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公开(公告)号：US08614229B2
公开(公告)日：2013-12-24
申请号：US12675891
申请日：2008-08-27
申请人： Gopinadhan N. Anilkumar , Frank Bennett , Tin-Yau Chan , Kevin X. Chen , Mousumi Sannigrahi , Francisco Velazquez , Srikanth Venkatraman , Qingbei Zeng , Jose S. Duca , Charles A. Lesburg , Joseph A. Kozlowski , F. George Njoroge , Stuart B. Rosenblum , Neng-Yang Shih
发明人： Gopinadhan N. Anilkumar , Frank Bennett , Tin-Yau Chan , Kevin X. Chen , Mousumi Sannigrahi , Francisco Velazquez , Srikanth Venkatraman , Qingbei Zeng , Jose S. Duca , Charles A. Lesburg , Joseph A. Kozlowski , F. George Njoroge , Stuart B. Rosenblum , Neng-Yang Shih
IPC分类号： A61K31/47 , A61K31/4402 , A61K31/426 , A61K31/428 , A61K31/4184 , A61K31/404 , C07D239/96 , C07D239/88 , C07D241/44 , C07D471/04 , C07D215/18 , C07D401/04 , C07D211/88 , C07D277/18 , C07D487/04 , C07D275/04 , C07D249/18
CPC分类号： C07D403/04 , C07D401/04
摘要： The present invention relates to Substituted Indole Derivatives, compositions comprising at least one Substituted Indole Derivative, and methods of using these Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译： 本发明涉及取代的吲哚衍生物，包含至少一种取代的吲哚衍生物的组合物，以及使用这些取代的吲哚衍生物来治疗或预防患者的病毒感染或病毒相关病症的方法。
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2.发明授权4,5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections 有权用于治疗或预防HCV和相关病毒感染的4,5环环状吲哚衍生物公开(公告)号：US08557848B2
公开(公告)日：2013-10-15
申请号：US12519715
申请日：2007-12-17
申请人： Kevin X. Chen , Srikanth Venkatraman , F. George Njoroge , Stuart B. Rosenblum , Charles A. Lesburg , Jose S. Duca , Neng-Yang Shih , Francisco Velazquez , Gopinadhan N. Anilkumar , Qingbei Zeng , Joseph A. Kozlowski
发明人： Kevin X. Chen , Srikanth Venkatraman , F. George Njoroge , Stuart B. Rosenblum , Charles A. Lesburg , Jose S. Duca , Neng-Yang Shih , Francisco Velazquez , Gopinadhan N. Anilkumar , Qingbei Zeng , Joseph A. Kozlowski
IPC分类号： A61K31/497 , A61K31/4353 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/498 , A61K31/517 , C07D215/12 , C07D401/14 , C07D241/44 , C07D239/88
CPC分类号： C07D491/04 , C07D401/04 , C07D487/04 , C07D495/04 , C07D513/04
摘要： The present invention relates to 4,5-ring annulated indole derivatives, compositions comprising at least one 4,5-ring annulated indole derivatives, and methods of using the 4,5-ring annulated indole derivatives for treating or preventing a viral infection or a virus-related disorder in a patient. Wherein ring Z, of formula (I), is a cyclopentyl, cyclopentenyl, 5-membered heterocycloalkyl, 5-membered heterocycloalkenyl or 5-membered heteroaryl ring.
摘要翻译： 本发明涉及4,5-环环状吲哚衍生物，包含至少一种4,5-环环状吲哚衍生物的组合物，以及使用4,5-环环状吲哚衍生物治疗或预防病毒感染或 患者病毒相关疾病。 其中式（I）的Z环是环戊基，环戊烯基，5元杂环烷基，5元杂环烯基或5元杂芳基环。
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3.发明授权公开(公告)号：US08377928B2
公开(公告)日：2013-02-19
申请号：US12743023
申请日：2008-11-13
IPC分类号： A61K31/404 , A61K31/549
CPC分类号： C07D417/14
摘要： The present invention relates to 3-Aminosulfonyl Substituted Indole Derivatives of Formula (I): The invention also relates to compositions comprising at least one 3-Aminosulfonyl Substituted Indole Derivative, and methods of using the 3-Aminosulfonyl Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译： 本发明涉及式（I）的3-氨基磺酰基取代的吲哚衍生物：本发明还涉及包含至少一种3-氨基磺酰基取代的吲哚衍生物的组合物，以及使用3-氨基磺酰基取代的吲哚衍生物用于治疗或预防 病毒感染或病毒相关疾病。
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4.发明申请TETRACYCLIC INDOLE DERIVATIVES AND THEIR USE FOR TREATING OR PREVENTING VIRAL INFECTIONS 审中-公开四环素衍生物及其用于治疗或预防病毒感染的用途公开(公告)号：US20110104109A1
公开(公告)日：2011-05-05
申请号：US12675277
申请日：2008-08-27
申请人： Frank Bennett , Qingbei Zeng , Srikanth Venkatraman , Mousumi Sannigrahi , Kevin X. Chen , Gopinadhan N. Anilkumar , Stuart B. Rosenblum , Joseph A. Kozlowski , F. George Njoroge
发明人： Frank Bennett , Qingbei Zeng , Srikanth Venkatraman , Mousumi Sannigrahi , Kevin X. Chen , Gopinadhan N. Anilkumar , Stuart B. Rosenblum , Joseph A. Kozlowski , F. George Njoroge
IPC分类号： A61K31/437 , C07D498/22 , C07D491/147 , C07D491/22 , C07D513/22 , C07D495/04 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/536 , A61K38/21 , A61K39/12 , A61K39/42 , A61K31/7088 , A61P31/12 , A61P37/04
CPC分类号： C07D491/147 , A61K38/21 , C07D491/22 , C07D498/22 , C07D513/22 , C07D519/00 , A61K2300/00
摘要： The present invention relates to Tetracyclic Indole Derivatives, compositions comprising at least one Tetracyclic Indole Derivative, and methods of using the Tetracyclic Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译： 本发明涉及四环吲哚衍生物，包含至少一种四环吲哚衍生物的组合物，以及使用四环吲哚衍生物治疗或预防患者病毒感染或病毒相关病症的方法。
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公开(公告)号：US20100322901A1
公开(公告)日：2010-12-23
申请号：US12519975
申请日：2007-12-17
申请人： Frank Bennett , Srikanth Venkatraman , F. George Njoroge , Kevin X. Chen , Neng-Yang Shih , Stuart B. Rosenblum , Joseph A. Kozlowski
发明人： Frank Bennett , Srikanth Venkatraman , F. George Njoroge , Kevin X. Chen , Neng-Yang Shih , Stuart B. Rosenblum , Joseph A. Kozlowski
IPC分类号： A61K31/4439 , C07D401/04 , C07D491/048 , C07D513/04 , C07D417/14 , C07D401/14 , C07D471/04 , A61K31/444 , A61K31/4709 , A61K31/519 , A61K31/517 , A61K31/4375 , A61K31/437 , A61K38/21 , A61K31/7088 , A61K39/00 , A61K39/395 , A61P31/12
CPC分类号： C07D513/04 , C07D401/04 , C07D471/04 , C07D491/04
摘要： The present invention relates to 5,6-ring annulated indole derivatives of the formula (I), compositions comprising at least one 5,6-ring annulated indole derivatives, and methods of using the 5,6-ring annulated indole derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译： 本发明涉及式（I）的5,6环环状吲哚衍生物，包含至少一种5,6环环状吲哚衍生物的组合物，以及使用5,6环环状吲哚衍生物用于治疗或 预防患者的病毒感染或病毒相关疾病。
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6.发明申请4,5-RING ANNULATED INDOLE DERIVATIVES FOR TREATING OR PREVENTING OF HCV AND RELATED VIRAL INFECTIONS 有权用于治疗或预防HCV和相关病毒感染的4,5环结构吲哚类衍生物公开(公告)号：US20100098661A1
公开(公告)日：2010-04-22
申请号：US12519715
申请日：2007-12-17
申请人： Kevin X. Chen , Srikanth Venkatraman , F. George Njoroge , Stuart B. Rosenblum , Charles A. Lesburg , Jose S. Duca , Neng-Yang Shih , Francisco Velazquez , Gopinadhan N. Anilkumar , Qingbei Zeng , Joseph A. Kozlowski
发明人： Kevin X. Chen , Srikanth Venkatraman , F. George Njoroge , Stuart B. Rosenblum , Charles A. Lesburg , Jose S. Duca , Neng-Yang Shih , Francisco Velazquez , Gopinadhan N. Anilkumar , Qingbei Zeng , Joseph A. Kozlowski
IPC分类号： A61K38/21 , C07D401/02 , A61K31/4439 , C07D417/14 , A61K31/4436 , C07D215/00 , A61K31/47 , C07D241/36 , A61K31/498 , C07D401/14 , A61K31/517 , A61K31/444 , A61K39/00 , A61K39/395 , A61P31/12
CPC分类号： C07D491/04 , C07D401/04 , C07D487/04 , C07D495/04 , C07D513/04
摘要： The present invention relates to 4,5-ring annulated indole derivatives, compositions comprising at least one 4,5-ring annulated indole derivatives, and methods of using the 4,5-ring annulated indole derivatives for treating or preventing a viral infection or a virus-related disorder in a patient. Wherein ring Z, of formula (I), is a cyclopentyl, cyclopentenyl, 5-membered heterocycloalkyl, 5-membered heterocycloalkenyl or 5-membered heteroaryl ring.
摘要翻译： 本发明涉及4,5-环环状吲哚衍生物，包含至少一个4,5-环环状吲哚衍生物的组合物，以及使用4,5-环环状吲哚衍生物治疗或预防病毒感染或 患者病毒相关疾病。 其中式（I）的Z环是环戊基，环戊烯基，5元杂环烷基，5元杂环烯基或5元杂芳基环。
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公开(公告)号：US07592316B2
公开(公告)日：2009-09-22
申请号：US11714457
申请日：2007-03-06
申请人： F. George Njoroge , Ashok Arasappan , Srikanth Venkatraman , Stephane L. Bogen , Kevin X. Chen , Frank Bennett
发明人： F. George Njoroge , Ashok Arasappan , Srikanth Venkatraman , Stephane L. Bogen , Kevin X. Chen , Frank Bennett
IPC分类号： A61K38/06
CPC分类号： C07K5/0804 , A61K38/00 , C07K5/0202 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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8.发明授权公开(公告)号：US07449447B2
公开(公告)日：2008-11-11
申请号：US10925329
申请日：2004-08-24
申请人： Kevin X. Chen , F. George Njoroge , Weiying Yang , Bancha Vibulbhan , Viyyoor M. Girijavallabhan , Srikanth Venkatraman , Francisco Velazquez
发明人： Kevin X. Chen , F. George Njoroge , Weiying Yang , Bancha Vibulbhan , Viyyoor M. Girijavallabhan , Srikanth Venkatraman , Francisco Velazquez
IPC分类号： A61K38/06 , C07K5/08 , C07D209/02
CPC分类号： C07K5/0202 , A61K31/40 , A61K38/00 , C07K5/021 , C07K5/0827 , C07K7/06
摘要： The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts or solvates of said compound, or of said prodrug, said compound having the general structure shown in Formula 1: useful in the treatment or prevention or amelioration of one or more symptoms of hepatitis C.
摘要翻译： 本申请公开了所述化合物或所述前药的药学上可接受的盐或溶剂化物的化合物或其对映异构体，立体异构体，旋转异构体，互变异构体，前体药物，所述化合物具有式1所示的一般结构：有用的 治疗或预防或改善一种或多种丙型肝炎症状。
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9.发明授权Macrocyclic NS-3 serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties 失效丙型肝炎病毒的大环NS-3丝氨酸蛋白酶抑制剂包含烷基和芳基丙氨酸P2部分公开(公告)号：US06914122B2
公开(公告)日：2005-07-05
申请号：US09836636
申请日：2001-04-17
申请人： Srikanth Venkatraman , Kevin X. Chen , Ashok Arasappan , F. George Njoroge , Viyyoor Moopil Girijavallabhan , Ashit K. Ganguly , Tin-Yau Chan , Brian Alexander Mc Kittrick , Nanhua Hugh Yao , Andrew Joseph Prongay , Vincent Stewart Madison
发明人： Srikanth Venkatraman , Kevin X. Chen , Ashok Arasappan , F. George Njoroge , Viyyoor Moopil Girijavallabhan , Ashit K. Ganguly , Tin-Yau Chan , Brian Alexander Mc Kittrick , Nanhua Hugh Yao , Andrew Joseph Prongay , Vincent Stewart Madison
IPC分类号： A61K45/00 , A61K31/7052 , A61K38/00 , A61K38/21 , A61P31/12 , A61P31/14 , A61P43/00 , C07D273/00 , C07K5/02 , C07K7/02 , C07K7/64 , C07K7/50
CPC分类号： C07K5/0202 , A61K38/00 , C07K7/02
摘要： The present invention discloses novel macrocyclic compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such macrocycles as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型大环化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这种大环化合物的药物组合物以及使用它们治疗与HCV蛋白酶相关的病症的方法。
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10.发明授权5′-substituted nucleoside analogs and methods of use thereof for the treatment of viral diseases 有权5'-取代的核苷类似物及其用于治疗病毒性疾病的方法公开(公告)号：US09408863B2
公开(公告)日：2016-08-09
申请号：US14232536
申请日：2012-07-10
IPC分类号： A01N43/04 , A61K31/70 , C07H19/20 , C07H19/10 , C07H19/04 , C07H19/048 , A61K31/7056 , A01N37/46 , C07H19/06 , C07H19/16 , A61K31/341 , A61K31/4196 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K45/06
CPC分类号： A61K31/7056 , A01N37/46 , A61K31/341 , A61K31/4196 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K45/06 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , A61K2300/00
摘要： The present invention relates to 5′-Substituted Nucleoside Analogs of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, Z, R1, R2, R3 and R3′ are as defined herein. The present invention also relates to compositions comprising at least one 5′-Substituted Nucleoside Analog, and methods of using the 5′-Substituted Nucleoside Analogs for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及式（I）的5'-取代的核苷类似物及其药学上可接受的盐，其中B，X，Z，R 1，R 2，R 3和R 3'如本文所定义。 本发明还涉及包含至少一种5'-取代的核苷类似物的组合物，以及使用5'-取代的核苷类似物来治疗或预防患者HCV感染的方法。
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