公开(公告)号：US07925352B2

公开(公告)日：2011-04-12

申请号：US12413495

申请日：2009-03-27

申请人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

发明人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

IPC分类号： A61N1/00

CPC分类号： A61N1/05 ,  A61N1/0558 ,  A61N1/36114 ,  A61N1/36117 ,  A61N2007/0043

摘要： Methods and systems are disclosed for stimulating contents of the carotid sheath using an intravascular pulse generator and lead. The lead carries an energy delivery device such as an electrode, which is anchor within the portion of the internal jugular vein that is disposed within the carotid sheath. The energy delivery device is energized to transvenously direct energy to target contents of the carotid sheath external to the internal jugular vein. Such target contents may include nervous system elements associated with the carotid sinus baroreceptors, the carotid sinus nerve and associated nerve branches, and or the vagus nerve and associated nerve branches. The system may be used to control blood pressure and/or to lower heart rate and may be suitable for treatment of hypertension, heart failure, or other conditions.

摘要翻译： 公开了使用血管内脉冲发生器和引线刺激颈动脉鞘的内容物的方法和系统。 引线携带能量递送装置，例如电极，其锚定在设置在颈动脉鞘内的颈内静脉的部分内。 能量递送装置被通电以将能量传递给颈内静脉外部的颈动脉鞘的目标物质。 这样的目标物质可以包括与颈动脉窦压力感受器，颈动脉窦神经和相关神经分支相关的神经系统元件，或迷走神经和相关联的神经分支。 该系统可用于控制血压和/或降低心率，并且可适用于治疗高血压，心力衰竭或其它病症。

公开(公告)号：US20070163654A1

公开(公告)日：2007-07-19

申请号：US11335364

申请日：2006-01-19

申请人： Lynn Elliott

发明人： Lynn Elliott

IPC分类号： F16K27/00

CPC分类号： F16K27/08 ,  F16K27/12 ,  Y10T137/0452 ,  Y10T137/4259 ,  Y10T137/5762

摘要： An improved stem protector system for valves including an assembly, preferably a sleeve assembly, structured and sized for surrounding a valve stem and for mating with a valve stem actuator, the assembly including at least one port system, the at least one port system having at least one port structure to pass lubricant from outside to inside the system and at least one drainage port to pass water from inside to outside the system. Preferably the lubricant port(s) and the water drainage port(s) are separate.

摘要翻译： 一种用于阀的改进的阀杆保护器系统，其包括组件，优选地是套筒组件，其被构造和定尺寸为围绕阀杆并与阀杆致动器配合，所述组件包括至少一个端口系统，所述至少一个端口系统具有 至少一个端口结构将润滑剂从外部传递到系统内部，并且至少一个排水口将水从内部传递到系统外部。 优选地，润滑剂端口和排水口是分开的。

公开(公告)号：US08428730B2

公开(公告)日：2013-04-23

申请号：US13286217

申请日：2011-11-01

申请人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

发明人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

IPC分类号： A61N1/00

CPC分类号： A61N1/05 ,  A61N1/0558 ,  A61N1/36114 ,  A61N1/36117 ,  A61N2007/0043

摘要： A transvascular electrode system includes an expandable electrode-carrying anchor. The anchor is intravascularly advanced in a compressed position to a first site in a blood vessel. A first portion of the anchor expands to position an electrode against the vessel wall, while a second portion remains is compressed. Mapping is performed by delivering stimulation energy from the electrode and measuring the response (e.g. blood pressure, heart rate, and/or related parameters). The first portion is at least partially collapsed and the electrode system is moved to a second site. The first portion is expanded to position the electrode into against the vessel wall, while the second portion remains compressed. Additional mapping is performed. The process is repeated until the anchor electrode position is optimized, at which point the second portion of the anchor is expanded to chronically retain the electrode in the vessel.

摘要翻译： 经血管电极系统包括可扩张电极承载锚。 锚固体在压缩位置中血管内前进到血管中的第一部位。 锚的第一部分膨胀以将电极定位在血管壁上，而第二部分保留被压缩。 通过从电极传递刺激能量并测量反应（例如血压，心率和/或相关参数）来进行测绘。 第一部分至少部分地折叠并且电极系统移动到第二部位。 第一部分被扩展以将电极定位在血管壁上，而第二部分保持压缩。 执行附加映射。 重复该过程直到锚定位置被优化，此时锚固体的第二部分被膨胀以将电极长期地保持在容器中。

公开(公告)号：US20070255379A1

公开(公告)日：2007-11-01

申请号：US11702000

申请日：2007-02-02

申请人： Michael Williams ,  Richard Stack ,  Lynn Elliott ,  Colleen N'diaye ,  Daniel Fifer

发明人： Michael Williams ,  Richard Stack ,  Lynn Elliott ,  Colleen N'diaye ,  Daniel Fifer

IPC分类号： A61N1/05

CPC分类号： A61N1/05 ,  A61M5/14276 ,  A61M2205/3523 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0551 ,  A61N1/057 ,  A61N1/3605 ,  A61N1/36071 ,  A61N1/36082 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/3627 ,  A61N2001/0585

摘要： The present disclosure describes intravascular systems that may be used for a variety of functions. The elements of the disclosed systems include at least one device body implanted within the vasculature. Electrodes on a lead and/or on the device body itself are used to direct electrical energy to neurological targets. These systems may additionally include one or more fluid reservoirs housing drugs or other agents to be delivered to tissue.

摘要翻译： 本公开描述了可用于各种功能的血管内系统。 所公开的系统的元件包括植入脉管系统内的至少一个装置体。 导线上的电极和/或器件本体上的电极用于将电能引导到神经系统的目标。 这些系统可以另外包括一个或多个容纳待递送至组织的药物或其它试剂的流体储存器。

公开(公告)号：US08489192B1

公开(公告)日：2013-07-16

申请号：US13523223

申请日：2012-06-14

申请人： Edwin J. Hlavka ,  Lynn Elliott

发明人： Edwin J. Hlavka ,  Lynn Elliott

IPC分类号： A61B5/04

CPC分类号： A61N1/3611 ,  A61B5/08 ,  A61B5/0823 ,  A61B5/4836 ,  A61B5/686 ,  A61B18/04 ,  A61B18/08 ,  A61B18/12 ,  A61B2018/00434 ,  A61B2018/00541 ,  A61N1/3601

摘要： A method of reducing bronchial constriction in a subject includes delivering energy to create one or more lesions on a main bronchus so as to transect pulmonary nerves sufficiently to reduce bronchial constriction in a lung of the patient distal to the main bronchus.

公开(公告)号：US20100023088A1

公开(公告)日：2010-01-28

申请号：US12413495

申请日：2009-03-27

申请人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

发明人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

IPC分类号： A61N1/36 ,  A61N7/00

CPC分类号： A61N1/05 ,  A61N1/0558 ,  A61N1/36114 ,  A61N1/36117 ,  A61N2007/0043

摘要： Methods and systems are disclosed for stimulating contents of the carotid sheath using an intravascular pulse generator and lead. The lead carries an energy delivery device such as an electrode, which is anchor within the portion of the internal jugular vein that is disposed within the carotid sheath. The energy delivery device is energized to transvenously direct energy to target contents of the carotid sheath external to the internal jugular vein. Such target contents may include nervous system elements associated with the carotid sinus baroreceptors, the carotid sinus nerve and associated nerve branches, and or the vagus nerve and associated nerve branches. The system may be used to control blood pressure and/or to lower heart rate and may be suitable for treatment of hypertension, heart failure, or other conditions.

摘要翻译： 公开了使用血管内脉冲发生器和引线刺激颈动脉鞘的内容物的方法和系统。 引线携带能量递送装置，例如电极，其锚定在设置在颈动脉鞘内的颈内静脉的部分内。 能量递送装置被通电以将能量传递给颈内静脉外部的颈动脉鞘的目标物质。 这样的目标物质可以包括与颈动脉窦压力感受器，颈动脉窦神经和相关神经分支相关的神经系统元件，或迷走神经和相关联的神经分支。 该系统可用于控制血压和/或降低心率，并且可适用于治疗高血压，心力衰竭或其它病症。

公开(公告)号：US06904319B2

公开(公告)日：2005-06-07

申请号：US09827775

申请日：2001-04-06

申请人： Gary Seim ,  Lynn Elliott ,  Milton Morris

发明人： Gary Seim ,  Lynn Elliott ,  Milton Morris

IPC分类号： A61N1/362 ,  A61N1/18

CPC分类号： A61N1/3622

摘要： A system and method provides for inhibiting delivery of atrial therapy under certain conditions. Inhibiting delivery of atrial therapy involves developing atrial intervals and ventricular intervals from sensed atrial and ventricular events, respectively. An average atrial rate and an average ventricular rate is developed from a predetermined number of the atrial and ventricular intervals, respectively. Delivery of atrial therapy is inhibited if the average atrial rate fails to exceed the average ventricular rate by at least a predetermined factor.

摘要翻译： 一种系统和方法提供在某些条件下抑制心房治疗的递送。 抑制心房治疗的交付包括分别从感觉到的心房和心室事件发展心房间隔和心室间隔。 平均心房率和平均心室率分别从预定数量的心房和心室间隔发展。 如果平均心房率不能超过平均心室率至少一个预定的因素，就可以抑制心房治疗的传递。