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11.发明申请METHODS FOR IDENTIFYING PURKINJE CELLS USING THE CORL2 GENE AS A TARGET 审中-公开使用CORL2基因作为目标鉴定胰腺细胞的方法公开(公告)号：US20090203046A1
公开(公告)日：2009-08-13
申请号：US11813743
申请日：2006-02-01
申请人： Yuichi Ono , Tomoya Nakatani
发明人： Yuichi Ono , Tomoya Nakatani
CPC分类号： C12Q1/6881 , C07K14/47 , C07K16/18 , C12Q2600/158 , G01N33/56966
摘要： Total RNAs were prepared from the ventral and dorsal regions of embryonic day 12.5 mouse mesencephalon, and a cDNA fragment was obtained by the subtraction method (N-RDA). The full-length cDNA was cloned and the nucleotide sequence was determined. The gene was named Corl2. The result of homology search showed that about 850 residues of Corl2 exhibited homology to the XM_355050 sequence deposited in GenBank; however, the remaining ˜150 residues showed no homology. Thus, Corl2 was demonstrated to be a novel gene. The Corl2 expression in various mouse organs was analyzed by RT-PCR, and the result showed that Corl2 expression was specific to brain. The result of immunostaining day 12.5 embryos and postnatal day 12 brains demonstrated that Corl2 is useful as a Purkinje cell marker at any differentiation stages.
摘要翻译： 从胚胎第12.5天小鼠中脑的腹侧和背部区域制备总RNA，通过减法法（N-RDA）获得cDNA片段。 克隆全长cDNA，测定核苷酸序列。 该基因命名为Corl2。 同源性检索结果表明，Corl2的约850个残基与存在于GenBank中的XM_355050序列具有同源性; 然而，剩余的〜150个残基显示没有同源性。 因此，Corl2被证明是一种新的基因。 通过RT-PCR分析各种小鼠器官中的Corl2表达，结果表明Corl2表达对脑有特异性。 免疫染色第12.5天胚胎和出生后12天脑的结果表明，Corl2在任何分化阶段用作浦肯野细胞标记。
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公开(公告)号：US20070254281A1
公开(公告)日：2007-11-01
申请号：US10580989
申请日：2004-11-26
申请人： Yuichi Ono , Yasuko Nakagawa , Tomoya Nakatani
发明人： Yuichi Ono , Yasuko Nakagawa , Tomoya Nakatani
CPC分类号： C12Q1/6881 , C12Q1/6883 , C12Q2600/158 , G01N33/6896 , G01N33/9413 , G01N2800/2835
摘要： The present invention identified Lmx1a genes, which are expressed in dopaminergic neurons at all differentiation stages, from proliferating dopaminergic neuron progenitor cells before cell cycle exit to cells after cell cycle exit. Lmx1a expression in cells can be used as an indicator when selecting cells suitable for transplantation therapy for neurodegenerative diseases such as Parkinson's disease, and is useful as a marker for screening agents involved in the induction of dopaminergic neuron differentiation.
摘要翻译： 本发明鉴定了在细胞周期退出至细胞周期后出现的细胞周期性增殖的多巴胺能神经元祖细胞中，在所有分化阶段的多巴胺能神经元中表达的Lmx1a基因。 当选择适合于帕金森病等神经变性疾病的移植治疗的细胞时，细胞中的Lmx1a表达可用作指示剂，并且可用作参与多巴胺能神经元分化诱导的筛选剂的标记。
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13.发明授权公开(公告)号：US08999523B2
公开(公告)日：2015-04-07
申请号：US13056257
申请日：2009-07-29
申请人： Tomoya Nakatani
发明人： Tomoya Nakatani
IPC分类号： H01L51/54 , C07C25/24 , C07C43/225 , C07D307/91 , C08G79/08 , C09K11/06 , C07C17/269 , C07C41/16 , C08G61/02 , C08G61/12 , H01L51/00 , H05B33/14 , H01L51/50
CPC分类号： C07C17/269 , C07C41/16 , C07C43/225 , C07C2603/18 , C08G61/02 , C08G61/12 , C08G61/126 , C08G2261/135 , C08G2261/15 , C08G2261/312 , C08G2261/3142 , C08G2261/3162 , C08G2261/3241 , C08G2261/3243 , C08G2261/51 , C09K11/06 , C09K2211/1416 , C09K2211/1425 , C09K2211/1433 , C09K2211/1458 , C09K2211/1466 , H01L51/0035 , H01L51/0036 , H01L51/0039 , H01L51/0042 , H01L51/0094 , H01L51/5048 , H05B33/14 , Y10S428/917
摘要： Disclosed is a compound containing a divalent group represented by formula (I). (In formula (I), Ar1 represents an arylene group, a divalent heterocyclic group or a divalent aromatic amine group; J1 represents a phenylene group; J2 represents an alkylene group; X represents an oxygen atom or a sulfur atom; j represents 0 or 1, k represents an integer of 0-3, and l represents 0 or 1, while satisfying 1≦j+k+l≦5; m represents 1 or 2; R1 represents a hydrogen atom, an alkyl group, an alkoxy group, an alkylthio group, an aryl group, an aryloxy group, an arylthio group, an arylalkyl group, an arylalkoxy group, an arylalkylthio group, an arylalkenyl group, an arylalkynyl group, an amino group, a substituted amino group, a silyl group, a substituted silyl group, a halogen atom, an acyl group, an acyloxy group, an imine residue, a carbamoyl group, an acid imide group, a monovalent heterocyclic group, a carboxyl group, a substituted carboxyl group, a cyano group or a nitro group; the plurality of R1's may be the same as or different from each other; and when there are a plurality of J1's, J2's, X's, j's, k's or l's, the J1's, J2's, X's, j's, k's or l's may be the same as or different from each other, respectively).
摘要翻译： 公开了含有式（I）表示的二价基团的化合物。 （式（I）中，Ar 1表示亚芳基，2价杂环基或2价芳香族胺基，J 1表示亚苯基，J2表示亚烷基，X表示氧原子或硫原子，j表示0或 1，k表示0-3的整数，l表示0或1，同时满足1＆nlE; j + k + 1＆nlE; 5; m表示1或2; R1表示氢原子，烷基，烷氧基， 烷硫基，芳基，芳氧基，芳硫基，芳基烷基，芳基烷氧基，芳基烷硫基，芳基烯基，芳基炔基，氨基，取代氨基，甲硅烷基， 取代甲硅烷基，卤素原子，酰基，酰氧基，亚胺残基，氨基甲酰基，酰亚胺基，1价杂环基，羧基，取代羧基，氰基或硝基 ;多个R1可以彼此相同或不同;并且当有一个 重新分配J1，J2，X，J，K或I，J1，J2，X，J，K或者可以分别相同或不相同）。
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公开(公告)号：US08877449B2
公开(公告)日：2014-11-04
申请号：US13141063
申请日：2009-12-18
申请人： Yuichi Ono , Tomoya Nakatani , Yasuko Nakagawa
发明人： Yuichi Ono , Tomoya Nakatani , Yasuko Nakagawa
CPC分类号： C12N5/0678
摘要： The present invention provides markers that can selectively distinguish pancreatic progenitor cells. The present invention also provides methods for distinguishing pancreatic progenitor cells by using the markers as an indicator, and reagents to be used in the methods.The present inventors successfully identified the surface marker Nephrin-like 3 (Neph3) which is specifically expressed in pancreatic progenitor cells, and isolated pancreatic progenitor cells using the marker as an indicator or such. Viable pancreatic progenitor cells can be selected by using Neph3 as an indicator without using translated products and transcripts of any foreign genes. The marker is useful in preparing and identifying pancreatic progenitor cells which are applied to regenerative medicine or such for treatment of pancreatic diseases.
摘要翻译： 本发明提供了可以选择性区分胰腺祖细胞的标志物。 本发明还提供了通过使用标记作为指标来区分胰腺祖细胞的方法，以及用于该方法的试剂。 本发明人成功地鉴定了在胰腺祖细胞中特异性表达的表面标记物Nephrin样3（Neph3），以及使用该标记作为指示剂的分离的胰腺祖细胞。 可以通过使用Neph3作为指标来选择可行的胰腺祖细胞，而不使用翻译的产物和任何外来基因的转录物。 该标记物可用于制备和鉴定适用于再生医学或胰腺疾病治疗的胰腺祖细胞。
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公开(公告)号：US08580523B2
公开(公告)日：2013-11-12
申请号：US13352241
申请日：2012-01-17
申请人： Yuichi Ono , Yasuko Nakagawa , Tomoya Nakatani
发明人： Yuichi Ono , Yasuko Nakagawa , Tomoya Nakatani
CPC分类号： C12Q1/6881 , C12Q1/6883 , C12Q2600/158 , G01N33/6896 , G01N33/9413 , G01N2800/2835
摘要： The present invention identified Lmx1a genes, which are expressed in dopaminergic neurons at all differentiation stages, from proliferating dopaminergic neuron progenitor cells before cell cycle exit to cells after cell cycle exit. Lmx1a expression in cells can be used as an indicator when selecting cells suitable for transplantation therapy for neurodegenerative diseases such as Parkinson's disease, and is useful as a marker for screening agents involved in the induction of dopaminergic neuron differentiation.
摘要翻译： 本发明鉴定了在细胞周期退出至细胞周期后出现的细胞周期性增殖的多巴胺能神经元祖细胞中，在所有分化阶段的多巴胺能神经元中表达的Lmx1a基因。 当选择适合于帕金森病等神经变性疾病的移植治疗的细胞时，细胞中的Lmx1a表达可用作指示剂，并且可用作参与多巴胺能神经元分化诱导的筛选剂的标记。
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公开(公告)号：US20130046073A1
公开(公告)日：2013-02-21
申请号：US13580919
申请日：2011-02-25
申请人： Osamu Goto , Daisuke Fukushima , Tomoya Nakatani
发明人： Osamu Goto , Daisuke Fukushima , Tomoya Nakatani
IPC分类号： C08G73/02
CPC分类号： C08G61/12 , C08G61/02 , C08G2261/3142 , C08G2261/3162 , C08G2261/411
摘要： The problem to be solved of the present invention is to provide a method for producing a polymer compound having an increased molecular weight through a short-time polymerization process. Means for solving the problem is a method for producing a polymer compound having a repeating unit represented by formula (2), which method comprising a step of polymerizing a first aromatic compound having at least two first functional groups each containing a boron atom with a second aromatic compound having at least two second functional groups which are capable of reacting with the first functional group, in the presence of an organic solvent, a palladium complex, a base and a compound represented by formula (1): wherein Ra, Rb, Rc, Rd, Re and Rf are the same or different, and each represents a hydrogen atom or a monovalent organic group, or any two of Ra to Rf are bound with each other to form a non-aromatic ring, and the remainder are the same or different, and each represents a hydrogen atom or a monovalent organic group; —Ar— (2) wherein Ar represents a divalent group resulting from the removal of two hydrogen atoms from an aromatic compound.
摘要翻译： 本发明要解决的问题是提供通过短时聚合方法制备分子量增加的高分子化合物的方法。 解决问题的手段是制备具有式（2）所示重复单元的高分子化合物的方法，该方法包括使具有至少两个含有硼原子的第一官能团的第一芳族化合物与第二芳族化合物聚合的步骤 在有机溶剂，钯络合物，碱和由式（1）表示的化合物的存在下，具有至少两个能够与第一官能团反应的第二官能团的芳族化合物：其中Ra，Rb，Rc ，Rd，Re和Rf相同或不同，各自表示氢原子或一价有机基团，或者Ra至Rf中的任意两个彼此结合形成非芳香环，其余部分相同 或不同，各自表示氢原子或一价有机基团; -Ar-（2）其中Ar表示从芳族化合物中除去两个氢原子而得到的二价基团。
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公开(公告)号：US20120306358A1
公开(公告)日：2012-12-06
申请号：US13516398
申请日：2010-12-20
申请人： Keiko Hirano , Tomoya Nakatani , Shigeru Sasaki
发明人： Keiko Hirano , Tomoya Nakatani , Shigeru Sasaki
CPC分类号： H01L51/0043 , C08G61/12 , C08G2261/1412 , C08G2261/1414 , C08G2261/1434 , C08G2261/148 , C08G2261/3142 , C08G2261/3162 , C08G2261/5222 , C08G2261/76 , C08G2261/95 , C08L65/00 , C08L2205/02 , C09K11/06 , C09K2211/1416 , C09K2211/1425 , C09K2211/1433 , C09K2211/145 , C09K2211/1466 , C09K2211/1475 , H01L51/0039 , H01L51/5012
摘要： A composition comprising (1) a first crosslinkable polymer compound having an aromatic conjugated repeating unit and a crosslinkable group and having at least one of a light emitting property and charge transportability, and (2) a second crosslinkable polymer compound having an aromatic conjugated repeating unit and a crosslinkable group at least one of which is different from the aromatic conjugated repeating unit in the first crosslinkable polymer compound and the crosslinkable group in the first crosslinkable polymer compound, and having at least one of a light emitting property and charge transportability, wherein at least one of the first crosslinkable polymer compound and the second crosslinkable polymer compound has a crosslinkable group represented by the following formula (Z-3) or (Z-4): in the formulae, Rc represents a hydrogen atom, or a substituent such as an unsubstituted or substituted alkyl group or the like, the plurality of Rc moieties may be the same or different.
摘要翻译： 一种组合物，其包含（1）具有芳香族共轭重复单元和交联性基团的具有发光特性和电荷输送性中的至少一种的第一交联性高分子化合物，和（2）具有芳香族共轭重复单元的第二交联性高分子化合物 以及交联性基团，其中至少一种不同于第一可交联聚合物化合物中的芳族共轭重复单元和第一可交联聚合物化合物中的可交联基团，并且具有发光特性和电荷传输性中的至少一种，其中在 第一可交联聚合物化合物和第二可交联聚合物化合物中的至少一种具有由下式（Z-3）或（Z-4）表示的交联性基团：式中，R c表示氢原子， 未取代或取代的烷基等，多个Rc部分可以相同或不同。
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公开(公告)号：US20110309341A1
公开(公告)日：2011-12-22
申请号：US13129964
申请日：2009-11-18
申请人： Kazuei Ohuchi , Tomoya Nakatani
发明人： Kazuei Ohuchi , Tomoya Nakatani
IPC分类号： H01L51/54 , H01B1/12 , C07D265/38 , C08G73/06 , C07C211/56 , C08G73/02 , C09K11/06
CPC分类号： C08G61/02 , C08G2261/3142 , C08G2261/5222 , C09B3/14 , C09B19/00 , C09B21/00 , C09B57/00 , C09B57/008 , C09B69/109 , C09K11/06 , H01L51/0039 , H01L51/0043 , H01L51/006 , H01L51/0085 , H01L51/5012 , H05B33/14
摘要： A polymer compound comprising a constituent unit represented by the following formula (1a): wherein ring A and ring B represent an aromatic hydrocarbon ring. R1 is a group represented by the following formula (2). R2 represents an aryl group or a monovalent aromatic heterocyclic group. wherein Ar1 represents an arylene group or a divalent group comprising two or more directly bonded arylene groups; Ar4 and Ar5 represent an aryl group or a monovalent aromatic heterocyclic group; Ar2 and Ar3 represent an arylene group or a divalent aromatic heterocyclic group; R6 represents a hydrogen atom, an alkyl group, an aryl group or a monovalent aromatic heterocyclic group.
摘要翻译： 包含由下式（1a）表示的构成单元的高分子化合物：其中环A和环B表示芳族烃环。 R1是由下式（2）表示的基团。 R2表示芳基或1价芳香族杂环基。 其中Ar1表示亚芳基或包含两个或更多个直接键合的亚芳基的二价基团; Ar 4和Ar 5表示芳基或1价芳香族杂环基; Ar 2和Ar 3表示亚芳基或二价芳族杂环基; R6表示氢原子，烷基，芳基或1价芳香族杂环基。
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公开(公告)号：US08067161B2
公开(公告)日：2011-11-29
申请号：US12064018
申请日：2006-08-18
CPC分类号： C07K16/18 , C07K14/47 , C12Q1/6881 , C12Q2600/158 , G01N33/5073
摘要： The present invention is a probe, a primer, and an antibody, for detecting a dopaminergic neuron proliferative progenitor cell. According to the present invention, there is provided a polynucleotide probe and a polynucleotide primer for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell, which can hybridize with a polynucleotide consisting of a nucleotide sequence of a Nato3 gene, or a complementary sequence thereto, and an antibody against a Nato3 protein, or a part thereof for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell.
摘要翻译： 本发明是用于检测多巴胺能神经元增殖祖细胞的探针，引物和抗体。 根据本发明，提供了用于检测或选择多巴胺能神经元增殖祖细胞的多核苷酸探针和多核苷酸引物，其可与由Nato3基因的核苷酸序列或互补的多核苷酸组成的多核苷酸杂交 序列，以及针对Nato3蛋白或其部分的抗体用于检测或选择多巴胺能神经元增殖祖细胞。
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20.发明申请公开(公告)号：US20100203505A1
公开(公告)日：2010-08-12
申请号：US12064019
申请日：2006-08-18
CPC分类号： G01N33/56966 , C07K16/18 , C12Q1/6881 , C12Q2600/158
摘要： The present invention is a probe, a primer, and an antibody, for detecting a dopaminergic neuron proliferative progenitor cell. According to the present invention, there is provided a polynucleotide probe and a polynucleotide primer for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell, which can hybridize with a polynucleotide consisting of a nucleotide sequence of an Msx1 gene or an Msx2 gene, or a complementary sequence thereto, and an antibody against an Msx1 protein or an Msx2 protein, or a part thereof for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell.
摘要翻译： 本发明是用于检测多巴胺能神经元增殖祖细胞的探针，引物和抗体。 根据本发明，提供了用于检测或选择多巴胺能神经元增殖祖细胞的多核苷酸探针和多核苷酸引物，其可以与由Msx1基因或Msx2基因的核苷酸序列组成的多核苷酸杂交 ，或其互补序列，以及针对用于检测或选择多巴胺能神经元增殖祖细胞的Msx1蛋白或Msx2蛋白或其一部分的抗体。
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