公开(公告)号：US08031945B2

公开(公告)日：2011-10-04

申请号：US11954781

申请日：2007-12-12

申请人： Shinichiro Gomi ,  Yusuke Nakamura ,  Masami Ogata

发明人： Shinichiro Gomi ,  Yusuke Nakamura ,  Masami Ogata

IPC分类号： G06K9/48

CPC分类号： G06T5/002 ,  G06T7/13 ,  G06T2207/20021 ,  G06T2207/20192

摘要： An image-processing device including a pulverization-core unit configured to divide input-image data into blocks, generate basic blocks by reducing each of the blocks in size, and arrange the basic blocks into the blocks so that processed-image data including at least one noise particle of the input-image data is generated, where the noise particle included in the processed-image data is reduced in size, an edge-detection unit configured to detect an edge degree from the input-image data, and an edge-blend unit configured to subject a pixel value of the input-image data and a pixel value of the processed-image data to load addition and output output-image data based on the detection result so that a weight to the pixel value of the input-image data increases as the edge degree increases is provided.

摘要翻译： 一种图像处理装置，包括被配置为将输入图像数据划分成块的粉碎核心单元，通过减小每个块的大小来生成基本块，并且将基本块排列成块，使得处理图像数据至少包括 产生输入图像数据的一个噪声粒子，其中包括在处理图像数据中的噪声粒子的尺寸减小，被配置为从输入图像数据检测边缘度的边缘检测单元， 混合单元，其被配置为对所述输入图像数据的像素值和所述经处理图像数据的像素值进行加载，并且基于所述检测结果来输出输出图像数据，使得对所述输入图像数据的像素值进行加权， 当提供边缘度增加时，图像数据增加。

公开(公告)号：US20100201783A1

公开(公告)日：2010-08-12

申请号：US12671367

申请日：2009-06-02

申请人： Kazuhiko Ueda ,  Masami Ogata ,  Yasunari Hatasawa ,  Shinichiro Gomi ,  Yusuke Nakamura

发明人： Kazuhiko Ueda ,  Masami Ogata ,  Yasunari Hatasawa ,  Shinichiro Gomi ,  Yusuke Nakamura

IPC分类号： G06K9/00

CPC分类号： G02B27/2228 ,  G06T15/20 ,  H04N13/302 ,  H04N13/363 ,  H04N13/373

摘要： Influences of physiological stereoscopic elements are removed by image processing using projection transformation. A horopter-plane image projection unit 311 is designed to project a non-stereo image supplied via a signal line 129 onto a cylindrical plane (horopter plane) including a horopter circle. The size of the horopter circle is specified using, for example, the radius as horopter circle information. Additionally, the relationship with two eyes is specified by the interocular distance. A display surface right-eye projection unit 316 is designed to project an image projected on the horopter plane onto a display surface for the right eye. A display surface left-eye projection unit 317 is designed to project the image projected on the horopter plane onto a display surface for the left eye. Therefore, retinal images that are identical to each other are supplied to the two eyes to remove influences of physiological stereoscopic elements, and stereoscopic depth is given.

摘要翻译： 通过使用投影变换的图像处理去除生理立体元素的影响。 双平面图像投影单元311被设计成将经由信号线129提供的非立体声图像投影到包括双眼立方圆的圆柱面（双眼飞机平面）上。 使用例如半径作为双眼圆圈信息来指定双眼轮的大小。 另外，两只眼睛之间的关系由眼间距离指定。 显示表面右眼投影单元316被设计成将投影在双眼器飞机上的图像投影到用于右眼的显示表面上。 显示表面左眼投影单元317被设计成将投影在双眼器平面上的图像投影到用于左眼的显示表面上。 因此，将彼此相同的视网膜图像提供给两只眼睛以去除生理立体元件的影响，并给出立体深度。

公开(公告)号：US08265417B2

公开(公告)日：2012-09-11

申请号：US12252559

申请日：2008-10-16

申请人： Yusuke Nakamura ,  Shinichiro Gomi ,  Masami Ogata

发明人： Yusuke Nakamura ,  Shinichiro Gomi ,  Masami Ogata

IPC分类号： G06K9/40 ,  H04N9/74

CPC分类号： G06T5/10 ,  G06T5/007 ,  G06T7/13 ,  G06T7/40

摘要： An image processing apparatus processes an input image while also considering the luminous intensity information thereof, and thereby generates an output image wherein the apparent object surface roughness has been enhanced with respect to the input image. The image processing apparatus includes a luminous intensity information separator that separates the input image information into global luminous intensity information and local luminous intensity information, a shadow component generator that generates a shadow component of the image on the basis of the local luminous intensity information, and an image compositor that generates an output image by adding shadow image information to the input image information, with the shadow image information being generated from the shadow component and from a value based on the input image information.

摘要翻译： 图像处理装置在考虑其输出图像的同时考虑其输入图像，并且产生相对于输入图像增强了表观物体表面粗糙度的输出图像。 该图像处理装置包括将输入图像信息分离为全局发光强度信息和局部发光强度信息的发光强度信息分离器，基于局部发光强度信息生成图像的阴影分量的阴影分量发生器，以及 图像合成器，其通过将阴影图像信息添加到输入图像信息，并且从阴影分量生成阴影图像信息和基于输入图像信息的值来生成输出图像。

公开(公告)号：US09507165B2

公开(公告)日：2016-11-29

申请号：US12671367

申请日：2009-06-02

申请人： Kazuhiko Ueda ,  Masami Ogata ,  Yasunari Hatasawa ,  Shinichiro Gomi ,  Yusuke Nakamura

发明人： Kazuhiko Ueda ,  Masami Ogata ,  Yasunari Hatasawa ,  Shinichiro Gomi ,  Yusuke Nakamura

IPC分类号： H04N13/02 ,  G02B27/22 ,  G06T15/20 ,  H04N13/04

CPC分类号： G02B27/2228 ,  G06T15/20 ,  H04N13/302 ,  H04N13/363 ,  H04N13/373

摘要： Influences of physiological stereoscopic elements are removed by image processing using projection transformation. A horopter-plane image projection unit 311 is designed to project a non-stereo image supplied via a signal line 129 onto a cylindrical plane (horopter plane) including a horopter circle. The size of the horopter circle is specified using, for example, the radius as horopter circle information. Additionally, the relationship with two eyes is specified by the interocular distance. A display surface right-eye projection unit 316 is designed to project an image projected on the horopter plane onto a display surface for the right eye. A display surface left-eye projection unit 317 is designed to project the image projected on the horopter plane onto a display surface for the left eye. Therefore, retinal images that are identical to each other are supplied to the two eyes to remove influences of physiological stereoscopic elements, and stereoscopic depth is given.

摘要翻译： 通过使用投影变换的图像处理去除生理立体元素的影响。 双平面图像投影单元311被设计成将经由信号线129提供的非立体声图像投影到包括双眼立方圆的圆柱面（双眼飞机平面）上。 使用例如半径作为双眼圆圈信息来指定双眼轮的大小。 另外，两只眼睛之间的关系由眼间距离指定。 显示表面右眼投影单元316被设计成将投影在双眼器飞机上的图像投影到用于右眼的显示表面上。 显示表面左眼投影单元317被设计成将投影在双眼器平面上的图像投影到用于左眼的显示表面上。 因此，将彼此相同的视网膜图像提供给两只眼睛以去除生理立体元件的影响，并给出立体深度。

公开(公告)号：US08565491B2

公开(公告)日：2013-10-22

申请号：US13036228

申请日：2011-02-28

申请人： Yusuke Nakamura ,  Shinichiro Gomi

发明人： Yusuke Nakamura ,  Shinichiro Gomi

IPC分类号： G06K9/00 ,  H04N7/14 ,  G01N37/00

CPC分类号： H04N17/002 ,  G06T7/0002 ,  G06T2207/30168

摘要： An apparatus for evaluating the quality of an input image is disclosed. The apparatus may include a composition pattern selection unit configured to select a composition pattern based on an attribute of the input image. The apparatus may also include a composition evaluation unit configured to evaluate the input image based on the composition pattern and the attribute. Additionally, the apparatus may include an evaluation result output unit configured to output to a display the input image and an indication of a result of the evaluation.

摘要翻译： 公开了一种用于评估输入图像的质量的装置。 该装置可以包括配置图案选择单元，其被配置为基于输入图像的属性来选择合成图案。 该装置还可以包括被配置为基于构图模式和属性来评估输入图像的构图评估单元。 此外，该装置可以包括评估结果输出单元，其被配置为向显示器输出输入图像和评估结果的指示。

公开(公告)号：US20120300996A1

公开(公告)日：2012-11-29

申请号：US13462949

申请日：2012-05-03

申请人： Yusuke Nakamura ,  Shinichiro Gomi

发明人： Yusuke Nakamura ,  Shinichiro Gomi

IPC分类号： G06K9/46

CPC分类号： G06K9/52 ,  A61B5/441 ,  G06K9/0014 ,  G06K9/46 ,  G06K2009/4666 ,  G06T7/0012 ,  G06T7/0014 ,  G06T7/40 ,  G06T2207/30088

摘要： An epidermis pattern detection unit detects epidermis patterns in an epidermis image captured from the epidermis of skin by an epidermis image capturing unit. An acquired element analysis unit analyzes uniformity of shapes of the epidermis patterns in the epidermis image. A texture evaluation unit evaluates a texture state of the skin based on the uniformity of shapes of the epidermis patterns. The present technology, for example, may be applied to systems that evaluate the texture state of the skin.

摘要翻译： 表皮图案检测单元通过表皮图像捕获单元检测从皮肤表皮捕获的表皮图像中的表皮图案。 获得性元素分析单元分析表皮形态中表皮形态的均匀性。 纹理评估单元基于表皮图案的形状的均匀性来评估皮肤的纹理状态。 例如，本技术可以应用于评估皮肤纹理状态的系统。

公开(公告)号：US09187556B2

公开(公告)日：2015-11-17

申请号：US14118693

申请日：2012-06-07

申请人： Takuya Tsunoda ,  Ryuji Osawa ,  Sachiko Yoshimura ,  Tomohisa Watanabe ,  Gaku Nakayama ,  Yusuke Nakamura

发明人： Takuya Tsunoda ,  Ryuji Osawa ,  Sachiko Yoshimura ,  Tomohisa Watanabe ,  Gaku Nakayama ,  Yusuke Nakamura

IPC分类号： C07K14/00 ,  C07K16/18 ,  C07K14/47 ,  G01N33/574 ,  A61K39/00 ,  A61K38/00

CPC分类号： C07K16/18 ,  A61K38/00 ,  A61K39/0011 ,  C07K14/4703 ,  G01N33/57492 ,  G01N2333/70539

摘要： As discussed in detail herein, isolated epitope peptides derived from SEMA5B bind to an HLA antigen and induce cytotoxic T lymphocytes (CTL) and thus are suitable for use in the context of cancer immunotherapy, more particularly cancer vaccines. The inventive peptides encompass both the above mentioned amino acid sequences and modified versions thereof, in which one, two, or several amino acids are substituted, deleted, inserted or added, provided such modified versions retain the requisite HLA binding and/or CTL inducibility of the original sequences. Further provided are polynucleotides encoding any of the aforementioned peptides as well pharmaceutical agents or compositions that include any of the aforementioned peptides or polynucleotides. The peptides, polynucleotides, pharmaceutical agents or compositions of this invention find particular utility in the treatment and/or prevention of cancers and tumors, including, for example, esophageal cancer, NSCLC, RCC and SCLC.

摘要翻译： 如本文详细讨论的，衍生自SEMA5B的分离的表位肽结合HLA抗原并诱导细胞毒性T淋巴细胞（CTL），因此适合用于癌症免疫治疗，尤其是癌症疫苗的上下文中。 本发明的肽包括上述氨基酸序列及其修饰形式，其中一个，两个或若干个氨基酸被取代，缺失，插入或添加，只要这些修饰版本保持必需的HLA结合和/或CTL诱导性 原始序列。 还提供了编码任何上述肽的多核苷酸以及包括任何上述肽或多核苷酸的药物试剂或组合物。 本发明的肽，多核苷酸，药物或组合物特别用于治疗和/或预防癌症和肿瘤，包括例如食管癌，NSCLC，RCC和SCLC。

公开(公告)号：US09045557B2

公开(公告)日：2015-06-02

申请号：US13256580

申请日：2010-03-15

申请人： Takuya Tsunoda ,  Ryuji Ohsawa ,  Sachiko Yoshimura ,  Tomohisa Watanabe ,  Yusuke Nakamura ,  Yoichi Furukawa

发明人： Takuya Tsunoda ,  Ryuji Ohsawa ,  Sachiko Yoshimura ,  Tomohisa Watanabe ,  Yusuke Nakamura ,  Yoichi Furukawa

IPC分类号： A61K38/00 ,  C07K14/47 ,  A61K39/00

CPC分类号： C07K14/4748 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/572 ,  C12N9/88 ,  C12Y402/99018 ,  Y02A50/396

摘要： The present invention provides isolated peptides or the fragments derived from SEQ ID NO: 45, which bind to an HLA antigen and induce cytotoxic T lymphocytes (CTL). The peptides may include the above mentioned amino acid sequence with substitution deletion, or addition of one, two, or several amino acids sequences. The invention also provides pharmaceutical compositions including these peptides. The peptides of this invention can be used for diagnosing or treating cancer.

摘要翻译： 本发明提供分离的肽或衍生自SEQ ID NO：45的片段，其结合HLA抗原并诱导细胞毒性T淋巴细胞（CTL）。 肽可以包括具有取代缺失的上述氨基酸序列，或加入一个，两个或几个氨基酸序列。 本发明还提供了包括这些肽的药物组合物。 本发明的肽可用于诊断或治疗癌症。

公开(公告)号：US08951975B2

公开(公告)日：2015-02-10

申请号：US13638272

申请日：2011-03-30

申请人： Yusuke Nakamura ,  Takuya Tsunoda ,  Ryuji Ohsawa ,  Sachiko Yoshimura ,  Tomohisa Watanabe

发明人： Yusuke Nakamura ,  Takuya Tsunoda ,  Ryuji Ohsawa ,  Sachiko Yoshimura ,  Tomohisa Watanabe

IPC分类号： A61K38/08 ,  A61K38/10 ,  A61K38/00 ,  A61K38/04 ,  C07K7/06 ,  A61K39/00

CPC分类号： C07K7/06 ,  A61K39/0011 ,  A61K2039/572

摘要： Isolated peptides derived from SEQ ID NO: 42 and fragments thereof that bind to an HLA antigen and induce cytotoxic T lymphocytes (CTL) and thus are suitable for use in the context of cancer immunotherapy, more particularly cancer vaccines, are described herein. The inventive peptides encompass both the afore-mentioned amino acid sequences and modified versions thereof, in which one, two, or several amino acids are substituted, deleted, inserted or added, provided such modified versions retain the requisite HLA binding and/or CTL inducibility of the original sequences. Further provided are nucleic acids encoding any of the aforementioned peptides as well as pharmaceutical agents, substances and/or compositions that include or incorporate any of the aforementioned peptides or nucleic acids. The peptides, nucleic acids, pharmaceutical agents, substances and compositions of this invention find particular utility in the treatment of cancers and tumors, including, for example, bladder cancer, breast cancer, cervical cancer, cholangiocellular carcinoma, CML, colorectal cancer, esophageal cancer, NSCLC, lymphoma, pancreatic cancer, prostate cancer, renal carcinoma and SCLC.

摘要翻译： 衍生自SEQ ID NO：42的分离的肽及其与HLA抗原结合并诱导细胞毒性T淋巴细胞（CTL）的片段，因此适用于癌症免疫治疗，特别是癌症疫苗的上下文中。 本发明的肽包括上述氨基酸序列及其修饰形式，其中一个，两个或几个氨基酸被取代，缺失，插入或添加，只要这些修饰版本保留所需的HLA结合和/或CTL诱导性 的原始序列。 还提供了编码任何前述肽的核酸以及包括或掺入任何前述肽或核酸的药物，物质和/或组合物。 本发明的肽，核酸，药物，物质和组合物在治疗癌症和肿瘤方面特别有用，包​​括例如膀胱癌，乳腺癌，子宫颈癌，胆管细胞癌，CML，结肠直肠癌，食管癌 ，NSCLC，淋巴瘤，胰腺癌，前列腺癌，肾癌和SCLC。

公开(公告)号：US08828712B2

公开(公告)日：2014-09-09

申请号：US12452345

申请日：2008-06-27

申请人： Masahiko Amano ,  Masaaki Chino ,  Hiroyuki Kuroki ,  Makiko Dejima ,  Tomoyuki Ozawa ,  Eiji Kawata ,  Ryoko Imagawa ,  Shuichi Akashi ,  Yusuke Nakamura ,  Eiji Yamamoto ,  Katsuhiro Tomaru ,  Hajime Mogi

发明人： Masahiko Amano ,  Masaaki Chino ,  Hiroyuki Kuroki ,  Makiko Dejima ,  Tomoyuki Ozawa ,  Eiji Kawata ,  Ryoko Imagawa ,  Shuichi Akashi ,  Yusuke Nakamura ,  Eiji Yamamoto ,  Katsuhiro Tomaru ,  Hajime Mogi

IPC分类号： C12M1/00 ,  C12M1/34 ,  C12M1/36 ,  C12M1/38 ,  C12M3/00 ,  B01L7/00 ,  B01L3/00 ,  G01N35/02 ,  G01N35/00

CPC分类号： B01L7/52 ,  B01L3/505 ,  B01L3/50851 ,  B01L7/5255 ,  B01L2200/0642 ,  B01L2300/0829 ,  B01L2300/123 ,  G01N35/026 ,  G01N2035/00346 ,  H01L2924/0002 ,  H01L2924/00

摘要： A genetic detection and determination apparatus which detects or determines genetic information, provided with a reaction container having a reaction vessel, including: a container set portion on which the reaction container is set; a moving mechanism which moves the container set portion along a track; a reaction vessel dividing portion which divides the reaction vessel into a plurality of reaction chambers by deforming the reaction vessel; a heating and cooling portion which heats and cools the reaction container; and a measuring portion which is movable above the container set portion in parallel to an upper surface of the reaction container provided on the container set portion and which measures a reaction within each of the reaction chambers.

摘要翻译： 一种检测或确定遗传信息的遗传检测和确定装置，其具有包括反应容器的反应容器，包括：设置反应容器的容器组合部分; 移动机构，其沿着轨道移动容器设定部; 反应容器分隔部，其通过使反应容器变形而将反应容器分割成多个反应室; 加热和冷却反应容器的加热和冷却部分; 以及测量部分，其在容器设置部分上方平行于设置在容器组部分上的反应容器的上表面上移动并且测量每个反应室内的反应。