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    Marker or filler forming fluid
    12.
    发明授权
    Marker or filler forming fluid 有权
    标记或填料成型液

    公开(公告)号：US08639315B2

    公开(公告)日：2014-01-28

    申请号：US13895927

    申请日：2013-05-16

    申请人： SenoRx, Inc.

    发明人： Fred H. Burbank ,  Michael L. Jones ,  Frank Louw ,  Paul Lubock

    IPC分类号： A61B6/00 ,  A61B10/00

    CPC分类号： A61B90/39 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3933 ,  A61B2090/3987 ,  A61K49/226

    摘要： A system for at least partially filling and marking a cavity at a site within a patient's body includes a marker delivery device having a chamber configured to contain a marking substance and having a mechanism configured to expel the marking substance. A quantity of the marking substance is contained within the chamber of the marker delivery device. The marking substance is configured to at least partially fill the cavity and form therein a porous bioabsorbable body. A delivery tube is coupled in fluid communication with the chamber of the marker delivery device. The delivery tube has a distal end with a discharge port through which the marking substance is expelled. A marker is configured to be delivered to the cavity from the distal end of the delivery tube and is configured to remain with the porous bioabsorbable body within the cavity upon the formation thereof.

    摘要翻译： 一种用于至少部分地填充和标记患者体内的部位的空腔的系统包括标记物输送装置，其具有被配置为容纳标记物质并具有被配置为排出标记物质的机构的室。 标记物质的量被容纳在标记物输送装置的室内。 标记物质构造成至少部分地填充空腔并在其中形成多孔生物可吸收体。 输送管与标记物递送装置的腔室流体连通地联接。 输送管具有远端，其具有排出口，排出标记物质。 标记被配置为从输送管的远端输送到空腔，并且构造成在其形成之后保留在空腔内的多孔生物可吸收体。

    IMAGEABLE BIOPSY SITE MARKER
    14.
    发明申请
    IMAGEABLE BIOPSY SITE MARKER 审中-公开
    可生物生物网站标记

    公开(公告)号：US20160128797A1

    公开(公告)日：2016-05-12

    申请号：US14925562

    申请日：2015-10-28

    申请人： SenoRx. Inc.

    发明人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones ,  Nancy Forcier

    IPC分类号： A61B90/00

    CPC分类号： A61B90/39 ,  A61B10/02 ,  A61B2017/00004 ,  A61B2090/3788 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3929 ,  A61B2090/3933 ,  A61B2090/395 ,  A61B2090/3975 ,  A61B2090/3987 ,  A61B2090/3995 ,  A61K49/006 ,  A61M37/0069

    摘要： A biopsy site marker having at least one small marker body or pellet of bioresorbable material such as gelatin, collagen, polylactic acid, polyglycolic acid which has a radiopaque object, preferably with a non-biological configuration. The at least one bioresorbable body or pellet with a radiopaque object is deposited into the biopsy site, by a delivery device that includes an elongated tubular body with a piston slidable within the tubular body. One end of the tube is placed into the biopsy site. At least one but preferably several marker bodies or pellets are deposited sequentially into the biopsy site through the tube. At least the bioresorbable materials of the detectable markers remain present in sufficient quantity to permit detection and location of the biopsy site at a first time point (e.g., 2 weeks) after introduction but clear from the biopsy site or otherwise do not interfere with imaging of tissues adjacent the biopsy site at a second time point (e.g., 5-7 months) after introduction.

    摘要翻译： 活检部位标记物，其具有至少一个生物可再吸收材料的小标记体或颗粒，例如具有不透射线对象的明胶，胶原，聚乳酸，聚乙醇酸，优选具有非生物构型。 具有不透射线物体的至少一个生物可吸收体或丸粒通过包括细长管状体的递送装置沉积到活检部位中，所述细长管状体具有可在管状体内滑动的活塞。 将管的一端放入活检部位。 至少一个但优选几个标记体或丸粒通过管子依次沉积到活检部位。 至少可检测标记的生物可吸收材料保持足够的量，以允许在引入之后的第一时间点（例如2周）检测和定位活检部位，但是从活组织检查部位清除，否则不干扰成像 导入后的第二时间点（如5-7个月）附近的组织组织。

    Cavity filling biopsy site markers
    15.
    发明授权
    Cavity filling biopsy site markers 有权
    腔填充活检部位标记

    公开(公告)号：US08965486B2

    公开(公告)日：2015-02-24

    申请号：US14099352

    申请日：2013-12-06

    申请人： SenoRx, Inc.

    发明人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones

    IPC分类号： A61B8/00 ,  A61B8/14 ,  A61B8/08 ,  A61B8/12 ,  A61B19/00 ,  A61K49/00 ,  A61K49/22 ,  A61M37/00 ,  A61B6/12 ,  A61B10/02 ,  A61B17/00

    CPC分类号： A61B8/481 ,  A61B6/12 ,  A61B8/0833 ,  A61B10/02 ,  A61B90/39 ,  A61B2017/00004 ,  A61B2090/3908 ,  A61B2090/392 ,  A61B2090/3925 ,  A61B2090/395 ,  A61B2090/3954 ,  A61B2090/3966 ,  A61B2090/3987 ,  A61B2090/3995 ,  A61K49/006 ,  A61K49/222 ,  A61M37/0069

    摘要： The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome® or SenoCor 360™ cannula.

    摘要翻译： 本发明提供用于在有限时间内标记活检部位的材料，装置和方法。 活检标记材料是可超声检测的生物可再吸收粉末，粉末颗粒通常在最大尺寸为约20微米至约800微米之间，更优选为约300微米至约500微米。 粉末可以由含有大约10微米至约500微米的空腔的聚合材料形成，并且还可以含有粘合剂，麻醉剂，止血剂和不透射线的标记物。 用于递送粉末的装置包括被配置为容纳粉末并且装配在活检插管内的管，粉末通过注射器的作用喷射。 系统可以包括含有粉末的管和含有无菌盐水的注射器。 管可以被配置成装配在活检插管内，例如Mammotome或SenoCor 360 TM插管。

    TISSUE SITE MARKERS FOR IN VIVO IMAGING
    16.
    发明申请
    TISSUE SITE MARKERS FOR IN VIVO IMAGING 审中-公开
    组织网站标记在VIVO成像

    公开(公告)号：US20140243675A1

    公开(公告)日：2014-08-28

    申请号：US14268373

    申请日：2014-05-02

    申请人： SenoRX, Inc.

    发明人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones ,  Richard L. Quick ,  Frank R. Louw ,  Stephen A. DeSantis

    IPC分类号： A61B19/00

    CPC分类号： A61B90/39 ,  A61B6/12 ,  A61B8/0833 ,  A61B2090/08021 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3987 ,  A61B2090/3991 ,  A61M37/0069

    摘要： The invention is directed biopsy site markers and methods of marking a biopsy site, so that the location of the biopsy cavity is readily visible by conventional imaging methods, particularly by ultrasonic imaging. The biopsy site markers of the invention have high ultrasound reflectivity, presenting a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The several disclosed embodiments of the biopsy site marker of the invention have a high contrast of acoustic impedance as placed in a tissue site, so as to efficiently reflect and scatter ultrasonic energy, and preferably include gas-filled internal pores. The markers may have a non-uniform surface contour to enhance the acoustic signature. The markers have a characteristic form which is recognizably artificial during medical imaging. The biopsy site marker may be accurately fixed to the biopsy site so as to resist migration from the biopsy cavity when a placement instrument is withdrawn, and when the marked tissue is subsequently moved or manipulated.

    摘要翻译： 本发明是针对活检部位标记和标记活检部位的方法，使得活检腔的位置通过常规成像方法，特别是通过超声成像容易看到。 本发明的活检部位标记物具有高的超声反射率，从小标记物呈现出实质的声学特征，以避免在随后的成像研究中掩盖诊断组织特征，并且可以容易地与生物特征区别开来。 本发明的活检部位标记物的几个公开的实施方案具有放置在组织部位中的声阻抗的高对比度，以便有效地反射和散射超声能量，并且优选地包括气体填充的内部孔。 标记可以具有不均匀的表面轮廓以增强声学特征。 标记具有在医学成像期间可识别人造的特征形式。 可以将活检部位标记物精确地固定到活检部位，以便当放置放置器械被取出时以及随后标记的组织被移动或操纵时抵抗从活检腔的迁移。