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11.发明授权Ketoamides with cyclic P4'S as inhibitors of NS3 protease of hepatitis C virus 有权具有环状P4'S的酮酰胺作为丙型肝炎病毒NS3蛋白酶的抑制剂公开(公告)号：US07173057B2
公开(公告)日：2007-02-06
申请号：US11065647
申请日：2005-02-24
申请人： Kevin X. Chen , F. George Njoroge , Mousumi Sannigrahi , Latha G. Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane L. Bogen , Frank Bennett , Viyyoor M. Girijavallabhan
发明人： Kevin X. Chen , F. George Njoroge , Mousumi Sannigrahi , Latha G. Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane L. Bogen , Frank Bennett , Viyyoor M. Girijavallabhan
IPC分类号： A61K31/4035 , A61K31/403 , A61K31/407 , A61K31/454 , A61K31/5355 , A61K31/4725 , A61K31/4166 , C07D209/48 , C07D209/52 , C07D209/02 , C07D471/02 , C07D401/12 , C07D413/12 , C07D217/24 , C07D233/02 , C07D233/74
CPC分类号： C07K5/0202 , A61K31/40 , A61K38/00 , C07K5/0205 , C12Q1/707
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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12.发明授权Diaryl peptides as NS3-serine protease inhibitors of hepatitis C virus 失效二芳基肽作为丙型肝炎病毒的NS3-丝氨酸蛋白酶抑制剂公开(公告)号：US06911428B2
公开(公告)日：2005-06-28
申请号：US10013071
申请日：2001-12-10
申请人： Zhaoning Zhu , Zhong-Yue Sun , Srikanth Venkatraman , F. George Njoroge , Ashok Arasappan , Bruce A. Malcolm , Viyyoor M. Girijavallabhan , Raymond G. Lovey , Kevin X. Chen
发明人： Zhaoning Zhu , Zhong-Yue Sun , Srikanth Venkatraman , F. George Njoroge , Ashok Arasappan , Bruce A. Malcolm , Viyyoor M. Girijavallabhan , Raymond G. Lovey , Kevin X. Chen
IPC分类号： C12N9/99 , A61K31/7042 , A61K38/00 , A61K38/21 , A61K45/00 , A61P31/12 , A61P31/14 , A61P43/00 , C07K5/02 , C07K5/06 , C07K5/08 , C07K5/10 , C07K5/103 , C07K5/107 , C07K7/00 , C07K14/81 , A61K38/17 , A61K31/33 , C07K7/64
CPC分类号： C07K5/0202 , A61K38/00 , C07K14/811
摘要： The present invention is directed to certain diaryl amide compounds as NS3-Serine protease inhibitors of hepatitis C virus. A particularly preferred compound is of the formula:
摘要翻译： 本发明涉及某些二芳基酰胺化合物作为丙型肝炎病毒的NS3-丝氨酸蛋白酶抑制剂。 特别优选的化合物具有下式：
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公开(公告)号：US07442695B2
公开(公告)日：2008-10-28
申请号：US11769455
申请日：2007-06-27
CPC分类号： C07K5/0827 , C07K5/0205 , C07K5/0812
摘要： The present invention discloses novel depeptidized compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型脱肽化合物以及包含这些化合物的药物组合物及其用于治疗与HCV蛋白酶相关的病症的方法。
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14.发明授权公开(公告)号：US07425576B2
公开(公告)日：2008-09-16
申请号：US11644708
申请日：2006-12-21
申请人： Ashok Arasappan , F. George Njoroge , Angela I. Padilla-Acevedo , Kevin X. Chen , Frank Bennett , Mousumi Sannigrahi , Stephane L. Bogen , Srikanth Venkatraman , Edwin E. Jao , Anil K. Saksena , Viyyoor M. Girijavallabhan
发明人： Ashok Arasappan , F. George Njoroge , Angela I. Padilla-Acevedo , Kevin X. Chen , Frank Bennett , Mousumi Sannigrahi , Stephane L. Bogen , Srikanth Venkatraman , Edwin E. Jao , Anil K. Saksena , Viyyoor M. Girijavallabhan
IPC分类号： A61K31/401 , C07D207/08
CPC分类号： C07D209/52 , A61K38/00 , C07K5/0202 , C07K5/06034 , C07K5/06078 , C07K5/06191 , C07K5/0808 , C07K5/0827
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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公开(公告)号：US07423058B2
公开(公告)日：2008-09-09
申请号：US11645181
申请日：2006-12-21
申请人： Stephane L. Bogen , Weidong Pan , Sumei Ruan , Kevin X. Chen , Ashok Arasappan , Srikanth Venkatraman , Latha G. Nair , Mousumi Sannigrahi , Frank Bennett , Anil K. Saksena , F. George Njoroge , Viyyoor M. Girijavallabhan
发明人： Stephane L. Bogen , Weidong Pan , Sumei Ruan , Kevin X. Chen , Ashok Arasappan , Srikanth Venkatraman , Latha G. Nair , Mousumi Sannigrahi , Frank Bennett , Anil K. Saksena , F. George Njoroge , Viyyoor M. Girijavallabhan
IPC分类号： A61K31/401 , C07D207/08
CPC分类号： C07D209/52 , A61K38/00 , C07D209/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/0205 , C07K5/0808 , C07K5/0812 , C07K5/0827
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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16.发明授权公开(公告)号：US07186747B2
公开(公告)日：2007-03-06
申请号：US11065531
申请日：2005-02-24
申请人： Ashok Arasappan , F. George Njoroge , Angela I. Padilla-Acevedo , Kevin X. Chen , Frank Bennett , Mousumi Sannigrahi , Stephane L. Bogen , Srikanth Venkatraman , Edwin Jao , Anil K. Saksena , Viyyoor M. Girijavallabhan
发明人： Ashok Arasappan , F. George Njoroge , Angela I. Padilla-Acevedo , Kevin X. Chen , Frank Bennett , Mousumi Sannigrahi , Stephane L. Bogen , Srikanth Venkatraman , Edwin Jao , Anil K. Saksena , Viyyoor M. Girijavallabhan
IPC分类号： A61K31/401 , C07D207/08
CPC分类号： C07D209/52 , A61K38/00 , C07K5/0202 , C07K5/06034 , C07K5/06078 , C07K5/06191 , C07K5/0808 , C07K5/0827
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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公开(公告)号：US07253160B2
公开(公告)日：2007-08-07
申请号：US10993394
申请日：2004-11-19
CPC分类号： C07K5/0827 , C07K5/0205 , C07K5/0812
摘要： The present invention discloses novel depeptidized compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型脱肽化合物以及包含这些化合物的药物组合物及其用于治疗与HCV蛋白酶相关的病症的方法。
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18.发明授权Benzo(5,6)cycloheptapyridine cyclic ureas and lactams useful as farnesyl protein transferase inhibitors 失效苯并（5,6）环庚吡啶环脲和用作法呢基蛋白转移酶抑制剂的内酰胺
公开(公告)号：US5852034A
公开(公告)日：1998-12-22
申请号：US877399
申请日：1997-06-17
IPC分类号： A61K31/4545 , A61K31/506 , A61K31/513 , A61P35/00 , A61P43/00 , C07D401/14 , A61K31/44 , A61K31/445 , C07D401/04 , C07D403/04
CPC分类号： C07D401/14
摘要： Compounds of the following formula useful for inhibiting Ras function and therefore inhibiting or treating the abnormal growth of cells are disclosed: ##STR1## or a pharmaceutically acceptable salt or solvate thereof, wherein: R and R.sup.2 are halo; R.sup.1 and R.sup.3 are H and halo, provided that at least one is H; W is N, CH or C when the double bond is present at the C-11 position; R.sup.4 is --(CH.sub.2).sub.n --R.sup.5 or ##STR2## R.sup.5 is ##STR3## R.sup.6 is R.sup.5 or ##STR4## Z.sup.1 and Z.sup.2 are independently selected from the group consisting of .dbd.O and .dbd.S; n is 1-6; and n.sub.1 is 0 or 1.
摘要翻译： 公开了可用于抑制Ras功能并因此抑制或治疗细胞异常生长的下式的化合物：或其溶剂合物，其中：R和R 2为卤素; R1和R3是H和卤素，条件是至少一个是H; 当双键存在于C-11位置时，W是N，CH或C; R 4是 - （CH 2）n -R 5或者R 5是R 6是R 5或Z 1，Z 2独立地选自= O和= S; n为1-6; n1为0或1。
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公开(公告)号：US07342016B2
公开(公告)日：2008-03-11
申请号：US10325896
申请日：2002-12-19
申请人： Hugh Y. Zhu , F. George Njoroge , Alan B. Cooper , Timothy J. Guzi , Dinanath F. Rane , Keith P. Minor , Ronald J. Doll , Viyyoor M. Girijavallabhan , Bama Santhanam , Patrick A. Pinto , Bancha Vibulbhan , Kartik M. Keertikar , Carmen S. Alvarez , John J. Baldwin , Ge Li , Chia-Yu Huang , Ray A. James , James J-S Wang , Jagdish A. Desai
发明人： Hugh Y. Zhu , F. George Njoroge , Alan B. Cooper , Timothy J. Guzi , Dinanath F. Rane , Keith P. Minor , Ronald J. Doll , Viyyoor M. Girijavallabhan , Bama Santhanam , Patrick A. Pinto , Bancha Vibulbhan , Kartik M. Keertikar , Carmen S. Alvarez , John J. Baldwin , Ge Li , Chia-Yu Huang , Ray A. James , James J-S Wang , Jagdish A. Desai
IPC分类号： A61K31/497 , A61K31/44 , C07D401/14 , C07D221/06
CPC分类号： C07D231/12 , C07D221/16 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/14
摘要： Disclosed are novel tricyclic compounds represented by the formula (1.0): and a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising compounds of formula 1.0. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
摘要翻译： 公开了由式（1.0）表示的新型三环化合物及其药学上可接受的盐或溶剂化物。 该化合物可用于抑制法呢基蛋白转移酶。 还公开了包含式1.0化合物的药物组合物。 还公开了使用式1.0化合物治疗癌症的方法。
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20.发明授权Benzo(5,6)cycloheptapyridine cyclic ureas and lactams useful as farnesyl protein transferase inhibitors 失效苯并（5,6）环庚吡啶环脲和用作法呢基蛋白转移酶抑制剂的内酰胺
公开(公告)号：US6039683A
公开(公告)日：2000-03-21
申请号：US162839
申请日：1998-09-29
IPC分类号： A61K31/4545 , A61K31/506 , A61K31/513 , A61P35/00 , A61P43/00 , C07D401/14 , A61K31/445 , A61K31/505 , C07D239/04 , C07D403/14
CPC分类号： C07D401/14
摘要： Compounds of the following formula useful for inhibiting Ras function and therefore inhibiting or treating the abnormal growth of cells are disclosed: ##STR1## or a pharmaceutically acceptable salt or solvate thereof, wherein: R and R.sup.2 are halo;R.sup.1 and R.sup.3 are H and halo, provided that at least one is H;W is N, CH or C when the double bond is present at the C-11 position;R.sup.4 is --(CH.sub.2).sub.n --R.sup.5 or ##STR2## R.sup.5 is ##STR3## R.sup.6 is R.sup.5 or ##STR4## Z.sup.1 and Z.sup.2 are independently selected from the group consisting of .dbd.O and .dbd.S;n is 1-6; andn.sub.1 is 0 or 1.
摘要翻译： 公开了可用于抑制Ras功能并因此抑制或治疗细胞异常生长的下式的化合物：或其药学上可接受的盐或溶剂合物，其中：R和R 2为卤素; R1和R3是H和卤素，条件是至少一个是H; 当双键存在于C-11位置时，W是N，CH或C; R4是 - （CH2）n-R5或R5是R6是R5或Z1，Z2独立地选自= O和= S; n为1-6; n1为0或1。
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