公开(公告)号：US20200302144A1

公开(公告)日：2020-09-24

申请号：US16851830

申请日：2020-04-17

Applicant: SCOPIO LABS LTD.

Inventor： Ben LESHEM ,  Eran SMALL ,  Itai HAYUT ,  Erez NA'AMAN ,  Eyal BEN-BASSAT

IPC: G06K9/00 ,  G01B11/06 ,  G01B11/22 ,  G01N21/25 ,  G06K9/46 ,  G06K9/20

Abstract: A microscope for adaptive sensing may comprise an illumination assembly, an image capture device configured to collect light from a sample illuminated by the assembly, and a processor. The processor may be configured to execute instructions which cause the microscope to capture, using the image capture device, an initial image set of the sample, identify, in response to the initial image set, an attribute of the sample, determine, in response to identifying the attribute, a three-dimensional (3D) process for sensing the sample, and generate, using the determined 3D process, an output image set comprising more than one focal plane. Various other methods, systems, and computer-readable media are also disclosed.

公开(公告)号：US20190235224A1

公开(公告)日：2019-08-01

申请号：US15775389

申请日：2016-11-10

Applicant: Scopio Labs Ltd.

Inventor： Eran SMALL ,  Ben LESHEM ,  Ittay MADAR ,  Erez NAAMAN ,  Itai HAYUT

IPC: G02B21/36 ,  G02B21/02 ,  G02B21/06 ,  H04N5/225 ,  G06K9/00

CPC classification number: G02B21/367 ,  G02B7/09 ,  G02B7/36 ,  G02B21/02 ,  G02B21/06 ,  G02B21/245 ,  G02B21/36 ,  G06K9/00134 ,  G06K9/00147 ,  H04N5/2253 ,  H04N5/2254 ,  H04N5/2256

Abstract: Systems and methods are disclosed for constructing an image of a sample using a plurality of images acquired under multiple illumination conditions. In one implementation, a microscope may include an image capture device, an illumination assembly, and a controller. The controller may cause the illumination assembly to illuminate the sample at a series of different illumination conditions. The controller may further acquire from image capture device a plurality of images of the sample, wherein the plurality of images includes at least one image for each illumination condition. The controller may also determine, from the at least one image, image data of the sample for each illumination condition. The controller may further generate, from the determined image data for each illumination condition and in a non-iterative process, a reconstructed image of the sample. The reconstructed image may have a second image resolution higher than the first image resolution.

公开(公告)号：US20220415480A1

公开(公告)日：2022-12-29

申请号：US17755356

申请日：2020-11-15

Applicant: SCOPIO LABS LTD.

Inventor： Ben LESHEM ,  Eran SMALL ,  Erez NA'AMAN ,  Itai HAYUT ,  Shahar KARNY ,  Ofek AIZENMAN

IPC: G16H30/40 ,  G06K9/62 ,  G06V10/22 ,  G06V20/69 ,  G16H50/20

Abstract: A microscope system for scanning a bone marrow aspirate (BMA) sample may include a scanning apparatus for scanning the BMA sample and a processor coupled to the scanning apparatus and a memory. The microscope system may obtain, using the scanning apparatus, scan data of the BMA sample and detect cells in the BMA sample from the scan data. The microscope system may also classify the detected cells into a plurality of cell types, and store, in the memory, cell data of the classified cells. The microscope system may include a display for presenting the cell data. Various other systems and methods are provided.

公开(公告)号：US20220350129A1

公开(公告)日：2022-11-03

申请号：US17812374

申请日：2022-07-13

Applicant: SCOPIO LABS LTD.

Inventor： Ittai MADAR ,  Eran SMALL ,  Itai HAYUT ,  Erez NA'AMAN

IPC: G02B21/36 ,  G02B21/00 ,  G02B21/12

Abstract: A microscope comprising an illumination assembly, an image capture device and a processor can be configured to selectively identify regions of a sample comprising artifacts or empty space. By selectively identifying regions of the sample that have artifacts or empty space, the amount of time to generate an image of the sample and resources used to generate the image can be decreased substantially while providing high resolution for appropriate regions of the computational image. The processor can be configured to change the imaging process in response to regions of the sample that comprises artifacts or empty space. The imaging process may comprise a higher resolution process to output higher resolution portions of the computational image for sample regions comprising valid sample material, and a lower resolution process to output lower resolution portions of the computational image for sample regions comprising valid sample material.

公开(公告)号：US20190384962A1

公开(公告)日：2019-12-19

申请号：US16338668

申请日：2017-10-26

Applicant: SCOPIO LABS LTD.

Inventor： Itai HAYUT ,  Erez NA'AMAN ,  Eran SMALL ,  Chen BRESTEL

IPC: G06K9/00 ,  G06T3/40 ,  G06T7/00 ,  G02B21/36 ,  G01N15/14

Abstract: Methods and systems are provided for improved imaging and analyzing of a sample with a large field-of-view at a high image resolution. A diagnostic system may comprise: a microscope comprising a low collection numerical aperture (NA); an imaging device coupled to the microscope; and a processor coupled to the imaging device. The imaging device may be configured to capture a plurality of low-resolution images of a region of a sample viewed by the microscope. The region of the sample may comprise cells. The processor may comprise instructions configured to reconstruct a high-resolution image of the region of the sample using the plurality of low-resolution images. The processor may further comprise instructions configured to analyze a spatial field of the high-resolution image to identify at least one of a cell type or a cell structure of at least one of the cells of the region of the sample.

公开(公告)号：US20180373016A1

公开(公告)日：2018-12-27

申请号：US15774855

申请日：2016-11-10

Applicant: SCOPIO LABS LTD.

Inventor： Ben LESHEM, III ,  Eran SMALL ,  Ittay MADAR ,  Erez NAAMAN ,  Itai HAYUT

IPC: G02B21/36 ,  G02B21/06 ,  G02B27/58 ,  G06T3/40

Abstract: A microscope includes an illumination assembly configured to illuminate a sample under two or more different illumination conditions, at least one image capture device configured to capture image information associated with the sample at each of the two or more different illumination conditions, at least one processing device programmed to generate an image of the sample based on a combination of image information captured at each of the two or more different illumination conditions, and at least one refractive index matching material between the illumination assembly and the sample. The refractive index matching material is different from a medium between the at least one image capture device and the sample.