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公开(公告)号：US08785382B2
公开(公告)日：2014-07-22
申请号：US11694793
申请日：2007-03-30
Applicant: Deborah Kilpatrick , Syed Faiyaz Ahmed Hossainy , Irina Astafieva , Florian N. Ludwig , Paul M. Consigny , Jeffrey T. Ellis , Florencia Lim
Inventor： Deborah Kilpatrick , Syed Faiyaz Ahmed Hossainy , Irina Astafieva , Florian N. Ludwig , Paul M. Consigny , Jeffrey T. Ellis , Florencia Lim
CPC classification number: A61K38/1709 , A61K9/0019 , A61K9/1275 , A61K9/1617 , A61K9/1658 , A61M1/3472 , A61M1/3486 , A61M2202/0456 , A61K2300/00
Abstract: A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo A1 comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo A1 and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCA1) transporter expression in macrophages and protect ABCA1 from thiol-mediated degradation.
Abstract translation: 一种方法，包括向血液中引入脱脂高密度脂蛋白（HDL）和生物活性剂。 包含脱脂高密度脂蛋白（HDL）和适合于输送到血管中的辅助剂的组合物。 包含Apo A1的组合物，其包含适于与细胞表面结合位点相互作用的疏水性配体。 一种组合物，其包含Apo A1和选择用于增加巨噬细胞中ATP结合盒蛋白1（ABCA1）转运蛋白表达的一种试剂，并保护ABCA1免受硫醇介导的降解。
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公开(公告)号：US07783338B2
公开(公告)日：2010-08-24
申请号：US12008381
申请日：2008-01-09
Applicant: Robert Ainsworth , Deborah Kilpatrick , Jeong S. Lee , Bridget A. Hurley , Jeffrey T. Ellis
Inventor： Robert Ainsworth , Deborah Kilpatrick , Jeong S. Lee , Bridget A. Hurley , Jeffrey T. Ellis
IPC: A61B5/00
CPC classification number: A61B5/0084 , A61B5/0086 , A61B5/02007 , A61B5/02154 , A61B5/1459 , A61B5/6853 , A61B2017/22001
Abstract: An apparatus and method to perform therapeutic treatment and diagnosis of a patient's vasculature through the use of an intravascular device having an optical fiber disposed therein. In an embodiment, the apparatus includes an intravascular device to perform a therapeutic treatment and at least one optical fiber disposed through the intravascular device. The optical fiber is configured to provide diagnostic information before, during, and after the therapeutic treatment. In an embodiment, diagnostic information includes vessel and blood characteristics such as hemodynamic characteristics, hematological parameters related to blood and blood components, and thermal parameters of the vasculature.
Abstract translation: 通过使用其中设置有光纤的血管内装置来对患者的脉管系统进行治疗处理和诊断的装置和方法。 在一个实施例中，该装置包括执行治疗性处理的血管内装置和通过血管内装置设置的至少一个光纤。 光纤被配置为在治疗之前，期间和之后提供诊断信息。 在一个实施方案中，诊断信息包括血管和血液特征，例如血液动力学特征，与血液和血液成分有关的血液学参数，以及脉管系统的热参数。
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公开(公告)号：US20080139897A1
公开(公告)日：2008-06-12
申请号：US12008381
申请日：2008-01-09
Applicant: Robert D. Ainsworth , Deborah Kilpatrick , Jeong S. Lee , Bridget A. Hurley , Jeffrey T. Ellis
Inventor： Robert D. Ainsworth , Deborah Kilpatrick , Jeong S. Lee , Bridget A. Hurley , Jeffrey T. Ellis
CPC classification number: A61B5/0084 , A61B5/0086 , A61B5/02007 , A61B5/02154 , A61B5/1459 , A61B5/6853 , A61B2017/22001
Abstract: An apparatus and method to perform therapeutic treatment and diagnosis of a patient's vasculature through the use of an intravascular device having an optical fiber disposed therein. In an embodiment, the apparatus includes an intravascular device to perform a therapeutic treatment and at least one optical fiber disposed through the intravascular device. The optical fiber is configured to provide diagnostic information before, during, and after the therapeutic treatment. In an embodiment, diagnostic information includes vessel and blood characteristics such as hemodynamic characteristics, hematological parameters related to blood and blood components, and thermal parameters of the vasculature.
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公开(公告)号：US20070232539A1
公开(公告)日：2007-10-04
申请号：US11694793
申请日：2007-03-30
Applicant: Deborah Kilpatrick , Syed Faiyaz Ahmed Hossainy , Irina Astafieva , Florian N. Ludwig , Paul M. Consigny , Jeffrey T. Ellis , Florencia Lim
Inventor： Deborah Kilpatrick , Syed Faiyaz Ahmed Hossainy , Irina Astafieva , Florian N. Ludwig , Paul M. Consigny , Jeffrey T. Ellis , Florencia Lim
IPC: A61K38/17
CPC classification number: A61K38/1709 , A61K9/0019 , A61K9/1275 , A61K9/1617 , A61K9/1658 , A61M1/3472 , A61M1/3486 , A61M2202/0456 , A61K2300/00
Abstract: A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo A1 comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo A1 and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCA1) transporter expression in macrophages and protect ABCA1 from thiol-mediated degradation.
Abstract translation: 一种方法，包括向血液中引入脱脂高密度脂蛋白（HDL）和生物活性剂。 包含脱脂高密度脂蛋白（HDL）和适合于输送到血管中的辅助剂的组合物。 包含Apo A1的组合物，其包含适于与细胞表面结合位点相互作用的疏水性配体。 一种组合物，其包含Apo A1和选择用于增加巨噬细胞中ATP结合盒蛋白1（ABCA1）转运蛋白表达的一种试剂，并保护ABCA1免受硫醇介导的降解。
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公开(公告)号：US08579967B2
公开(公告)日：2013-11-12
申请号：US13084411
申请日：2011-04-11
Applicant: William E. Webler , James D. Breeding , Brad D. Bisson , Firas Mourtada , Gregory M. Hyde , Stephanie A. Szobota , Gabriel Asongwe , Jeffrey T. Ellis
Inventor： William E. Webler , James D. Breeding , Brad D. Bisson , Firas Mourtada , Gregory M. Hyde , Stephanie A. Szobota , Gabriel Asongwe , Jeffrey T. Ellis
IPC: A61F2/24
CPC classification number: A61F2/246 , A61B17/00234 , A61B17/0401 , A61B17/0487 , A61B17/064 , A61B17/0644 , A61B2017/00783 , A61B2017/0417 , A61B2017/06176 , A61B2017/0641 , A61F2/2454 , A61F2/2457
Abstract: An apparatus including a tether, and an aptation device coupled to the tether at a position corresponding to a location to contact cusps of an atrioventricular valve during systole, wherein the tether and aptation device are suitable for percutaneous delivery to a patient. An apparatus including a support annulus comprising a length corresponding to a circumference of one of an interior portion of an atrium and an atrioventricular valve annulus; and an aptation device coupled to the support annulus corresponding to a location to contact cusps of an atrioventricular valve during at least one of systole when the support annulus is seated in one of an atrium and an atrioventricular valve annulus, wherein the support annulus and aptation device are suitable for percutaneous delivery to a patient. Also, a method of introducing an aptation device to contact cusps or leaflets of an atrioventricular valve.
Abstract translation: 一种装置，包括系绳，以及适配装置，其在对应于在收缩期间接触房室瓣的尖端的位置处的位置处联接到系链，其中所述系链和适配装置适于经皮递送给患者。 一种包括支撑环的装置，其包括对应于心房的内部部分和房室瓣膜环之一的周长的长度; 以及联接到所述支撑环的适应装置，所述适配装置在所述支撑环位于心房和房室瓣膜环之一中时在至少一个收缩期期间对应于接触房室瓣的尖端的位置，其中所述支撑环和适配装置 适合经皮给患者输送。 另外，引入适应装置以接触房室瓣的尖头或小叶的方法。
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Patent Agency Ranking
公开(公告)号：US07025734B1
公开(公告)日：2006-04-11
申请号：US09967186
申请日：2001-09-28
Applicant: Jeffrey T. Ellis , Robert D. Ainsworth , Deborah L. Kilpatrick , Alex Q. Tilson , Bridget A. Hurley
Inventor： Jeffrey T. Ellis , Robert D. Ainsworth , Deborah L. Kilpatrick , Alex Q. Tilson , Bridget A. Hurley
CPC classification number: A61B5/14542 , A61B5/14552 , A61B5/1459 , A61B5/6851
Abstract: A guidewire with a sensor which can detect NO and/or superoxide levels is disclosed. This invention can be useful for in vivo analysis of vascular health.
Abstract translation: 公开了一种具有可检测NO和/或超氧化物浓度的传感器的导丝。 本发明可用于血管健康的体内分析。
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公开(公告)号：US07842012B2
公开(公告)日：2010-11-30
申请号：US11346771
申请日：2006-02-03
Applicant: Jeffrey T. Ellis , Robert D. Ainsworth , Deborah L. Kilpatrick , Alex Q. Tilson , Bridget A. Hurley
Inventor： Jeffrey T. Ellis , Robert D. Ainsworth , Deborah L. Kilpatrick , Alex Q. Tilson , Bridget A. Hurley
CPC classification number: A61B5/14542 , A61B5/14552 , A61B5/1459 , A61B5/6851
Abstract: A guidewire with a sensor which can detect NO and/or superoxide levels is disclosed. This invention can be useful for in vivo analysis of vascular health.
Abstract translation: 公开了一种具有可检测NO和/或超氧化物浓度的传感器的导丝。 本发明可用于血管健康的体内分析。
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公开(公告)号：US20080125861A1
公开(公告)日：2008-05-29
申请号：US12026439
申请日：2008-02-05
Applicant: William E. Webler , James D. Breeding , Brad D. Bisson , Firas Mourtada , Gregory M. Hyde , Stephanie A. Szobota , Gabriel Asongwe , Jeffrey T. Ellis
Inventor： William E. Webler , James D. Breeding , Brad D. Bisson , Firas Mourtada , Gregory M. Hyde , Stephanie A. Szobota , Gabriel Asongwe , Jeffrey T. Ellis
IPC: A61F2/24
CPC classification number: A61F2/246 , A61B17/00234 , A61B17/0401 , A61B17/0487 , A61B17/064 , A61B17/0644 , A61B2017/00783 , A61B2017/0417 , A61B2017/06176 , A61B2017/0641 , A61F2/2454 , A61F2/2457
Abstract: An apparatus including a tether, and an aptation device coupled to the tether at a position corresponding to a location to contact cusps of an atrioventricular valve during systole, wherein the tether and aptation device are suitable for percutaneous delivery to a patient. An apparatus including a support annulus comprising a length corresponding to a circumference of one of an interior portion of an atrium and an atrioventricular valve annulus; and an aptation device coupled to the support annulus corresponding to a location to contact cusps of an atrioventricular valve during at least one of systole when the support annulus is seated in one of an atrium and an atrioventricular valve annulus, wherein the support annulus and aptation device are suitable for percutaneous delivery to a patient. Also, a method of introducing an aptation device to contact cusps or leaflets of an atrioventricular valve.
Abstract translation: 一种装置，包括系绳，以及适配装置，其在对应于在收缩期间接触房室瓣的尖端的位置处的位置处联接到系链，其中所述系链和适配装置适于经皮递送给患者。 一种包括支撑环的装置，其包括对应于心房的内部部分和房室瓣膜环之一的周长的长度; 以及联接到所述支撑环的适应装置，所述适配装置在所述支撑环位于心房和房室瓣膜环之一中时在至少一个收缩期期间对应于接触房室瓣的尖端的位置，其中所述支撑环和适配装置 适合经皮给患者输送。 另外，引入适应装置以接触房室瓣的尖头或小叶的方法。
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公开(公告)号：US07329223B1
公开(公告)日：2008-02-12
申请号：US09872310
申请日：2001-05-31
Applicant: Robert Ainsworth , Deborah Kilpatrick , Jeong S. Lee , Bridget A. Hurley , Jeffrey T. Ellis
Inventor： Robert Ainsworth , Deborah Kilpatrick , Jeong S. Lee , Bridget A. Hurley , Jeffrey T. Ellis
IPC: A61B5/00
CPC classification number: A61B5/0084 , A61B5/0086 , A61B5/02007 , A61B5/02154 , A61B5/1459 , A61B5/6853 , A61B2017/22001
Abstract: An apparatus and method to perform therapeutic treatment and diagnosis of a patient's vasculature through the use of an intravascular device having an optical fiber disposed therein. In an embodiment, the apparatus includes an intravascular device to perform a therapeutic treatment and at least one optical fiber disposed through the intravascular device. The optical fiber is configured to provide diagnostic information before, during, and after the therapeutic treatment. In an embodiment, diagnostic information includes vessel and blood characteristics such as hemodynamic characteristics, hematological parameters related to blood and blood components, and thermal parameters of the vasculature.
Abstract translation: 通过使用其中设置有光纤的血管内装置来对患者的脉管系统进行治疗处理和诊断的装置和方法。 在一个实施例中，该装置包括执行治疗性处理的血管内装置和通过血管内装置设置的至少一个光纤。 光纤被配置为在治疗之前，期间和之后提供诊断信息。 在一个实施方案中，诊断信息包括血管和血液特征，例如血液动力学特征，与血液和血液成分有关的血液学参数，以及脉管系统的热参数。
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公开(公告)号：US07942928B2
公开(公告)日：2011-05-17
申请号：US12026407
申请日：2008-02-05
Applicant: William E. Webler , James D. Breeding , Brad D. Bisson , Firas Mourtada , Gregory M. Hyde , Stephanie A. Szobota , Gabriel Asongwe , Jeffrey T. Ellis
Inventor： William E. Webler , James D. Breeding , Brad D. Bisson , Firas Mourtada , Gregory M. Hyde , Stephanie A. Szobota , Gabriel Asongwe , Jeffrey T. Ellis
IPC: A61F2/24
CPC classification number: A61F2/246 , A61B17/00234 , A61B17/0401 , A61B17/0487 , A61B17/064 , A61B17/0644 , A61B2017/00783 , A61B2017/0417 , A61B2017/06176 , A61B2017/0641 , A61F2/2454 , A61F2/2457
Abstract: An apparatus including a tether, and an aptation device coupled to the tether at a position corresponding to a location to contact cusps of an atrioventricular valve during systole, wherein the tether and aptation device are suitable for percutaneous delivery to a patient. An apparatus including a support annulus comprising a length corresponding to a circumference of one of an interior portion of an atrium and an atrioventricular valve annulus; and an aptation device coupled to the support annulus corresponding to a location to contact cusps of an atrioventricular valve during at least one of systole when the support annulus is seated in one of an atrium and an atrioventricular valve annulus, wherein the support annulus and aptation device are suitable for percutaneous delivery to a patient. Also, a method of introducing an aptation device to contact cusps or leaflets of an atrioventricular valve.
Abstract translation: 一种装置，包括系绳，以及适配装置，其在对应于在收缩期间接触房室瓣的尖端的位置处的位置处联接到系链，其中所述系链和适配装置适于经皮递送给患者。 一种包括支撑环的装置，其包括对应于心房的内部部分和房室瓣膜环之一的周长的长度; 以及联接到所述支撑环的适应装置，所述适配装置在所述支撑环位于心房和房室瓣膜环之一中时在至少一个收缩期期间对应于接触房室瓣的尖端的位置，其中所述支撑环和适配装置 适合经皮给患者输送。 另外，引入适应装置以接触房室瓣的尖头或小叶的方法。
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