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    Azole mycocide and method of treating mycosis
    15.
    发明授权
    Azole mycocide and method of treating mycosis 失效
    唑类霉菌和治疗真菌病的方法

    公开(公告)号：US5162356A

    公开(公告)日：1992-11-10

    申请号：US666488

    申请日：1991-03-06

    申请人： Masato Arahira ,  Toshihide Saishoji ,  Susumu Ikeda ,  Satoru Kumazawa

    发明人： Masato Arahira ,  Toshihide Saishoji ,  Susumu Ikeda ,  Satoru Kumazawa

    IPC分类号： A61K31/415 ,  A61P31/04 ,  A61P31/10 ,  C07D233/60 ,  C07D233/61 ,  C07D249/08 ,  C07D521/00

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： Disclosed herein are azole derivatives or the salts thereof which are represented by the general formula (I): ##STR1## wherein X represents a halogen atom, an alkyl group having 1 to 5 carbon atoms, a haloalkyl group, a phenyl group, a cyano group, or a nitro group, Xs being either the same or different from each other; n represents an integer of 1 to 5; A represents a nitrogen atom or CH; and one of R.sub.1 and R.sub.2 represents an alkyl group having 1 to 5 carbon atoms and the other a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, with the proviso that when n is 1 or 2, X does not represent a halogen atom, an alkyl group having 1 to 5 carbon atoms or a phenyl group, and mycocides comprising an effective amount of azole derivative or medically or veterinarily acceptable salt thereof, said azole derivative being represented by the general formula (II): ##STR2## wherein X represents a halogen atom, an alkyl group having 1 to 5 carbon atoms, a haloalkyl group, a phenyl group, a cyano group, or a nitro group, Xs being either the same or different from each other; n represents an integer of 0 to 5; A represents a nitrogen atom or CH; and R.sub.1 and R.sub.2 respectively represent a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, and a diluent or a carrier which is medically or veterinarily acceptable.

    摘要翻译： 本文公开的是由通式（I）表示的唑衍生物或其盐：其中X表示卤素原子，具有1至5个碳原子的烷基，卤代烷基，苯基 ，氰基或硝基，Xs彼此相同或不同; n表示1〜5的整数， A表示氮原子或CH; R1和R2之一表示碳原子数为1〜5的烷基，另一个为氢原子或碳原子数为1〜5的烷基，条件是当n为1或2时，X不表示卤素 原子，具有1〜5个碳原子的烷基或苯基，以及包含有效量的唑衍生物或其医学上或兽医学上可接受的盐的霉菌，所述唑衍生物由通式（II）表示： II）其中X表示卤素原子，具有1至5个碳原子的烷基，卤代烷基，苯基，氰基或硝基，X可以相同或不同; n表示0〜5的整数， A表示氮原子或CH; R 1和R 2分别表示氢原子或碳原子数1〜5的烷基，以及在医学上或兽医学上可接受的稀释剂或载体。

    Process for production of (azolylmethyl)-(biphenylmethyl)cyclopentanol derivatives
    18.
    发明授权
    Process for production of (azolylmethyl)-(biphenylmethyl)cyclopentanol derivatives 失效
    （唑基甲基） - （联苯甲基）环戊醇衍生物的制备方法

    公开(公告)号：US5468869A

    公开(公告)日：1995-11-21

    申请号：US124763

    申请日：1993-09-22

    申请人： Satoru Kumazawa ,  Hiroyuki Enari

    发明人： Satoru Kumazawa ,  Hiroyuki Enari

    IPC分类号： A01N43/50 ,  A01N43/653 ,  A61K31/41 ,  A61K31/415 ,  A61P31/04 ,  C07D233/60 ,  C07D249/08 ,  C07D521/00

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： This invention provides a simple process for production of an (azolylmethyl)(biphenylmethyl)cyclopentanol derivative represented by the following formula (I) in a good yield. This process comprises, as described in the following reaction formula, reacting an (azolylmethyl)(halogenophenylmethyl)cyclopentanol derivative represented by the following formula (II) with a benzene derivative represented by the following formula (III) by light irradiation. ##STR1## wherein X denotes a halogen atom, R.sup.1 and R.sup.2 denote independently a hydrogen atom or a C1-C5 alkyl group, R.sup.3 denotes a C1-C5 alkyl group, n means an integer of 0-2, and A represents CH or N.

    摘要翻译： 本发明提供以良好的产率制备由下式（I）表示的（唑基甲基）（联苯甲基）环戊醇衍生物的简单方法。 该方法如下述反应式所示，通过光照射使由下式（II）表示的（唑基甲基）（卤代苯基甲基）环戊醇衍生物与下式（III）表示的苯衍生物反应。 其中X表示卤素原子，R1和R2分别独立地表示氢原子或C1-C5烷基，R3表示C1-C5烷基，n表示0〜2的整数，A表示 CH或N.