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公开(公告)号：US20150174384A1
公开(公告)日：2015-06-25
申请号：US14641109
申请日：2015-03-06
Applicant: SurModics, Inc.
Inventor： Ralph A. Chappa , Mark F. Carlson
CPC classification number: A61M25/1029 , A61M25/1018 , A61M25/1027 , A61M2025/1031 , A61M2025/105 , B05B13/0214 , B05B13/0228 , B05C13/00 , B05D1/002 , B05D1/02 , B05D3/12
Abstract: A coating apparatus for coating the balloon portion of a balloon catheter is described. The coating apparatus includes a rotatable member in which the catheter portion of the balloon catheter is mounted and fixed, and which causes rotation of the balloon catheter. The apparatus also includes a support member in which the distal tip of the catheter is inserted and free to rotate; and a spray nozzle directing sprayed material on the balloon surface. The inventive configuration of the coating apparatus allows the balloon catheter to be rotated along its axis with insubstantial or no wobble, which significantly improves the quality of the coating applied to the surface of the balloon.
Abstract translation: 描述了一种用于涂覆球囊导管的球囊部分的涂覆装置。 涂覆装置包括可旋转构件，其中气囊导管的导管部分被安装和固定，并且引起气囊导管的旋转。 该装置还包括支撑构件，其中导管的远侧末端插入并自由旋转; 以及将喷射材料引导到气球表面上的喷嘴。 涂覆装置的本发明构造允许球囊导管沿着其轴线旋转，具有非实质或无摆动，这显着地改善了施加到气球表面的涂层的质量。
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公开(公告)号：US20140121597A1
公开(公告)日：2014-05-01
申请号：US14063113
申请日：2013-10-25
Applicant: SurModics, Inc.
Inventor： Ralph A. Chappa , Mark F. Carlson
IPC: A61M25/10
CPC classification number: A61M25/1029 , A61L2400/10 , A61L2420/02 , A61M25/0009 , A61M25/0045 , A61M2025/1031 , B05B13/0228 , B05D1/002
Abstract: Embodiments of the invention include apparatus and methods for coating medical devices. In an embodiment, the invention includes a coating apparatus including a coating application unit including a fluid applicator; a first rotation mechanism and a second rotation mechanism; and a controller, wherein the controller causes the first rotation mechanism and the second rotation mechanism to rotate a medical device at substantially the same speed, wherein the speed is greater than 500 rotations per minute. In an embodiment, the invention includes a method of coating a medical device including rotating a medical device with a rotation mechanism at a speed of greater than 500 rotations per minute; contacting the medical device with a fluid applicator; and applying a coating solution to the device. In an embodiment, the invention includes a medical device. In some embodiments a surface of a shaft of the device comprises high points and low points.
Abstract translation: 本发明的实施例包括用于涂覆医疗装置的装置和方法。 在一个实施例中，本发明包括涂覆装置，其包括涂布施加单元，其包括流体施加器; 第一旋转机构和第二旋转机构; 以及控制器，其中所述控制器使得所述第一旋转机构和所述第二旋转机构以基本上相同的速度旋转医疗装置，其中所述速度大于每分钟500转。 在一个实施例中，本发明包括一种涂覆医疗装置的方法，包括以大于每分钟500转的速度旋转具有旋转机构的医疗装置; 使所述医疗装置与流体施加器接触; 并将涂布溶液涂布到该装置上。 在一个实施例中，本发明包括医疗装置。 在一些实施例中，装置的轴的表面包括高点和低点。
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公开(公告)号：US11628466B2
公开(公告)日：2023-04-18
申请号：US16696234
申请日：2019-11-26
Applicant: Surmodics, Inc.
Inventor： Ralph A. Chappa , Michael Militello
Abstract: Embodiments of the invention include apparatus and methods for coating drug coated medical devices. In an embodiment, the invention includes a coating apparatus including a coating application unit. The coating application unit can include a fluid applicator having a lengthwise axis and a width. The fluid applicator can include a tip comprising a first face across the width of the fluid applicator. The first face of the fluid applicator can be oriented at an angle of from about 15 to about 75 degrees with respect to the lengthwise axis of the fluid applicator. The fluid applicator can define a second face intersecting the first face. The coating apparatus can further include a rotation mechanism and an axial motion mechanism. Other embodiments are also included herein.
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公开(公告)号：US11027049B2
公开(公告)日：2021-06-08
申请号：US15994263
申请日：2018-05-31
Applicant: Surmodics, Inc.
Inventor： Ralph A. Chappa , Andrew G. Bach
Abstract: Embodiments of the invention include bioactive agent eluting devices. In an embodiment the invention includes a bioactive agent delivery device including a substrate, a hydrophilic polymer disposed on the substrate, and a substantially amorphous bioactive agent disposed on the surface of the hydrophilic polymer. In an embodiment, the invention includes a method of making a bioactive agent delivery device including depositing a hydrophilic polymer on a substrate forming a hydrophilic surface and depositing a substantially amorphous bioactive agent on the hydrophilic surface. In an embodiment, the invention includes a bioactive agent-eluting catheter including a catheter shaft and an expandable balloon disposed on the catheter shaft. Other embodiments are included herein.
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公开(公告)号：US20190351200A1
公开(公告)日：2019-11-21
申请号：US16363644
申请日：2019-03-25
Applicant: Surmodics, Inc.
Inventor： Ralph A. Chappa , Mark F. Carlson
Abstract: A coating apparatus for coating the balloon portion of a balloon catheter is described. The coating apparatus includes a rotatable member in which the catheter portion of the balloon catheter is mounted and fixed, and which causes rotation of the balloon catheter. The apparatus also includes a support member in which the distal tip of the catheter is inserted and free to rotate; and a spray nozzle directing sprayed material on the balloon surface. The inventive configuration of the coating apparatus allows the balloon catheter to be rotated along its axis with insubstantial or no wobble, which significantly improves the quality of the coating applied to the surface of the balloon.
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Patent Agency Ranking
公开(公告)号：US10238844B2
公开(公告)日：2019-03-26
申请号：US15434556
申请日：2017-02-16
Applicant: Surmodics, Inc.
Inventor： Ralph A. Chappa , Mark F. Carlson
Abstract: A coating apparatus for coating the balloon portion of a balloon catheter is described. The coating apparatus includes a rotatable member in which the catheter portion of the balloon catheter is mounted and fixed, and which causes rotation of the balloon catheter. The apparatus also includes a support member in which the distal tip of the catheter is inserted and free to rotate; and a spray nozzle directing sprayed material on the balloon surface. The inventive configuration of the coating apparatus allows the balloon catheter to be rotated along its axis with insubstantial or no wobble, which significantly improves the quality of the coating applied to the surface of the balloon.
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公开(公告)号：US20180036519A1
公开(公告)日：2018-02-08
申请号：US15783554
申请日：2017-10-13
Applicant: Surmodics, Inc.
Inventor： Ralph A. Chappa , Andrew G. Bach , Mark MacGregor
CPC classification number: A61M25/1029 , A61M2025/1031 , B05B13/0442
Abstract: Embodiments herein include apparatus and methods for coating medical devices. In an embodiment, a coating apparatus is included having a coating application unit including a movement restriction structure, a fluid applicator having a lengthwise major axis, a fluid distribution bar having a body angled with respect to the major lengthwise axis of the fluid applicator between 0 and 20 degrees, a rotation mechanism and an axial motion mechanism. The axial motion mechanism configured to cause movement of at least one of the coating application unit and the rotation mechanism with respect to one another. Other embodiments are also included herein.
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公开(公告)号：US09827401B2
公开(公告)日：2017-11-28
申请号：US14272204
申请日：2014-05-07
Applicant: SurModics, Inc.
Inventor： Ralph A. Chappa , Andrew G. Bach , Mark MacGregor
CPC classification number: A61M25/1029 , A61M2025/1031 , B05B13/0442
Abstract: Embodiments of the invention include apparatus and methods for coating drug eluting medical devices. In an embodiment, the invention includes a coating apparatus including a coating application unit comprising a movement restriction structure; a fluid applicator; and an air nozzle. The apparatus can further include a rotation mechanism and an axial motion mechanism, the axial motion mechanism configured to cause movement of at least one of the coating application unit and the rotation mechanism with respect to one another. Other embodiments are also included herein.
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公开(公告)号：US20170095559A1
公开(公告)日：2017-04-06
申请号：US15373174
申请日：2016-12-08
Applicant: Surmodics, Inc.
Inventor： Ralph A. Chappa
CPC classification number: A61K47/22 , A61K9/0019 , A61K31/337 , A61K31/436 , A61L29/16 , A61L2300/416 , A61M25/0009 , A61M25/0026 , A61M25/0045 , A61M25/1011 , A61M25/1029 , A61M2025/1004 , A61M2025/1013 , A61M2025/105 , A61M2025/1088
Abstract: The present invention relates to a pharmaceutical composition for intravascular delivery of a therapeutic agent, such as paclitaxel, rapamycin, or an analog thereof. The composition includes the therapeutic agent and a biocompatible solvent, such as glycofurol. The composition can aid tissue penetration by the therapeutic agent. A catheter assembly that protects the pharmaceutical composition from the surroundings can be used for its intravascular delivery.
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公开(公告)号：US09579491B2
公开(公告)日：2017-02-28
申请号：US14641109
申请日：2015-03-06
Applicant: SurModics, Inc.
Inventor： Ralph A. Chappa , Mark F. Carlson
CPC classification number: A61M25/1029 , A61M25/1018 , A61M25/1027 , A61M2025/1031 , A61M2025/105 , B05B13/0214 , B05B13/0228 , B05C13/00 , B05D1/002 , B05D1/02 , B05D3/12
Abstract: A coating apparatus for coating the balloon portion of a balloon catheter is described. The coating apparatus includes a rotatable member in which the catheter portion of the balloon catheter is mounted and fixed, and which causes rotation of the balloon catheter. The apparatus also includes a support member in which the distal tip of the catheter is inserted and free to rotate; and a spray nozzle directing sprayed material on the balloon surface. The inventive configuration of the coating apparatus allows the balloon catheter to be rotated along its axis with insubstantial or no wobble, which significantly improves the quality of the coating applied to the surface of the balloon.
Abstract translation: 描述了一种用于涂覆球囊导管的球囊部分的涂覆装置。 涂覆装置包括可旋转构件，其中气囊导管的导管部分被安装和固定，并且引起气囊导管的旋转。 该装置还包括支撑构件，其中导管的远侧末端插入并自由旋转; 以及将喷射材料引导到气球表面上的喷嘴。 涂覆装置的本发明构造允许球囊导管沿着其轴线旋转，具有非实质或无摆动，这显着地改善了施加到气球表面的涂层的质量。
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