公开(公告)号：US09896475B2

公开(公告)日：2018-02-20

申请号：US15505327

申请日：2015-08-26

Applicant: Trustees of Dartmouth College

Inventor： Gordon W. Gribble ,  Michael B. Sporn ,  Karen T. Liby ,  Evans O. Onyango ,  Martine Cao

IPC: C07J61/00

CPC classification number: C07J61/00 ,  C07D233/54 ,  C07D401/04

Abstract: Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl) imidazole and pharmaceutical compositions containing the same are provided. The present invention is a tnterpenoid compound of Formula I, or a hydrate, isomer, prodrug or pharmaceutically acceptable salt thereof: wherein one or more of R, R or R is independently a substituted or unsubstituted aryl group, heteroaryl group, cycloalkyl group or heterocyclyl group, and the remaining R groups are hydrogen. The pyridyl analogs of CD-DO-1m 1 have been developed, which are more stable in human plasma and achieve a higher concentration in target tissues such as liver, pancreas, kidney and lungs.

公开(公告)号：US09539287B2

公开(公告)日：2017-01-10

申请号：US14496488

申请日：2014-09-25

Applicant: Trustees of Dartmouth College

Inventor： Gordon W. Gribble ,  Liangfeng Fu ,  Michael B. Sporn ,  Karen T. Liby

IPC: A61K31/56 ,  C07J63/00 ,  A61K35/44 ,  C07C61/29 ,  C07C62/38 ,  C07C229/50 ,  C07C235/78 ,  C07C255/47 ,  C07C291/10 ,  C07C317/44 ,  C07C323/55 ,  A61K35/12 ,  C07C62/32 ,  C07J71/00

CPC classification number: A61K35/44 ,  A61K31/56 ,  A61K35/12 ,  C07C61/29 ,  C07C62/32 ,  C07C62/38 ,  C07C229/50 ,  C07C235/78 ,  C07C255/47 ,  C07C291/10 ,  C07C317/44 ,  C07C323/55 ,  C07C2603/52 ,  C07J63/008 ,  C07J71/0005

Abstract: The present invention provides triterpenoids produced from natural compounds such as oleanolic acid, ursolic acid, betulinic acid, and hederagenin.

Abstract translation: 本发明提供由天然化合物如齐墩果酸，熊果酸，桦木酸和雌雄agen素生产的三萜类化合物。

公开(公告)号：US10377716B2

公开(公告)日：2019-08-13

申请号：US15785193

申请日：2017-10-16

Applicant: TRUSTEES OF DARTMOUTH COLLEGE

Inventor： F. Jon Kull ,  Ronald K. Taylor ,  Gordon W. Gribble ,  Evans O. Onyango ,  Anne R. Kelley

IPC: C07D217/12 ,  C07D209/12 ,  C07D215/14 ,  A23L33/10

Abstract: Bicyclic compounds for decreasing the expression of bacterial virulence factors thereby preventing, mitigating, or treating bacterial infection are provided.

公开(公告)号：US09796679B2

公开(公告)日：2017-10-24

申请号：US15117940

申请日：2015-02-09

Applicant: Trustees of Dartmouth College

Inventor： Ronald K. Taylor ,  Gordon W. Gribble

IPC: C07D215/00 ,  C07D215/42

CPC classification number: C07D215/42

Abstract: Compounds for inhibiting Type 4 Prepilin Peptidases are provided as are methods of using the compounds as anti-bacterial agents.

公开(公告)号：US09757359B2

公开(公告)日：2017-09-12

申请号：US13886053

申请日：2013-05-02

Applicant: REATA PHARMACEUTICALS, INC. ,  TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Michael B. Sporn ,  Karen T. Liby ,  Gordon W. Gribble ,  Tadashi Honda ,  Robert M. Kral ,  Colin J. Meyer

IPC: A61K31/21 ,  A61K31/4174 ,  A61K31/275 ,  A61K31/4164 ,  A61K31/277

CPC classification number: A61K31/4174 ,  A61K31/275 ,  A61K31/277 ,  A61K31/4164 ,  A61K2300/00

Abstract: The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease using synthetic triterpenoids, optionally in combination with a second treatment or prophylaxis.

公开(公告)号：US09278913B2

公开(公告)日：2016-03-08

申请号：US14059185

申请日：2013-10-21

Applicant: TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Gordon W. Gribble ,  Tadashi Honda ,  Michael B. Sporn ,  Nanjoo Suh

IPC: C07C255/47 ,  A61K31/275 ,  A61K31/19 ,  A61K31/277 ,  A61K31/35

CPC classification number: C07C255/47 ,  A61K31/19 ,  A61K31/275 ,  A61K31/277 ,  A61K31/35

Abstract: Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.

公开(公告)号：US20150011627A1

公开(公告)日：2015-01-08

申请号：US14496488

申请日：2014-09-25

Applicant: Trustees of Dartmouth College

Inventor： Gordon W. Gribble ,  Liangfeng Fu ,  Michael B. Sporn ,  Karen T. Liby

IPC: C07C62/38 ,  C07C229/50 ,  C07C255/47 ,  C07C323/55 ,  C07C317/44 ,  C07C291/10 ,  C07C235/78

CPC classification number: A61K35/44 ,  A61K31/56 ,  A61K35/12 ,  C07C61/29 ,  C07C62/32 ,  C07C62/38 ,  C07C229/50 ,  C07C235/78 ,  C07C255/47 ,  C07C291/10 ,  C07C317/44 ,  C07C323/55 ,  C07C2603/52 ,  C07J63/008 ,  C07J71/0005

Abstract: The present invention provides triterpenoids produced from natural compounds such as oleanolic acid, ursolic acid, betulinic acid, and hederagenin.

Abstract translation: 本发明提供由天然化合物如齐墩果酸，熊果酸，桦木酸和雌雄agen素生产的三萜类化合物。

公开(公告)号：US20130122053A1

公开(公告)日：2013-05-16

申请号：US13625527

申请日：2012-09-24

Applicant: Trustees of Dartmouth College ,  Osteoscreen, Inc. ,  The Regents of the University of California ,  Rutgers, The State University of new Jersey

Inventor： Michael B. SPORN ,  Karen T. Liby ,  Tadashi Honda ,  Gregory Mundy ,  Ross Garrett ,  Hari Reddi ,  Gordon W. Gribble ,  Takahiro Niikura ,  Nanjoo Suh

IPC: A61K31/4164 ,  A61K38/18 ,  A61K35/32 ,  A61K31/277 ,  A61K9/00

CPC classification number: A61K31/4164 ,  A61K9/00 ,  A61K31/26 ,  A61K31/277 ,  A61K35/32 ,  A61K38/1841 ,  C12N5/0655 ,  C12N2501/999 ,  Y02A50/395 ,  A61K2300/00

Abstract: The present invention concerns methods for stimulating the growth and repair of bone and cartilage using synthetic triterpenoids and tricyclic-bis-enones. Examples of suitable triterpenoids include CDDO, CDDO-Me, CDDO-Im, and CDDO-Ethylamide. Examples of tricyclic-bis-enones include TBE-31 and TBE-34.

Abstract translation: 本发明涉及使用合成三萜类化合物和三环双酮来刺激骨和软骨的生长和修复的方法。 合适的三萜类化合物的实例包括CDDO，CDDO-Me，CDDO-Im和CDDO-乙酰胺。 三环双酮的实例包括TBE-31和TBE-34。

公开(公告)号：US20180029990A1

公开(公告)日：2018-02-01

申请号：US15785193

申请日：2017-10-16

Applicant: TRUSTEES OF DARTMOUTH COLLEGE

Inventor： F. Jon Kull ,  Ronald K. Taylor ,  Gordon W. Gribble ,  Evans O. Onyango ,  Anne R. Kelley

IPC: C07D217/12 ,  C07D209/12 ,  A23L33/10 ,  C07D215/14

CPC classification number: C07D217/12 ,  A23L33/10 ,  C07D209/12 ,  C07D215/14

Abstract: Bicyclic compounds for decreasing the expression of bacterial virulence factors thereby preventing, mitigating, or treating bacterial infection are provided.

公开(公告)号：US09790186B2

公开(公告)日：2017-10-17

申请号：US14837139

申请日：2015-08-27

Applicant: Trustees of Dartmouth College

Inventor： F. Jon Kull ,  Ronald K. Taylor ,  Gordon W. Gribble ,  Evans O. Onyango ,  Anne R. Kelley

IPC: C07D217/12 ,  C07D209/12 ,  C07D215/14 ,  A23L33/10

CPC classification number: C07D217/12 ,  A23L33/10 ,  C07D209/12 ,  C07D215/14

Abstract: Bicyclic compounds for decreasing the expression of bacterial virulence factors thereby preventing, mitigating, or treating bacterial infection are provided.