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公开(公告)号：US20110250185A1
公开(公告)日：2011-10-13
申请号：US13164378
申请日：2011-06-20
申请人： Casper Paludan , James W. Edinger , Ryhor Harbacheuski , RoseAnn Murray , Robert J. Hariri , Qian Ye
发明人： Casper Paludan , James W. Edinger , Ryhor Harbacheuski , RoseAnn Murray , Robert J. Hariri , Qian Ye
CPC分类号： C12N5/0693 , A61K35/12 , A61K35/48 , C12N5/0605 , C12N5/0668 , C12N5/0694 , C12N2501/23 , C12N2501/24 , C12N2502/025 , C12N2502/1388 , C12N2510/00
摘要： The present invention provides methods of suppression of tumor cell proliferation and tumor growth using placental stem cells and placental stem cell populations. The invention also provides methods of producing and selecting placental cells and cell populations on the basis of tumor suppression, and compositions comprising such cells and cell populations.
摘要翻译： 本发明提供使用胎盘干细胞和胎盘干细胞群抑制肿瘤细胞增殖和肿瘤生长的方法。 本发明还提供了基于肿瘤抑制产生和选择胎盘细胞和细胞群的方法，以及包含这种细胞和细胞群的组合物。
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12.发明申请COMPOSITION FOR COLLECTING AND PRESERVING PLACENTAL STEM CELLS AND METHODS OF USING THE COMPOSITION 有权用于收集和保存整体干细胞的组合物和使用组合物的方法公开(公告)号：US20100291679A1
公开(公告)日：2010-11-18
申请号：US12846765
申请日：2010-07-29
CPC分类号： C12N5/0605 , C12N2501/48 , C12N2501/999
摘要： The present invention provides improved compositions and methods for the collection of stem cells from an organ, e.g., placenta. The invention provides a stem cell collection composition comprising an apoptosis inhibitor and, optionally, an enzyme such as a protease or mucolytic enzyme, vasodilator, necrosis inhibitor, oxygen-carrying perfluorocarbon, or an organ preserving compound. The invention provides methods of using the stem cell collection composition to collect stem cells and to preserve populations of stem cells.
摘要翻译： 本发明提供了用于从器官例如胎盘收集干细胞的改进的组合物和方法。 本发明提供一种干细胞收集组合物，其包含凋亡抑制剂和任选的酶如蛋白酶或粘液分解酶，血管扩张剂，坏死抑制剂，携氧全氟化碳或器官保存化合物。 本发明提供使用干细胞收集组合物收集干细胞并保留干细胞群体的方法。
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13.发明申请Hepatocytes and Chondrocytes from Adherent Placental StemCells; And CD34+ ,CD45- Placental Stem Cell-Enriched Cell Populations 审中-公开来自粘附胎盘干细胞的肝细胞和软骨细胞; 和CD34 +，CD45-胎盘干细胞富集细胞群体公开(公告)号：US20080206343A1
公开(公告)日：2008-08-28
申请号：US12030170
申请日：2008-02-12
申请人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Marian Pereira , Sascha Dawn Abramson , Kristen S. Labazzo
发明人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Marian Pereira , Sascha Dawn Abramson , Kristen S. Labazzo
CPC分类号： C12N5/067 , A01K67/0271 , A01K2267/0337 , A61K2035/128 , C12N5/0605 , C12N5/0607 , C12N5/0655 , C12N2500/30 , C12N2500/36 , C12N2500/62 , C12N2501/15 , C12N2501/999 , C12N2506/02 , C12N2506/03 , C12N2533/32 , C12N2533/40 , C12N2533/74
摘要： Provided herein are methods and compositions for the production of hepatocytes from placenta stem cells. Further provided herein is the use of such hepatocytes in the treatment of, and intervention in, for example, trauma, inflammation, and degenerative disorders of the liver. Also provided herein are compositions and methods relating to combinations of nanofibrous scaffolds and adherent placental stem cells and methods of using the same in cartilage repair. Finally, provided herein are compositions and methods relating to nonadherent, CD34+CD45− stem cells from placenta.
摘要翻译： 本文提供了用于从胎盘干细胞产生肝细胞的方法和组合物。 本文进一步提供的是这种肝细胞在治疗和干预例如肝脏的创伤，炎症和退行性疾病中的用途。 本文还提供了与纳米纤维支架和粘附性胎盘干细胞的组合相关的组合物和方法及其在软骨修复中的使用方法。 最后，本文提供的是与来自胎盘的非粘附的CD34 + CD45 +干细胞相关的组合物和方法。
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14.发明授权公开(公告)号：US09725694B2
公开(公告)日：2017-08-08
申请号：US12846765
申请日：2010-07-29
CPC分类号： C12N5/0605 , C12N2501/48 , C12N2501/999
摘要： The present invention provides improved compositions and methods for the collection of stem cells from an organ, e.g., placenta. The invention provides a stem cell collection composition comprising an apoptosis inhibitor and, optionally, an enzyme such as a protease or mucolytic enzyme, vasodilator, necrosis inhibitor, oxygen-carrying perfluorocarbon, or an organ preserving compound. The invention provides methods of using the stem cell collection composition to collect stem cells and to preserve populations of stem cells.
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公开(公告)号：US09598669B2
公开(公告)日：2017-03-21
申请号：US11648812
申请日：2006-12-28
CPC分类号： C12N5/0605 , C12N2501/48 , C12N2501/999
摘要： The present invention provides improved compositions and methods for the collection of stem cells from an organ, e.g., placenta. The invention provides a stem cell collection composition comprising an apoptosis inhibitor and, optionally, an enzyme such as a protease or mucolytic enzyme, vasodilator, necrosis inhibitor, oxygen-carrying perfluorocarbon, or an organ preserving compound. The invention provides methods of using the stem cell collection composition to collect stem cells and to preserve populations of stem cells.
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16.发明授权Human placental collagen compositions, and methods of making and using the same 有权人胎盘胶原组合物及其制备和使用方法公开(公告)号：US08877180B2
公开(公告)日：2014-11-04
申请号：US13467736
申请日：2012-05-09
申请人： Mohit Bhatia , Chris Lugo , Qian Ye , James W. Edinger
发明人： Mohit Bhatia , Chris Lugo , Qian Ye , James W. Edinger
CPC分类号： A61K38/39 , A61K8/65 , A61K2800/92 , A61Q19/00 , A61Q19/08 , C07K1/02 , C07K1/34 , C07K14/78 , A61K2300/00
摘要： The present invention provides compositions comprising human placental telopeptide collagen, methods of preparing the compositions, methods of their use and kits comprising the compositions. The compositions, kits and methods are useful, for example, for augmenting or replacing tissue of a mammal.
摘要翻译： 本发明提供了包含人胎盘肽肽胶原的组合物，制备组合物的方法，它们的使用方法和包含该组合物的试剂盒。 组合物，试剂盒和方法可用于例如增强或替代哺乳动物的组织。
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17.发明授权Methods and compositions for treatment of bone defects with placental cell populations 有权用于治疗胎盘细胞群体骨缺损的方法和组合物公开(公告)号：US08562972B2
公开(公告)日：2013-10-22
申请号：US11877475
申请日：2007-10-23
申请人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Kristen S. Labazzo , Marian Pereira , Sascha Dawn Abramson
发明人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Kristen S. Labazzo , Marian Pereira , Sascha Dawn Abramson
CPC分类号： A61K35/50 , A61K9/0019 , A61K35/12 , A61K47/36 , A61K47/42 , A61L27/3834 , A61L27/3847 , C12N5/0605 , C12N5/0654 , C12N5/0668 , C12N2500/38 , C12N2500/42 , C12N2501/39 , C12N2506/025 , C12N2506/03 , C12N2533/18 , C12N2533/54
摘要： Provided herein are methods of using adherent placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. Also provided herein are methods of differentiating the placental stem cells. Further provided herein are methods of using the placental stem cells to formulate implantable or injectable compositions suitable for administration to a subject. Still further provided herein are provides methods for treating bone defects with stem cells and compositions comprising stem cells.
摘要翻译： 本文提供了使用粘附性胎盘干细胞和胎盘干细胞群的方法，以及培养，增殖和扩增其的方法。 本文还提供了区分胎盘干细胞的方法。 本文进一步提供了使用胎盘干细胞来配制适于给予受试者的可植入或可注射组合物的方法。 本文进一步提供的是用干细胞治疗骨缺损的方法和包含干细胞的组合物。
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公开(公告)号：US08460650B2
公开(公告)日：2013-06-11
申请号：US12030161
申请日：2008-02-12
申请人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Herbert Faleck
发明人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Herbert Faleck
IPC分类号： A01N65/00
CPC分类号： A61K35/50 , A61K35/644 , A61K38/21 , A61K45/06 , A61K2035/122 , C12N5/0605 , C12N2500/25 , C12N2500/36 , C12N2501/11 , C12N2501/135 , C12N2501/39 , A61K2300/00
摘要： Provided herein are methods of treatment of individuals having an immune-related disease, disorder or condition, for example, inflammatory bowel disease, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis, psoriasis, lupus erythematosus, diabetes, mycosis fungoides (Alibert-Bazin syndrome), or scleroderma using placental stem cells or umbilical cord stem cells.
摘要翻译： 本文提供了治疗具有免疫相关疾病，病症或病症的个体的方法，例如炎性肠病，移植物抗宿主病，多发性硬化，类风湿性关节炎，银屑病，红斑狼疮，糖尿病，蕈样真菌病（Alibert -Bazin综合征）或使用胎盘干细胞或脐带干细胞的硬皮病。
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公开(公告)号：US20080152624A1
公开(公告)日：2008-06-26
申请号：US11888926
申请日：2007-08-03
申请人： Casper Paludan , James W. Edinger , Ryhor Harbacheuski , RoseAnn Murray , Robert J. Hariri , Qian Ye
发明人： Casper Paludan , James W. Edinger , Ryhor Harbacheuski , RoseAnn Murray , Robert J. Hariri , Qian Ye
CPC分类号： C12N5/0693 , A61K35/12 , A61K35/48 , C12N5/0605 , C12N5/0668 , C12N5/0694 , C12N2501/23 , C12N2501/24 , C12N2502/025 , C12N2502/1388 , C12N2510/00
摘要： The present invention provides methods of suppression of tumor cell proliferation and tumor growth using placental stem cells and placental stem cell populations. The invention also provides methods of producing and selecting placental cells and cell populations on the basis of tumor suppression, and compositions comprising such cells and cell populations.
摘要翻译： 本发明提供使用胎盘干细胞和胎盘干细胞群抑制肿瘤细胞增殖和肿瘤生长的方法。 本发明还提供了基于肿瘤抑制产生和选择胎盘细胞和细胞群的方法，以及包含这种细胞和细胞群的组合物。
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公开(公告)号：US08753883B2
公开(公告)日：2014-06-17
申请号：US13107778
申请日：2011-05-13
申请人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Herbert Faleck
发明人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Herbert Faleck
CPC分类号： A61K35/50 , A61K35/644 , A61K38/21 , A61K45/06 , A61K2035/122 , C12N5/0605 , C12N2500/25 , C12N2500/36 , C12N2501/11 , C12N2501/135 , C12N2501/39 , A61K2300/00
摘要： Provided herein are methods of treatment of individuals having an immune-related disease, disorder or condition, for example, inflammatory bowel disease, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis, psoriasis, lupus erythematosus, diabetes, mycosis fungoides (Alibert-Bazin syndrome), or scleroderma using placental stem cells or umbilical cord stem cells.
摘要翻译： 本文提供了治疗具有免疫相关疾病，病症或病症的个体的方法，例如炎性肠病，移植物抗宿主病，多发性硬化，类风湿性关节炎，银屑病，红斑狼疮，糖尿病，蕈样真菌病（Alibert -Bazin综合征）或使用胎盘干细胞或脐带干细胞的硬皮病。
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