公开(公告)号：US10962495B2

公开(公告)日：2021-03-30

申请号：US16087438

申请日：2017-02-17

Applicant: Sony Corporation

Inventor： Yoshihito Hayashi ,  Marcaurele Brun ,  Kenzo Machida ,  Aya Murata ,  Shinji Omori ,  Seungmin Lee ,  Kaori Kawaguchi

IPC: G01N33/86 ,  G01N27/22 ,  G01N33/49

Abstract: To provide a system capable of evaluating a deficiency and/or a lowered function of extrinsic coagulation factors or intrinsic coagulation factors with high sensitivity by adding new procedures and apparatuses to a blood coagulation system analysis procedure, an apparatus, or the like.
A blood coagulation system analysis system includes a blood coagulation system measurement apparatus that performs blood coagulation system measurement of a blood sample; and a blood coagulation system analysis apparatus including a coagulation parameter extraction unit that extracts a coagulation parameter from a measurement result by the blood coagulation system measurement apparatus, and a blood coagulation evaluation unit that evaluates a level of blood coagulation of the blood sample on the basis of the coagulation parameter, the measurement by the blood coagulation system measurement apparatus being performed under an extrinsic system acceleration condition and an intrinsic system acceleration condition.

公开(公告)号：US10739359B2

公开(公告)日：2020-08-11

申请号：US15302562

申请日：2015-02-19

Applicant: Sony Corporation

Inventor： Yoshihito Hayashi ,  Marcaurele Brun ,  Kenzo Machida

IPC: G01N33/86 ,  G01N33/49 ,  G01N27/02

Abstract: To provide a technology that allows for simple and highly accurate evaluation of the condition of blood. Provided is a blood condition analysis device, for analyzing the condition of a blood sample having added thereto at least one kind of drug selected from the group consisting of anticoagulation treatment cancelling agents, coagulation activators, anticoagulants, platelet activators, and antiplatelet agents, the device including a drug dosage control unit for controlling the dosage of the drug to be added to the blood sample on the basis of the hematocrit and/or hemoglobin content of the blood sample.

公开(公告)号：US20190162690A1

公开(公告)日：2019-05-30

申请号：US16087438

申请日：2017-02-17

Applicant: Sony Corporation

Inventor： Yoshihito Hayashi ,  Marcaurele Brun ,  Kenzo Machida ,  Aya Murata ,  Shinji Omori ,  Seungmin Lee ,  Kaori Kawaguchi

IPC: G01N27/22 ,  G01N33/86

Abstract: To provide a system capable of evaluating a deficiency and/or a lowered function of extrinsic coagulation factors or intrinsic coagulation factors with high sensitivity by adding new procedures and apparatuses to a blood coagulation system analysis procedure, an apparatus, or the like.A blood coagulation system analysis system includes a blood coagulation system measurement apparatus that performs blood coagulation system measurement of a blood sample; and a blood coagulation system analysis apparatus including a coagulation parameter extraction unit that extracts a coagulation parameter from a measurement result by the blood coagulation system measurement apparatus, and a blood coagulation evaluation unit that evaluates a level of blood coagulation of the blood sample on the basis of the coagulation parameter, the measurement by the blood coagulation system measurement apparatus being performed under an extrinsic system acceleration condition and an intrinsic system acceleration condition.

公开(公告)号：US20190049428A1

公开(公告)日：2019-02-14

申请号：US16077305

申请日：2016-11-16

Applicant: Sony Corporation

Inventor： Aya Murata ,  Yoshihito Hayashi ,  Kenzo Machida ,  Marcaurele Brun

IPC: G01N33/49 ,  G01N11/00 ,  G01N27/22 ,  G01N35/00 ,  G01N33/50

Abstract: There are provided a new device and a new method for measurement of platelet aggregability which can be used for monitoring in an anti-platelet therapy.A platelet aggregability analyzing device includes: a blood coagulation system analyzing section that analyzes platelet aggregability on the basis of measurement data on a coagulation process of a platelet-containing sample to which a platelet inducing substance has been added; and an output control section that controls output of a result of an analysis by the blood coagulation system analyzing section.

公开(公告)号：US20180052181A1

公开(公告)日：2018-02-22

申请号：US15556135

申请日：2016-02-09

Applicant: Sony Corporation

Inventor： Kenzo Machida ,  Marcaurele Brun ,  Yoshihito Hayashi ,  Kaori Kawaguchi ,  Seungmin Lee

IPC: G01N33/86 ,  G01N33/50 ,  G01N27/22

CPC classification number: G01N33/86 ,  G01N27/22 ,  G01N27/221 ,  G01N33/49 ,  G01N33/5094 ,  G01N33/53 ,  G01N33/556

Abstract: Provided is a technology useful for verifying measurement accuracy before measurement of an electrical characteristic of blood samples.A sample for use in electrical characteristic measurement is provided including erythrocytes incompletely fixed with a fixative, the fixed erythrocytes being such that an electrical characteristic of a mixture of the fixed erythrocytes and plasma components can change over time. An electrical characteristic measurement method is provided including measuring an electrical characteristic of the sample for use in electrical characteristic measurement over time before measuring an electrical characteristic of blood samples over time. An electrical characteristic measurement device is provided including a determination unit configured to determine measurement accuracy on the basis of a predetermined reference value and measured values based on the electrical characteristic measured using the sample for use in electrical characteristic measurement.

公开(公告)号：US20170030934A1

公开(公告)日：2017-02-02

申请号：US15302914

申请日：2015-04-09

Applicant: Sony Corporation

Inventor： Yoshihito Hayashi ,  Marcaurele Brun ,  Kenzo Machida

IPC: G01N33/86 ,  G01N33/49

CPC classification number: G01N33/86 ,  G01N33/4905 ,  G01N33/491

Abstract: A blood state analysis device (1) that analyzes a state of a blood sample, as used for clotting time testing, said blood sample comprising a plasma and at least one reagent, including a correction unit (11) configured to correct a measured blood coagulation evaluation result of the blood sample based on a relation between reference concentrations of the at least one reagent in plasma and reference blood coagulation evaluation results, the at least one reagent is an anticoagulation treatment releasing agent, a coagulation activator, an anticoagulant, a platelet activator, an antiplatelet drug, or a combination thereof and is present in the blood sample. For instance, such device (1) allows to correct blood clotting time results with respect to concentrations of an anti-coagulant drug present in the blood sample.

Abstract translation: 1.一种血液状态分析装置（1），其用于凝血时间检测时使用的血液样本的状态，所述血液样本包括等离子体和至少一种试剂，该校正单元（11）构成为校正测定的血液凝固 基于血浆中的至少一种试剂的参考浓度与参照血液凝固评价结果之间的关系的血液样品的评价结果​​，所述至少一种试剂是抗凝治疗脱模剂，凝血活化剂，抗凝血剂，血小板活化剂 ，抗血小板药物或其组合，并存在于血液样品中。 例如，这种装置（1）允许相对于存在于血液样品中的抗凝剂药物的浓度校正血液凝固时间结果。

公开(公告)号：US20140134077A1

公开(公告)日：2014-05-15

申请号：US14073382

申请日：2013-11-06

Applicant: Sony Corporation

Inventor： Tasuku Yotoriyama ,  Yuji Segawa ,  Michihiro Ohnishi ,  Yoshiaki Kato ,  Tomoteru Abe ,  Kenzo Machida ,  Masahiro Matsumoto ,  Tomohiko Nakamura ,  Naohisa Sakamoto ,  Hidetoshi Watanabe ,  Takanori Anaguchi ,  Masayoshi Akita ,  Masahiro Miyachi

IPC: B01L3/02 ,  B01L7/00

CPC classification number: B01L3/502715 ,  B01L3/502753 ,  B01L7/00 ,  B01L2200/027 ,  B01L2300/044 ,  B01L2300/0672 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0832 ,  B01L2300/0835 ,  B01L2300/1822 ,  B01L2400/0478 ,  B01L2400/0481 ,  B01L2400/049

Abstract: There is provided a sample liquid injection tool including a reservoir section configured to store a sample liquid, a channel having one end protruding from an outer surface and configured to discharge the sample liquid therein from a protrusion end to an outside, and a heating unit and a filter installed between the reservoir section and the channel to enable passage of the liquid.

Abstract translation: 提供了一种样品液体注入工具，其包括：储存部，其构造成存储样品液体;通道，其一端从外表面突出，并且构造成将其中的样品液体从突出端排出到外部;以及加热单元， 安装在储存器部分和通道之间以使液体通过的过滤器。

公开(公告)号：US20140038280A1

公开(公告)日：2014-02-06

申请号：US13953914

申请日：2013-07-30

Applicant: Sony Corporation

Inventor： Masaki Sato ,  Tomohiko Nakamura ,  Kenzo Machida ,  Toshio Watanabe ,  Yoshiaki Kato ,  Michihiro Ohnishi

IPC: C12Q1/68

CPC classification number: C12Q1/6844 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2200/16 ,  B01L2300/046 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/043 ,  B01L2400/049 ,  B01L2400/086

Abstract: There is provided a microchip for a nucleic acid amplification reaction including a reagent accommodation region including a solid-phase reagent and a particle, the solid-phase reagent containing a substance necessary for a nucleic acid amplification reaction.

Abstract translation: 提供了用于核酸扩增反应的微芯片，其包括包含固相试剂和颗粒的试剂容纳区域，所述固相试剂含有核酸扩增反应所必需的物质。