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118 条记录 (耗时 0.029 秒)

    Poly(ester amide) block copolymers
    13.
    发明授权
    Poly(ester amide) block copolymers 有权
    聚（酯酰胺）嵌段共聚物

    公开(公告)号：US07699889B2

    公开(公告)日：2010-04-20

    申请号：US12114645

    申请日：2008-05-02

    申请人： Syed Faiyaz Ahmed Hossainy

    发明人： Syed Faiyaz Ahmed Hossainy

    IPC分类号： A61L9/16 ,  C08G69/44 ,  A61L31/16 ,  A61L31/10 ,  A61K47/48

    CPC分类号： C08G69/44 ,  A61K47/593 ,  A61K47/595 ,  A61K47/64 ,  A61L27/34 ,  A61L31/10 ,  C08L77/12

    摘要： Provided herein is a copolymer that includes a soft block (A) and a hard block (B) comprising a tyrosine di-peptide. The copolymer can be any of AB, ABA or BAB type block copolymers. The soft block can include a PEA polymer. A coating formed of the copolymer may also include a bioactive agent. The implantable device can be implanted in a patient to treat, prevent, or ameliorate a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, and/or tumor obstruction.

    摘要翻译： 本文提供了包含软嵌段（A）和包含酪氨酸二肽的硬嵌段（B）的共聚物。 共聚物可以是AB，ABA或BAB型嵌段共聚物中的任一种。 软块可以包括PEA聚合物。 由共聚物形成的涂层也可以包括生物活性剂。 可植入装置可以植入患者体内以治疗，预防或改善诸如动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉吻合增殖等障碍 人工移植物，胆管阻塞，输尿管梗阻和/或肿瘤阻塞。

    Heparin prodrugs and drug delivery stents formed therefrom
    14.
    发明授权
    Heparin prodrugs and drug delivery stents formed therefrom 失效
    肝素前药和由其形成的药物递送支架

    公开(公告)号：US07563780B1

    公开(公告)日：2009-07-21

    申请号：US10871658

    申请日：2004-06-18

    申请人： Syed Faiyaz Ahmed Hossainy ,  Ni Ding

    发明人： Syed Faiyaz Ahmed Hossainy ,  Ni Ding

    IPC分类号： C08B37/10 ,  A61K31/727 ,  A61P7/02

    CPC分类号： A61K31/727 ,  A61K47/61 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/606 ,  A61L2300/80 ,  C08B37/0075 ,  C09D105/10

    摘要： A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a medical device. The polymeric material can be a hydrophobic polymer, a hydrophilic polymer, a non-fouling polymer, or combinations thereof. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

    摘要翻译： 提供了包含肝素和药物的前药。 前药可用于在医疗装置上形成涂层。 前药还可以与聚合物材料一起使用以在医疗装置上形成涂层。 聚合物材料可以是疏水性聚合物，亲水性聚合物，非结垢聚合物，或其组合。 医疗器械可以植入人类用于治疗动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等疾病 ，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。

    Heparin prodrugs and drug delivery stents formed therefrom
    16.
    发明授权
    Heparin prodrugs and drug delivery stents formed therefrom 有权
    肝素前药和由其形成的药物递送支架

    公开(公告)号：US07396541B2

    公开(公告)日：2008-07-08

    申请号：US11228420

    申请日：2005-09-15

    申请人： Syed Faiyaz Ahmed Hossainy ,  Ni Ding

    发明人： Syed Faiyaz Ahmed Hossainy ,  Ni Ding

    IPC分类号： A61F2/00

    CPC分类号： A61K31/727 ,  A61K47/61 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/606 ,  A61L2300/80 ,  C08B37/0075 ,  C09D105/10

    摘要： A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a medical device. The polymeric material can be a hydrophobic polymer, a hydrophilic polymer, a non-fouling polymer, or combinations thereof. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

    摘要翻译： 提供了包含肝素和药物的前药。 前药可用于在医疗装置上形成涂层。 前药还可以与聚合物材料一起使用以在医疗装置上形成涂层。 聚合物材料可以是疏水性聚合物，亲水性聚合物，非结垢聚合物，或其组合。 医疗器械可以植入人类用于治疗动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等疾病 ，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。

    Device and method for combining a treatment agent and a gel
    18.
    发明授权
    Device and method for combining a treatment agent and a gel 有权
    用于组合处理剂和凝胶的装置和方法

    公开(公告)号：US07361368B2

    公开(公告)日：2008-04-22

    申请号：US10187007

    申请日：2002-06-28

    申请人： Charles D. Claude ,  Paul J. Kawula ,  Syed Faiyaz Ahmed Hossainy ,  Kimchi Tran

    发明人： Charles D. Claude ,  Paul J. Kawula ,  Syed Faiyaz Ahmed Hossainy ,  Kimchi Tran

    IPC分类号： A61F2/00 ,  A61K9/22

    CPC分类号： A61K9/0024 ,  A61K9/06

    摘要： A method including introducing a treatment agent at a treatment site within a mammalian host; and introducing a bioerodable gel material at the treatment site. An apparatus including a first annular member having a first lumen disposed about a length of the first annular member and a first entry port at a proximal end of the first annular member, and a second annular member coupled to the first annular member having a second lumen disposed about a length of the second annular member and a second entry port at a proximal end of the second annular member, wherein the first annular member and the second annular member are positioned to allow a combining of treatment agents introduced through each annular member at the treatment site.

    摘要翻译： 一种方法，包括在哺乳动物宿主内的处理部位引入处理剂; 并在处理部位引入可生物浸渍的凝胶材料。 一种包括第一环形构件的装置，所述第一环形构件具有围绕所述第一环形构件的长度设置的第一腔和在所述第一环形构件的近端处的第一入口，以及联接到所述第一环形构件的第二环形构件，所述第二环形构件具有第二内腔 设置在所述第二环形构件的大约一定长度处和在所述第二环形构件的近端处的第二入口，其中所述第一环形构件和所述第二环形构件被定位成允许通过每个环形构件引入的处理剂在 治疗部位。