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    COMPOSITIONS COMPRISING THIENOPYRIMIDINE AND THIENOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF
    13.
    发明申请
    COMPOSITIONS COMPRISING THIENOPYRIMIDINE AND THIENOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF 有权
    包含三亚甲基嘧啶和三烯吡啶化合物的组合物及其使用方法

    公开(公告)号：US20160046647A1

    公开(公告)日：2016-02-18

    申请号：US14773686

    申请日：2014-03-10

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： Jolanta Grembecka ,  Tomasz Cierpicki ,  Dmitry Borkin ,  Jay Hess ,  Duxin Sun ,  Xiaoqin Li

    IPC: C07D495/04

    CPC classification number: C07D495/04 ,  C07D495/16 ,  C07D519/00

    Abstract: The present invention relates generally to thienopyrimidine and thienopyridine class compounds and methods of use thereof. In particular embodiments, the present invention provides compositions comprising thienopyrimidine and thienopyridine class compounds and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins (e.g., for the treatment of leukemia, solid cancers and other diseases dependent on activity of MLL1, MLL2, MLL fusion proteins, and/or menin).

    Abstract translation: 本发明一般涉及噻吩并嘧啶和噻吩并吡啶类化合物及其使用方法。 在具体实施方案中，本发明提供了包含噻吩并嘧啶和噻吩并吡啶类化合物的组合物和用于抑制menin与MLL1，MLL2和MLL-融合癌蛋白相互作用的方法（例如，用于治疗白血病，固体癌症和依赖于 MLL1，MLL2，MLL融合蛋白和/或menin的活性）。

    Conjugated gold nanoparticles
    14.
    发明授权
    Conjugated gold nanoparticles 有权
    共轭金纳米颗粒

    公开(公告)号：US09234078B2

    公开(公告)日：2016-01-12

    申请号：US14212594

    申请日：2014-03-14

    Applicant: The Regents of the University of Michigan ,  IMRA of America, Inc.

    Inventor： Duxin Sun ,  Hongwei Chen ,  Wei Qian ,  Yong Che ,  Masayuki Ito ,  Hayley Paholak ,  Kanokwan Sansanaphongpricha

    IPC: C08G65/48 ,  A61K47/48 ,  C08G65/334 ,  A61K41/00 ,  A61K49/00

    CPC classification number: C08G65/48 ,  A61K41/0052 ,  A61K47/50 ,  A61K47/60 ,  A61K49/0065 ,  C08G65/3344

    Abstract: The present invention relates to methods, compositions, and kits for generating conjugated gold nanoparticles. In certain embodiments, the present invention provides methods of generating unsaturated conjugated gold nanoparticles by mixing naked gold nanoparticles with a first type of attachment molecules at a molar ratio such that the attachment molecules attach to the naked gold particles at a density level below the saturation level of the naked gold particles (e.g., at a saturation level of 1-99%). In some embodiments, a second type of attachment molecules (e.g., with the opposite charge as the first type of attachment molecules) are mixed with the unsaturated conjugated gold nanoparticles to generate double-conjugated gold nanoparticles (e.g., that are zwitterionic).

    Abstract translation: 本发明涉及用于产生共轭金纳米颗粒的方法，组合物和试剂盒。 在某些实施方案中，本发明提供了通过将裸金纳米颗粒与第一类型附着分子以摩尔比混合以使得附着分子以低于饱和水平的密度水平附着于裸金颗粒的方式来产生不饱和共轭金纳米颗粒的方法 的裸金粒子（例如，在1-99％的饱和度水平）。 在一些实施方案中，将第二类型的附着分子（例如，具有相反电荷作为第一类型的附着分子）与不饱和共轭金纳米颗粒混合以产生双共轭金纳米颗粒（例如，两性离子）。

    PHOTOTHERMAL THERAPY USING MAGNETIC NANOPARTICLES
    16.
    发明申请
    PHOTOTHERMAL THERAPY USING MAGNETIC NANOPARTICLES 有权
    使用磁性纳米粒子的光热疗法

    公开(公告)号：US20150051534A1

    公开(公告)日：2015-02-19

    申请号：US14457650

    申请日：2014-08-12

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： Hongwei Chen ,  Duxin Sun

    IPC: A61K41/00 ,  A61K33/26 ,  A61N5/06

    CPC classification number: A61K41/0052 ,  A61K33/26 ,  A61N5/062 ,  A61N2005/0659 ,  A61N2005/0662

    Abstract: The present invention provides methods, systems, and devices for performing photothermal therapy (e.g., to treat cancer) using photothermal nanoparticles with a biocompatible coating surrounding a highly crystallized Fe3O4 core. In certain embodiments, the highly crystallized Fe3O4 core of the photothermal nanoparticles has an X-ray diffraction (XRD) pattern where the brightest diffraction ring is from the 440 plane. In some embodiments, the photothermal therapy is conducted with a device configured to emit electromagnetic radiation in the wavelengths between about 650 nm and 1000 nm, wherein the device further comprises a visible light source that allows a user to determine where the electromagnetic radiation is contacting a subject.

    Abstract translation: 本发明提供了使用具有围绕高度结晶的Fe 3 O 4核心的生物相容性涂层的光热纳米颗粒进行光热治疗（例如治疗癌症）的方法，系统和装置。 在某些实施方案中，光热纳米颗粒的高度结晶的Fe 3 O 4核心具有X射线衍射（XRD）图案，其中最亮的衍射环来自440平面。 在一些实施例中，光热疗法是用配置成发射大约650nm和1000nm之间的波长的电磁辐射的装置进行的，其中所述装置还包括可见光源，其允许用户确定电磁辐射在哪里接触 学科。

    Nano-satellite complexes
    18.
    发明授权
    Nano-satellite complexes 有权

    公开(公告)号：US12226491B2

    公开(公告)日：2025-02-18

    申请号：US17232751

    申请日：2021-04-16

    Applicant: The Regents of the University of Michigan

    Inventor： Duxin Sun ,  Ryan Clauson ,  Hongwei Chen ,  Chengyi Li ,  Wei Gao ,  Luke Bugada ,  Fei Wen ,  Brett Hill ,  Syed Monem Rizvi

    IPC: A61K47/69 ,  A61K9/16 ,  A61K38/19 ,  A61K39/00 ,  A61K39/295 ,  A61K39/39 ,  A61K45/06 ,  A61K47/02 ,  A61K47/64 ,  A61P35/00

    Abstract: The present invention provides, in some embodiments, methods, compositions, systems, and kits comprising nano-satellite complexes comprising: a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; 3-25 satellite particles attached to, or absorbed to, said biocompatible coating; a plurality of antigenic peptides conjugated to, or absorbed to, said satellite particles; and at least one additional property. In other embodiments, provided herein are nano-satellite complexes comprising: a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; a plurality of satellite particles attached to, or absorbed to, said biocompatible coating; a plurality of antigenic peptides conjugated to, or absorbed to, said satellite particles; and a plurality of LIGHT (TNFSF14) peptides conjugated to, or absorbed to, said satellite particles. In some embodiments, administration of the nanosatellite complexes to a subject with cancer achieves long-term cancer remission (e.g., when combined with an immune checkpoint inhibitor, such as αPD1).

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