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公开(公告)号：US09631188B2
公开(公告)日：2017-04-25
申请号：US15015477
申请日：2016-02-04
Inventor： Jan P. Kraus
CPC classification number: C12N9/88 , A61K38/00 , C12Y402/01022
Abstract: Human cystathionine β-synthase variants are disclosed, as well as a method to produce recombinant human cystathionine β-synthase and variants thereof. More particularly, the role of both the N-terminal and C-terminal regions of human CBS has been studied, and a variety of truncation mutants and modified CBS homologues are described. In addition, a method to express and purify recombinant human cystathionine β-synthase (CBS) and variants thereof which have only one or two additional amino acid residues at the N-terminus are described.
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12.发明授权公开(公告)号：US09011844B2
公开(公告)日：2015-04-21
申请号：US13826024
申请日：2013-03-14
Inventor： Jan P. Kraus
IPC: C12N9/88
CPC classification number: C12N9/88 , A61K38/00 , C12Y402/01022
Abstract: Human cystathionine β-synthase variants are disclosed, as well as a method to produce recombinant human cystathionine β-synthase and variants thereof. More particularly, the role of both the N-terminal and C-terminal regions of human CBS has been studied, and a variety of truncation mutants and modified CBS homologs are described. In addition, a method to express and purify recombinant human cystathionine β-synthase (CBS) and variants thereof which have only one or two additional amino acid residues at the N-terminus are described.
Abstract translation: 公开了人胱硫醚和bgr- -Synthase变体，以及一种产生重组人胱硫醚及其变体的方法。 更具体地，已经研究了人CBS的N-末端和C-末端区域的作用，并且描述了各种截短突变体和修饰的CBS同系物。 另外，描述了在N末端仅具有一个或两个另外的氨基酸残基的重组人胱硫醚和bgr.Synthase（CBS）及其变体的表达和纯化方法。
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公开(公告)号：US20220125896A1
公开(公告)日：2022-04-28
申请号：US17362633
申请日：2021-06-29
Inventor： Jan P. Kraus , Tomas Majtan , Erez Bublil
IPC: A61K38/51 , A61K47/60 , A61K9/00 , A61K31/198 , A61K31/205 , A61K31/385 , A61K45/06 , C12N9/88 , C12N9/96
Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
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公开(公告)号：US10941392B2
公开(公告)日：2021-03-09
申请号：US16739169
申请日：2020-01-10
Inventor： Richard Carrillo , Jan P. Kraus , Tomas Majtan , David Naveh
Abstract: This invention provides chromatographic methods for the purification of a cystathionine β-Synthase (CBS) protein, particularly truncated variants thereof and compositions and pharmaceutical compositions prepared therefrom.
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公开(公告)号：US20200276282A1
公开(公告)日：2020-09-03
申请号：US16824931
申请日：2020-03-20
Inventor： Jan P. Kraus , Tomas Majtan , Erez Bublil
IPC: A61K38/51 , A61K31/205 , A61K47/60 , A61K9/00 , A61K45/06 , C12N9/88 , C12N9/96 , A61K31/198 , A61K31/385
Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
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Patent Agency Ranking
公开(公告)号：US10653755B2
公开(公告)日：2020-05-19
申请号：US15774755
申请日：2016-11-09
Inventor： Jan P. Kraus , Tomas Majtan , Erez Bublil
IPC: A61K38/51 , A61K31/385 , A61K31/198 , A61K47/60 , C12N9/96 , C12N9/88 , A61K45/06 , A61K9/00 , A61K31/205
Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
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公开(公告)号：US20180318404A1
公开(公告)日：2018-11-08
申请号：US15774755
申请日：2016-11-09
Inventor： Jan P. Kraus , Tomas Majtan , Erez Bublil
IPC: A61K38/51 , A61K31/205 , A61K47/60 , C12N9/96 , A61K9/00 , A61K45/06 , C12N9/88 , A61K31/198 , A61K31/385
CPC classification number: A61K38/51 , A61K9/0019 , A61K31/198 , A61K31/205 , A61K31/385 , A61K45/06 , A61K47/48215 , A61K47/60 , A61K2300/00 , C12N9/88 , C12N9/96 , C12Y402/01022
Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
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公开(公告)号：US11324811B2
公开(公告)日：2022-05-10
申请号：US16605918
申请日：2018-04-17
Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE , Travere Therapeutics Switzerland GmbH
Inventor： Tomas Majtan , Jan P. Kraus , Erez M. Bublil , Frank Glavin , Marcia Sellos-Moura
Abstract: The present invention provides a method of PEGylating a human truncated cystathionine β-synthase protein containing a mutation of a cysteine to a serine at amino acid position 15 (htCBS C15S). The htCBS C15S was PEGylated with one of 5 kDa, 10 kDa, or 20 kDa NHS ester PEG molecules. In-process monitoring of the PEGylation process was used in the method to reduce levels of unPEGylated htCBS C15S and htCBS C15S with insufficient PEGylation. Administration of the PEGylated htCBS C15S had efficacy throughout the course of treatment for homocystinuria.
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公开(公告)号：US11077175B2
公开(公告)日：2021-08-03
申请号：US16824931
申请日：2020-03-20
Inventor： Jan P. Kraus , Tomas Majtan , Erez Bublil
IPC: A61K38/51 , A61K47/60 , A61K9/00 , A61K31/198 , A61K31/205 , A61K31/385 , A61K45/06 , C12N9/88 , C12N9/96 , A61P43/00 , A61P27/02 , A61P19/10 , A61P17/14 , A61P13/02
Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
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公开(公告)号：US10406214B2
公开(公告)日：2019-09-10
申请号：US15571640
申请日：2016-05-03
Inventor： Jan P. Kraus
Abstract: This invention provides compositions of human propionyl-CoA carboxylase (PCC) and pharmaceutical compositions of human PCC and methods for treating conditions such as propionic acidemia (PA), propionic aciduria, propionyl-CoA carboxylase deficiency and ketotic glycinemia.
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