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公开(公告)号：US20210392304A1
公开(公告)日：2021-12-16
申请号：US17304331
申请日：2021-06-18
Applicant: SCOPIO LABS LTD.
Inventor： Ben LESHEM , Eran SMALL , Itai HAYUT , Erez NA'AMAN , Eyal BEN-BASSAT
Abstract: A microscope for computational imaging may include an illumination source configured to illuminate a sample with a plurality of wavelengths, an image sensor, an objective lens to image the sample onto the image sensor, and a processor operatively coupled to the illumination assembly and the image sensor. The processor may be configured to acquire a first image dataset from the sample illuminated using a first set of illumination conditions at a first wavelength. The processor may also be configured to acquire a second image dataset from the sample illuminated using a second set of illumination conditions having a second number of illumination conditions at a second wavelength. The second set of illumination conditions comprises fewer illumination conditions than the first set in order to decrease acquisition time. The processor may be configured to combine the first and second image datasets into a computationally reconstructed image of the sample.
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公开(公告)号：US20210149170A1
公开(公告)日：2021-05-20
申请号：US17098099
申请日：2020-11-13
Applicant: SCOPIO LABS LTD.
Inventor： Ben LESHEM , Eran SMALL , Erez NA'AMAN
Abstract: A scanning microscope for z-stack acquisition may include, a stage to hold a sample, an illumination source to illuminate the sample, and an image capture device configured to capture multiple images of the sample within a field of view of the image capture device. The microscope may also include a lateral actuator for changing a relative lateral position between the image capture device and an imaged portion of the sample within the field of view of the image capture device for each of the images, and a focus actuator configured to adjust a focal distance between the sample and the image capture device between each of the images. The microscope may further include a processor connected to the lateral actuator and the focus actuator to move the sample laterally relative to the field of view and capture an area of the sample for each of multiple movement paths.
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公开(公告)号：US20230005281A1
公开(公告)日：2023-01-05
申请号：US17931271
申请日：2022-09-12
Applicant: SCOPIO LABS LTD.
Inventor： Ben LESHEM , Eran SMALL , Itai HAYUT , Erez NA'AMAN , Eyal BEN-BASSAT
Abstract: A microscope for adaptive sensing may comprise an illumination assembly, an image capture device configured to collect light from a sample illuminated by the assembly, and a processor. The processor may be configured to execute instructions which cause the microscope to capture, using the image capture device, an initial image set of the sample, identify, in response to the initial image set, an attribute of the sample, determine, in response to identifying the attribute, a three-dimensional (3D) process for sensing the sample, and generate, using the determined 3D process, an output image set comprising more than one focal plane. Various other methods, systems, and computer-readable media are also disclosed.
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公开(公告)号：US20200302144A1
公开(公告)日：2020-09-24
申请号：US16851830
申请日：2020-04-17
Applicant: SCOPIO LABS LTD.
Inventor： Ben LESHEM , Eran SMALL , Itai HAYUT , Erez NA'AMAN , Eyal BEN-BASSAT
Abstract: A microscope for adaptive sensing may comprise an illumination assembly, an image capture device configured to collect light from a sample illuminated by the assembly, and a processor. The processor may be configured to execute instructions which cause the microscope to capture, using the image capture device, an initial image set of the sample, identify, in response to the initial image set, an attribute of the sample, determine, in response to identifying the attribute, a three-dimensional (3D) process for sensing the sample, and generate, using the determined 3D process, an output image set comprising more than one focal plane. Various other methods, systems, and computer-readable media are also disclosed.
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5.发明申请公开(公告)号：US20190235224A1
公开(公告)日：2019-08-01
申请号：US15775389
申请日：2016-11-10
Applicant: Scopio Labs Ltd.
Inventor： Eran SMALL , Ben LESHEM , Ittay MADAR , Erez NAAMAN , Itai HAYUT
CPC classification number: G02B21/367 , G02B7/09 , G02B7/36 , G02B21/02 , G02B21/06 , G02B21/245 , G02B21/36 , G06K9/00134 , G06K9/00147 , H04N5/2253 , H04N5/2254 , H04N5/2256
Abstract: Systems and methods are disclosed for constructing an image of a sample using a plurality of images acquired under multiple illumination conditions. In one implementation, a microscope may include an image capture device, an illumination assembly, and a controller. The controller may cause the illumination assembly to illuminate the sample at a series of different illumination conditions. The controller may further acquire from image capture device a plurality of images of the sample, wherein the plurality of images includes at least one image for each illumination condition. The controller may also determine, from the at least one image, image data of the sample for each illumination condition. The controller may further generate, from the determined image data for each illumination condition and in a non-iterative process, a reconstructed image of the sample. The reconstructed image may have a second image resolution higher than the first image resolution.
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Patent Agency Ranking
公开(公告)号：US20240420828A1
公开(公告)日：2024-12-19
申请号：US18705277
申请日：2022-11-17
Applicant: SCOPIO LABS LTD.
Inventor： Ittai MADAR , Ben LESHEM , Erez NA'AMAN , Eran SMALL
Abstract: An apparatus configured to process a sample to detect a pathogen receives a slide with the sample on the slide, in which the sample has been stained with one or more of a Gram stain, an Acid-Fast stain, or a Giemsa stain. An area of at least 5 mm2 of the sample is imaged at a rate of at least 15 mm2 per minute and a resolution of 0.3 pm or better to generate one or more images. The one or more images of the sample are processed with a classifier configured to detect the pathogen in the sample. In some embodiments, a plurality of cultured and stained samples on a plurality of slides are imaged at the resolution and processed with the classifier, which can increase the area processed and analyzed in order to decrease the culture time and corresponding time to diagnose the patient.
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公开(公告)号：US20220415480A1
公开(公告)日：2022-12-29
申请号：US17755356
申请日：2020-11-15
Applicant: SCOPIO LABS LTD.
Inventor： Ben LESHEM , Eran SMALL , Erez NA'AMAN , Itai HAYUT , Shahar KARNY , Ofek AIZENMAN
Abstract: A microscope system for scanning a bone marrow aspirate (BMA) sample may include a scanning apparatus for scanning the BMA sample and a processor coupled to the scanning apparatus and a memory. The microscope system may obtain, using the scanning apparatus, scan data of the BMA sample and detect cells in the BMA sample from the scan data. The microscope system may also classify the detected cells into a plurality of cell types, and store, in the memory, cell data of the classified cells. The microscope system may include a display for presenting the cell data. Various other systems and methods are provided.
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公开(公告)号：US20240160000A1
公开(公告)日：2024-05-16
申请号：US18559473
申请日：2022-05-26
Applicant: SCOPIO LABS LTD.
Inventor： Ben LESHEM , Erez NA'AMAN , Eran SMALL , Ben SARUSI
Abstract: A microscope system may be integrated with a coverslipping device. A method of preparing a microscope slide for imaging a sample on the microscope slide may include placing a transparent flowable material on the sample while the slide is supported with one or more linkages coupled to a processor, covering the sample with a coverslip, and placing the microscope slide on a microscope stage with the one or more linkages coupled to the slide and the processor. Various other systems and methods are provided.
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9.发明公开公开(公告)号：US20230384205A1
公开(公告)日：2023-11-30
申请号：US18248566
申请日：2021-11-09
Applicant: SCOPIO LABS LTD.
Inventor： Shahar KARNY , Ben LESHEM , Erez NA'AMAN , Eran SMALL , Itai HAYUT
CPC classification number: G01N15/1434 , G06T7/0012 , G06T3/4053 , G06V20/698 , G06V20/693 , G02B21/008 , G01N2015/008
Abstract: A microscope system for full field morphology analysis may include an optical scanning apparatus to scan the sample with an effective numerical aperture of at least 0.8, and a processor coupled to the scanning apparatus. The processor may be configured to: scan the sample with the optical scanning apparatus to produce a plurality of images of the sample, the plurality of images comprising at least 500 blood cells, analyze the plurality of images to determine at least 10 morphology parameters for each of the at least 500 blood cells, and output the at least 10 morphology parameters. The microscope system may include a display for presenting data. Various other systems and methods are provided.
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公开(公告)号：US20210149169A1
公开(公告)日：2021-05-20
申请号：US17098058
申请日：2020-11-13
Applicant: SCOPIO LABS LTD.
Inventor： Ben LESHEM , Eran SMALL , Erez NA'AMAN , Ittai MADAR
Abstract: A microscope for computational microscopic layer separation may include an imaging device that includes a lens and an image sensor, an illumination system for illuminating a sample, and an actuator to adjust an axial position of a focal plane with respect to the sample. The microscope may also include a processor operatively coupled to the imaging device and the illumination system. The processor may be configured to measure, using the image sensor and the illumination system, optical aberrations of the imaging device at the axial position, and determine whether to adjust the focal plane with respect to the sample in response to the one or more optical aberrations. Various other systems and methods are also disclosed.
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