公开(公告)号：US20100204062A1

公开(公告)日：2010-08-12

申请号：US12614239

申请日：2009-11-06

申请人： Mark Thompson ,  Richard Roberts ,  Richard Cote ,  Chongwu Zhou

发明人： Mark Thompson ,  Richard Roberts ,  Richard Cote ,  Chongwu Zhou

IPC分类号： C40B40/06 ,  C40B40/10 ,  G01N35/00

CPC分类号： B82Y15/00 ,  B82Y35/00 ,  G01N27/4146 ,  G01N33/54373 ,  G01N35/00693

摘要： The present invention relates to the calibration of devices using a secondary binding agent or reference material. In one embodiment, the present invention provides a method of calibrating a nanosensor by providing a nanosensor comprising an analyte binder attached to a reference binder, extracting a calibration curve from binding a reference material to the reference binder, and calibrating the nanosensor by using the calibration curve to correct for device variation.

摘要翻译： 本发明涉及使用二次结合剂或参考物质的装置的校准。 在一个实施方案中，本发明提供了一种校准纳米传感器的方法，该方法通过提供纳米传感器，该纳米传感器包括附着于参考粘合剂的分析物粘合剂，从校正曲线结合参考物质到参考粘合剂，以及通过使用校准来校准纳米传感器 曲线以校正设备变化。

公开(公告)号：USD596754S1

公开(公告)日：2009-07-21

申请号：US29284849

申请日：2007-09-17

申请人： Richard Cote ,  Gary E. Nelson ,  Gregory Mathus ,  George Kalmakis ,  Laurence Keene ,  Samuel Millen ,  David E. Roche

设计人： Richard Cote ,  Gary E. Nelson ,  Gregory Mathus ,  George Kalmakis ,  Laurence Keene ,  Samuel Millen ,  David E. Roche

公开(公告)号：US20080285763A1

公开(公告)日：2008-11-20

申请号：US10588987

申请日：2004-12-06

申请人： Richard Cote ,  Simon Roy

发明人： Richard Cote ,  Simon Roy

IPC分类号： H04R5/00

CPC分类号： H04S3/00

摘要： To increase the stereophonic potential of an ordinary stereo source, a device (20) eliminates the common signals from a stereo source. The device is installed in relation to four loudspeakers, two primary (38, 40) and two secondary (42, 44), and it includes a stereo input (34, 36) and an electric circuit that links the two secondary loudspeakers. The primary loudspeakers reproduce unaltered stereo signals and the secondary loudspeakers reproduce altered signals where (by hand: when) the circuit has eliminated the common signals from the two channels of the primary stereo source. Since all “mono” components of the sound [by hand: same amplitude, same frequency] have been eliminated from the secondary outputs, we obtain a “purely stereo” source. An additional channel (45) can be added in order to reproduce the common components of the stereo source.

摘要翻译： 为了增加普通立体声源的立体声电位，设备（20）消除了来自立体声源的公共信号。 该装置相对于四个扬声器，两个主要（38,40）和两个次要（42,44）安装，并且其包括立体声输入（3​​4,36）和连接两个二次扬声器的电路。 主扬声器再现未改变的立体声信号，次级扬声器再​​现改变的信号，其中（手动：何时）电路已经消除了来自主立体声源的两个声道的公共信号。 由于二次输出中已经消除了声音[手动相同的幅度，相同频率]的所有“单声道”分量，所以我们获得了一个“纯立体声”源。 可以添加附加通道（45）以便再现立体声源的公共部件。

公开(公告)号：US20050262951A1

公开(公告)日：2005-12-01

申请号：US10855690

申请日：2004-05-27

申请人： Richard Cote

发明人： Richard Cote

IPC分类号： B01L3/02 ,  G01N1/00

CPC分类号： B01L3/0224 ,  B01L2300/027

摘要： A hand-held pipette includes a piston driven by an actuator assembly contained within a housing having first and second mutually spaced non-adjustable stops. The actuator assembly is subdivided into first and second sections respectively provided with first and second contact surfaces. The actuator assembly is arranged to reciprocate between a rest position at which the first contact surface is in contact with the first stop and the second contact surface is spaced from the second stop by a control distance, and an advanced position at which the second contact surface is in contact with the second stop and the first contact surface is spaced from the first stop, with the stroke of the actuator assembly and the stroke of the piston being equal to the control distance. A motor-driven mechanism is arranged to displace one section of the actuator assembly relative to the other section, resulting in a corresponding change to both the overall length of the actuator assembly and the control distance.

摘要翻译： 手持移液器包括由容纳在具有第一和第二相互间隔的不可调节止挡件的壳体内的致动器组件驱动的活塞。 致动器组件被细分为分别具有第一和第二接触表面的第一和第二部分。 所述致动器组件布置成在所述第一接触表面与所述第一止动件接触的静止位置和所述第二接触表面与所述第二止动件间隔一个控制距离之间往复运动，并且所述第二接触表面 与第二止动件接触，并且第一接触表面与第一止动件间隔开，致动器组件的行程和活塞的行程等于控制距离。 电机驱动机构布置成相对于另一部分移动致动器组件的一部分，导致致动器组件的总长度和控制距离的相应变化。

公开(公告)号：US20050158214A1

公开(公告)日：2005-07-21

申请号：US11081395

申请日：2005-03-16

申请人： Richard Cote ,  Robert Zier

发明人： Richard Cote ,  Robert Zier

IPC分类号： G01N1/00 ,  B01L3/02 ,  G10L15/00 ,  G10L15/26

CPC分类号： B01L3/0224 ,  B01L3/0227 ,  B01L3/0279 ,  G10L15/26

摘要： A hand-held pipettor comprising a piston received in one end of a cylinder, a pipettor tip removably secured to an opposite end of said cylinder, means for reciprocating said piston through a selected stroke to aspirate fluid into and to expel the thus aspirated fluid from said pipettor tip, mutually spaced stop members operatively associated with said manually driven means for defining the range of said stroke and motor driven means for varying the spacing between said stop members to thereby vary the volume of fluid being aspirated into and expelled from said pipettor tip.

摘要翻译： 一种手持移液器，包括容纳在气缸的一端的活塞，可移除地固定到所述气缸的相对端的移液器吸头，用于使所述活塞通过选定行程往复运动的装置，以将流体吸入并排出由此吸出的流体 所述移液器末端，与所述手动驱动装置可操作地相关联的相互间隔开的止动构件，用于限定所述冲程和马达驱动装置的范围，用于改变所述止动构件之间的间隔，从而改变被吸入和从所述移液器吸头排出的流体体积 。

公开(公告)号：US08501118B2

公开(公告)日：2013-08-06

申请号：US12578714

申请日：2009-10-14

申请人： Gregory Mathus ,  Terrence Kelly ,  Richard Cote

发明人： Gregory Mathus ,  Terrence Kelly ,  Richard Cote

IPC分类号： B01L3/02

CPC分类号： B01L3/0217 ,  B01L3/0275 ,  B01L3/0279 ,  B01L2200/023 ,  B01L2200/025 ,  B01L2200/0689 ,  B01L2200/087 ,  B01L2300/027 ,  Y10T137/0318 ,  Y10T436/2575

摘要： A disposable pipette tip having that is configured to mount on a tip mounting shaft having a locking section and a separate sealing section. The locking section has outwardly extending locking lobes circumferentially spaced around the mounting shaft and located above a stop member that separates the lower sealing section from the upper locking section. The collar flexes out of round when it is mounted over the locking lobes on the mounting shaft. The circumferential shelf on the tip isolates the tip barrel from distortion to enable robust sealing in the barrel below the shelf.

摘要翻译： 具有该移液管尖头的一次性移液管尖端配置成安装在具有锁定部分和单独的密封部分的尖端安装轴上。 锁定部分具有沿安装轴周向间隔开的向外延伸的锁定凸角，并且位于将下部密封部分与上部锁定部分分离的止挡部件上方。 当套环安装在安装轴上的锁定凸角上时，套环会弹出。 尖端的圆周架子将尖端筒体分离，以防止变形，从而能够在机架下方的筒体上牢固地密封。

公开(公告)号：US08372356B2

公开(公告)日：2013-02-12

申请号：US13099782

申请日：2011-05-03

申请人： Julian Warhurst ,  Gary Nelson ,  Richard Cote

发明人： Julian Warhurst ,  Gary Nelson ,  Richard Cote

IPC分类号： B01L3/02

CPC分类号： B01L3/0227 ,  B01L3/0234 ,  B01L3/0237 ,  B01L9/523 ,  B01L2200/087 ,  B01L2200/146 ,  B01L2300/027 ,  B01L2300/06 ,  B01L2300/0829 ,  B01L2400/0478

摘要： A manually directed, multi-channel electronic pipetting system is designed to transfer liquids from a standard multi-well plate, deep-well plate or reservoir into another multi-well plate. The preferred pipetting head includes an array of 96-tip fittings. A deck with at least one but preferably two or more wellplate nesting receptacles holds one or more multi-well plates or reagent reservoirs for access by an array of disposable pipette tips mounted to the pipetting head. The electronic motion control system includes a control handle that is mounted to a load cell, the carriage for the pipetting head and is held in the palm of the user. In use, the user grasps the control handle and operates the system in a manner similar to one using a handheld electronic pipettor.

摘要翻译： 手动导向的多通道电子移液系统被设计成将液体从标准的多孔板，深井板或储存器转移到另一个多孔板中。 优选的移液头包括96针头配件的阵列。 具有至少一个但优选两个或更多个孔板嵌套容器的甲板容纳一个或多个多孔板或试剂储存器，用于通过安装到移液头的一次性吸头的阵列进入。 电子运动控制系统包括安装到称重传感器的控制手柄，用于移液头的托架并保持在使用者手掌中。 在使用中，用户抓住控制手柄并以类似于使用手持电子移液器的方式操作系统。

公开(公告)号：US08029742B2

公开(公告)日：2011-10-04

申请号：US12115005

申请日：2008-05-05

申请人： David E. Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

发明人： David E. Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

IPC分类号： B01L3/00 ,  B01L3/02

CPC分类号： B01L3/0237 ,  B01L3/0217 ,  B01L3/0227 ,  B01L2200/022

摘要： A hand-held, multi-channel pipettor has an electronically controlled motor to reposition pipette tips for different center to center spacing. Each repositionable tip fitting assembly has a cam following pin that is driven by cam tracks in a motor driven roller drum. Stationary ports for the multiple aspiration cylinders are strategically placed to simplify management of flexible tubes leading to the repositionable pipette tip fitting assemblies. The pipettor has a user interface that can be operated conveniently by one hand to reposition pipette tips. It has a pipette tip ejection mechanism with a sinusoidal stripper bar.

摘要翻译： 手持式多通道移液器具有电子控制电机，用于重新定位不同中心间距的吸头。 每个可重新定位的尖端配件组件具有凸轮跟随销，该凸轮跟随销由马达驱动滚筒中的凸轮轨道驱动。 用于多个抽吸气瓶的固定端口有策略地放置，以简化导向可重新定位的移液管尖端配件组件的柔性管的管理。 移液器具有可以用一只手方便地操作以重新定位移液器吸头的用户界面。 它具有带有正弦剥离器条的移液管尖端喷射机构。

公开(公告)号：US20110076205A1

公开(公告)日：2011-03-31

申请号：US12568801

申请日：2009-09-29

申请人： Terrence Kelly ,  Richard Cote ,  Gregory Mathus

发明人： Terrence Kelly ,  Richard Cote ,  Gregory Mathus

IPC分类号： B01L3/02

CPC分类号： B01L3/0279 ,  B01L3/021 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2400/0487

摘要： A pipette tip mounting shaft includes outwardly circumferentially extending locking lobes over which the pipette tip collar is mounted. The locking lobes preferably include an inclining ramp portion that gently flexes and distorts the pipette tip collar out-of-round as the mounting shaft is inserted into the pipette tip, rather than the stretching tip collar. Each locking lobe also includes a declining ramp portion which extends upward along the mounting shaft. The peak of the lobes is preferably curved. When the pipette tip is fully mounted on the mounting shaft, a locking ring on the inside surface of the tip collar engages the declining ramp of the lobes to provide an over-center engagement, however, the required ejection force is small.

摘要翻译： 移液管尖端安装轴包括向外周向延伸的锁定凸耳，移液管尖端套环安装在该凸起上。 锁定凸耳优选地包括倾斜斜面部分，当倾斜安装轴插入移液管尖端而不是拉伸尖端套环时，倾斜斜坡部分轻轻地弯曲和扭曲移液管尖端轴环。 每个锁定凸耳还包括沿安装轴向上延伸的下降斜面部分。 裂片的峰最好是弯曲的。 当移液管末端完全安装在安装轴上时，尖端套环的内表面上的锁定环接合凸角的下降斜面以提供过中心接合，然而，所需的弹出力很小。

公开(公告)号：US07662344B2

公开(公告)日：2010-02-16

申请号：US11934381

申请日：2007-11-02

申请人： Gregory Mathus ,  Terrence Kelly ,  Richard Cote

发明人： Gregory Mathus ,  Terrence Kelly ,  Richard Cote

IPC分类号： B01L3/02

CPC分类号： B01L3/0217 ,  B01L3/0275 ,  B01L3/0279 ,  B01L2200/023 ,  B01L2200/025 ,  B01L2200/0689 ,  B01L2200/087 ,  B01L2300/027 ,  Y10T137/0318 ,  Y10T436/2575

摘要： The invention relates to a pipette tip mounting shaft configuration and a disposable pipette tip having a matching configuration. The mounting shaft includes a locking section located above a lower sealing section. The locking section has outwardly extending locking lobes circumferentially spaced around the mounting shaft and located above a stop member that separates the lower sealing section from the upper locking section. In certain embodiments, the diameter of the mounting shaft below the stop member is reduced in order to lessen insertion and ejection forces, which is particularly helpful for hand-held multi-channel pipettors. In these embodiments, the lower sealing section contains either a frustoconical sealing section, or an annular groove and a sealing ring, such as a flouroelastomeric O-ring seal.

摘要翻译： 本发明涉及移液器吸头安装轴构造和具有匹配构型的一次性吸头。 安装轴包括位于下密封部分上方的锁定部分。 锁定部分具有沿安装轴周向间隔开的向外延伸的锁定凸角，并且位于将下部密封部分与上部锁定部分分离的止挡部件上方。 在某些实施例中，降低止动件下方的安装轴的直径以减小插入和弹出力，这对手持式多通道移液器特别有帮助。 在这些实施例中，下密封部分包含截头圆锥形密封部分或环形凹槽和密封环，例如光滑弹性O形环密封件。