the microscope at an investigative depth level that is based on the identified depth level. Other applications are also described.
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公开(公告)号：US20230342925A1
公开(公告)日：2023-10-26
申请号：US18214568
申请日：2023-06-27
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Noam YORAV-RAPHAEL , Uri Wolfovitz , Joseph Joel Pollak
CPC classification number: G06T7/0012 , G02B21/244 , G06T7/0002 , G06T7/90 , G06T2207/10056 , G06T2207/10061 , G06T2207/30072 , G06T2207/30168
Abstract: Apparatus and methods are described for use with a digital microscope unit that includes a digital microscope. A biological cell sample that is disposed within a sample carrier is received into the digital microscope unit. It is determined that there is a variation in the focal depth of the biological sample with respect to the microscope due to curvature in the sample carrier and/or due to tolerance in setup of the microscope. In response to determining that there is the variation in the focal depth of the biological sample with respect to the microscope, the variation in the focal depth of the biological sample with respect to the microscope is accounted for. Other applications are also described.
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